Clcn3 (chloride channel, voltage-sensitive 3) - Rat Genome Database

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Gene: Clcn3 (chloride channel, voltage-sensitive 3) Mus musculus
Analyze
Symbol: Clcn3
Name: chloride channel, voltage-sensitive 3
RGD ID: 730987
MGI Page MGI
Description: Enables antiporter activity. Involved in synaptic vesicle lumen acidification. Acts upstream of or within several processes, including chemical synaptic transmission; photoreceptor cell maintenance; and positive regulation of reactive oxygen species biosynthetic process. Located in several cellular components, including endosome membrane; lysosomal membrane; and synaptic vesicle. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and heart. Used to study neuronal ceroid lipofuscinosis 3. Orthologous to human CLCN3 (chloride voltage-gated channel 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride channel 3; chloride channel protein 3; chloride transporter ClC-3; Clc; clC-3; Clc3; H(+)/Cl(-) exchange transporter 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,363,423 - 61,436,351 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl861,363,423 - 61,436,334 (-)EnsemblGRCm39 Ensembl
GRCm38860,910,389 - 60,983,317 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,910,389 - 60,983,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv37863,389,186 - 63,462,108 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,802,531 - 63,875,442 (-)NCBIMGSCv36mm8
Celera863,477,568 - 63,550,480 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetazolamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
benzo[a]pyrene  (EXP)
beta-carotene  (EXP)
bisphenol A  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (ISO)
D-mannitol  (ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
flutamide  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
indinavir  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
lamivudine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
saquinavir  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal fat pad morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal behavioral response to xenobiotic  (IAGP)
abnormal brain morphology  (IAGP)
abnormal entorhinal cortex morphology  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal gait  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal ileum morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal posture  (IAGP)
abnormal renal protein reabsorption  (IAGP)
abnormal response to new environment  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal synaptic vesicle morphology  (IAGP)
astrocytosis  (IAGP)
blindness  (IAGP)
congestive heart failure  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased cerebral cortex pyramidal cell number  (IAGP)
decreased circulating glucose level  (IAGP)
decreased hippocampus pyramidal cell number  (IAGP)
decreased retina photoreceptor cell number  (IAGP)
decreased susceptibility to pharmacologically induced seizures  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
enlarged heart  (IAGP)
enlarged lateral ventricles  (IAGP)
gliosis  (IAGP)
hippocampal neuron degeneration  (IAGP)
hippocampus atrophy  (IAGP)
hyperactivity  (IAGP)
impaired coordination  (IAGP)
impaired neutrophil phagocytosis  (IAGP)
impaired synaptic plasticity  (IAGP)
increased heart weight  (IAGP)
increased locomotor activity  (IAGP)
increased susceptibility to age-related retinal degeneration  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
loss of GABAergic neurons  (IAGP)
myocardium hypertrophy  (IAGP)
photoreceptor inner segment degeneration  (IAGP)
photoreceptor outer segment degeneration  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
seizures  (IAGP)
sepsis  (IAGP)
small hippocampus  (IAGP)
stereotypic behavior  (IAGP)
tonic-clonic seizures  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Yoshikawa M, etal., Genes Cells 2002 Jun;7(6):597-605.
Additional References at PubMed
PMID:7613034   PMID:7665160   PMID:8812471   PMID:8889548   PMID:9166581   PMID:9680377   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11182090   PMID:11217851  
PMID:11773602   PMID:12433961   PMID:12470859   PMID:12477932   PMID:12904583   PMID:14610273   PMID:14754994   PMID:15073168   PMID:15319524   PMID:15504734   PMID:15706348   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16222710   PMID:16522634   PMID:16985003   PMID:17046694   PMID:17110406   PMID:17442672   PMID:17673675   PMID:17699636   PMID:17908687   PMID:17967808  
PMID:18234851   PMID:18799693   PMID:18815226   PMID:18840613   PMID:18923035   PMID:19169251   PMID:19339555   PMID:19615374   PMID:19808023   PMID:19808024   PMID:19926787   PMID:20351103  
PMID:20506205   PMID:21071705   PMID:21267068   PMID:21378974   PMID:21732368   PMID:21873635   PMID:22179014   PMID:22534482   PMID:22847174   PMID:23006728   PMID:23115349   PMID:23165767  
PMID:23786998   PMID:24194600   PMID:24603049   PMID:24611720   PMID:24850147   PMID:25218423   PMID:25433636   PMID:25798587   PMID:25979088   PMID:26342074   PMID:26363227   PMID:26436462  
PMID:26562480   PMID:26794461   PMID:26925421   PMID:27363391   PMID:27460962   PMID:27760895   PMID:28437476   PMID:28468943   PMID:28972156   PMID:29158167   PMID:29949674   PMID:31679624  
PMID:32118314   PMID:32290105   PMID:34186028   PMID:34391093   PMID:35098884   PMID:35175311   PMID:35792204   PMID:36536096  


Genomics

Comparative Map Data
Clcn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,363,423 - 61,436,351 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl861,363,423 - 61,436,334 (-)EnsemblGRCm39 Ensembl
GRCm38860,910,389 - 60,983,317 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,910,389 - 60,983,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv37863,389,186 - 63,462,108 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,802,531 - 63,875,442 (-)NCBIMGSCv36mm8
Celera863,477,568 - 63,550,480 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.9NCBI
CLCN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384169,620,578 - 169,723,673 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4169,612,633 - 169,723,673 (+)EnsemblGRCh38hg38GRCh38
GRCh374170,541,729 - 170,644,824 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,778,297 - 170,878,732 (+)NCBINCBI36Build 36hg18NCBI36
Build 344170,916,451 - 171,016,886NCBI
Celera4167,874,695 - 167,975,138 (+)NCBICelera
Cytogenetic Map4q33NCBI
HuRef4166,296,448 - 166,399,155 (+)NCBIHuRef
CHM1_14170,518,267 - 170,620,908 (+)NCBICHM1_1
T2T-CHM13v2.04172,980,359 - 173,083,792 (+)NCBIT2T-CHM13v2.0
Clcn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,138,004 - 34,210,984 (+)NCBIGRCr8
mRatBN7.21629,127,152 - 29,200,133 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1629,127,419 - 29,200,119 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1632,722,030 - 32,795,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,155,756 - 36,228,732 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,357,272 - 32,430,251 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,448,821 - 32,520,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,449,116 - 32,519,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,283,743 - 32,355,489 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,447,259 - 32,518,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,447,333 - 32,517,457 (+)NCBI
Celera1629,122,247 - 29,193,279 (+)NCBICelera
Cytogenetic Map16p12NCBI
Clcn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540336,625,770 - 36,710,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540336,625,871 - 36,710,201 (-)NCBIChiLan1.0ChiLan1.0
CLCN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23167,391,806 - 167,499,903 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14167,747,607 - 167,855,715 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04161,838,061 - 161,943,072 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14173,909,980 - 174,014,786 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,925,474 - 174,011,681 (+)Ensemblpanpan1.1panPan2
CLCN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12520,528,708 - 20,616,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2520,528,699 - 20,615,070 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2521,198,852 - 21,249,735 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02520,704,517 - 20,792,549 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2520,704,520 - 20,792,546 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12520,623,955 - 20,675,230 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02520,560,112 - 20,611,064 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02520,659,558 - 20,710,662 (+)NCBIUU_Cfam_GSD_1.0
Clcn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494321,264,313 - 21,345,811 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365161,678,653 - 1,760,294 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365161,678,610 - 1,760,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,026,685 - 20,127,155 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11420,037,628 - 20,127,160 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,332,126 - 21,421,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17115,826,756 - 115,926,842 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7115,826,778 - 115,928,609 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603795,772,878 - 95,874,689 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247691,156,460 - 1,232,612 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247691,156,522 - 1,246,531 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clcn3
2400 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2988
Count of miRNA genes:620
Interacting mature miRNAs:796
Transcripts:ENSMUST00000004430, ENSMUST00000056508, ENSMUST00000093490, ENSMUST00000110301, ENSMUST00000110302, ENSMUST00000129672, ENSMUST00000132234, ENSMUST00000145493, ENSMUST00000145741, ENSMUST00000147824
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse

Markers in Region
RH129711  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38860,910,505 - 60,910,688UniSTSGRCm38
MGSCv37863,389,302 - 63,389,485UniSTSGRCm37
Celera863,477,684 - 63,477,867UniSTS
Cytogenetic Map8B3.1UniSTS
Clcn3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38860,982,927 - 60,983,122UniSTSGRCm38
MGSCv37863,461,724 - 63,461,919UniSTSGRCm37
Celera863,550,096 - 63,550,291UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map832.2UniSTS
Clcn3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38860,982,927 - 60,983,081UniSTSGRCm38
MGSCv37863,461,724 - 63,461,878UniSTSGRCm37
Celera863,550,096 - 63,550,250UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map832.2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001416732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_184390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001778397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF029347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI849432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB657631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB864905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB723319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF536658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX237945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000004430   ⟹   ENSMUSP00000004430
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,364,957 - 61,436,273 (-)Ensembl
GRCm38.p6 Ensembl860,911,923 - 60,983,239 (-)Ensembl
RefSeq Acc Id: ENSMUST00000056508   ⟹   ENSMUSP00000058648
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,363,423 - 61,408,267 (-)Ensembl
GRCm38.p6 Ensembl860,910,389 - 60,955,233 (-)Ensembl
RefSeq Acc Id: ENSMUST00000093490   ⟹   ENSMUSP00000091202
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,363,423 - 61,436,334 (-)Ensembl
GRCm38.p6 Ensembl860,910,389 - 60,983,300 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110301   ⟹   ENSMUSP00000105930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,364,957 - 61,436,273 (-)Ensembl
GRCm38.p6 Ensembl860,911,923 - 60,983,239 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110302   ⟹   ENSMUSP00000105931
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,364,930 - 61,407,782 (-)Ensembl
GRCm38.p6 Ensembl860,911,896 - 60,954,748 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,364,957 - 61,408,267 (-)Ensembl
GRCm38.p6 Ensembl860,911,923 - 60,955,233 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,381,329 - 61,407,813 (-)Ensembl
GRCm38.p6 Ensembl860,928,295 - 60,954,779 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145493
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,391,674 - 61,436,320 (-)Ensembl
GRCm38.p6 Ensembl860,938,640 - 60,983,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145741
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,363,895 - 61,375,994 (-)Ensembl
GRCm38.p6 Ensembl860,910,861 - 60,922,960 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,388,391 - 61,436,278 (-)Ensembl
GRCm38.p6 Ensembl860,935,357 - 60,983,244 (-)Ensembl
RefSeq Acc Id: NM_001416732   ⟹   NP_001403661
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,407,804 (-)NCBI
RefSeq Acc Id: NM_001416733   ⟹   NP_001403662
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,436,318 (-)NCBI
RefSeq Acc Id: NM_001416734   ⟹   NP_001403663
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,418,485 (-)NCBI
RefSeq Acc Id: NM_007711   ⟹   NP_031737
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,436,318 (-)NCBI
GRCm38860,910,389 - 60,983,311 (-)ENTREZGENE
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173873   ⟹   NP_776298
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,436,318 (-)NCBI
GRCm38860,910,389 - 60,983,311 (-)ENTREZGENE
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173874   ⟹   NP_776299
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,436,318 (-)NCBI
GRCm38860,910,389 - 60,983,311 (-)ENTREZGENE
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173876   ⟹   NP_776301
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,407,804 (-)NCBI
GRCm38860,910,389 - 60,954,799 (-)NCBI
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_184390
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,426 - 61,436,318 (-)NCBI
RefSeq Acc Id: XM_017312552   ⟹   XP_017168041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,892 - 61,399,447 (-)NCBI
GRCm38860,910,860 - 60,946,442 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312553   ⟹   XP_017168042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,376,229 - 61,436,347 (-)NCBI
GRCm38860,923,195 - 60,983,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153740   ⟹   XP_036009633
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,892 - 61,418,340 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001778397
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,423 - 61,436,351 (-)NCBI
GRCm38860,910,389 - 60,983,317 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001403661 (Get FASTA)   NCBI Sequence Viewer  
  NP_001403662 (Get FASTA)   NCBI Sequence Viewer  
  NP_001403663 (Get FASTA)   NCBI Sequence Viewer  
  NP_031737 (Get FASTA)   NCBI Sequence Viewer  
  NP_776298 (Get FASTA)   NCBI Sequence Viewer  
  NP_776299 (Get FASTA)   NCBI Sequence Viewer  
  NP_776301 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168041 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168042 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009633 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB95162 (Get FASTA)   NCBI Sequence Viewer  
  AAH57133 (Get FASTA)   NCBI Sequence Viewer  
  AAH57855 (Get FASTA)   NCBI Sequence Viewer  
  AAM89113 (Get FASTA)   NCBI Sequence Viewer  
  AAM89114 (Get FASTA)   NCBI Sequence Viewer  
  AAM89115 (Get FASTA)   NCBI Sequence Viewer  
  AAM89116 (Get FASTA)   NCBI Sequence Viewer  
  AAM89117 (Get FASTA)   NCBI Sequence Viewer  
  AAM89118 (Get FASTA)   NCBI Sequence Viewer  
  BAE24568 (Get FASTA)   NCBI Sequence Viewer  
  BAE28786 (Get FASTA)   NCBI Sequence Viewer  
  BAE29767 (Get FASTA)   NCBI Sequence Viewer  
  BAE35298 (Get FASTA)   NCBI Sequence Viewer  
  BAE36325 (Get FASTA)   NCBI Sequence Viewer  
  BAE37002 (Get FASTA)   NCBI Sequence Viewer  
  BAE41053 (Get FASTA)   NCBI Sequence Viewer  
  CAA55476 (Get FASTA)   NCBI Sequence Viewer  
  EDL28642 (Get FASTA)   NCBI Sequence Viewer  
  EDL28643 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000004430
  ENSMUSP00000004430.8
  ENSMUSP00000058648
  ENSMUSP00000058648.6
  ENSMUSP00000091202
  ENSMUSP00000091202.3
  ENSMUSP00000105930
  ENSMUSP00000105930.2
  ENSMUSP00000105931
  ENSMUSP00000105931.2
GenBank Protein P51791 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031737   ⟸   NM_007711
- Peptide Label: isoform a
- UniProtKB: Q790S0 (UniProtKB/TrEMBL),   Q6PGA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_776301   ⟸   NM_173876
- Peptide Label: isoform c
- UniProtKB: Q8K4W8 (UniProtKB/TrEMBL),   Q6PGA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_776299   ⟸   NM_173874
- Peptide Label: isoform e
- UniProtKB: Q3TTK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_776298   ⟸   NM_173873
- Peptide Label: isoform b
- UniProtKB: Q8K4X1 (UniProtKB/Swiss-Prot),   Q8K4X0 (UniProtKB/Swiss-Prot),   Q3TF45 (UniProtKB/Swiss-Prot),   P51791 (UniProtKB/Swiss-Prot),   A0A6Q6Q7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168041   ⟸   XM_017312552
- Peptide Label: isoform X2
- UniProtKB: Q8K4W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168042   ⟸   XM_017312553
- Peptide Label: isoform X4
- UniProtKB: Q3UEX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000105930   ⟸   ENSMUST00000110301
RefSeq Acc Id: ENSMUSP00000105931   ⟸   ENSMUST00000110302
RefSeq Acc Id: ENSMUSP00000091202   ⟸   ENSMUST00000093490
RefSeq Acc Id: ENSMUSP00000058648   ⟸   ENSMUST00000056508
RefSeq Acc Id: ENSMUSP00000004430   ⟸   ENSMUST00000004430
RefSeq Acc Id: XP_036009633   ⟸   XM_036153740
- Peptide Label: isoform X2
- UniProtKB: Q8K4W7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403662   ⟸   NM_001416733
- Peptide Label: isoform h
- UniProtKB: Q8K4W7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403663   ⟸   NM_001416734
- Peptide Label: isoform i
- UniProtKB: Q790S0 (UniProtKB/TrEMBL),   Q6PGA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403661   ⟸   NM_001416732
- Peptide Label: isoform g
- UniProtKB: E9Q2I1 (UniProtKB/TrEMBL),   Q8K4W9 (UniProtKB/TrEMBL)
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51791-F1-model_v2 AlphaFold P51791 1-818 view protein structure

Promoters
RGD ID:8667141
Promoter ID:EPDNEW_M11601
Type:initiation region
Name:Clcn3_2
Description:Mus musculus chloride channel, voltage-sensitive 3 , transcriptvariant b, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11602  EPDNEW_M11603  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38860,954,770 - 60,954,830EPDNEW
RGD ID:8667143
Promoter ID:EPDNEW_M11602
Type:single initiation site
Name:Clcn3_3
Description:Mus musculus chloride channel, voltage-sensitive 3 , transcriptvariant b, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11601  EPDNEW_M11603  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38860,965,451 - 60,965,511EPDNEW
RGD ID:8667145
Promoter ID:EPDNEW_M11603
Type:initiation region
Name:Clcn3_1
Description:Mus musculus chloride channel, voltage-sensitive 3 , transcriptvariant b, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11601  EPDNEW_M11602  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38860,983,251 - 60,983,311EPDNEW
RGD ID:6842943
Promoter ID:MM_KWN:54489
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000053286
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,401,449 - 63,401,949 (-)MPROMDB
RGD ID:6842941
Promoter ID:MM_KWN:54490
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Brain,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000110302,   OTTMUST00000053284,   OTTMUST00000053290,   OTTMUST00000053291
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,433,189 - 63,433,689 (-)MPROMDB
RGD ID:6842821
Promoter ID:MM_KWN:54492
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK050074_B230317F23RIK,   NM_007711,   NM_173873,   NM_173874,   UC009LTP.1,   UC009LTQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,461,916 - 63,462,416 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103555 AgrOrtholog
Ensembl Genes ENSMUSG00000004319 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004430 ENTREZGENE
  ENSMUST00000004430.14 UniProtKB/Swiss-Prot
  ENSMUST00000056508 ENTREZGENE
  ENSMUST00000056508.12 UniProtKB/TrEMBL
  ENSMUST00000093490 ENTREZGENE
  ENSMUST00000093490.9 UniProtKB/TrEMBL
  ENSMUST00000110301 ENTREZGENE
  ENSMUST00000110301.2 UniProtKB/TrEMBL
  ENSMUST00000110302 ENTREZGENE
  ENSMUST00000110302.8 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1280.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12725 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103555 ENTREZGENE
NCBI Gene 12725 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  H(+)/CL(-) EXCHANGE TRANSPORTER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clcn3 PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLCHANNEL3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6Q6Q7B9 ENTREZGENE, UniProtKB/TrEMBL
  CLCN3_MOUSE UniProtKB/Swiss-Prot
  E9Q2I1 ENTREZGENE, UniProtKB/TrEMBL
  P51791 ENTREZGENE
  Q3TF45 ENTREZGENE
  Q3TTK0 ENTREZGENE, UniProtKB/TrEMBL
  Q3UEX5 ENTREZGENE, UniProtKB/TrEMBL
  Q6PEV2_MOUSE UniProtKB/TrEMBL
  Q6PGA5 ENTREZGENE, UniProtKB/TrEMBL
  Q790S0 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4W7 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4W8 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4W9 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4X0 ENTREZGENE
  Q8K4X1 ENTREZGENE
UniProt Secondary Q3TF45 UniProtKB/Swiss-Prot
  Q8K4X0 UniProtKB/Swiss-Prot
  Q8K4X1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-20 Clcn3  chloride channel, voltage-sensitive 3    chloride channel 3  Symbol and/or name change 5135510 APPROVED