CALCA (calcitonin related polypeptide alpha) - Rat Genome Database

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Gene: CALCA (calcitonin related polypeptide alpha) Homo sapiens
Analyze
Symbol: CALCA
Name: calcitonin related polypeptide alpha
RGD ID: 730992
HGNC Page HGNC:1437
Description: Enables calcitonin receptor binding activity; hormone activity; and identical protein binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of macromolecule metabolic process; and regulation of myeloid leukocyte differentiation. Acts upstream of or within negative regulation of blood pressure and nervous system process involved in regulation of systemic arterial blood pressure. Located in cytoplasm. Is active in extracellular space. Implicated in migraine and osteoporosis. Biomarker of COVID-19 and pyelonephritis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alpha-type CGRP; CALC1; calcitonin; calcitonin 1; calcitonin gene-related peptide 1; calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT; katacalcin; KC; MGC126648; PCT
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,966,668 - 14,972,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,966,622 - 14,972,354 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,988,214 - 14,993,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,944,792 - 14,950,408 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,946,625 - 14,950,427NCBI
Celera1115,115,335 - 15,120,952 (-)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,671,857 - 14,677,473 (-)NCBIHuRef
CHM1_11114,987,226 - 14,992,843 (-)NCBICHM1_1
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-methylcatechol  (ISO)
5-azacytidine  (EXP)
6-oxoprostaglandin F1alpha  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
allyl isothiocyanate  (ISO)
amiloride  (ISO)
aminoguanidine  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Anetholtrithion  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
ATP  (ISO)
atropine  (ISO)
Azoxymethane  (ISO)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
bethanechol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
Botulinum toxin type A  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium atom  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP,ISO)
carbon dioxide  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
chelerythrine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt atom  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
corn oil  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
disodium cromoglycate  (ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
eletriptan  (ISO)
entinostat  (EXP)
epothilone B  (ISO)
ergotamine  (ISO)
ethanol  (ISO)
etoposide  (EXP)
Evodiamine  (ISO)
fentanyl  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
fructose  (EXP,ISO)
Gallopamil  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Ginkgolide A  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
glyphosate  (ISO)
GR 127935  (ISO)
haloperidol  (ISO)
histamine  (ISO)
hydrogen chloride  (ISO)
ibuprofen  (ISO)
ICI 118551  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
ionomycin  (EXP,ISO)
isoflurane  (EXP)
isoprenaline  (ISO)
KT 5720  (ISO)
Lafutidine  (EXP,ISO)
lead diacetate  (ISO)
lidocaine  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
lycopene  (ISO)
magnesium atom  (ISO)
melatonin  (ISO)
methimazole  (ISO)
methylene blue  (ISO)
methylmercury chloride  (EXP)
methysergide  (ISO)
Mibefradil  (ISO)
morphine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (ISO)
nefopam  (ISO)
nimodipine  (ISO)
nitrendipine  (ISO)
nitrofen  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (ISO)
nizatidine  (EXP)
NONOate(1-)  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
pemirolast  (ISO)
phenol  (ISO)
Phenoxybenzamine  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
procaine  (ISO)
progesterone  (ISO)
propanal  (EXP)
propranolol  (ISO)
prostaglandin E2  (ISO)
ranitidine  (EXP)
rebaudioside A  (EXP)
resiniferatoxin  (ISO)
resveratrol  (ISO)
Rizatriptan benzoate  (ISO)
rofecoxib  (ISO)
ruthenium red  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
safranal  (ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
serotonin  (ISO)
sevoflurane  (EXP)
silicon carbide  (ISO)
silicon dioxide  (EXP,ISO)
sodium chloride  (ISO)
Soman  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulprostone  (ISO)
sumatriptan  (EXP,ISO)
suramin  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topiramate  (ISO)
trichostatin A  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tryptanthrine  (EXP)
Tungsten carbide  (EXP)
UTP  (ISO)
valproic acid  (EXP)
verapamil  (EXP)
veratridine  (ISO)
vorinostat  (EXP)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IDA,ISO)
activation of protein kinase activity  (IDA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA,ISO)
amylin receptor 1 signaling pathway  (IDA)
amylin receptor 2 signaling pathway  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA)
artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure  (ISO)
calcitonin family receptor signaling pathway  (IDA,IEA)
calcitonin gene-related peptide receptor signaling pathway  (IDA)
cell adhesion  (ISO)
cell-cell signaling  (TAS)
cellular response to nerve growth factor stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
embryo implantation  (IDA)
endothelial cell migration  (IDA)
endothelial cell proliferation  (IDA)
feeding behavior  (ISO)
G protein-coupled receptor internalization  (IDA)
inflammatory response  (ISO)
innate immune response  (IDA)
intracellular calcium ion homeostasis  (ISO)
leukocyte cell-cell adhesion  (IDA)
monocyte chemotaxis  (IDA)
negative regulation of blood pressure  (IDA,IEA,ISO)
negative regulation of bone resorption  (IDA)
negative regulation of calcium ion transport into cytosol  (IDA)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of ossification  (ISO)
negative regulation of osteoclast differentiation  (IDA)
negative regulation of smooth muscle contraction  (IEA,ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (IDA)
neuropeptide signaling pathway  (ISO)
ossification  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of cell adhesion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of interleukin-1 alpha production  (IDA)
positive regulation of interleukin-8 production  (IDA)
positive regulation of macrophage differentiation  (IDA)
protein phosphorylation  (IDA)
receptor internalization  (IDA)
regulation of blood pressure  (NAS)
regulation of cytosolic calcium ion concentration  (IBA,IDA)
response to heat  (ISO)
response to pain  (ISO)
smooth muscle contraction  (ISO)
vasculature development  (IDA)
vasodilation  (IDA,IEA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. Abdelmagid N, etal., PLoS Pathog. 2012;8(6):e1002753. doi: 10.1371/journal.ppat.1002753. Epub 2012 Jun 28.
2. Pattern of distribution of calcitonin gene-related Peptide in the dorsal root ganglion of animal models of diabetes mellitus. Adeghate E, etal., Ann N Y Acad Sci. 2006 Nov;1084:296-303.
3. Altered calcitonin gene in a young patient with osteoporosis. Alevizaki M, etal., BMJ 1989 May 6;298(6682):1215-6.
4. The calcitonin/calcitonin gene related peptide-alpha gene is not required for 1alpha,25-dihydroxyvitamin D3-mediated suppression of experimental autoimmune encephalomyelitis. Becklund BR, etal., Arch Biochem Biophys. 2009 Aug 15;488(2):105-8. Epub 2009 Jun 27.
5. Role of calcitonin gene-related peptide in hypertension-induced renal damage. Bowers MC, etal., Hypertension. 2005 Jul;46(1):51-7. Epub 2005 May 31.
6. Nerve Growth Factor Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes. Cheng HT, etal., J Neuropathol Exp Neurol. 2009 Oct 7.
7. Intranasal Calcitonin Gene-Related Peptide Protects Against Focal Cerebral Ischemic Injury in Rats Through the Wnt/β-Catenin Pathway. Du Z, etal., Med Sci Monit. 2018 Dec 7;24:8860-8869. doi: 10.12659/MSM.913777.
8. The protective effects of calcitonin gene-related peptide on gastric mucosa injury after cerebral ischemia reperfusion in rats. Feng G, etal., Regul Pept. 2010 Feb 25;160(1-3):121-8. Epub 2009 Nov 10.
9. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
10. Anti-inflammatory effects of limb ischaemic preconditioning are mediated by sensory nerve activation in rats. Hartmann P, etal., Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb;383(2):179-89. Epub 2010 Dec 23.
11. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
12. Serum procalcitonin and C-reactive protein concentrations to distinguish mildly infected from non-infected diabetic foot ulcers: a pilot study. Jeandrot A, etal., Diabetologia. 2008 Feb;51(2):347-52. Epub 2007 Oct 13.
13. BDNF and CGRP interaction: implications in migraine susceptibility. Lemos C, etal., Cephalalgia. 2010 Nov;30(11):1375-82. Epub 2010 May 10.
14. Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. Lin YT, etal., J Neuroinflammation. 2011 Sep 30;8:126. doi: 10.1186/1742-2094-8-126.
15. Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion. Liu Z, etal., Regul Pept. 2011 Nov 10;171(1-3):19-25. Epub 2011 Jun 28.
16. Association study of calcitonin gene-related polypeptide-alpha (CALCA) gene polymorphism with migraine. Menon S, etal., Brain Res. 2011 Mar 10;1378:119-24. Epub 2010 Dec 31.
17. Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats. Mizutani A, etal., Anesthesiology. 2009 Feb;110(2):361-9. doi: 10.1097/ALN.0b013e3181942f3c.
18. Neuropeptides in the rat corpus cavernosum and seminal vesicle: effects of age and two types of diabetes. Morrison JF, etal., Auton Neurosci. 2009 Mar 12;146(1-2):76-80. Epub 2009 Jan 17.
19. Procalcitonin: a marker of severity of acute pyelonephritis among children. Pecile P, etal., Pediatrics. 2004 Aug;114(2):e249-54.
20. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Qiu H, etal., Lancet Infect Dis. 2020 Jun;20(6):689-696. doi: 10.1016/S1473-3099(20)30198-5. Epub 2020 Mar 25.
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Calcitonin gene-related peptide expression levels predict motor neuron vulnerability in the superoxide dismutase 1-G93A mouse model of amyotrophic lateral sclerosis. Ringer C, etal., Neurobiol Dis. 2012 Jan;45(1):547-54. Epub 2011 Sep 21.
23. Protective effects and anti-inflammatory pathways of exogenous calcitonin gene-related peptide in severe necrotizing pancreatitis. Schneider L, etal., Pancreatology. 2009;9(5):662-9. Epub 2009 Aug 14.
24. Calcitonin gene-related peptide protects against hypertension-induced heart and kidney damage. Supowit SC, etal., Hypertension. 2005 Jan;45(1):109-14. Epub 2004 Dec 6.
25. Clinical features and treatment of COVID-19 patients in northeast Chongqing. Wan S, etal., J Med Virol. 2020 Jul;92(7):797-806. doi: 10.1002/jmv.25783. Epub 2020 Apr 1.
26. Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. Yan Y, etal., BMJ Open Diabetes Res Care. 2020 Apr;8(1). pii: 8/1/e001343. doi: 10.1136/bmjdrc-2020-001343.
27. Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine. Zhang Y, etal., J Headache Pain. 2020 Jun 10;21(1):72. doi: 10.1186/s10194-020-01145-y.
Additional References at PubMed
PMID:1318039   PMID:1326102   PMID:1761559   PMID:1988044   PMID:2001366   PMID:2039456   PMID:2408883   PMID:2571128   PMID:2578663   PMID:2673764   PMID:2983422   PMID:3001670  
PMID:3034287   PMID:3259294   PMID:3266556   PMID:3485540   PMID:3492492   PMID:3549095   PMID:3872459   PMID:5760861   PMID:6132180   PMID:6148938   PMID:6327497   PMID:6546550  
PMID:6609312   PMID:6610687   PMID:8078488   PMID:8405394   PMID:8468047   PMID:8626685   PMID:8940110   PMID:9620797   PMID:9685362   PMID:10642343   PMID:10754330   PMID:10822112  
PMID:10882736   PMID:11014233   PMID:11185743   PMID:11317366   PMID:11337490   PMID:11389975   PMID:11803621   PMID:12036966   PMID:12063634   PMID:12198603   PMID:12213903   PMID:12220731  
PMID:12231407   PMID:12234182   PMID:12359227   PMID:12369791   PMID:12446725   PMID:12477932   PMID:12517415   PMID:12529288   PMID:12540523   PMID:12590613   PMID:12594852   PMID:12728303  
PMID:12871824   PMID:12917321   PMID:14586070   PMID:14627864   PMID:14654229   PMID:14668209   PMID:14684361   PMID:14722252   PMID:14745805   PMID:14759258   PMID:14984255   PMID:15155765  
PMID:15168342   PMID:15203218   PMID:15248232   PMID:15300632   PMID:15319367   PMID:15449935   PMID:15489334   PMID:15621724   PMID:15696922   PMID:15761041   PMID:15761654   PMID:15784626  
PMID:15880427   PMID:16014619   PMID:16236878   PMID:16386179   PMID:16439457   PMID:16511394   PMID:16531504   PMID:16574742   PMID:16597919   PMID:16611736   PMID:16710309   PMID:16712930  
PMID:16720289   PMID:16840549   PMID:16890288   PMID:16904178   PMID:16996466   PMID:17026622   PMID:17038199   PMID:17087112   PMID:17101796   PMID:17123735   PMID:17149558   PMID:17207965  
PMID:17241109   PMID:17251226   PMID:17267696   PMID:17381353   PMID:17441790   PMID:17481780   PMID:17485015   PMID:17535749   PMID:17552872   PMID:17558349   PMID:17669797   PMID:17676478  
PMID:17689535   PMID:17710246   PMID:17785463   PMID:17941085   PMID:17983652   PMID:18000879   PMID:18039931   PMID:18057382   PMID:18167349   PMID:18180663   PMID:18197882   PMID:18211417  
PMID:18240029   PMID:18295515   PMID:18384419   PMID:18403669   PMID:18525431   PMID:18556380   PMID:18574663   PMID:18577758   PMID:18603306   PMID:18626012   PMID:18779512   PMID:18784182  
PMID:18941191   PMID:18953261   PMID:18959118   PMID:19078972   PMID:19086053   PMID:19236383   PMID:19282810   PMID:19299090   PMID:19440016   PMID:19447044   PMID:19453261   PMID:19484659  
PMID:19485922   PMID:19541012   PMID:19541585   PMID:19543500   PMID:19589278   PMID:19623026   PMID:19685709   PMID:19715516   PMID:19736013   PMID:19797133   PMID:19829249   PMID:19909213  
PMID:19913121   PMID:20010500   PMID:20046084   PMID:20131075   PMID:20143189   PMID:20146868   PMID:20146986   PMID:20173430   PMID:20214413   PMID:20233513   PMID:20375903   PMID:20441469  
PMID:20530033   PMID:20595156   PMID:20596610   PMID:20628086   PMID:20654671   PMID:20654748   PMID:20699253   PMID:20803037   PMID:20805714   PMID:20832068   PMID:20890583   PMID:20929576  
PMID:20930646   PMID:21078153   PMID:21083886   PMID:21211657   PMID:21216873   PMID:21219690   PMID:21289592   PMID:21352816   PMID:21391919   PMID:21423046   PMID:21457239   PMID:21541027  
PMID:21550738   PMID:21658317   PMID:21703310   PMID:21778801   PMID:21843355   PMID:21873635   PMID:21937947   PMID:21996233   PMID:22019953   PMID:22074408   PMID:22079264   PMID:22149667  
PMID:22200484   PMID:22207498   PMID:22208649   PMID:22233274   PMID:22371911   PMID:22399852   PMID:22429353   PMID:22550867   PMID:22561677   PMID:22573121   PMID:22607374   PMID:22631226  
PMID:22652631   PMID:22677443   PMID:22685586   PMID:22819536   PMID:22898635   PMID:22960196   PMID:22961239   PMID:23010746   PMID:23086568   PMID:23118979   PMID:23123709   PMID:23128457  
PMID:23214280   PMID:23237777   PMID:23313519   PMID:23327335   PMID:23356193   PMID:23395606   PMID:23436675   PMID:23461295   PMID:23490535   PMID:23510625   PMID:23519568   PMID:23552643  
PMID:23575548   PMID:23580106   PMID:23597562   PMID:23682219   PMID:23682226   PMID:23702052   PMID:23708553   PMID:23722301   PMID:23731651   PMID:23787145   PMID:23799041   PMID:23813138  
PMID:23835994   PMID:23968948   PMID:23975872   PMID:24012914   PMID:24065474   PMID:24081951   PMID:24120103   PMID:24125506   PMID:24135723   PMID:24140435   PMID:24254894   PMID:24315546  
PMID:24320627   PMID:24349237   PMID:24363525   PMID:24379064   PMID:24393388   PMID:24439927   PMID:24440185   PMID:24522762   PMID:24612487   PMID:24640865   PMID:24672147   PMID:24673487  
PMID:24685732   PMID:24798190   PMID:24853718   PMID:24858965   PMID:24877114   PMID:24908181   PMID:24943060   PMID:24991721   PMID:25015815   PMID:25034373   PMID:25035980   PMID:25055485  
PMID:25132401   PMID:25135735   PMID:25152987   PMID:25159654   PMID:25194863   PMID:25208829   PMID:25218831   PMID:25273597   PMID:25283849   PMID:25288608   PMID:25293477   PMID:25298068  
PMID:25319702   PMID:25319789   PMID:25370803   PMID:25436308   PMID:25445228   PMID:25469944   PMID:25561281   PMID:25575698   PMID:25578228   PMID:25578529   PMID:25638513   PMID:25691533  
PMID:25697203   PMID:25750561   PMID:25872263   PMID:25923821   PMID:25926728   PMID:25963492   PMID:25975456   PMID:25982244   PMID:25992537   PMID:25997247   PMID:26018813   PMID:26040439  
PMID:26046926   PMID:26096246   PMID:26175307   PMID:26188130   PMID:26191294   PMID:26271020   PMID:26339947   PMID:26377840   PMID:26472337   PMID:26481456   PMID:26482503   PMID:26495299  
PMID:26596282   PMID:26636517   PMID:26644355   PMID:26666342   PMID:26748496   PMID:26933799   PMID:26986140   PMID:27002098   PMID:27012052   PMID:27035229   PMID:27096761   PMID:27124563  
PMID:27157798   PMID:27197849   PMID:27203410   PMID:27288020   PMID:27382274   PMID:27497681   PMID:27553072   PMID:27553639   PMID:27597981   PMID:27752903   PMID:27762068   PMID:27805517  
PMID:27805529   PMID:27884320   PMID:27922893   PMID:27940880   PMID:28005932   PMID:28010128   PMID:28125806   PMID:28164563   PMID:28166595   PMID:28182347   PMID:28255555   PMID:28266954  
PMID:28272093   PMID:28358790   PMID:28387421   PMID:28429221   PMID:28431586   PMID:28454850   PMID:28550906   PMID:28572046   PMID:28691801   PMID:28706425   PMID:28736121   PMID:28777420  
PMID:28817088   PMID:28851219   PMID:28884411   PMID:28898742   PMID:28904199   PMID:28918433   PMID:28920169   PMID:29091592   PMID:29111402   PMID:29148033   PMID:29153041   PMID:29169190  
PMID:29179592   PMID:29226635   PMID:29305753   PMID:29382396   PMID:29427369   PMID:29446357   PMID:29479870   PMID:29479871   PMID:29480416   PMID:29567889   PMID:29635700   PMID:29687858  
PMID:29707993   PMID:29723719   PMID:29745819   PMID:29804483   PMID:29891911   PMID:29967770   PMID:30143494   PMID:30205824   PMID:30209400   PMID:30245756   PMID:30256701   PMID:30262140  
PMID:30268671   PMID:30274796   PMID:30332466   PMID:30415778   PMID:30583086   PMID:30595763   PMID:30700848   PMID:31013271   PMID:31014225   PMID:31018157   PMID:31036824   PMID:31178365  
PMID:31238099   PMID:31307162   PMID:31324271   PMID:31358829   PMID:31420921   PMID:31441843   PMID:31469126   PMID:31559719   PMID:31692350   PMID:31732153   PMID:31821331   PMID:31841042  
PMID:31894031   PMID:31969379   PMID:31974673   PMID:31994614   PMID:32076108   PMID:32093657   PMID:32103345   PMID:32141647   PMID:32196744   PMID:32286239   PMID:32296183   PMID:32425062  
PMID:32425063   PMID:32433223   PMID:32572710   PMID:32666766   PMID:32679129   PMID:32920797   PMID:32952850   PMID:32966166   PMID:32996054   PMID:33029089   PMID:33067662   PMID:33086087  
PMID:33145348   PMID:33149301   PMID:33220639   PMID:33275269   PMID:33322922   PMID:33345630   PMID:33402576   PMID:33479472   PMID:33550165   PMID:33602864   PMID:33730732   PMID:33757513  
PMID:33893251   PMID:33961781   PMID:34018843   PMID:34101898   PMID:34136020   PMID:34151489   PMID:34162572   PMID:34163006   PMID:34275653   PMID:34519193   PMID:34702217   PMID:34721303  
PMID:34853395   PMID:34871241   PMID:34958058   PMID:35115501   PMID:35280443   PMID:35324283   PMID:35743990   PMID:35757476   PMID:35781017   PMID:35922609   PMID:36222615   PMID:36430285  
PMID:36705344   PMID:36883206   PMID:36883492   PMID:36949711   PMID:37013432   PMID:37443709   PMID:37569575   PMID:37714688   PMID:37777916   PMID:37852938   PMID:38164981   PMID:38193350  
PMID:38256423   PMID:38308939   PMID:38423011   PMID:38447930   PMID:38501491   PMID:38522929   PMID:38583945   PMID:38603770   PMID:38627623   PMID:38750917  


Genomics

Comparative Map Data
CALCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,966,668 - 14,972,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,966,622 - 14,972,354 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,988,214 - 14,993,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,944,792 - 14,950,408 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,946,625 - 14,950,427NCBI
Celera1115,115,335 - 15,120,952 (-)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,671,857 - 14,677,473 (-)NCBIHuRef
CHM1_11114,987,226 - 14,992,843 (-)NCBICHM1_1
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBIT2T-CHM13v2.0
Calca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397114,225,223 - 114,236,145 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7114,230,713 - 114,235,592 (-)EnsemblGRCm39 Ensembl
GRCm387114,625,981 - 114,636,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7114,631,478 - 114,636,357 (-)EnsemblGRCm38mm10GRCm38
MGSCv377121,774,992 - 121,779,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367114,422,640 - 114,427,439 (-)NCBIMGSCv36mm8
Celera7114,584,937 - 114,589,792 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.99NCBI
Calca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,312,636 - 178,317,588 (-)NCBIGRCr8
mRatBN7.21168,878,212 - 168,883,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,878,214 - 168,883,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,192,440 - 177,197,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,378,496 - 184,383,399 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,090,892 - 177,095,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,184,018 - 184,188,922 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,184,020 - 184,188,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,158,061 - 191,162,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,686,168 - 172,691,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,824,299 - 172,827,127 (-)NCBI
Celera1166,711,610 - 166,716,491 (-)NCBICelera
RH 3.4 Map11317.6RGD
RH 2.0 Map1757.3RGD
Cytogenetic Map1q34NCBI
CALCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,335,385 - 17,340,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,296,273 - 17,300,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,055,897 - 15,061,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,745,588 - 14,751,267 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,745,588 - 14,751,267 (-)Ensemblpanpan1.1panPan2
CRSP-3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12137,676,841 - 37,680,643 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2137,676,841 - 37,680,645 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2137,176,307 - 37,180,108 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02138,770,713 - 38,774,520 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2138,770,713 - 38,774,522 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02137,993,320 - 37,997,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02138,281,026 - 38,284,825 (+)NCBIUU_Cfam_GSD_1.0
Calca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494747,766,690 - 47,772,207 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365283,800,577 - 3,805,004 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365283,800,801 - 3,806,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1244,043,135 - 44,048,651 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2247,248,414 - 47,253,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103239768
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1149,946,574 - 49,956,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl149,951,694 - 49,954,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038147,447,203 - 147,453,110 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,766,185 - 6,768,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247666,764,388 - 6,771,396 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CALCA
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001033953.3(CALCA):c.228-215= single nucleotide variant Calcitonin polymorphism [RCV000019204] Chr11:14968069 [GRCh38]
Chr11:14989615 [GRCh37]
Chr11:11p15.2		 benign
GRCh38/hg38 11p15.2(chr11:14924804-15253488)x3 copy number gain See cases [RCV000051696] Chr11:14924804..15253488 [GRCh38]
Chr11:14991411..15275034 [GRCh37]
Chr11:14902926..15231610 [NCBI36]
Chr11:11p15.2		 uncertain significance
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13		 pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1		 pathogenic
GRCh38/hg38 11p15.2(chr11:14619894-15179026)x3 copy number gain See cases [RCV000135655] Chr11:14619894..15179026 [GRCh38]
Chr11:14641440..15200572 [GRCh37]
Chr11:14598016..15157148 [NCBI36]
Chr11:11p15.2		 uncertain significance
GRCh38/hg38 11p15.4-15.2(chr11:9989516-16825806)x1 copy number loss See cases [RCV000136773] Chr11:9989516..16825806 [GRCh38]
Chr11:10011063..16847353 [GRCh37]
Chr11:9967639..16803929 [NCBI36]
Chr11:11p15.4-15.2		 pathogenic
GRCh38/hg38 11p15.2(chr11:14914381-15240180)x3 copy number gain See cases [RCV000140067] Chr11:14914381..15240180 [GRCh38]
Chr11:14935927..15261726 [GRCh37]
Chr11:14892503..15218302 [NCBI36]
Chr11:11p15.2		 likely benign
GRCh38/hg38 11p15.2(chr11:14684722-15210307)x3 copy number gain See cases [RCV000142263] Chr11:14684722..15210307 [GRCh38]
Chr11:14706268..15231853 [GRCh37]
Chr11:14662844..15188429 [NCBI36]
Chr11:11p15.2		 uncertain significance
GRCh37/hg19 11p15.2(chr11:14924646-15279421)x3 copy number gain See cases [RCV000448423] Chr11:14924646..15279421 [GRCh37]
Chr11:11p15.2		 uncertain significance
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.2(chr11:14460052-15556068)x3 copy number gain See cases [RCV000510874] Chr11:14460052..15556068 [GRCh37]
Chr11:11p15.2		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001741.3(CALCA):c.334G>T (p.Gly112Trp) single nucleotide variant not specified [RCV004313308] Chr11:14968891 [GRCh38]
Chr11:14990437 [GRCh37]
Chr11:11p15.2		 uncertain significance
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3		 pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001741.3(CALCA):c.318C>T (p.Phe106=) single nucleotide variant not provided [RCV000967193] Chr11:14968907 [GRCh38]
Chr11:14990453 [GRCh37]
Chr11:11p15.2		 benign
NM_001741.3(CALCA):c.378G>A (p.Leu126=) single nucleotide variant not provided [RCV000947328] Chr11:14968847 [GRCh38]
Chr11:14990393 [GRCh37]
Chr11:11p15.2		 benign
GRCh37/hg19 11p15.2-14.1(chr11:13970757-27565888)x3 copy number gain not provided [RCV001006388] Chr11:13970757..27565888 [GRCh37]
Chr11:11p15.2-14.1		 pathogenic
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p15.2(chr11:14938595-15277484)x3 copy number gain not provided [RCV001006389] Chr11:14938595..15277484 [GRCh37]
Chr11:11p15.2		 uncertain significance
GRCh37/hg19 11p15.3-13(chr11:11053978-34732891)x3 copy number gain not provided [RCV001006387] Chr11:11053978..34732891 [GRCh37]
Chr11:11p15.3-13		 pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11p15.5-14.2(chr11:230615-26881146)x3 copy number gain See cases [RCV002286351] Chr11:230615..26881146 [GRCh37]
Chr11:11p15.5-14.2		 pathogenic
NM_001741.3(CALCA):c.31G>A (p.Ala11Thr) single nucleotide variant not specified [RCV004086272] Chr11:14971162 [GRCh38]
Chr11:14992708 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001741.3(CALCA):c.122C>T (p.Thr41Met) single nucleotide variant not specified [RCV004188690] Chr11:14970040 [GRCh38]
Chr11:14991586 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001033953.3(CALCA):c.277C>T (p.Arg93Trp) single nucleotide variant not specified [RCV004196359] Chr11:14967805 [GRCh38]
Chr11:14989351 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001033953.3(CALCA):c.272C>A (p.Thr91Asn) single nucleotide variant not specified [RCV004280507] Chr11:14967810 [GRCh38]
Chr11:14989356 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001033953.3(CALCA):c.375C>A (p.Asp125Glu) single nucleotide variant not specified [RCV004353183] Chr11:14967707 [GRCh38]
Chr11:14989253 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001033953.3(CALCA):c.278G>A (p.Arg93Gln) single nucleotide variant not specified [RCV004434487] Chr11:14967804 [GRCh38]
Chr11:14989350 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001741.3(CALCA):c.52T>A (p.Leu18Met) single nucleotide variant not specified [RCV004434489] Chr11:14971141 [GRCh38]
Chr11:14992687 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001033953.3(CALCA):c.367C>T (p.Arg123Cys) single nucleotide variant not specified [RCV004434488] Chr11:14967715 [GRCh38]
Chr11:14989261 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001033953.3(CALCA):c.353C>T (p.Ala118Val) single nucleotide variant not specified [RCV004895386] Chr11:14967729 [GRCh38]
Chr11:14989275 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001741.3(CALCA):c.409C>A (p.Pro137Thr) single nucleotide variant not specified [RCV004895387] Chr11:14968816 [GRCh38]
Chr11:14990362 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001741.3(CALCA):c.50T>C (p.Leu17Pro) single nucleotide variant not specified [RCV004892611] Chr11:14971143 [GRCh38]
Chr11:14992689 [GRCh37]
Chr11:11p15.2		 uncertain significance
NM_001741.3(CALCA):c.106C>A (p.Pro36Thr) single nucleotide variant not specified [RCV004895385] Chr11:14970056 [GRCh38]
Chr11:14991602 [GRCh37]
Chr11:11p15.2		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1769
Count of miRNA genes:791
Interacting mature miRNAs:914
Transcripts:ENST00000331587, ENST00000359642, ENST00000361010, ENST00000396372, ENST00000469608, ENST00000486207, ENST00000494746
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576345LVC1_HLeft ventricular contractility QTL 1 (human)3.93Left ventricular contractility11797076733970767Human
2289313BW388_HBody weight QTL 388 (human)1.570.00356Body fat amountabdominal11443467130434671Human
1559107SCL32_HSerum cholesterol level QTL 32 (human)3.27Lipid levelLDL cholesterol11289243028892430Human
597297906GWAS1393980_HBMI-adjusted hip circumference QTL GWAS1393980 (human)5e-09BMI-adjusted hip circumferencehip circumference (CMO:0000014)111496996514969966Human
1559113SCL31_HSerum cholesterol level QTL 31 (human)3.72Lipid levelLDL cholesterol11289243028892430Human

Markers in Region
G42969  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,989,010 - 14,989,227UniSTSGRCh37
Build 361114,945,586 - 14,945,803RGDNCBI36
Celera1115,116,130 - 15,116,347RGD
Cytogenetic Map11p15.2UniSTS
HuRef1114,672,652 - 14,672,869UniSTS
GDB:197828  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,994,867 - 14,995,291UniSTSGRCh37
Build 361114,951,443 - 14,951,867RGDNCBI36
Celera1115,121,987 - 15,122,411RGD
Cytogenetic Map11p15.2UniSTS
HuRef1114,678,508 - 14,678,932UniSTS
D11S4427  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,990,064 - 14,990,338UniSTSGRCh37
Build 361114,946,640 - 14,946,914RGDNCBI36
Celera1115,117,184 - 15,117,458RGD
Cytogenetic Map11p15.2UniSTS
HuRef1114,673,706 - 14,673,980UniSTS
Stanford-G3 RH Map11567.0UniSTS
Whitehead-YAC Contig Map11 UniSTS
NCBI RH Map11114.8UniSTS
GeneMap99-G3 RH Map11567.0UniSTS
STS-X15943  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,988,203 - 14,988,389UniSTSGRCh37
Build 361114,944,779 - 14,944,965RGDNCBI36
Celera1115,115,323 - 15,115,509RGD
Cytogenetic Map11p15.2UniSTS
HuRef1114,671,845 - 14,672,031UniSTS
GeneMap99-GB4 RH Map1164.81UniSTS
CALCA_3026  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,989,987 - 14,990,573UniSTSGRCh37
Build 361114,946,563 - 14,947,149RGDNCBI36
Celera1115,117,107 - 15,117,693RGD
HuRef1114,673,629 - 14,674,215UniSTS
G06648  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,988,588 - 14,989,371UniSTSGRCh37
Celera1115,115,708 - 15,116,491UniSTS
Cytogenetic Map11p15.2UniSTS
HuRef1114,672,230 - 14,673,013UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
886 1777 1843 1905 3245 1514 2044 556 788 417 1205 4966 4323 18 2835 1 641 1355 1365 142 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_015960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_125898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_166196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054369928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054369929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A15601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB259617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF447272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF942024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX094781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB048118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD612754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ080435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ080436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB571423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB571425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB571427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FO082042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000331587   ⟹   ENSP00000331746
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,968,501 - 14,972,351 (-)Ensembl
Ensembl Acc Id: ENST00000361010   ⟹   ENSP00000354286
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,966,669 - 14,972,286 (-)Ensembl
Ensembl Acc Id: ENST00000396372   ⟹   ENSP00000379657
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,968,706 - 14,972,273 (-)Ensembl
Ensembl Acc Id: ENST00000469608   ⟹   ENSP00000420618
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,967,040 - 14,972,272 (-)Ensembl
Ensembl Acc Id: ENST00000486207   ⟹   ENSP00000417833
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,966,668 - 14,972,351 (-)Ensembl
Ensembl Acc Id: ENST00000494746
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,966,671 - 14,970,016 (-)Ensembl
Ensembl Acc Id: ENST00000706042   ⟹   ENSP00000516203
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,966,622 - 14,972,354 (-)Ensembl
Ensembl Acc Id: ENST00000706043   ⟹   ENSP00000516204
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1114,967,682 - 14,972,347 (-)Ensembl
RefSeq Acc Id: NM_001033952   ⟹   NP_001029124
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,968,501 - 14,972,351 (-)NCBI
GRCh371114,988,214 - 14,993,879 (-)NCBI
Build 361114,946,623 - 14,950,408 (-)NCBI Archive
HuRef1114,671,857 - 14,677,473 (-)ENTREZGENE
CHM1_11114,989,058 - 14,992,843 (-)NCBI
T2T-CHM13v2.01115,064,858 - 15,068,708 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001033953   ⟹   NP_001029125
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,966,668 - 14,972,351 (-)NCBI
GRCh371114,988,214 - 14,993,879 (-)NCBI
Build 361114,944,792 - 14,950,408 (-)NCBI Archive
HuRef1114,671,857 - 14,677,473 (-)ENTREZGENE
CHM1_11114,987,226 - 14,992,843 (-)NCBI
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001378949   ⟹   NP_001365878
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,968,501 - 14,972,351 (-)NCBI
T2T-CHM13v2.01115,064,858 - 15,068,708 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001378950   ⟹   NP_001365879
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,966,668 - 14,972,351 (-)NCBI
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001741   ⟹   NP_001732
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,968,501 - 14,972,351 (-)NCBI
GRCh371114,988,214 - 14,993,879 (-)NCBI
Build 361114,946,623 - 14,950,408 (-)NCBI Archive
HuRef1114,671,857 - 14,677,473 (-)ENTREZGENE
CHM1_11114,989,058 - 14,992,843 (-)NCBI
T2T-CHM13v2.01115,064,858 - 15,068,708 (-)NCBI
Sequence:
RefSeq Acc Id: NR_125898
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,966,668 - 14,972,351 (-)NCBI
CHM1_11114,987,226 - 14,992,843 (-)NCBI
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBI
Sequence:
RefSeq Acc Id: NR_166196
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,966,668 - 14,972,351 (-)NCBI
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054369928   ⟹   XP_054225903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBI
RefSeq Acc Id: XM_054369929   ⟹   XP_054225904
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001029124 (Get FASTA)   NCBI Sequence Viewer  
  NP_001029125 (Get FASTA)   NCBI Sequence Viewer  
  NP_001365878 (Get FASTA)   NCBI Sequence Viewer  
  NP_001365879 (Get FASTA)   NCBI Sequence Viewer  
  NP_001732 (Get FASTA)   NCBI Sequence Viewer  
  XP_054225903 (Get FASTA)   NCBI Sequence Viewer  
  XP_054225904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35501 (Get FASTA)   NCBI Sequence Viewer  
  AAA51912 (Get FASTA)   NCBI Sequence Viewer  
  AAA52011 (Get FASTA)   NCBI Sequence Viewer  
  AAA52012 (Get FASTA)   NCBI Sequence Viewer  
  AAA52124 (Get FASTA)   NCBI Sequence Viewer  
  AAA58403 (Get FASTA)   NCBI Sequence Viewer  
  AAH69684 (Get FASTA)   NCBI Sequence Viewer  
  AAH69704 (Get FASTA)   NCBI Sequence Viewer  
  AAH69760 (Get FASTA)   NCBI Sequence Viewer  
  AAH69778 (Get FASTA)   NCBI Sequence Viewer  
  AAH93753 (Get FASTA)   NCBI Sequence Viewer  
  AAI01600 (Get FASTA)   NCBI Sequence Viewer  
  AAI43563 (Get FASTA)   NCBI Sequence Viewer  
  AAY68212 (Get FASTA)   NCBI Sequence Viewer  
  AAY68213 (Get FASTA)   NCBI Sequence Viewer  
  BAF51579 (Get FASTA)   NCBI Sequence Viewer  
  CAA01243 (Get FASTA)   NCBI Sequence Viewer  
  CAA25103 (Get FASTA)   NCBI Sequence Viewer  
  CAA26189 (Get FASTA)   NCBI Sequence Viewer  
  CAA26190 (Get FASTA)   NCBI Sequence Viewer  
  CAA27299 (Get FASTA)   NCBI Sequence Viewer  
  CAA34070 (Get FASTA)   NCBI Sequence Viewer  
  CAR95129 (Get FASTA)   NCBI Sequence Viewer  
  CAR95130 (Get FASTA)   NCBI Sequence Viewer  
  CAR95131 (Get FASTA)   NCBI Sequence Viewer  
  EAW68468 (Get FASTA)   NCBI Sequence Viewer  
  EAW68469 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000331746
  ENSP00000331746.4
  ENSP00000379657
  ENSP00000379657.2
  ENSP00000417833
  ENSP00000417833.1
  ENSP00000420618.1
  ENSP00000516203
  ENSP00000516203.1
  ENSP00000516204.1
GenBank Protein P01258 (Get FASTA)   NCBI Sequence Viewer  
  P06881 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001029125   ⟸   NM_001033953
- Peptide Label: isoform alpha-CGRP preproprotein
- UniProtKB: Q93048 (UniProtKB/Swiss-Prot),   Q9UCP0 (UniProtKB/Swiss-Prot),   P06881 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001732   ⟸   NM_001741
- Peptide Label: isoform CT preproprotein
- UniProtKB: Q13937 (UniProtKB/Swiss-Prot),   Q13935 (UniProtKB/Swiss-Prot),   B7ZL39 (UniProtKB/Swiss-Prot),   Q52LX7 (UniProtKB/Swiss-Prot),   P01258 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001029124   ⟸   NM_001033952
- Peptide Label: isoform CT preproprotein
- UniProtKB: Q13937 (UniProtKB/Swiss-Prot),   Q13935 (UniProtKB/Swiss-Prot),   B7ZL39 (UniProtKB/Swiss-Prot),   Q52LX7 (UniProtKB/Swiss-Prot),   P01258 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001365879   ⟸   NM_001378950
- Peptide Label: isoform alpha-CGRP preproprotein
- UniProtKB: Q93048 (UniProtKB/Swiss-Prot),   P06881 (UniProtKB/Swiss-Prot),   Q9UCP0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001365878   ⟸   NM_001378949
- Peptide Label: isoform CT preproprotein
- UniProtKB: Q13937 (UniProtKB/Swiss-Prot),   Q13935 (UniProtKB/Swiss-Prot),   P01258 (UniProtKB/Swiss-Prot),   B7ZL39 (UniProtKB/Swiss-Prot),   Q52LX7 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSP00000331746   ⟸   ENST00000331587
Ensembl Acc Id: ENSP00000354286   ⟸   ENST00000361010
Ensembl Acc Id: ENSP00000420618   ⟸   ENST00000469608
Ensembl Acc Id: ENSP00000417833   ⟸   ENST00000486207
Ensembl Acc Id: ENSP00000379657   ⟸   ENST00000396372
Ensembl Acc Id: ENSP00000516203   ⟸   ENST00000706042
Ensembl Acc Id: ENSP00000516204   ⟸   ENST00000706043
RefSeq Acc Id: XP_054225903   ⟸   XM_054369928
- Peptide Label: isoform X1
- UniProtKB: Q13937 (UniProtKB/Swiss-Prot),   Q13935 (UniProtKB/Swiss-Prot),   P01258 (UniProtKB/Swiss-Prot),   B7ZL39 (UniProtKB/Swiss-Prot),   Q52LX7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054225904   ⟸   XM_054369929
- Peptide Label: isoform X1
- UniProtKB: Q13937 (UniProtKB/Swiss-Prot),   Q13935 (UniProtKB/Swiss-Prot),   P01258 (UniProtKB/Swiss-Prot),   B7ZL39 (UniProtKB/Swiss-Prot),   Q52LX7 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01258-F1-model_v2 AlphaFold P01258 1-141 view protein structure

Promoters
RGD ID:6849986
Promoter ID:EP29004
Type:single initiation site
Name:HS_CALCA
Description:Calcitonin/alpha-calcitonin gene-related peptide, CALCA orCALC1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 156; Mammalian calcitonin gene.
Experiment Methods:Nuclease protection; experiments performed with closely related; gene; Sequencing of a full-length cDNA; experiments performed with; closely related gene; Primer extension; transfected or transformed cells; experiments; performed with closely related gene
Regulation:thyroid C (repressed by or weakly expressed in) cells, CNS, pituitary
Position:
Human AssemblyChrPosition (strand)Source
Build 361114,950,474 - 14,950,534EPD
RGD ID:7219733
Promoter ID:EPDNEW_H15612
Type:multiple initiation site
Name:CALCA_1
Description:calcitonin related polypeptide alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381114,972,351 - 14,972,411EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1437 AgrOrtholog
COSMIC CALCA COSMIC
Ensembl Genes ENSG00000110680 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000331587 ENTREZGENE
  ENST00000331587.9 UniProtKB/Swiss-Prot
  ENST00000396372 ENTREZGENE
  ENST00000396372.2 UniProtKB/Swiss-Prot
  ENST00000469608.5 UniProtKB/Swiss-Prot
  ENST00000486207 ENTREZGENE
  ENST00000486207.6 UniProtKB/Swiss-Prot
  ENST00000706042 ENTREZGENE
  ENST00000706042.1 UniProtKB/Swiss-Prot
  ENST00000706043.1 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.2190 UniProtKB/Swiss-Prot
GTEx ENSG00000110680 GTEx
HGNC ID HGNC:1437 ENTREZGENE
Human Proteome Map CALCA Human Proteome Map
InterPro Calcitonin UniProtKB/Swiss-Prot
  Calcitonin-like UniProtKB/Swiss-Prot
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot
  Calcitonin_CS UniProtKB/Swiss-Prot
  Calcitonin_gene-rel_peptide UniProtKB/Swiss-Prot
  Calcitonin_peptide-like UniProtKB/Swiss-Prot
KEGG Report hsa:796 UniProtKB/Swiss-Prot
NCBI Gene 796 ENTREZGENE
OMIM 114130 OMIM
PANTHER CALCITONIN UniProtKB/Swiss-Prot
  CALCITONIN GENE-RELATED PEPTIDE 2 UniProtKB/Swiss-Prot
  PTHR10505 UniProtKB/Swiss-Prot
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot
PharmGKB CALCA RGD, PharmGKB
PRINTS CALCITONINA UniProtKB/Swiss-Prot
  CALCITONINB UniProtKB/Swiss-Prot
PROSITE CALCITONIN UniProtKB/Swiss-Prot
SMART CALCITONIN UniProtKB/Swiss-Prot
UniProt B7ZL39 ENTREZGENE
  CALC_HUMAN UniProtKB/Swiss-Prot
  CALCA_HUMAN UniProtKB/Swiss-Prot
  P01258 ENTREZGENE
  P06881 ENTREZGENE
  Q13935 ENTREZGENE
  Q13937 ENTREZGENE
  Q52LX7 ENTREZGENE
  Q93048 ENTREZGENE
  Q9UCP0 ENTREZGENE
UniProt Secondary B7ZL39 UniProtKB/Swiss-Prot
  Q13935 UniProtKB/Swiss-Prot
  Q13937 UniProtKB/Swiss-Prot
  Q52LX7 UniProtKB/Swiss-Prot
  Q93048 UniProtKB/Swiss-Prot
  Q9UCP0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 CALCA  calcitonin related polypeptide alpha    calcitonin-related polypeptide alpha  Symbol and/or name change 5135510 APPROVED