Prss8 (serine protease 8 (prostasin)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prss8 (serine protease 8 (prostasin)) Mus musculus
Analyze
Symbol: Prss8
Name: serine protease 8 (prostasin)
RGD ID: 730926
MGI Page MGI
Description: Enables sodium channel regulator activity. Involved in transepithelial transport. Acts upstream of or within hair follicle development and positive regulation of sodium ion transport. Located in external side of plasma membrane and membrane raft. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Used to study autosomal recessive congenital ichthyosis 4B and congenital secretory sodium diarrhea 3. Orthologous to human PRSS8 (serine protease 8).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410039E18Rik; AI313909; C79772; CA; CAP1; channel activating protease 1; channel-activating protease 1; f; fr; mCA; mCAP1; prostasin; protease, serine 8 (prostasin); protease, serine, 8 (prostasin); serine protease 8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,524,889 - 127,529,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,524,888 - 127,529,276 (-)EnsemblGRCm39 Ensembl
GRCm387127,925,717 - 127,930,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,925,716 - 127,930,104 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,069,231 - 135,073,627 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,716,865 - 127,721,242 (-)NCBIMGSCv36mm8
Celera7127,760,906 - 127,765,302 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diethyl maleate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
folpet  (EXP)
genistein  (ISO)
glycine betaine  (EXP)
inulin  (EXP)
isotretinoin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
mercury dibromide  (ISO)
Muraglitazar  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
panobinostat  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal coat appearance  (IAGP)
abnormal corneocyte morphology  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IEA)
abnormal hair medulla  (IEA)
abnormal hair shaft morphology  (IEA)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal vibrissa morphology  (IEA)
absent vibrissae  (IAGP)
cataract  (IEA)
curly tail  (IAGP)
curly vibrissae  (IAGP)
decreased birth weight  (IAGP)
decreased body weight  (IAGP)
decreased colon goblet cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased intestine length  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased survivor rate  (IAGP)
decreased thigmotaxis  (IEA)
dehydration  (IAGP)
delayed emergence of vibrissae  (IAGP)
delayed wound healing  (IAGP)
disheveled coat  (IEA)
dry skin  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
exencephaly  (IAGP)
impaired skin barrier function  (IAGP)
intestinal hemorrhage  (IAGP)
kinked vibrissae  (IAGP)
no abnormal phenotype detected  (IAGP)
orthokeratosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reddish skin  (IAGP)
rough coat  (IEA)
short hair  (IEA)
short vibrissae  (IAGP)
small intestinal villus atrophy  (IAGP)
sparse hair  (IAGP)
spina bifida  (IAGP)
thymus medulla hypoplasia  (IAGP)
underdeveloped hair follicles  (IAGP)
weight loss  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation. Chen LM and Chai KX, Int J Cancer. 2002 Jan 20;97(3):323-9.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Blood-borne RT-PCR assay for prostasin- specific transcripts to identify circulating prostate cells in cancer patients. Laribi A, etal., Eur Urol. 2001 Jan;39(1):65-71.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology. Mok SC, etal., J Natl Cancer Inst. 2001 Oct 3;93(19):1458-64.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The mouse frizzy (fr) and rat 'hairless' (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8). Spacek DV, etal., Exp Dermatol. 2010 Jun;19(6):527-32. doi: 10.1111/j.1600-0625.2009.01054.x. Epub 2010 Feb 25.
13. Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Takahashi S, etal., Prostate. 2003 Feb 15;54(3):187-93.
14. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:621381   PMID:1063212   PMID:7738386   PMID:8889548   PMID:9484788   PMID:10349636   PMID:10770960   PMID:11042159   PMID:11076861   PMID:11828000   PMID:11857812   PMID:12149280  
PMID:12195039   PMID:12477932   PMID:12959947   PMID:14610273   PMID:16061697   PMID:16141072   PMID:16141073   PMID:16524950   PMID:16602821   PMID:16638913   PMID:16822939   PMID:16941024  
PMID:16980306   PMID:17174946   PMID:17328885   PMID:17471493   PMID:17940283   PMID:18177347   PMID:18287559   PMID:18799693   PMID:18832587   PMID:19592578   PMID:19793956   PMID:20043279  
PMID:20152175   PMID:21267068   PMID:21873635   PMID:22705055   PMID:22952456   PMID:23405214   PMID:23671076   PMID:24194600   PMID:24480829   PMID:24614850   PMID:24706745   PMID:24962579  
PMID:25078604   PMID:25138159   PMID:25157135   PMID:25209858   PMID:25264521   PMID:26243870   PMID:26673890   PMID:26719335   PMID:27385010   PMID:27982104   PMID:28490634   PMID:29617460  
PMID:30115975   PMID:30623107   PMID:30875130   PMID:31628112   PMID:31916038   PMID:32325033   PMID:34361079   PMID:35312839   PMID:35743186   PMID:37277555   PMID:37660780   PMID:37830556  
PMID:37873566   PMID:38355793  


Genomics

Comparative Map Data
Prss8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,524,889 - 127,529,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,524,888 - 127,529,276 (-)EnsemblGRCm39 Ensembl
GRCm387127,925,717 - 127,930,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,925,716 - 127,930,104 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,069,231 - 135,073,627 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,716,865 - 127,721,242 (-)NCBIMGSCv36mm8
Celera7127,760,906 - 127,765,302 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.84NCBI
PRSS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,131,433 - 31,135,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,131,433 - 31,135,727 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,142,754 - 31,147,048 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,050,255 - 31,054,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 341631,050,256 - 31,054,652NCBI
Celera1629,150,870 - 29,155,267 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,703,907 - 28,708,304 (-)NCBIHuRef
CHM1_11632,460,477 - 32,464,874 (-)NCBICHM1_1
T2T-CHM13v2.01631,518,914 - 31,523,208 (-)NCBIT2T-CHM13v2.0
Prss8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,966,701 - 191,971,271 (-)NCBIGRCr8
mRatBN7.21182,536,229 - 182,540,745 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,536,229 - 182,540,815 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,886,770 - 190,891,286 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,072,862 - 198,077,378 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,743,263 - 190,747,782 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,372,519 - 199,377,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,372,519 - 199,377,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,395,299 - 206,399,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,210,556 - 187,215,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,360,436 - 187,364,953 (-)NCBI
Celera1180,187,038 - 180,191,554 (-)NCBICelera
Cytogenetic Map1q37NCBI
Prss8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,971,609 - 7,976,666 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,970,929 - 7,976,885 (-)NCBIChiLan1.0ChiLan1.0
PRSS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,337,449 - 34,341,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,138,848 - 39,143,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,833,127 - 23,837,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,500,225 - 31,504,555 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,500,225 - 31,504,623 (-)Ensemblpanpan1.1panPan2
PRSS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,110,251 - 17,114,564 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,110,300 - 17,114,816 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,685,630 - 18,689,940 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,241,173 - 17,245,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,241,217 - 17,244,733 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,041,381 - 17,045,690 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,960,412 - 16,964,722 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,272,597 - 17,276,908 (+)NCBIUU_Cfam_GSD_1.0
Prss8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,389,779 - 125,393,813 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,485,310 - 13,491,905 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,487,863 - 13,491,837 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,357,802 - 17,362,220 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,357,793 - 17,362,223 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,510,112 - 17,514,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,820,898 - 27,827,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,817,830 - 27,824,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,641,573 - 1,646,053 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,169,866 - 14,173,676 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,169,204 - 14,177,137 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prss8
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:191
Interacting mature miRNAs:212
Transcripts:ENSMUST00000032988
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse

Markers in Region
RH126736  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387127,925,919 - 127,926,136UniSTSGRCm38
MGSCv377135,069,433 - 135,069,650UniSTSGRCm37
Celera7127,761,108 - 127,761,325UniSTS
Cytogenetic Map7F3UniSTS
cM Map757.0UniSTS
cM Map762.2UniSTS
Whitehead/MRC_RH71294.29UniSTS
AI313909  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387127,925,835 - 127,925,940UniSTSGRCm38
MGSCv377135,069,349 - 135,069,454UniSTSGRCm37
Celera7127,761,024 - 127,761,129UniSTS
Cytogenetic Map7F3UniSTS
cM Map757.0UniSTS
cM Map762.2UniSTS
Whitehead/MRC_RH71293.5UniSTS
Prss8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387127,927,018 - 127,927,086UniSTSGRCm38
MGSCv377135,070,532 - 135,070,600UniSTSGRCm37
Celera7127,762,207 - 127,762,275UniSTS
Cytogenetic Map7F3UniSTS
cM Map769.84UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032988   ⟹   ENSMUSP00000032988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,524,888 - 127,529,276 (-)Ensembl
GRCm38.p6 Ensembl7127,925,716 - 127,930,104 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206124   ⟹   ENSMUSP00000145904
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,524,888 - 127,529,276 (-)Ensembl
GRCm38.p6 Ensembl7127,925,716 - 127,930,104 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206568   ⟹   ENSMUSP00000146313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,525,934 - 127,529,267 (-)Ensembl
GRCm38.p6 Ensembl7127,926,762 - 127,930,095 (-)Ensembl
RefSeq Acc Id: NM_001407961   ⟹   NP_001394890
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,524,889 - 127,529,266 (-)NCBI
RefSeq Acc Id: NM_133351   ⟹   NP_579929
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,524,889 - 127,529,266 (-)NCBI
GRCm387127,925,717 - 127,930,113 (-)NCBI
MGSCv377135,069,231 - 135,073,627 (-)RGD
Celera7127,760,906 - 127,765,302 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_176434
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,524,889 - 127,529,266 (-)NCBI
RefSeq Acc Id: NP_579929   ⟸   NM_133351
- Peptide Label: precursor
- UniProtKB: Q99L44 (UniProtKB/TrEMBL),   Q8BJV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000032988   ⟸   ENSMUST00000032988
Ensembl Acc Id: ENSMUSP00000145904   ⟸   ENSMUST00000206124
Ensembl Acc Id: ENSMUSP00000146313   ⟸   ENSMUST00000206568
RefSeq Acc Id: NP_001394890   ⟸   NM_001407961
- Peptide Label: precursor
- UniProtKB: Q8BJV6 (UniProtKB/TrEMBL),   Q99L44 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESD1-F1-model_v2 AlphaFold Q9ESD1 1-342 view protein structure

Promoters
RGD ID:8665737
Promoter ID:EPDNEW_M10899
Type:initiation region
Name:Prss8_1
Description:Mus musculus protease, serine 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387127,930,094 - 127,930,154EPDNEW
RGD ID:6841851
Promoter ID:MM_KWN:52832
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000084541,   ENSMUST00000098016,   NM_133351_PRSS8,   UC009JXI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367135,073,261 - 135,073,761 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923810 AgrOrtholog
Ensembl Genes ENSMUSG00000030800 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032988 ENTREZGENE
  ENSMUST00000032988.10 UniProtKB/TrEMBL
  ENSMUST00000206124 ENTREZGENE
  ENSMUST00000206124.2 UniProtKB/TrEMBL
  ENSMUST00000206568.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1923810 ENTREZGENE
NCBI Gene 76560 ENTREZGENE
PANTHER PROSTASIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss8 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RQA6_MOUSE UniProtKB/TrEMBL
  PRSS8_MOUSE UniProtKB/Swiss-Prot
  Q8BJV6 ENTREZGENE, UniProtKB/TrEMBL
  Q8C1L4_MOUSE UniProtKB/TrEMBL
  Q99L44 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESD1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-29 Prss8  serine protease 8 (prostasin)  Prss8  protease, serine 8 (prostasin)  Symbol and/or name change 5135510 APPROVED
2013-11-26 Prss8  protease, serine 8 (prostasin)    protease, serine, 8 (prostasin)  Symbol and/or name change 5135510 APPROVED