E2f1 (E2F transcription factor 1) - Rat Genome Database

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Gene: E2f1 (E2F transcription factor 1) Mus musculus
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Symbol: E2f1
Name: E2F transcription factor 1
RGD ID: 730924
MGI Page MGI
Description: Enables DNA-binding transcription activator activity and transcription cis-regulatory region binding activity. Involved in DNA-templated transcription; negative regulation of fat cell differentiation; and negative regulation of fat cell proliferation. Acts upstream of or within several processes, including anoikis; lens fiber cell apoptotic process; and quinolinate biosynthetic process. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2F-1; KIAA4009; mKIAA4009; Tg(Wnt1-cre)2Sor; transcription factor E2F1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,401,320 - 154,411,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)Ensemblmm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBIMGSCv36mm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyltryptophan  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
26-hydroxycholesterol  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-nitroso-8-quinolinol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
adenine  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alvocidib  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
androstane  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
Aspidin  (ISO)
atrazine  (EXP,ISO)
auraptene  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[d]isothiazol-3-one  (ISO)
benzophenanthridine  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
camptothecin  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
Cardanol  (ISO)
carmustine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
DDT  (EXP)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethanolamine  (EXP,ISO)
dihydroxyacetone  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
escitalopram  (ISO)
etoposide  (ISO)
eugenol  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
harmine  (ISO)
heparin  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
inulin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead nitrate  (ISO)
leptomycin B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP)
LY294002  (EXP)
maneb  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
melatonin  (EXP)
menadione  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenytoin  (EXP)
phosphoramide mustard  (ISO)
phthalaldehyde  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
plumbagin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propylparaben  (ISO)
PX-866  (ISO)
quercetin  (ISO)
quinoline  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rifampicin  (EXP)
ritonavir  (ISO)
royal jelly  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (EXP)
trabectedin  (EXP,ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vinyl carbamate  (EXP)
wortmannin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal cortex morphology  (IAGP)
abnormal alisphenoid bone morphology  (IAGP)
abnormal amacrine cell morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal bone collagen fibril morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal brain size  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell death  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal cilium physiology  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal cranial blood vasculature morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal cranial neural crest cell migration  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal DNA-templated transcription  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic tissue physiology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal exorbital lacrimal gland morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eyelid development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal frontonasal prominence morphology  (IAGP)
abnormal geniculate ganglion morphology  (IAGP)
abnormal gland morphology  (IAGP)
abnormal glossopharyngeal nerve morphology  (IAGP)
abnormal head development  (IAGP)
abnormal head morphology  (IAGP)
abnormal head shape  (IAGP)
abnormal heart morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal intracellular organelle physiology  (IAGP)
abnormal intramembranous bone ossification  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mandibular nerve morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal maxillary nerve morphology  (IAGP)
abnormal maxillary prominence morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal metopic suture morphology  (IAGP)
abnormal midface morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal nasal cartilage morphology  (IAGP)
abnormal nasopharynx morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal nose morphology  (IAGP)
abnormal ophthalmic nerve morphology  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal palatal shelf bone ossification  (IAGP)
abnormal palatal shelf elevation  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palatal shelf morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal parotid gland morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal premaxilla morphology  (IAGP)
abnormal pterygoid bone morphology  (IAGP)
abnormal Reichert's cartilage morphology  (IAGP)
abnormal retina bipolar cell morphology  (IAGP)
abnormal retina inner plexiform layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina progenitor cell morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal scalp morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal snout skin morphology  (IAGP)
abnormal submandibular gland morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal tongue position  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal vagus nerve morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vestibular ganglion morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent aorticopulmonary septum  (IAGP)
absent frontonasal prominence  (IAGP)
absent gastric milk in neonates  (IAGP)
absent hyoid bone  (IAGP)
absent incisors  (IAGP)
absent lower incisors  (IAGP)
absent mandibular angle  (IAGP)
absent mandibular condyloid process  (IAGP)
absent mandibular coronoid process  (IAGP)
absent maxillary prominence  (IAGP)
absent nasal bone  (IAGP)
absent nasal septum  (IAGP)
absent palatine bone  (IAGP)
absent palatine bone horizontal plate  (IAGP)
absent pterygoid process  (IAGP)
absent temporal bone squamous part  (IAGP)
absent tympanic ring  (IAGP)
absent upper incisors  (IAGP)
absent zygomatic arch  (IAGP)
absent zygomatic bone  (IAGP)
adrenal medulla hyperplasia  (IAGP)
athymia  (IAGP)
basisphenoid bone hypoplasia  (IAGP)
belly spot  (IAGP)
bicuspid aortic valve  (IAGP)
calcified skin  (IAGP)
calcinosis  (IAGP)
cleft hard palate  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
decreased apoptosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone ossification  (IAGP)
decreased bone resorption  (IAGP)
decreased bone trabecula number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating growth hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased digit pigmentation  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased insulin secretion  (IAGP)
decreased maxillary shelf size  (IAGP)
decreased middle ear ossicle number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased palatal shelf size  (IAGP)
decreased palatine bone horizontal plate size  (IAGP)
decreased pancreas weight  (IAGP)
decreased pancreatic islet number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased salivation  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell proliferation  (IAGP)
decreased testis weight  (IAGP)
decreased tongue size  (IAGP)
decreased total body fat amount  (IAGP)
decreased white adipose tissue amount  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IAGP)
delayed intramembranous bone ossification  (IAGP)
domed cranium  (IAGP)
double outlet right ventricle  (IAGP)
ectopic bone  (IAGP)
ectopic cartilage  (IAGP)
ectopic cranial bone  (IAGP)
ectopic neuron  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lateral ventricles  (IAGP)
enlarged neurocranium  (IAGP)
enlarged thymus  (IAGP)
exencephaly  (IAGP)
eyelids open at birth  (IAGP)
female infertility  (IAGP)
first pharyngeal arch hypoplasia  (IAGP)
flat head  (IAGP)
frontal bone hypoplasia  (IAGP)
frontonasal prominence hypoplasia  (IAGP)
gonial bone hypoplasia  (IAGP)
hindbrain hypoplasia  (IAGP)
hunched posture  (IAGP)
hyoid bone hypoplasia  (IAGP)
hypopigmentation  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired base-excision repair  (IAGP)
impaired cranial neural crest cell differentiation  (IAGP)
impaired double-strand DNA break repair  (IAGP)
impaired glucose tolerance  (IAGP)
impaired ossification of basisphenoid bone  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased hemangioma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased incidence of tumors by UV-induction  (IAGP)
increased insulin sensitivity  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased Leydig cell number  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased pituitary gland tumor incidence  (IAGP)
increased reproductive system tumor incidence  (IAGP)
increased sensitivity to skin irradiation  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased thymocyte number  (IAGP)
increased thymus weight  (IAGP)
increased thyroid adenoma incidence  (IAGP)
increased tumor incidence  (IAGP)
insulitis  (IAGP)
interparietal bone hypoplasia  (IAGP)
interrupted aortic arch, type b  (IAGP)
large anterior fontanelle  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
male infertility  (IAGP)
malleus hypoplasia  (IAGP)
mandible hypoplasia  (IAGP)
mandibular condyloid process hypoplasia  (IAGP)
mandibular prominence hypoplasia  (IAGP)
maxilla hypoplasia  (IAGP)
maxillary prominence hypoplasia  (IAGP)
Meckel's cartilage hypoplasia  (IAGP)
microcephaly  (IAGP)
micrognathia  (IAGP)
midbrain hypoplasia  (IAGP)
middle ear ossicle hypoplasia  (IAGP)
midface hypoplasia  (IAGP)
midline facial cleft  (IAGP)
narrow face  (IAGP)
nasal bone hypoplasia  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ovary hypoplasia  (IAGP)
overriding aortic valve  (IAGP)
palatal shelf hypoplasia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
palatine bone hypoplasia  (IAGP)
parietal bone hypoplasia  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
pharyngeal arch hypoplasia  (IAGP)
polyploidy  (IAGP)
poor arterial differentiation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
premaxilla hypoplasia  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
pterygoid bone hypoplasia  (IAGP)
pulmonary trunk hypoplasia  (IAGP)
retrognathia  (IAGP)
salivary gland inflammation  (IAGP)
seminiferous tubule degeneration  (IAGP)
short frontal bone  (IAGP)
short mandible  (IAGP)
short Meckel's cartilage  (IAGP)
short premaxilla  (IAGP)
short snout  (IAGP)
short tongue  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small dorsal root ganglion  (IAGP)
small ears  (IAGP)
small frontal bone  (IAGP)
small mandible  (IAGP)
small maxilla  (IAGP)
small nasal bone  (IAGP)
small pancreatic islets  (IAGP)
small parietal bone  (IAGP)
small temporal bone squamous part  (IAGP)
temporal bone squamous part hypoplasia  (IAGP)
testicular atrophy  (IAGP)
testis hypoplasia  (IAGP)
thin cerebral cortex  (IAGP)
thin epidermis  (IAGP)
thin retina outer nuclear layer  (IAGP)
tongue hypoplasia  (IAGP)
triangular face  (IAGP)
tympanic ring hypoplasia  (IAGP)
upper jaw to lower jaw transformation  (IAGP)
uterine hemorrhage  (IAGP)
ventricular septal defect  (IAGP)
wide metopic suture  (IAGP)
zygomatic bone hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. Alonso MM, etal., J Natl Cancer Inst. 2005 Nov 2;97(21):1589-600. doi: 10.1093/jnci/dji340.
2. Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. Chen L, etal., J Biol Chem. 2013 May 17;288(20):14510-21. doi: 10.1074/jbc.M113.458737. Epub 2013 Mar 29.
3. The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study. Chen S, etal., Int J Biol Macromol. 2017 Sep;102:718-728. doi: 10.1016/j.ijbiomac.2017.03.123. Epub 2017 Mar 23.
4. Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemia. Cokic VP, etal., Blood Cells Mol Dis. 2015 Dec;55(4):373-81. doi: 10.1016/j.bcmd.2015.08.002. Epub 2015 Aug 7.
5. Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma. Eymin B, etal., Oncogene. 2001 Mar 29;20(14):1678-87. doi: 10.1038/sj.onc.1204242.
6. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. Gorgoulis VG, etal., J Pathol. 2002 Oct;198(2):142-56. doi: 10.1002/path.1121.
7. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. Iglesias A, etal., J Clin Invest 2004 May;113(10):1398-407.
8. Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. Jordan-Sciutto KL, etal., J Neuropathol Exp Neurol. 2002 Apr;61(4):358-67.
9. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. Jordan-Sciutto KL, etal., J Neurosci. 2002 Mar 15;22(6):2185-95.
10. Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis. Kuhn H, etal., Eur Respir J. 2002 Sep;20(3):703-9.
11. Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. Lee JS, etal., J Clin Oncol. 2010 Jun 1;28(16):2660-7. doi: 10.1200/JCO.2009.25.0977. Epub 2010 Apr 26.
12. Tumour growth-suppressive effect of arsenic trioxide in squamous cell lung carcinoma. Leung LL, etal., Oncol Lett. 2017 Sep;14(3):3748-3754. doi: 10.3892/ol.2017.6646. Epub 2017 Jul 21.
13. Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype. Li Z, etal., BMC Cancer. 2014 Apr 22;14:276. doi: 10.1186/1471-2407-14-276.
14. TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer. Liu L, etal., Oncol Rep. 2017 Jun;37(6):3597-3605. doi: 10.3892/or.2017.5638. Epub 2017 May 11.
15. Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome. Loukopoulos P, etal., Cancer Sci. 2007 Mar;98(3):392-400. doi: 10.1111/j.1349-7006.2007.00395.x. Epub 2007 Jan 12.
16. The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma. Ma L, etal., Cancer Biol Ther. 2016 Oct 2;17(10):1051-1061. doi: 10.1080/15384047.2016.1219814. Epub 2016 Aug 29.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia. Motonaga K, etal., Brain Res. 2001 Jun 29;905(1-2):250-3.
19. Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid. Pelegri C, etal., Int J Dev Neurosci. 2008 Nov;26(7):665-71. Epub 2008 Aug 12.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression. Wang Z, etal., Int J Oncol. 2017 Dec;51(6):1639-1650. doi: 10.3892/ijo.2017.4165. Epub 2017 Oct 16.
25. Gene expression profiling of lung adenocarcinoma in Xuanwei, China. Wu H, etal., Eur J Cancer Prev. 2016 Nov;25(6):508-17. doi: 10.1097/CEJ.0000000000000214.
26. Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2). Xia G, etal., J Exp Clin Cancer Res. 2017 Aug 10;36(1):107. doi: 10.1186/s13046-017-0579-0.
27. Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3ß-E2F1 Axis Linking Reversely with Survival in Gliomas. Xiao D, etal., Theranostics. 2017 Jan 1;7(1):132-143. doi: 10.7150/thno.17032. eCollection 2017.
28. Antitumor and modeling studies of a penetratin-peptide that targets E2F-1 in small cell lung cancer. Xie X, etal., Cancer Biol Ther. 2013 Aug;14(8):742-51. doi: 10.4161/cbt.25184. Epub 2013 Jun 3.
29. Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study. Yamazaki K, etal., Pathol Res Pract. 2003;199(1):23-8. doi: 10.1078/0344-0338-00348.
Additional References at PubMed
PMID:2419335   PMID:7624053   PMID:7642525   PMID:7675450   PMID:7739537   PMID:7781998   PMID:7797074   PMID:7958837   PMID:8021288   PMID:8114719   PMID:8210997   PMID:8405995  
PMID:8413252   PMID:8576256   PMID:8611632   PMID:8653789   PMID:8653790   PMID:8657141   PMID:8661722   PMID:8788032   PMID:8892111   PMID:8918469   PMID:8923205   PMID:8930397  
PMID:8964504   PMID:9009839   PMID:9121444   PMID:9125176   PMID:9149906   PMID:9367638   PMID:9376316   PMID:9422723   PMID:9426068   PMID:9426200   PMID:9468140   PMID:9537419  
PMID:9610736   PMID:9627115   PMID:9666304   PMID:9671769   PMID:9674698   PMID:9676193   PMID:9694791   PMID:9774967   PMID:9774968   PMID:9858765   PMID:9861012   PMID:10072353  
PMID:10082561   PMID:10099828   PMID:10333731   PMID:10341706   PMID:10349636   PMID:10436023   PMID:10454586   PMID:10454591   PMID:10508527   PMID:10511428   PMID:10547281   PMID:10597240  
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PMID:12973018   PMID:14555651   PMID:14566047   PMID:14593116   PMID:14610273   PMID:14627987   PMID:14667810   PMID:14684737   PMID:14685160   PMID:14688249   PMID:14703996   PMID:14716294  
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PMID:16054035   PMID:16116476   PMID:16141072   PMID:16141073   PMID:16205640   PMID:16249342   PMID:16277552   PMID:16465443   PMID:16484221   PMID:16581768   PMID:16582589   PMID:16678773  
PMID:16717102   PMID:16741925   PMID:16766265   PMID:16835303   PMID:16924238   PMID:16943360   PMID:17006541   PMID:17008321   PMID:17108174   PMID:17127213   PMID:17167174   PMID:17177285  
PMID:17178835   PMID:17210791   PMID:17218262   PMID:17255939   PMID:17290223   PMID:17360686   PMID:17452331   PMID:17452454   PMID:17459956   PMID:17464290   PMID:17599912   PMID:17608565  
PMID:17609112   PMID:17630509   PMID:17655524   PMID:17728064   PMID:17786044   PMID:17855529   PMID:17881568   PMID:17923680   PMID:17932104   PMID:18003834   PMID:18037375   PMID:18215118  
PMID:18287559   PMID:18323664   PMID:18348985   PMID:18367454   PMID:18375440   PMID:18385796   PMID:18390708   PMID:18424712   PMID:18523788   PMID:18524851   PMID:18550711   PMID:18550843  
PMID:18583939   PMID:18594513   PMID:18606816   PMID:18663357   PMID:18667418   PMID:18722373   PMID:18794805   PMID:18806759   PMID:18818403   PMID:18819932   PMID:18951482   PMID:19015245  
PMID:19142862   PMID:19188449   PMID:19276117   PMID:19376752   PMID:19457859   PMID:19474320   PMID:19597485   PMID:19629135   PMID:19640839   PMID:19741146   PMID:19749980   PMID:19864318  
PMID:19874716   PMID:19900401   PMID:19934373   PMID:19966223   PMID:20016601   PMID:20016602   PMID:20059953   PMID:20096375   PMID:20176812   PMID:20197382   PMID:20211142   PMID:20224195  
PMID:20224733   PMID:20299467   PMID:20392944   PMID:20404092   PMID:20410283   PMID:20412781   PMID:20421650   PMID:20530543   PMID:20616879   PMID:20663889   PMID:20676136   PMID:20890301  
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PMID:35225962   PMID:35242053   PMID:35263589   PMID:35323233   PMID:35372344   PMID:35593225   PMID:35678423   PMID:35714603   PMID:35781329   PMID:35947949   PMID:36012294   PMID:36125128  
PMID:36198264   PMID:36247013   PMID:36282910   PMID:36319118   PMID:36323247   PMID:36602864   PMID:36606407   PMID:36632449   PMID:36689330   PMID:36724256   PMID:36728660   PMID:36749647  
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PMID:38728328   PMID:38783241   PMID:38787382   PMID:38810379   PMID:38814743   PMID:38951500   PMID:39132860   PMID:39292749   PMID:39461490   PMID:39532850   PMID:39603235   PMID:39746830  
PMID:39787221   PMID:39846506   PMID:40015278   PMID:40183774   PMID:40280384   PMID:40360730   PMID:40362273   PMID:40371470   PMID:40456777   PMID:40631762  


Genomics

Comparative Map Data
E2f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,401,320 - 154,411,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)Ensemblmm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBIMGSCv36mm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
E2F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,675,477 - 33,686,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,675,477 - 33,686,385 (-)Ensemblhg38GRCh38
GRCh372032,263,283 - 32,274,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,727,150 - 31,737,854 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342031,727,149 - 31,737,854NCBI
Celera2029,016,324 - 29,027,242 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,049,266 - 29,060,184 (-)NCBIHuRef
CHM1_12032,164,384 - 32,175,302 (-)NCBICHM1_1
T2T-CHM13v2.02035,402,008 - 35,412,916 (-)NCBIT2T-CHM13v2.0
E2f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,524,739 - 163,535,563 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3163,524,739 - 163,535,563 (-)EnsemblGRCr8
mRatBN7.23143,064,535 - 143,075,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3146,931,136 - 146,941,990 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,549,300 - 155,560,154 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,288,668 - 153,299,512 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)Ensemblrn6Rnor6.0
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3141,799,009 - 141,809,945 (-)NCBICelera
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Cytogenetic Map3q41NCBI
E2f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,633,827 - 27,642,241 (+)Ensembl
ChiLan1.0NW_00495542227,638,625 - 27,643,261 (+)NCBIChiLan1.0ChiLan1.0
E2F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,366,654 - 39,382,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,359,755 - 39,370,541 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,963,083 - 29,973,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,103,764 - 31,115,211 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,103,764 - 31,110,604 (-)EnsemblpanPan2panpan1.1
E2F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,895,149 - 22,904,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,878,402 - 22,904,656 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2422,540,395 - 22,549,906 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02423,581,877 - 23,591,392 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,581,862 - 23,616,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,874,367 - 22,883,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,967,923 - 22,977,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,399,012 - 23,408,523 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
E2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,848,495 - 171,859,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,896,063 - 6,900,026 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,894,827 - 6,901,058 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,178,599 - 37,189,883 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11737,178,587 - 37,190,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,116,195 - 42,125,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
E2F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,968,541 - 37,980,461 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,968,556 - 37,980,326 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605088,901,404 - 88,913,369 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,602,432 - 5,612,951 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248425,602,432 - 5,612,951 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
E2f1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15133,928,146 - 133,947,590 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in E2f1
529 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1274
Count of miRNA genes:400
Interacting mature miRNAs:469
Transcripts:ENSMUST00000000894, ENSMUST00000103145
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
13524521Bodwtq2_mbody wweight QTL 2 (mouse)2153456184156386184Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse

Markers in Region
UniSTS:234576  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,562,950 - 154,563,162UniSTSGRCm38
MGSCv372154,388,686 - 154,388,898UniSTSGRCm37
Celera2160,479,359 - 160,479,571UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
PMC149902P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,569,831 - 154,569,954UniSTSGRCm38
MGSCv372154,395,567 - 154,395,690UniSTSGRCm37
Celera2160,486,230 - 160,486,353UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
PMC152357P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,569,732 - 154,569,812UniSTSGRCm38
MGSCv372154,395,468 - 154,395,548UniSTSGRCm37
Celera2160,486,131 - 160,486,211UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
PMC152357P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,569,546 - 154,569,622UniSTSGRCm38
MGSCv372154,395,282 - 154,395,358UniSTSGRCm37
Celera2160,485,945 - 160,486,021UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
D2Ertd48e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,567,496 - 154,567,698UniSTSGRCm38
MGSCv372154,393,232 - 154,393,434UniSTSGRCm37
Celera2160,483,899 - 160,484,101UniSTS
Cytogenetic Map2H1UniSTS
cM Map290.0UniSTS
E2f1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,559,730 - 154,560,591UniSTSGRCm38
MGSCv372154,385,466 - 154,386,327UniSTSGRCm37
Celera2160,474,318 - 160,475,561UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
cM Map284.0UniSTS
E2f1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382154,560,706 - 154,561,380UniSTSGRCm38
MGSCv372154,386,442 - 154,387,116UniSTSGRCm37
Celera2160,475,676 - 160,476,350UniSTS
Cytogenetic Map2H1UniSTS
cM Map284.0UniSTS
E2f1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF483514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF483515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL772292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY254403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L21973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000894   ⟹   ENSMUSP00000000894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2154,401,554 - 154,411,640 (-)Ensembl
GRCm38.p6 Ensembl2154,559,634 - 154,569,720 (-)Ensembl
Ensembl Acc Id: ENSMUST00000103145   ⟹   ENSMUSP00000099434
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)Ensembl
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)Ensembl
RefSeq Acc Id: NM_001291105   ⟹   NP_001278034
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392154,401,320 - 154,411,346 (-)NCBI
GRCm382154,559,400 - 154,569,426 (-)NCBI
Celera2160,473,988 - 160,486,291 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007891   ⟹   NP_031917
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392154,401,320 - 154,411,812 (-)NCBI
GRCm382154,559,400 - 154,569,892 (-)NCBI
MGSCv372154,385,375 - 154,395,588 (-)RGD
Celera2160,473,988 - 160,486,291 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031917   ⟸   NM_007891
- Peptide Label: isoform a
- UniProtKB: Q80VZ3 (UniProtKB/Swiss-Prot),   Q61501 (UniProtKB/Swiss-Prot),   Q547J6 (UniProtKB/TrEMBL),   Q571G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278034   ⟸   NM_001291105
- Peptide Label: isoform b precursor
- UniProtKB: Q9CYB4 (UniProtKB/TrEMBL),   Q571G3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000000894   ⟸   ENSMUST00000000894
Ensembl Acc Id: ENSMUSP00000099434   ⟸   ENSMUST00000103145
Protein Domains
E2F/DP family winged-helix DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61501-F1-model_v2 AlphaFold Q61501 1-430 view protein structure

Promoters
RGD ID:6831838
Promoter ID:MM_KWN:32486
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000000894,   ENSMUST00000109704,   OTTMUST00000037809,   UC008NJL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362154,394,951 - 154,396,022 (-)MPROMDB
RGD ID:6879314
Promoter ID:EPDNEW_M3108
Type:initiation region
Name:E2f1_2
Description:Mus musculus E2F transcription factor 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3109  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382154,569,396 - 154,569,456EPDNEW
RGD ID:6879316
Promoter ID:EPDNEW_M3109
Type:multiple initiation site
Name:E2f1_1
Description:Mus musculus E2F transcription factor 1 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3108  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382154,569,854 - 154,569,914EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101941 AgrOrtholog
Ensembl Genes ENSMUSG00000027490 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000894 ENTREZGENE
  ENSMUST00000103145 ENTREZGENE
  ENSMUST00000103145.11 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  6.10.250.540 UniProtKB/Swiss-Prot
InterPro E2F UniProtKB/Swiss-Prot
  E2F-DP_heterodim UniProtKB/Swiss-Prot
  E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_WHTH_DNA-bd_dom UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:13555 UniProtKB/Swiss-Prot
MGD MGI:101941 ENTREZGENE
NCBI Gene 13555 ENTREZGENE
PANTHER PTHR12081 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR E2F1 UniProtKB/Swiss-Prot
Pfam E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_TDP UniProtKB/Swiss-Prot
PharmGKB E2F1 RGD
PhenoGen E2f1 PhenoGen
SMART E2F_TDP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF144074 UniProtKB/Swiss-Prot
  SSF46785 UniProtKB/Swiss-Prot
UniProt E2F1_MOUSE UniProtKB/Swiss-Prot
  Q547J6 ENTREZGENE, UniProtKB/TrEMBL
  Q571G3 ENTREZGENE, UniProtKB/TrEMBL
  Q61501 ENTREZGENE
  Q80VZ3 ENTREZGENE
  Q9CYB4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q80VZ3 UniProtKB/Swiss-Prot