Gene: CDC42 (cell division cycle 42) Homo sapiens
Symbol: CDC42
Name: cell division cycle 42
Description: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC42Hs; cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa); dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K; G25K GTP-binding protein; growth-regulating protein; GTP binding protein, 25kDa; GTP-binding protein, 25kD; OTTHUMP00000002834; OTTHUMP00000002926; OTTHUMP00000002927; small GTP binding protein CDC42; TKS
Mus musculus (house mouse) : Cdc42 (cell division cycle 42)  MGI  AGR
Rattus norvegicus (Norway rat) : Cdc42 (cell division cycle 42)  AGR
Chinchilla lanigera (long-tailed chinchilla) : Cdc42 (cell division cycle 42)
Pan paniscus (bonobo/pygmy chimpanzee) : CDC42 (cell division cycle 42)
Canis lupus familiaris (dog) : CDC42 (cell division cycle 42)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdc42 (cell division cycle 42)
more info ...
Related Pseudogenes: CDC42P1   CDC42P2   CDC42P3   CDC42P4   CDC42P5   CDC42P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38122,052,627 - 22,092,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37122,379,120 - 22,419,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,251,707 - 22,292,023 (+)NCBINCBI36hg18NCBI36
Build 34122,124,487 - 22,164,741NCBI
Celera120,702,109 - 20,742,389 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef120,622,960 - 20,663,212 (+)NCBIHuRef
CHM1_1122,491,651 - 22,531,931 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDC42
AGR Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730976
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2018-01-02
Status: ACTIVE