E2f1 (E2F transcription factor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: E2f1 (E2F transcription factor 1) Mus musculus
Analyze
Symbol: E2f1
Name: E2F transcription factor 1
RGD ID: 730924
MGI Page MGI
Description: Enables DNA-binding transcription activator activity and transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; and response to lipopolysaccharide. Acts upstream of or within several processes, including anoikis; intrinsic apoptotic signaling pathway by p53 class mediator; and lens fiber cell apoptotic process. Located in chromatin and cytoplasm. Part of transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2F-1; KIAA4009; mKIAA4009; Tg(Wnt1-cre)2Sor; transcription factor E2F1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,401,320 - 154,411,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)EnsemblGRCm39 Ensembl
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBIMGSCv36mm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyltryptophan  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
26-hydroxycholesterol  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-nitroso-8-quinolinol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alvocidib  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
androstane  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
Aspidin  (ISO)
atrazine  (EXP,ISO)
auraptene  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[d]isothiazol-3-one  (ISO)
benzophenanthridine  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bortezomib  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
camptothecin  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
Cardanol  (ISO)
carmustine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
DDT  (EXP)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethanolamine  (EXP,ISO)
dihydroxyacetone  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
etoposide  (ISO)
eugenol  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
harmine  (ISO)
heparin  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
inulin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead nitrate  (ISO)
leptomycin B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP)
LY294002  (EXP)
maneb  (EXP)
melatonin  (EXP)
menadione  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenytoin  (EXP)
phosphoramide mustard  (ISO)
phthalaldehyde  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
plumbagin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propylparaben  (ISO)
PX-866  (ISO)
quercetin  (ISO)
quinoline  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rifampicin  (EXP)
ritonavir  (ISO)
royal jelly  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (EXP)
trabectedin  (EXP,ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vinyl carbamate  (EXP)
wortmannin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal cortex morphology  (IAGP)
abnormal alisphenoid bone morphology  (IAGP)
abnormal amacrine cell morphology  (IAGP)
abnormal base-excision repair  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal bone collagen fibril morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal brain size  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell death  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal cilium physiology  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal cranial blood vasculature morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal cranial neural crest cell migration  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal DNA-templated transcription  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal double-strand DNA break repair  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic tissue physiology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal exorbital lacrimal gland morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eyelid development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal frontonasal prominence morphology  (IAGP)
abnormal geniculate ganglion morphology  (IAGP)
abnormal gland morphology  (IAGP)
abnormal glossopharyngeal nerve morphology  (IAGP)
abnormal head development  (IAGP)
abnormal head morphology  (IAGP)
abnormal head shape  (IAGP)
abnormal heart morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal intracellular organelle physiology  (IAGP)
abnormal intramembranous bone ossification  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mandibular nerve morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal maxillary nerve morphology  (IAGP)
abnormal maxillary prominence morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal metopic suture morphology  (IAGP)
abnormal midface morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal nasal cartilage morphology  (IAGP)
abnormal nasopharynx morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal nose morphology  (IAGP)
abnormal ophthalmic nerve morphology  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal palatal shelf bone ossification  (IAGP)
abnormal palatal shelf elevation  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palatal shelf morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal parotid gland morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal premaxilla morphology  (IAGP)
abnormal pterygoid bone morphology  (IAGP)
abnormal Reichert's cartilage morphology  (IAGP)
abnormal retina bipolar cell morphology  (IAGP)
abnormal retina inner plexiform layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina progenitor cell morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal scalp morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal snout skin morphology  (IAGP)
abnormal submandibular gland morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal tongue position  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal vagus nerve morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vestibular ganglion morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent aorticopulmonary septum  (IAGP)
absent frontonasal prominence  (IAGP)
absent gastric milk in neonates  (IAGP)
absent hyoid bone  (IAGP)
absent incisors  (IAGP)
absent lower incisors  (IAGP)
absent mandibular angle  (IAGP)
absent mandibular condyloid process  (IAGP)
absent mandibular coronoid process  (IAGP)
absent maxillary prominence  (IAGP)
absent middle ear ossicles  (IAGP)
absent nasal bone  (IAGP)
absent nasal septum  (IAGP)
absent palatine bone  (IAGP)
absent palatine bone horizontal plate  (IAGP)
absent pterygoid process  (IAGP)
absent temporal bone squamous part  (IAGP)
absent tympanic ring  (IAGP)
absent upper incisors  (IAGP)
absent zygomatic arch  (IAGP)
absent zygomatic bone  (IAGP)
adrenal medulla hyperplasia  (IAGP)
athymia  (IAGP)
basisphenoid bone hypoplasia  (IAGP)
belly spot  (IAGP)
bicuspid aortic valve  (IAGP)
calcified skin  (IAGP)
calcinosis  (IAGP)
cleft hard palate  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
decreased apoptosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone ossification  (IAGP)
decreased bone resorption  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating growth hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased digit pigmentation  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased insulin secretion  (IAGP)
decreased maxillary shelf size  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased palatal shelf size  (IAGP)
decreased palatine bone horizontal plate size  (IAGP)
decreased pancreas weight  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased salivation  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell proliferation  (IAGP)
decreased testis weight  (IAGP)
decreased tongue size  (IAGP)
decreased total body fat amount  (IAGP)
decreased white adipose tissue amount  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IAGP)
delayed intramembranous bone ossification  (IAGP)
domed cranium  (IAGP)
double outlet right ventricle  (IAGP)
ectopic bone  (IAGP)
ectopic cartilage  (IAGP)
ectopic cranial bone  (IAGP)
ectopic neuron  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lateral ventricles  (IAGP)
enlarged neurocranium  (IAGP)
enlarged thymus  (IAGP)
exencephaly  (IAGP)
eyelids open at birth  (IAGP)
female infertility  (IAGP)
first pharyngeal arch hypoplasia  (IAGP)
flat head  (IAGP)
frontal bone hypoplasia  (IAGP)
frontonasal prominence hypoplasia  (IAGP)
gonial bone hypoplasia  (IAGP)
hindbrain hypoplasia  (IAGP)
hunched posture  (IAGP)
hyoid bone hypoplasia  (IAGP)
hypopigmentation  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired cranial neural crest cell differentiation  (IAGP)
impaired glucose tolerance  (IAGP)
impaired ossification of basisphenoid bone  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased hemangioma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased incidence of tumors by UV-induction  (IAGP)
increased insulin sensitivity  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased Leydig cell number  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased pituitary gland tumor incidence  (IAGP)
increased reproductive system tumor incidence  (IAGP)
increased sensitivity to skin irradiation  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased thymocyte number  (IAGP)
increased thymus weight  (IAGP)
increased thyroid adenoma incidence  (IAGP)
increased tumor incidence  (IAGP)
insulitis  (IAGP)
interparietal bone hypoplasia  (IAGP)
interrupted aortic arch, type b  (IAGP)
large anterior fontanelle  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
male infertility  (IAGP)
malleus hypoplasia  (IAGP)
mandible hypoplasia  (IAGP)
mandibular condyloid process hypoplasia  (IAGP)
mandibular prominence hypoplasia  (IAGP)
maxilla hypoplasia  (IAGP)
maxillary prominence hypoplasia  (IAGP)
Meckel's cartilage hypoplasia  (IAGP)
microcephaly  (IAGP)
micrognathia  (IAGP)
midbrain hypoplasia  (IAGP)
middle ear ossicle hypoplasia  (IAGP)
midface hypoplasia  (IAGP)
midline facial cleft  (IAGP)
narrow face  (IAGP)
nasal bone hypoplasia  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ovary hypoplasia  (IAGP)
overriding aortic valve  (IAGP)
palatal shelf hypoplasia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
palatine bone hypoplasia  (IAGP)
parietal bone hypoplasia  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
pharyngeal arch hypoplasia  (IAGP)
polyploidy  (IAGP)
poor arterial differentiation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
premaxilla hypoplasia  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
pterygoid bone hypoplasia  (IAGP)
pulmonary trunk hypoplasia  (IAGP)
retrognathia  (IAGP)
salivary gland inflammation  (IAGP)
seminiferous tubule degeneration  (IAGP)
short frontal bone  (IAGP)
short mandible  (IAGP)
short Meckel's cartilage  (IAGP)
short premaxilla  (IAGP)
short snout  (IAGP)
short tongue  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small dorsal root ganglion  (IAGP)
small ears  (IAGP)
small frontal bone  (IAGP)
small mandible  (IAGP)
small maxilla  (IAGP)
small nasal bone  (IAGP)
small pancreatic islets  (IAGP)
small parietal bone  (IAGP)
small temporal bone squamous part  (IAGP)
temporal bone squamous part hypoplasia  (IAGP)
testicular atrophy  (IAGP)
testis hypoplasia  (IAGP)
thin cerebral cortex  (IAGP)
thin epidermis  (IAGP)
thin retina outer nuclear layer  (IAGP)
tongue hypoplasia  (IAGP)
triangular face  (IAGP)
upper jaw to lower jaw transformation  (IAGP)
uterine hemorrhage  (IAGP)
ventricular septal defect  (IAGP)
wide metopic suture  (IAGP)
zygomatic bone hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. Alonso MM, etal., J Natl Cancer Inst. 2005 Nov 2;97(21):1589-600. doi: 10.1093/jnci/dji340.
2. Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. Chen L, etal., J Biol Chem. 2013 May 17;288(20):14510-21. doi: 10.1074/jbc.M113.458737. Epub 2013 Mar 29.
3. The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study. Chen S, etal., Int J Biol Macromol. 2017 Sep;102:718-728. doi: 10.1016/j.ijbiomac.2017.03.123. Epub 2017 Mar 23.
4. Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemia. Cokic VP, etal., Blood Cells Mol Dis. 2015 Dec;55(4):373-81. doi: 10.1016/j.bcmd.2015.08.002. Epub 2015 Aug 7.
5. Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma. Eymin B, etal., Oncogene. 2001 Mar 29;20(14):1678-87. doi: 10.1038/sj.onc.1204242.
6. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. Gorgoulis VG, etal., J Pathol. 2002 Oct;198(2):142-56. doi: 10.1002/path.1121.
7. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. Iglesias A, etal., J Clin Invest 2004 May;113(10):1398-407.
8. Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. Jordan-Sciutto KL, etal., J Neuropathol Exp Neurol. 2002 Apr;61(4):358-67.
9. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. Jordan-Sciutto KL, etal., J Neurosci. 2002 Mar 15;22(6):2185-95.
10. Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis. Kuhn H, etal., Eur Respir J. 2002 Sep;20(3):703-9.
11. Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. Lee JS, etal., J Clin Oncol. 2010 Jun 1;28(16):2660-7. doi: 10.1200/JCO.2009.25.0977. Epub 2010 Apr 26.
12. Tumour growth-suppressive effect of arsenic trioxide in squamous cell lung carcinoma. Leung LL, etal., Oncol Lett. 2017 Sep;14(3):3748-3754. doi: 10.3892/ol.2017.6646. Epub 2017 Jul 21.
13. Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype. Li Z, etal., BMC Cancer. 2014 Apr 22;14:276. doi: 10.1186/1471-2407-14-276.
14. TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer. Liu L, etal., Oncol Rep. 2017 Jun;37(6):3597-3605. doi: 10.3892/or.2017.5638. Epub 2017 May 11.
15. Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Loukopoulos P, etal., Cancer Sci. 2007 Mar;98(3):392-400. doi: 10.1111/j.1349-7006.2007.00395.x. Epub 2007 Jan 12.
16. The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma. Ma L, etal., Cancer Biol Ther. 2016 Oct 2;17(10):1051-1061. doi: 10.1080/15384047.2016.1219814. Epub 2016 Aug 29.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia. Motonaga K, etal., Brain Res. 2001 Jun 29;905(1-2):250-3.
19. Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid. Pelegri C, etal., Int J Dev Neurosci. 2008 Nov;26(7):665-71. Epub 2008 Aug 12.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression. Wang Z, etal., Int J Oncol. 2017 Dec;51(6):1639-1650. doi: 10.3892/ijo.2017.4165. Epub 2017 Oct 16.
25. Gene expression profiling of lung adenocarcinoma in Xuanwei, China. Wu H, etal., Eur J Cancer Prev. 2016 Nov;25(6):508-17. doi: 10.1097/CEJ.0000000000000214.
26. Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2). Xia G, etal., J Exp Clin Cancer Res. 2017 Aug 10;36(1):107. doi: 10.1186/s13046-017-0579-0.
27. Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3ß-E2F1 Axis Linking Reversely with Survival in Gliomas. Xiao D, etal., Theranostics. 2017 Jan 1;7(1):132-143. doi: 10.7150/thno.17032. eCollection 2017.
28. Antitumor and modeling studies of a penetratin-peptide that targets E2F-1 in small cell lung cancer. Xie X, etal., Cancer Biol Ther. 2013 Aug;14(8):742-51. doi: 10.4161/cbt.25184. Epub 2013 Jun 3.
29. Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. Yamazaki K, etal., Pathol Res Pract. 2003;199(1):23-8. doi: 10.1078/0344-0338-00348.
Additional References at PubMed
PMID:7624053   PMID:7642525   PMID:7675450   PMID:7739537   PMID:7781998   PMID:7797074   PMID:7958837   PMID:8021288   PMID:8114719   PMID:8210997   PMID:8405995   PMID:8413252  
PMID:8576256   PMID:8611632   PMID:8653789   PMID:8653790   PMID:8657141   PMID:8661722   PMID:8788032   PMID:8892111   PMID:8918469   PMID:8923205   PMID:8930397   PMID:8964504  
PMID:9009839   PMID:9121444   PMID:9125176   PMID:9149906   PMID:9367638   PMID:9376316   PMID:9422723   PMID:9426068   PMID:9426200   PMID:9468140   PMID:9537419   PMID:9610736  
PMID:9627115   PMID:9666304   PMID:9671769   PMID:9674698   PMID:9676193   PMID:9694791   PMID:9774967   PMID:9774968   PMID:9858765   PMID:9861012   PMID:10072353   PMID:10082561  
PMID:10099828   PMID:10333731   PMID:10341706   PMID:10349636   PMID:10436023   PMID:10454586   PMID:10454591   PMID:10508527   PMID:10511428   PMID:10547281   PMID:10597240   PMID:10616908  
PMID:10656985   PMID:10714765   PMID:10766769   PMID:10779331   PMID:10828046   PMID:10851232   PMID:10853823   PMID:10854251   PMID:10913163   PMID:11004506   PMID:11042159   PMID:11042693  
PMID:11071387   PMID:11076674   PMID:11076861   PMID:11095619   PMID:11146559   PMID:11217851   PMID:11331592   PMID:11389439   PMID:11471062   PMID:11511364   PMID:11570822   PMID:11672531  
PMID:11704831   PMID:11713289   PMID:11719808   PMID:11754817   PMID:11790795   PMID:11839803   PMID:11850820   PMID:11904439   PMID:11909960   PMID:11980867   PMID:12007404   PMID:12036945  
PMID:12065245   PMID:12082524   PMID:12082609   PMID:12110166   PMID:12198120   PMID:12351630   PMID:12389032   PMID:12401450   PMID:12401786   PMID:12444919   PMID:12466851   PMID:12477723  
PMID:12477932   PMID:12511608   PMID:12593856   PMID:12718877   PMID:12724419   PMID:12799438   PMID:12833065   PMID:12851485   PMID:12893818   PMID:12944911   PMID:12947005   PMID:12973018  
PMID:14555651   PMID:14566047   PMID:14593116   PMID:14610273   PMID:14627987   PMID:14667810   PMID:14684737   PMID:14685160   PMID:14688249   PMID:14703996   PMID:14716294   PMID:14739777  
PMID:14742445   PMID:14743444   PMID:15014447   PMID:15073182   PMID:15105421   PMID:15123636   PMID:15124020   PMID:15140942   PMID:15181537   PMID:15195696   PMID:15207641   PMID:15232580  
PMID:15240700   PMID:15304485   PMID:15377996   PMID:15448153   PMID:15459106   PMID:15470032   PMID:15489334   PMID:15525772   PMID:15531911   PMID:15618518   PMID:15664192   PMID:15713665  
PMID:15716352   PMID:15722552   PMID:15735727   PMID:15767783   PMID:15782199   PMID:15843406   PMID:15867358   PMID:15869948   PMID:15936277   PMID:15976820   PMID:16002659   PMID:16054035  
PMID:16116476   PMID:16141072   PMID:16141073   PMID:16205640   PMID:16249342   PMID:16277552   PMID:16465443   PMID:16484221   PMID:16581768   PMID:16582589   PMID:16678773   PMID:16717102  
PMID:16741925   PMID:16766265   PMID:16835303   PMID:16924238   PMID:17006541   PMID:17008321   PMID:17108174   PMID:17127213   PMID:17167174   PMID:17177285   PMID:17178835   PMID:17210791  
PMID:17218262   PMID:17255939   PMID:17290223   PMID:17360686   PMID:17452331   PMID:17452454   PMID:17459956   PMID:17464290   PMID:17599912   PMID:17608565   PMID:17609112   PMID:17630509  
PMID:17655524   PMID:17728064   PMID:17786044   PMID:17855529   PMID:17881568   PMID:17923680   PMID:17932104   PMID:18003834   PMID:18037375   PMID:18215118   PMID:18287559   PMID:18323664  
PMID:18348985   PMID:18367454   PMID:18375440   PMID:18385796   PMID:18390708   PMID:18424712   PMID:18523788   PMID:18524851   PMID:18550711   PMID:18550843   PMID:18583939   PMID:18594513  
PMID:18606816   PMID:18663357   PMID:18667418   PMID:18722373   PMID:18794805   PMID:18806759   PMID:18818403   PMID:18819932   PMID:18951482   PMID:19015245   PMID:19142862   PMID:19188449  
PMID:19276117   PMID:19376752   PMID:19457859   PMID:19474320   PMID:19597485   PMID:19629135   PMID:19640839   PMID:19741146   PMID:19749980   PMID:19864318   PMID:19874716   PMID:19900401  
PMID:19934373   PMID:19966223   PMID:20016601   PMID:20016602   PMID:20059953   PMID:20096375   PMID:20176812   PMID:20197382   PMID:20211142   PMID:20224195   PMID:20224733   PMID:20299467  
PMID:20392944   PMID:20404092   PMID:20410283   PMID:20412781   PMID:20421650   PMID:20530543   PMID:20616879   PMID:20663889   PMID:20676136   PMID:20890301   PMID:20952509   PMID:20979052  
PMID:21115501   PMID:21159655   PMID:21185283   PMID:21187395   PMID:21194568   PMID:21245101   PMID:21267068   PMID:21292160   PMID:21490060   PMID:21512314   PMID:21519154   PMID:21536733  
PMID:21641965   PMID:21653699   PMID:21715977   PMID:21731673   PMID:21738823   PMID:21788450   PMID:21799732   PMID:21841792   PMID:21844226   PMID:21873635   PMID:21910723   PMID:21964190  
PMID:22022495   PMID:22079090   PMID:22184068   PMID:22206758   PMID:22286767   PMID:22310660   PMID:22341444   PMID:22403008   PMID:22456337   PMID:22560297   PMID:22569253   PMID:22678059  
PMID:22699903   PMID:22707615   PMID:22711520   PMID:22714890   PMID:22885183   PMID:22890321   PMID:22988430   PMID:23015754   PMID:23036195   PMID:23064264   PMID:23064266   PMID:23223288  
PMID:23359713   PMID:23396440   PMID:23403926   PMID:23558950   PMID:23574720   PMID:23648512   PMID:23749232   PMID:23868976   PMID:23912710   PMID:24014029   PMID:24038143   PMID:24044950  
PMID:24105743   PMID:24142690   PMID:24173284   PMID:24250814   PMID:24276244   PMID:24316397   PMID:24362522   PMID:24398673   PMID:24453336   PMID:24460902   PMID:24516045   PMID:24531537  
PMID:24531548   PMID:24619556   PMID:24632684   PMID:24652995   PMID:24662053   PMID:24726645   PMID:24740996   PMID:24741006   PMID:24792116   PMID:24828505   PMID:24865965   PMID:24934442  
PMID:24952961   PMID:24959908   PMID:25053435   PMID:25079229   PMID:25088905   PMID:25150253   PMID:25246633   PMID:25257171   PMID:25301066   PMID:25341896   PMID:25344604   PMID:25453829  
PMID:25515778   PMID:25627688   PMID:25656653   PMID:25725491   PMID:25759071   PMID:25923845   PMID:25934441   PMID:25940086   PMID:25956904   PMID:25959802   PMID:26018557   PMID:26184432  
PMID:26192440   PMID:26238290   PMID:26238783   PMID:26279143   PMID:26311345   PMID:26386275   PMID:26438843   PMID:26487685   PMID:26505089   PMID:26510456   PMID:26527687   PMID:26542706  
PMID:26619117   PMID:26639898   PMID:26657772   PMID:26718006   PMID:26777404   PMID:26966181   PMID:27001308   PMID:27029528   PMID:27348588   PMID:27430240   PMID:27488639   PMID:27490344  
PMID:27821477   PMID:27826253   PMID:27840000   PMID:27889452   PMID:27932351   PMID:28003426   PMID:28082865   PMID:28122228   PMID:28134624   PMID:28286175   PMID:28334780   PMID:28515357  
PMID:28559429   PMID:28592560   PMID:28663257   PMID:28698574   PMID:28714851   PMID:28751573   PMID:28791750   PMID:28794159   PMID:28825879   PMID:28830910   PMID:28844842   PMID:28885142  
PMID:28941984   PMID:28947535   PMID:29016745   PMID:29026085   PMID:29115005   PMID:29437554   PMID:29445148   PMID:29526568   PMID:29617434   PMID:29662228   PMID:29691401   PMID:29797482  
PMID:29805042   PMID:29920846   PMID:29967281   PMID:29975682   PMID:30104253   PMID:30109252   PMID:30143570   PMID:30169530   PMID:30206933   PMID:30220967   PMID:30242109   PMID:30253032  
PMID:30297736   PMID:30389914   PMID:30401820   PMID:30415995   PMID:30425120   PMID:30659012   PMID:30660360   PMID:30819894   PMID:30870413   PMID:30914194   PMID:30967472   PMID:31017901  
PMID:31152247   PMID:31189118   PMID:31241461   PMID:31320326   PMID:31336386   PMID:31341204   PMID:31393264   PMID:31494101   PMID:31539501   PMID:31582804   PMID:31602642   PMID:31666529  
PMID:31922321   PMID:31928974   PMID:32062842   PMID:32071286   PMID:32223017   PMID:32290105   PMID:32326181   PMID:32349192   PMID:32390226   PMID:32413023   PMID:32427396   PMID:32439983  
PMID:32471461   PMID:32482448   PMID:32554568   PMID:32580934   PMID:32616504   PMID:32664967   PMID:32800757   PMID:32801116   PMID:32888429   PMID:32991838   PMID:33012048   PMID:33103996  
PMID:33127760   PMID:33176144   PMID:33184218   PMID:33268364   PMID:33328171   PMID:33340715   PMID:33363172   PMID:33441379   PMID:33497358   PMID:33601405   PMID:33731940   PMID:33750945  
PMID:33771899   PMID:33932339   PMID:33935652   PMID:33996804   PMID:34032267   PMID:34052210   PMID:34100719   PMID:34211969   PMID:34246625   PMID:34346313   PMID:34450025   PMID:34502498  
PMID:34593632   PMID:34671205   PMID:34746147   PMID:34783308   PMID:34819874   PMID:35008734   PMID:35013307   PMID:35087060   PMID:35108221   PMID:35143327   PMID:35166239   PMID:35175194  
PMID:35180326   PMID:35225962   PMID:35242053   PMID:35263589   PMID:35323233   PMID:35372344   PMID:35593225   PMID:35678423   PMID:35714603   PMID:35781329   PMID:35947949   PMID:36012294  
PMID:36125128   PMID:36198264   PMID:36247013   PMID:36319118   PMID:36323247   PMID:36606407   PMID:36632449   PMID:36689330   PMID:36724256   PMID:36728660   PMID:36749647   PMID:36763499  
PMID:37198101   PMID:37207995   PMID:37216637   PMID:37225711   PMID:37255601   PMID:37422706   PMID:37532804   PMID:38113115   PMID:38113888   PMID:38234039   PMID:38414860   PMID:38517430  
PMID:38518774   PMID:38580088   PMID:38602508   PMID:38619396   PMID:38630655   PMID:38643416   PMID:38728328   PMID:38783241   PMID:38814743   PMID:38951500  


Genomics

Comparative Map Data
E2f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,401,320 - 154,411,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)EnsemblGRCm39 Ensembl
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBIMGSCv36mm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
E2F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,675,477 - 33,686,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,675,477 - 33,686,385 (-)EnsemblGRCh38hg38GRCh38
GRCh372032,263,283 - 32,274,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,727,150 - 31,737,854 (-)NCBINCBI36Build 36hg18NCBI36
Build 342031,727,149 - 31,737,854NCBI
Celera2029,016,324 - 29,027,242 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,049,266 - 29,060,184 (-)NCBIHuRef
CHM1_12032,164,384 - 32,175,302 (-)NCBICHM1_1
T2T-CHM13v2.02035,402,008 - 35,412,916 (-)NCBIT2T-CHM13v2.0
E2f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,524,739 - 163,535,563 (-)NCBIGRCr8
mRatBN7.23143,064,535 - 143,075,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,931,136 - 146,941,990 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,549,300 - 155,560,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,288,668 - 153,299,512 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Celera3141,799,009 - 141,809,945 (-)NCBICelera
Cytogenetic Map3q41NCBI
E2f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,633,827 - 27,642,241 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542227,638,625 - 27,643,261 (+)NCBIChiLan1.0ChiLan1.0
E2F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,366,654 - 39,382,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,359,755 - 39,370,541 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,963,083 - 29,973,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,103,764 - 31,115,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,103,764 - 31,110,604 (-)Ensemblpanpan1.1panPan2
NECAB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,895,149 - 22,904,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,878,402 - 22,904,656 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2422,540,395 - 22,549,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,581,877 - 23,591,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,581,862 - 23,616,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,874,367 - 22,883,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,967,923 - 22,977,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,399,012 - 23,408,523 (-)NCBIUU_Cfam_GSD_1.0
E2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,848,495 - 171,859,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,896,063 - 6,900,026 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,894,827 - 6,901,058 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,178,599 - 37,189,883 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,178,587 - 37,190,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,116,195 - 42,125,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
E2F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,968,541 - 37,980,461 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,968,556 - 37,980,326 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605088,901,404 - 88,913,369 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,602,432 - 5,612,951 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,602,432 - 5,612,951 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in E2f1
261 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1274
Count of miRNA genes:400
Interacting mature miRNAs:469
Transcripts:ENSMUST00000000894, ENSMUST00000103145
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
13524521Bodwtq2_mbody wweight QTL 2 (mouse)2153456184156386184Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse

Markers in Region
UniSTS:234576  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,562,950 - 154,563,162UniSTSGRCm38
MGSCv372154,388,686 - 154,388,898UniSTSGRCm37
Celera2160,479,359 - 160,479,571UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
PMC149902P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,569,831 - 154,569,954UniSTSGRCm38
MGSCv372154,395,567 - 154,395,690UniSTSGRCm37
Celera2160,486,230 - 160,486,353UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
PMC152357P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,569,732 - 154,569,812UniSTSGRCm38
MGSCv372154,395,468 - 154,395,548UniSTSGRCm37
Celera2160,486,131 - 160,486,211UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
PMC152357P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,569,546 - 154,569,622UniSTSGRCm38
MGSCv372154,395,282 - 154,395,358UniSTSGRCm37
Celera2160,485,945 - 160,486,021UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
D2Ertd48e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,567,496 - 154,567,698UniSTSGRCm38
MGSCv372154,393,232 - 154,393,434UniSTSGRCm37
Celera2160,483,899 - 160,484,101UniSTS
Cytogenetic Map2H1UniSTS
cM Map290.0UniSTS
E2f1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,559,730 - 154,560,591UniSTSGRCm38
MGSCv372154,385,466 - 154,386,327UniSTSGRCm37
Celera2160,474,318 - 160,475,561UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
cM Map284.0UniSTS
E2f1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,560,706 - 154,561,380UniSTSGRCm38
MGSCv372154,386,442 - 154,387,116UniSTSGRCm37
Celera2160,475,676 - 160,476,350UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
E2f1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF483514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF483515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL772292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY254403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L21973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000894   ⟹   ENSMUSP00000000894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2154,401,554 - 154,411,640 (-)Ensembl
GRCm38.p6 Ensembl2154,559,634 - 154,569,720 (-)Ensembl
Ensembl Acc Id: ENSMUST00000103145   ⟹   ENSMUSP00000099434
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)Ensembl
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)Ensembl
RefSeq Acc Id: NM_001291105   ⟹   NP_001278034
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392154,401,320 - 154,411,346 (-)NCBI
GRCm382154,559,400 - 154,569,426 (-)NCBI
Celera2160,473,988 - 160,486,291 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007891   ⟹   NP_031917
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392154,401,320 - 154,411,812 (-)NCBI
GRCm382154,559,400 - 154,569,892 (-)NCBI
MGSCv372154,385,375 - 154,395,588 (-)RGD
Celera2160,473,988 - 160,486,291 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031917   ⟸   NM_007891
- Peptide Label: isoform a
- UniProtKB: Q80VZ3 (UniProtKB/Swiss-Prot),   Q61501 (UniProtKB/Swiss-Prot),   Q547J6 (UniProtKB/TrEMBL),   Q571G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278034   ⟸   NM_001291105
- Peptide Label: isoform b precursor
- UniProtKB: Q9CYB4 (UniProtKB/TrEMBL),   Q571G3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000000894   ⟸   ENSMUST00000000894
Ensembl Acc Id: ENSMUSP00000099434   ⟸   ENSMUST00000103145
Protein Domains
E2F/DP family winged-helix DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61501-F1-model_v2 AlphaFold Q61501 1-430 view protein structure

Promoters
RGD ID:6831838
Promoter ID:MM_KWN:32486
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000000894,   ENSMUST00000109704,   OTTMUST00000037809,   UC008NJL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362154,394,951 - 154,396,022 (-)MPROMDB
RGD ID:6879314
Promoter ID:EPDNEW_M3108
Type:initiation region
Name:E2f1_2
Description:Mus musculus E2F transcription factor 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3109  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382154,569,396 - 154,569,456EPDNEW
RGD ID:6879316
Promoter ID:EPDNEW_M3109
Type:multiple initiation site
Name:E2f1_1
Description:Mus musculus E2F transcription factor 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3108  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382154,569,854 - 154,569,914EPDNEW

Additional Information