TACR1 (tachykinin receptor 1) - Rat Genome Database

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Gene: TACR1 (tachykinin receptor 1) Homo sapiens
Analyze
Symbol: TACR1
Name: tachykinin receptor 1
RGD ID: 731008
HGNC Page HGNC:11526
Description: Enables substance P receptor activity. Involved in positive regulation of cytosolic calcium ion concentration; positive regulation of flagellated sperm motility; and tachykinin receptor signaling pathway. Located in plasma membrane; sperm head; and sperm midpiece. Implicated in developmental disorder of mental health and exercise-induced bronchoconstriction. Biomarker of asthma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; NK1R; NKIR; SPR; substance-P receptor; TAC1R; tachykinin 1 receptor (substance P receptor, neurokinin 1 receptor); tachykinin receptor 1 (substance P receptor, neurokinin-1 receptor)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38275,046,463 - 75,199,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl275,046,463 - 75,199,520 (-)EnsemblGRCh38hg38GRCh38
GRCh37275,273,590 - 75,426,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36275,129,738 - 75,279,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 34275,189,817 - 75,337,838NCBI
Celera275,104,880 - 75,257,954 (-)NCBICelera
Cytogenetic Map2p12NCBI
HuRef275,010,440 - 75,164,411 (-)NCBIHuRef
CHM1_1275,202,888 - 75,356,007 (-)NCBICHM1_1
T2T-CHM13v2.0275,055,302 - 75,208,694 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP)
alpha-amyrin  (ISO)
ammonium chloride  (ISO)
aprepitant  (EXP,ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
Bardoxolone methyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-amyrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
capsaicin  (ISO)
capsazepine  (ISO)
casopitant  (EXP)
CGP 52608  (EXP)
clothianidin  (EXP)
cocaine  (ISO)
CP-96345(1+)  (ISO)
cyclophosphamide  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
dobutamine  (EXP)
dydrogesterone  (ISO)
ethylparaben  (EXP)
famotidine  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (ISO)
gentamycin  (ISO)
hydrogen chloride  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
Mecamylamine  (ISO)
methyllycaconitine  (ISO)
morphine  (ISO)
nicotine  (ISO)
nitroprusside  (ISO)
omeprazole  (ISO)
phenyl biguanide  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sodium arsenite  (ISO)
sodium cyanide  (ISO)
sucrose  (ISO)
suramin  (ISO)
taurine  (EXP)
testosterone  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aggressive behavior  (IEA,ISO)
angiotensin-mediated drinking behavior  (IEA,ISO)
associative learning  (IEA,ISO)
behavioral response to pain  (IEA,ISO)
detection of abiotic stimulus  (TAS)
eating behavior  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA)
inflammatory response  (TAS)
learning or memory  (IEA,ISO)
long-term memory  (IEA,ISO)
operant conditioning  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (TAS)
positive regulation of action potential  (IEA,ISO)
positive regulation of blood pressure  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IDA,IEA,ISO)
positive regulation of epithelial cell migration  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of flagellated sperm motility  (IBA,IMP)
positive regulation of hormone secretion  (IEA,ISO)
positive regulation of leukocyte migration  (IEA,ISO)
positive regulation of lymphocyte proliferation  (IEA,ISO)
positive regulation of ossification  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of synaptic transmission, cholinergic  (IEA,ISO)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO)
positive regulation of uterine smooth muscle contraction  (IEA,ISO)
positive regulation of vascular permeability  (IEA,ISO)
positive regulation of vasoconstriction  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of smooth muscle cell migration  (IEA,ISO)
regulation of smooth muscle cell proliferation  (IEA,ISO)
regulation of uterine smooth muscle contraction  (IEA)
response to auditory stimulus  (IEA,ISO)
response to electrical stimulus  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to hormone  (IEA,ISO)
response to nicotine  (IEA,ISO)
response to ozone  (IEA,ISO)
response to pain  (IEA)
response to progesterone  (IEA,ISO)
signal transduction  (IEA)
smooth muscle contraction involved in micturition  (IEA,ISO)
sperm ejaculation  (IEA,ISO)
tachykinin receptor signaling pathway  (IDA,IEA,IMP,TAS)

Cellular Component
cell body  (IEA,ISO)
cell periphery  (IEA)
cell surface  (IEA,ISO)
dendrite  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,TAS)
postsynaptic membrane  (IEA)
sperm flagellum  (IDA)
sperm head  (IDA)
sperm midpiece  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. Adcock IM, etal., J Mol Endocrinol. 1993 Aug;11(1):1-7.
2. Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction. Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6.
3. Substance P receptor blockade decreases stretch-induced lung cytokines and lung injury in rats. Bregeon F, etal., J Physiol. 2010 Apr 15;588(Pt 8):1309-19. Epub 2010 Feb 22.
4. Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2. Camargo EA, etal., Pancreas. 2008 Jul;37(1):50-5.
5. Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats. Chen CY, etal., J Neurosci. 2009 Mar 4;29(9):2754-61.
6. Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension. Chen MJ and Lai YL, Toxicol Appl Pharmacol. 2003 Mar 15;187(3):178-85.
7. Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation. De Swert KO, etal., Respir Res. 2009 May 15;10:37.
8. A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury. Dib M, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L687-97. Epub 2009 Jul 24.
9. Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. Evangelista S, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19.
10. Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. Hegde A, etal., J Leukoc Biol. 2007 Sep;82(3):678-85. Epub 2007 Jun 12.
11. LIF upregulates expression of NK-1R in NHBE cells. Hu CP, etal., Mediators Inflamm. 2006;2006(5):84829.
12. A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients. Ichinose M, etal., Am J Respir Crit Care Med. 1996 Mar;153(3):936-41.
13. Neurokinin-1 receptor mediates stress-exacerbated allergic airway inflammation and airway hyperresponsiveness in mice. Joachim RA, etal., Psychosom Med. 2004 Jul-Aug;66(4):564-71.
14. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Karagiannides I, etal., Endocrinology. 2011 Jun;152(6):2197-205. Epub 2011 Apr 5.
15. Substance P is involved in the cutaneous blood flow increase response to sympathetic nerve stimulation in persistently inflamed rats. Koeda T, etal., J Physiol Sci. 2007 Dec;57(6):361-6. Epub 2007 Dec 4.
16. The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Lau HY and Bhatia M, J Pathol. 2006 Feb;208(3):364-71.
17. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure. Li PC, etal., Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L912-20. Epub 2008 Mar 7.
18. [The relationship between leukemia inhibitory factor and neurokinin receptors in a rat model of asthma]. Lin MJ, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2005 Dec;28(12):820-4.
19. Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK(1) receptors. Linares-Fernandez BE and Alfieri AB, J Urol. 2007 Apr;177(4):1531-6.
20. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
21. Estrogen determines sex differences in airway responsiveness after allergen exposure. Matsubara S, etal., Am J Respir Cell Mol Biol. 2008 May;38(5):501-8. Epub 2007 Dec 6.
22. Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. McKay LC and Feldman JL, Am J Respir Crit Care Med. 2008 Jul 1;178(1):89-95. Epub 2008 Apr 17.
23. NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin. Pacharinsak C, etal., Pain. 2008 Sep 30;139(1):34-46. Epub 2008 Apr 14.
24. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Piedimonte G, etal., Am J Physiol. 1999 Oct;277(4 Pt 1):L831-40.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. [Role of neurokinin-1 receptor in lung injury in rats with acute necrotizing pancreatitis]. Shi X, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Jul;15(7):422-5.
29. Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. Sio SW, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):36-46. Epub 2009 Oct 1.
30. The neuropeptide substance P is a critical mediator of burn-induced acute lung injury. Sio SW, etal., J Immunol. 2008 Jun 15;180(12):8333-41.
31. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Wang Y, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1517-23. Epub 2008 Mar 12.
32. [Expression of substance P receptor mRNA in nasal mucosa of rat in allergic rhinitis model]. Xue J, etal., Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Aug;35(4):247-50.
33. Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. Zhang X, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R2084-96. Epub 2008 Oct 22.
Additional References at PubMed
PMID:1280161   PMID:1281469   PMID:1310144   PMID:1312928   PMID:1374227   PMID:1657150   PMID:1659396   PMID:1718267   PMID:1723045   PMID:1883349   PMID:2548782   PMID:7692486  
PMID:7782081   PMID:8384323   PMID:8702757   PMID:8985172   PMID:9537323   PMID:9733503   PMID:9754802   PMID:10611312   PMID:10854844   PMID:11698023   PMID:11786503   PMID:11857684  
PMID:11864635   PMID:11906947   PMID:11950831   PMID:12067742   PMID:12130725   PMID:12147210   PMID:12151774   PMID:12383866   PMID:12393913   PMID:12427486   PMID:12477932   PMID:12528114  
PMID:12548712   PMID:12594338   PMID:12686752   PMID:12716968   PMID:12727971   PMID:12752772   PMID:12810079   PMID:14601651   PMID:15130944   PMID:15452121   PMID:15452552   PMID:15489334  
PMID:15590676   PMID:15664664   PMID:15690122   PMID:16123103   PMID:16154193   PMID:16305827   PMID:16344560   PMID:16618119   PMID:16670094   PMID:16675550   PMID:16754659   PMID:16815618  
PMID:16893949   PMID:16901764   PMID:17023511   PMID:17050807   PMID:17370082   PMID:17437961   PMID:17443717   PMID:17448763   PMID:17525212   PMID:17563389   PMID:17602742   PMID:17667845  
PMID:17713785   PMID:17986524   PMID:18085301   PMID:18095097   PMID:18180429   PMID:18187929   PMID:18203813   PMID:18289674   PMID:18363037   PMID:18394729   PMID:18452185   PMID:18572194  
PMID:18713853   PMID:18835556   PMID:19036058   PMID:19086053   PMID:19204064   PMID:19207952   PMID:19222484   PMID:19351798   PMID:19545476   PMID:19553914   PMID:19805509   PMID:19885583  
PMID:19903051   PMID:20008142   PMID:20021265   PMID:20074437   PMID:20117843   PMID:20137858   PMID:20160043   PMID:20173430   PMID:20237496   PMID:20379614   PMID:20398908   PMID:20468064  
PMID:20940324   PMID:21034671   PMID:21091716   PMID:21120581   PMID:21188466   PMID:21478256   PMID:21577011   PMID:21873635   PMID:21925840   PMID:21969570   PMID:22057425   PMID:22115773  
PMID:22225860   PMID:22554585   PMID:22733436   PMID:23024816   PMID:23078527   PMID:23142211   PMID:23166329   PMID:23235155   PMID:23257919   PMID:23345604   PMID:23420374   PMID:23471985  
PMID:23553861   PMID:23582152   PMID:23597562   PMID:23754948   PMID:23807418   PMID:23827863   PMID:23916293   PMID:23933301   PMID:23979140   PMID:24030979   PMID:24155873   PMID:24190675  
PMID:24412605   PMID:24548567   PMID:24552486   PMID:24817687   PMID:24831006   PMID:24898255   PMID:25130457   PMID:25204428   PMID:25659767   PMID:25684939   PMID:25783846   PMID:25786041  
PMID:25817575   PMID:25841180   PMID:26012530   PMID:26371842   PMID:26516161   PMID:26673553   PMID:26817501   PMID:26981525   PMID:27146034   PMID:27456549   PMID:27458061   PMID:27501920  
PMID:27835606   PMID:28030866   PMID:28154998   PMID:28291261   PMID:28341744   PMID:28460633   PMID:28500728   PMID:28514442   PMID:28566424   PMID:28774868   PMID:28871952   PMID:28931039  
PMID:29061788   PMID:29331576   PMID:29430989   PMID:30019968   PMID:30301182   PMID:30334298   PMID:30502362   PMID:30538204   PMID:30576949   PMID:30582709   PMID:30604743   PMID:30684188  
PMID:30903649   PMID:31109645   PMID:31579977   PMID:32067964   PMID:32266968   PMID:32296183   PMID:32380077   PMID:32471973   PMID:32600668   PMID:33099677   PMID:33248147   PMID:33640716  
PMID:33961781   PMID:34395609   PMID:34692834   PMID:34773642   PMID:35013118   PMID:35049682   PMID:35434136   PMID:35600049   PMID:35726575   PMID:36001730   PMID:36629320   PMID:36651605  
PMID:37013432   PMID:37408182   PMID:37454559   PMID:39265714  


Genomics

Comparative Map Data
TACR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38275,046,463 - 75,199,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl275,046,463 - 75,199,520 (-)EnsemblGRCh38hg38GRCh38
GRCh37275,273,590 - 75,426,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36275,129,738 - 75,279,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 34275,189,817 - 75,337,838NCBI
Celera275,104,880 - 75,257,954 (-)NCBICelera
Cytogenetic Map2p12NCBI
HuRef275,010,440 - 75,164,411 (-)NCBIHuRef
CHM1_1275,202,888 - 75,356,007 (-)NCBICHM1_1
T2T-CHM13v2.0275,055,302 - 75,208,694 (-)NCBIT2T-CHM13v2.0
Tacr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,378,990 - 82,537,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,379,315 - 82,537,085 (+)EnsemblGRCm39 Ensembl
GRCm38682,402,003 - 82,560,104 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,402,334 - 82,560,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,352,469 - 82,510,098 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,368,133 - 82,525,757 (+)NCBIMGSCv36mm8
Celera684,384,420 - 84,542,486 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Tacr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,478,617 - 116,647,492 (+)NCBIGRCr8
mRatBN7.24114,920,844 - 115,089,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4114,920,844 - 115,089,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4120,383,645 - 120,552,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,158,843 - 116,327,453 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04114,778,790 - 114,948,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,247,236 - 113,416,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,247,795 - 113,414,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04177,926,094 - 178,095,041 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44116,610,595 - 116,780,394 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14116,855,058 - 117,024,964 (+)NCBI
Celera4103,918,032 - 104,086,347 (+)NCBICelera
Cytogenetic Map4q34NCBI
Tacr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,614,340 - 10,761,872 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542410,614,340 - 10,761,872 (+)NCBIChiLan1.0ChiLan1.0
TACR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,188,457 - 51,344,443 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,191,211 - 51,347,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A75,111,339 - 75,267,320 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,614,478 - 76,771,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,614,478 - 76,771,018 (-)Ensemblpanpan1.1panPan2
TACR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,038,010 - 48,178,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,038,010 - 48,178,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1747,681,510 - 47,821,826 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01748,900,538 - 49,041,473 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1748,899,743 - 49,044,192 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11747,916,025 - 48,056,577 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01747,980,726 - 48,121,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,542,868 - 48,683,479 (+)NCBIUU_Cfam_GSD_1.0
Tacr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,315,839 - 9,471,281 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,266,613 - 1,421,275 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,266,621 - 1,421,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TACR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl367,839,411 - 68,021,724 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1367,839,367 - 68,021,733 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TACR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,080,319 - 32,236,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,083,615 - 32,233,596 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,940,541 - 80,098,197 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tacr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,243,640 - 28,455,086 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,243,667 - 28,455,012 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TACR1
38 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001058.3(TACR1):c.585-32031G>C single nucleotide variant Lung cancer [RCV000092314] Chr2:75085786 [GRCh38]
Chr2:75312913 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.3(TACR1):c.130G>A (p.Val44Met) single nucleotide variant Malignant melanoma [RCV000065689] Chr2:75198805 [GRCh38]
Chr2:75425931 [GRCh37]
Chr2:75279439 [NCBI36]
Chr2:2p12		 not provided
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2		 pathogenic
GRCh38/hg38 2p13.1-12(chr2:74432069-75181627)x3 copy number gain See cases [RCV000136651] Chr2:74432069..75181627 [GRCh38]
Chr2:74659196..75408753 [GRCh37]
Chr2:74512704..75262261 [NCBI36]
Chr2:2p13.1-12		 likely benign|uncertain significance
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p13.1-12(chr2:74375779-75517520)x1 copy number loss See cases [RCV000143456] Chr2:74375779..75517520 [GRCh38]
Chr2:74602906..75744646 [GRCh37]
Chr2:74456414..75598154 [NCBI36]
Chr2:2p13.1-12		 likely pathogenic
GRCh37/hg19 2p12(chr2:75185398-75314020)x3 copy number gain not provided [RCV000753024] Chr2:75185398..75314020 [GRCh37]
Chr2:2p12		 benign
GRCh37/hg19 2p12(chr2:75265687-77573171)x3 copy number gain See cases [RCV000449198] Chr2:75265687..77573171 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p12(chr2:75276316-75374390)x1 copy number loss See cases [RCV000447676] Chr2:75276316..75374390 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p13.1-11.2(chr2:74365484-89129064)x1 copy number loss See cases [RCV000510763] Chr2:74365484..89129064 [GRCh37]
Chr2:2p13.1-11.2		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_001058.4(TACR1):c.563C>T (p.Pro188Leu) single nucleotide variant not specified [RCV004281901] Chr2:75120595 [GRCh38]
Chr2:75347721 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.703C>T (p.Arg235Cys) single nucleotide variant not specified [RCV004281948] Chr2:75053637 [GRCh38]
Chr2:75280764 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p12(chr2:75132410-75348185)x3 copy number gain not provided [RCV000682034] Chr2:75132410..75348185 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p12(chr2:75185910-76183197)x3 copy number gain not provided [RCV000682112] Chr2:75185910..76183197 [GRCh37]
Chr2:2p12		 uncertain significance
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3		 likely pathogenic
GRCh37/hg19 2p13.1-11.2(chr2:74527522-89125488)x1 copy number loss not provided [RCV000682167] Chr2:74527522..89125488 [GRCh37]
Chr2:2p13.1-11.2		 pathogenic
Single allele duplication not provided [RCV000677942] Chr2:63671346..85698002 [GRCh37]
Chr2:2p15-11.2		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p12(chr2:75363423-75374043)x1 copy number loss not provided [RCV000753025] Chr2:75363423..75374043 [GRCh37]
Chr2:2p12		 benign
GRCh37/hg19 2p12(chr2:75170336-75314020)x3 copy number gain not provided [RCV000753023] Chr2:75170336..75314020 [GRCh37]
Chr2:2p12		 benign
GRCh37/hg19 2p12(chr2:75374043-75389492)x1 copy number loss not provided [RCV000753026] Chr2:75374043..75389492 [GRCh37]
Chr2:2p12		 benign
GRCh37/hg19 2p12(chr2:75050732-75307296)x1 copy number loss not provided [RCV000753020] Chr2:75050732..75307296 [GRCh37]
Chr2:2p12		 benign
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p13.1-12(chr2:74972080-83043893)x1 copy number loss not provided [RCV000846568] Chr2:74972080..83043893 [GRCh37]
Chr2:2p13.1-12		 pathogenic
GRCh37/hg19 2p13.1-12(chr2:74928349-77095981)x3 copy number gain not provided [RCV000849780] Chr2:74928349..77095981 [GRCh37]
Chr2:2p13.1-12		 uncertain significance
GRCh37/hg19 2p13.1-12(chr2:74895347-75829809)x3 copy number gain not provided [RCV000849901] Chr2:74895347..75829809 [GRCh37]
Chr2:2p13.1-12		 uncertain significance
NM_001058.4(TACR1):c.564G>A (p.Pro188=) single nucleotide variant not provided [RCV000935205] Chr2:75120594 [GRCh38]
Chr2:75347720 [GRCh37]
Chr2:2p12		 likely benign
GRCh37/hg19 2p13.1-12(chr2:74825161-75308974)x3 copy number gain not provided [RCV001260150] Chr2:74825161..75308974 [GRCh37]
Chr2:2p13.1-12		 likely benign
GRCh37/hg19 2p13.1-12(chr2:74780969-75444113)x3 copy number gain not provided [RCV001260151] Chr2:74780969..75444113 [GRCh37]
Chr2:2p13.1-12		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p12(chr2:75265687-77573171) copy number gain not specified [RCV002053161] Chr2:75265687..77573171 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
NM_001058.4(TACR1):c.540C>G (p.Cys180Trp) single nucleotide variant not specified [RCV004111944] Chr2:75120618 [GRCh38]
Chr2:75347744 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p12(chr2:75042935-75308974)x1 copy number loss not provided [RCV002475710] Chr2:75042935..75308974 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.512C>G (p.Thr171Arg) single nucleotide variant not specified [RCV004187615] Chr2:75120646 [GRCh38]
Chr2:75347772 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.304C>G (p.Leu102Val) single nucleotide variant not specified [RCV004187927] Chr2:75198631 [GRCh38]
Chr2:75425757 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.933G>T (p.Arg311Ser) single nucleotide variant not specified [RCV004155730] Chr2:75049723 [GRCh38]
Chr2:75276850 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.451A>C (p.Ile151Leu) single nucleotide variant not specified [RCV004160961] Chr2:75120707 [GRCh38]
Chr2:75347833 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.719T>C (p.Val240Ala) single nucleotide variant not specified [RCV004213748] Chr2:75053621 [GRCh38]
Chr2:75280748 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.581A>G (p.Lys194Arg) single nucleotide variant not specified [RCV004177564] Chr2:75120577 [GRCh38]
Chr2:75347703 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.1019G>A (p.Arg340Gln) single nucleotide variant not specified [RCV004329093] Chr2:75049637 [GRCh38]
Chr2:75276764 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.1057C>T (p.Arg353Cys) single nucleotide variant not specified [RCV004269243] Chr2:75049599 [GRCh38]
Chr2:75276726 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p13.1-12(chr2:73716761-75347894)x1 copy number loss not provided [RCV003223078] Chr2:73716761..75347894 [GRCh37]
Chr2:2p13.1-12		 uncertain significance
NM_001058.4(TACR1):c.118A>G (p.Thr40Ala) single nucleotide variant not specified [RCV004354491] Chr2:75198817 [GRCh38]
Chr2:75425943 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.1049A>C (p.Lys350Thr) single nucleotide variant not specified [RCV004353096] Chr2:75049607 [GRCh38]
Chr2:75276734 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.1105C>A (p.Pro369Thr) single nucleotide variant not specified [RCV004352377] Chr2:75049551 [GRCh38]
Chr2:75276678 [GRCh37]
Chr2:2p12		 uncertain significance
GRCh37/hg19 2p13.3-12(chr2:71076472-76368354)x1 copy number loss not specified [RCV003986388] Chr2:71076472..76368354 [GRCh37]
Chr2:2p13.3-12		 likely pathogenic
NM_001058.4(TACR1):c.771C>T (p.Phe257=) single nucleotide variant TACR1-related disorder [RCV003977129] Chr2:75051412 [GRCh38]
Chr2:75278539 [GRCh37]
Chr2:2p12		 likely benign
NM_001058.4(TACR1):c.1134G>A (p.Ser378=) single nucleotide variant TACR1-related disorder [RCV003981873] Chr2:75049522 [GRCh38]
Chr2:75276649 [GRCh37]
Chr2:2p12		 benign
NM_001058.4(TACR1):c.604G>C (p.Val202Leu) single nucleotide variant not specified [RCV004466252] Chr2:75053736 [GRCh38]
Chr2:75280863 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.1060C>A (p.Leu354Met) single nucleotide variant not specified [RCV004466251] Chr2:75049596 [GRCh38]
Chr2:75276723 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.978C>G (p.Ile326Met) single nucleotide variant not specified [RCV004466254] Chr2:75049678 [GRCh38]
Chr2:75276805 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.68A>G (p.Asn23Ser) single nucleotide variant not specified [RCV004466253] Chr2:75198867 [GRCh38]
Chr2:75425993 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.380C>T (p.Ala127Val) single nucleotide variant not specified [RCV004671066] Chr2:75198555 [GRCh38]
Chr2:75425681 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.757G>A (p.Val253Met) single nucleotide variant TACR1-related disorder [RCV004759179] Chr2:75051426 [GRCh38]
Chr2:75278553 [GRCh37]
Chr2:2p12		 likely benign
NM_001058.4(TACR1):c.652G>A (p.Val218Ile) single nucleotide variant not specified [RCV004874107] Chr2:75053688 [GRCh38]
Chr2:75280815 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.313T>G (p.Cys105Gly) single nucleotide variant not specified [RCV004874112] Chr2:75198622 [GRCh38]
Chr2:75425748 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.1030A>C (p.Thr344Pro) single nucleotide variant not specified [RCV004874113] Chr2:75049626 [GRCh38]
Chr2:75276753 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.938G>T (p.Arg313Leu) single nucleotide variant not specified [RCV004874114] Chr2:75049718 [GRCh38]
Chr2:75276845 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.1115G>T (p.Gly372Val) single nucleotide variant not specified [RCV004874115] Chr2:75049541 [GRCh38]
Chr2:75276668 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.796A>C (p.Ile266Leu) single nucleotide variant not specified [RCV004874109] Chr2:75051387 [GRCh38]
Chr2:75278514 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.653T>C (p.Val218Ala) single nucleotide variant not specified [RCV004874111] Chr2:75053687 [GRCh38]
Chr2:75280814 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.664A>T (p.Thr222Ser) single nucleotide variant not specified [RCV004874110] Chr2:75053676 [GRCh38]
Chr2:75280803 [GRCh37]
Chr2:2p12		 uncertain significance
NM_001058.4(TACR1):c.985G>A (p.Gly329Ser) single nucleotide variant not specified [RCV004874108] Chr2:75049671 [GRCh38]
Chr2:75276798 [GRCh37]
Chr2:2p12		 uncertain significance
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR519Bhsa-miR-519b-3pOncomiRDBexternal_infoNANA22981979

Predicted Target Of
Summary Value
Count of predictions:1308
Count of miRNA genes:799
Interacting mature miRNAs:911
Transcripts:ENST00000305249, ENST00000409848, ENST00000497764
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597063591GWAS1159665_Hbody weight QTL GWAS1159665 (human)0.000003body mass (VT:0001259)body weight (CMO:0000012)27504894975048950Human
597161413GWAS1257487_Hnucleotide measurement QTL GWAS1257487 (human)0.000003nucleotide metabolism trait (VT:0003806)27511806975118070Human
597247291GWAS1343365_Hbipolar disorder, sex interaction measurement QTL GWAS1343365 (human)0.000005bipolar disorder, sex interaction measurement27513089975130900Human
596954097GWAS1073616_Halcohol consumption measurement QTL GWAS1073616 (human)0.000008alcohol consumption measurement27513027675130277Human
597251279GWAS1347353_Hescherichia seropositivity QTL GWAS1347353 (human)1e-08escherichia seropositivity27509257575092576Human
407159011GWAS807987_Hgut microbiome measurement QTL GWAS807987 (human)0.000004gut microbiome measurement27515558475155585Human
597191808GWAS1287882_Hbirth weight, pelvic organ prolapse QTL GWAS1287882 (human)0.000006birth weight, pelvic organ prolapseneonatal body weight (CMO:0002079)27517433875174339Human
597162108GWAS1258182_Hcarbohydrate measurement QTL GWAS1258182 (human)0.000004carbohydrate measurement27511399975114000Human
597332407GWAS1428481_HR-6-hydroxywarfarin measurement QTL GWAS1428481 (human)0.000002R-6-hydroxywarfarin measurement27504984275049843Human
597443297GWAS1539371_H4-ethylphenylsulfate measurement QTL GWAS1539371 (human)0.00000064-ethylphenylsulfate measurement27518895775188958Human
597024362GWAS1120436_Hpursuit maintenance gain measurement QTL GWAS1120436 (human)0.000002pursuit maintenance gain measurement27516579675165797Human

Markers in Region
D2S286  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,342,133 - 75,342,276UniSTSGRCh37
GRCh37275,342,191 - 75,342,430UniSTSGRCh37
Build 36275,195,641 - 75,195,784RGDNCBI36
Celera275,173,415 - 75,173,550RGD
Celera275,173,473 - 75,173,706UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map2p13UniSTS
HuRef275,079,552 - 75,079,687UniSTS
HuRef275,079,610 - 75,079,843UniSTS
Marshfield Genetic Map294.05UniSTS
Marshfield Genetic Map294.05RGD
Genethon Genetic Map298.4UniSTS
TNG Radiation Hybrid Map246234.0UniSTS
deCODE Assembly Map299.99UniSTS
GeneMap99-GB4 RH Map2235.97UniSTS
Whitehead-RH Map2322.6UniSTS
Whitehead-YAC Contig Map2 UniSTS
GeneMap99-G3 RH Map23161.0UniSTS
SHGC-12520  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,278,183 - 75,278,366UniSTSGRCh37
Build 36275,131,691 - 75,131,874RGDNCBI36
Celera275,109,473 - 75,109,656RGD
Cytogenetic Map2p12UniSTS
HuRef275,015,033 - 75,015,216UniSTS
GeneMap99-G3 RH Map23161.0UniSTS
RH69174  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,276,308 - 75,276,468UniSTSGRCh37
Build 36275,129,816 - 75,129,976RGDNCBI36
Celera275,107,598 - 75,107,758RGD
Cytogenetic Map2p12UniSTS
HuRef275,013,158 - 75,013,318UniSTS
GeneMap99-GB4 RH Map2222.62UniSTS
WI-18908  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,276,353 - 75,276,499UniSTSGRCh37
Build 36275,129,861 - 75,130,007RGDNCBI36
Celera275,107,643 - 75,107,789RGD
Cytogenetic Map2p12UniSTS
HuRef275,013,203 - 75,013,349UniSTS
GeneMap99-GB4 RH Map2235.77UniSTS
Whitehead-RH Map2323.5UniSTS
SHGC-30537  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,273,610 - 75,273,737UniSTSGRCh37
Build 36275,127,118 - 75,127,245RGDNCBI36
Celera275,104,900 - 75,105,027RGD
Cytogenetic Map2p12UniSTS
HuRef275,010,460 - 75,010,587UniSTS
TNG Radiation Hybrid Map246581.0UniSTS
Stanford-G3 RH Map23262.0UniSTS
GeneMap99-GB4 RH Map2233.33UniSTS
Whitehead-RH Map2322.1UniSTS
GeneMap99-G3 RH Map23173.0UniSTS
G43577  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,392,945 - 75,393,094UniSTSGRCh37
Build 36275,246,453 - 75,246,602RGDNCBI36
Celera275,224,252 - 75,224,401RGD
Cytogenetic Map2p12UniSTS
HuRef275,130,707 - 75,130,856UniSTS
G59805  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,392,969 - 75,393,078UniSTSGRCh37
Build 36275,246,477 - 75,246,586RGDNCBI36
Celera275,224,276 - 75,224,385RGD
Cytogenetic Map2p12UniSTS
HuRef275,130,731 - 75,130,840UniSTS
TNG Radiation Hybrid Map246219.0UniSTS
G60248  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,276,371 - 75,276,496UniSTSGRCh37
Build 36275,129,879 - 75,130,004RGDNCBI36
Celera275,107,661 - 75,107,786RGD
Cytogenetic Map2p12UniSTS
HuRef275,013,221 - 75,013,346UniSTS
TNG Radiation Hybrid Map246610.0UniSTS
SHGC-12799  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,276,232 - 75,276,555UniSTSGRCh37
Build 36275,129,740 - 75,130,063RGDNCBI36
Celera275,107,522 - 75,107,845RGD
Cytogenetic Map2p12UniSTS
HuRef275,013,082 - 75,013,405UniSTS
TNG Radiation Hybrid Map246607.0UniSTS
GeneMap99-GB4 RH Map2222.69UniSTS
Whitehead-RH Map2310.0UniSTS
Whitehead-YAC Contig Map2 UniSTS
GeneMap99-G3 RH Map23161.0UniSTS
SHGC-37085  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,403,002 - 75,403,134UniSTSGRCh37
Build 36275,256,510 - 75,256,642RGDNCBI36
Celera275,234,309 - 75,234,441RGD
Cytogenetic Map2p12UniSTS
HuRef275,140,764 - 75,140,896UniSTS
TNG Radiation Hybrid Map246208.0UniSTS
Stanford-G3 RH Map23250.0UniSTS
GeneMap99-G3 RH Map23161.0UniSTS
G31043  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,372,063 - 75,372,211UniSTSGRCh37
Build 36275,225,571 - 75,225,719RGDNCBI36
Celera275,203,365 - 75,203,513RGD
Cytogenetic Map2p12UniSTS
HuRef275,109,508 - 75,109,656UniSTS
STS-T91312  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,402,932 - 75,403,133UniSTSGRCh37
Build 36275,256,440 - 75,256,641RGDNCBI36
Celera275,234,239 - 75,234,440RGD
Cytogenetic Map2p12UniSTS
HuRef275,140,694 - 75,140,895UniSTS
A008C01  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,275,068 - 75,275,225UniSTSGRCh37
Build 36275,128,576 - 75,128,733RGDNCBI36
Celera275,106,358 - 75,106,515RGD
Cytogenetic Map2p12UniSTS
HuRef275,011,918 - 75,012,075UniSTS
GeneMap99-GB4 RH Map2232.65UniSTS
D2S286  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2p12UniSTS
TNG Radiation Hybrid Map246234.0UniSTS
GeneMap99-G3 RH Map23161.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2312 2782 2177 4729 1579 2131 3 497 1405 338 2193 6429 5856 18 3558 794 1666 1527 168

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW206679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY462098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB203452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000305249   ⟹   ENSP00000303522
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl275,046,463 - 75,199,520 (-)Ensembl
Ensembl Acc Id: ENST00000409848   ⟹   ENSP00000386448
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl275,051,036 - 75,199,057 (-)Ensembl
Ensembl Acc Id: ENST00000497764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl275,118,807 - 75,120,766 (-)Ensembl
RefSeq Acc Id: NM_001058   ⟹   NP_001049
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38275,046,463 - 75,199,520 (-)NCBI
GRCh37275,273,590 - 75,426,645 (-)ENTREZGENE
Build 36275,129,738 - 75,279,781 (-)NCBI Archive
HuRef275,010,440 - 75,164,411 (-)ENTREZGENE
CHM1_1275,202,888 - 75,356,007 (-)NCBI
T2T-CHM13v2.0275,055,302 - 75,208,694 (-)NCBI
Sequence:
RefSeq Acc Id: NM_015727   ⟹   NP_056542
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38275,051,036 - 75,199,520 (-)NCBI
GRCh37275,273,590 - 75,426,645 (-)ENTREZGENE
Build 36275,131,671 - 75,279,691 (-)NCBI Archive
HuRef275,010,440 - 75,164,411 (-)ENTREZGENE
CHM1_1275,207,461 - 75,356,007 (-)NCBI
T2T-CHM13v2.0275,059,875 - 75,208,694 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001049   ⟸   NM_001058
- Peptide Label: isoform long
- UniProtKB: A8K150 (UniProtKB/Swiss-Prot),   P25103 (UniProtKB/Swiss-Prot),   Q4VBL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_056542   ⟸   NM_015727
- Peptide Label: isoform short
- UniProtKB: P25103 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000386448   ⟸   ENST00000409848
Ensembl Acc Id: ENSP00000303522   ⟸   ENST00000305249
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25103-F1-model_v2 AlphaFold P25103 1-407 view protein structure

Promoters
RGD ID:6860814
Promoter ID:EPDNEW_H3572
Type:initiation region
Name:TACR1_1
Description:tachykinin receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3573  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38275,199,519 - 75,199,579EPDNEW
RGD ID:6798296
Promoter ID:HG_KWN:33378
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000409848,   OTTHUMT00000252239
Position:
Human AssemblyChrPosition (strand)Source
Build 36275,279,826 - 75,280,326 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11526 AgrOrtholog
COSMIC TACR1 COSMIC
Ensembl Genes ENSG00000115353 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000305249 ENTREZGENE
  ENST00000305249.10 UniProtKB/Swiss-Prot
  ENST00000409848 ENTREZGENE
  ENST00000409848.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000115353 GTEx
HGNC ID HGNC:11526 ENTREZGENE
Human Proteome Map TACR1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurokn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NK1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6869 UniProtKB/Swiss-Prot
NCBI Gene 6869 ENTREZGENE
OMIM 162323 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBSTANCE-P RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36302 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROKININ1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K150 ENTREZGENE
  NK1R_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q4VBL8 ENTREZGENE, UniProtKB/TrEMBL
  Q53TQ2_HUMAN UniProtKB/TrEMBL
  Q53TR1_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K150 UniProtKB/Swiss-Prot