Ccnd2 (cyclin D2) - Rat Genome Database

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Gene: Ccnd2 (cyclin D2) Mus musculus
Analyze
Symbol: Ccnd2
Name: cyclin D2
RGD ID: 730904
MGI Page MGI
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Acts upstream of or within several processes, including adult locomotory behavior; cellular response to X-ray; and long-term memory. Located in nucleus. Part of cyclin D2-CDK4 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer (multiple); carcinoma (multiple); ductal carcinoma in situ; liver disease (multiple); and prostate cancer. Orthologous to human CCND2 (cyclin D2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2600016F06Rik; AI256817; BF642806; C86853; cD2; G1/S-specific cyclin-D2; V; Vi; Vin-1; Vin1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,102,125 - 127,131,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,102,125 - 127,129,156 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386127,125,162 - 127,152,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,125,162 - 127,152,193 (-)Ensemblmm10GRCm38
MGSCv376127,075,726 - 127,101,066 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366127,091,327 - 127,116,667 (-)NCBIMGSCv36mm8
Celera6128,802,274 - 128,827,610 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
bilateral perisylvian polymicrogyria  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Chronic Hepatitis C  (ISO)
colon adenoma  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
ductal carcinoma in situ  (ISO)
epilepsy  (ISO)
episodic ataxia type 1  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
germinoma  (ISO)
glaucoma  (ISO)
granulosa cell tumor  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
hydrocephalus  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
impotence  (ISO)
invasive lobular carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cancer  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoproliferative syndrome 2  (ISO)
Macrocephaly  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1  (ISO)
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 3  (ISO)
multiple myeloma  (ISO)
Myocardial Ischemia  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephroblastoma  (ISO)
Ovarian Neoplasms  (ISO)
Postaxial Polydactyly, Type A1  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renovascular hypertension  (ISO)
seminoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Testicular Neoplasms  (ISO)
transitional cell carcinoma  (IDA)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
9,10-anthraquinone  (ISO)
acetamide  (ISO)
acetazolamide  (EXP)
acrylamide  (ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP)
alachlor  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
AM-251  (EXP)
ammonium chloride  (ISO)
aniline  (ISO)
antimycin A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzoates  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
captan  (EXP)
celecoxib  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
chromium(6+)  (EXP,ISO)
chrysene  (EXP)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyanamide  (EXP)
Cyclopamine  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP)
DDT  (ISO)
delta-tocotrienol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethanolamine  (EXP,ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
everolimus  (ISO)
fenamidone  (EXP)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
fucoidan  (ISO)
furan  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
glucose  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
iodoacetic acid  (EXP)
isobutanol  (ISO)
isoliquiritigenin  (EXP)
L-ascorbic acid  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (EXP)
lithium hydride  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
monosodium L-glutamate  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methylformamide  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
pevonedistat  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
PhIP  (ISO)
picrotoxin  (ISO)
piperine  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
propanal  (ISO)
prostaglandin F2alpha  (ISO)
pyrogallol  (EXP)
quercetin  (EXP,ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
ritonavir  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sorafenib  (ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
teriflunomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thimerosal  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
Tomentosin  (ISO)
trans-piceid  (EXP)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vismodegib  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP)
wortmannin  (ISO)
XAV939  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cyclin D2-CDK4 complex  (IDA,IEA,ISO)
cyclin-dependent protein kinase holoenzyme complex  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
membrane  (IEA)
microtubule organizing center  (IBA)
nuclear membrane  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cranium morphology  (IEA)
abnormal definitive hematopoiesis  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovulation  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal spine curvature  (IEA)
absent Purkinje cell layer  (IAGP)
anemia  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased testis weight  (IAGP)
decreased total body fat amount  (IEA)
ectopic Purkinje cell  (IAGP)
female infertility  (IAGP)
hydrops fetalis  (IAGP)
hyperactivity  (IEA)
impaired coordination  (IAGP)
impaired glucose tolerance  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased circulating glucose level  (IEA)
increased circulating iron level  (IEA)
increased circulating phosphate level  (IEA)
increased fasting circulating glucose level  (IEA)
increased grip strength  (IEA)
increased lean body mass  (IEA)
increased mean corpuscular volume  (IEA)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
low mean erythrocyte cell number  (IAGP)
macrocytic anemia  (IAGP)
macrocytosis  (IAGP)
oligozoospermia  (IAGP)
postnatal lethality  (IAGP)
reduced cerebellar foliation  (IAGP)
retina hypoplasia  (IAGP)
small cerebellum  (IAGP)
small testis  (IEA)
thin external granule cell layer  (IAGP)
thin ventricular wall  (IAGP)
trunk curl  (IEA)
References

References - curated
# Reference Title Reference Citation
1. LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype. Anwar SL, etal., PLoS One. 2019 May 6;14(5):e0216374. doi: 10.1371/journal.pone.0216374. eCollection 2019.
2. Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. Bartkova J, etal., Gastroenterology. 2001 Jun;120(7):1680-8. doi: 10.1053/gast.2001.24880.
3. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Bergsagel PL, etal., Blood. 2005 Jul 1;106(1):296-303. Epub 2005 Mar 8.
4. Mycophenolate mofetil and roscovitine decrease cyclin expression and increase p27(kip1) expression in anti Thy1 mesangial proliferative nephritis. Chiara M, etal., Clin Exp Immunol. 2005 Feb;139(2):225-35.
5. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
6. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Diederichs S, etal., Int J Cancer. 2005 Aug 20;116(2):207-17.
7. Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation. Evron E, etal., Cancer Res. 2001 Mar 15;61(6):2782-7.
8. DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Fackler MJ, etal., Int J Cancer. 2003 Dec 20;107(6):970-5.
9. Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor. Faussillon M, etal., Cancer Lett. 2005 Apr 18;221(1):67-75.
10. Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Fujiwara K, etal., Carcinogenesis. 2004 Aug;25(8):1495-505. Epub 2004 Apr 1.
11. The Vin-1 gene, identified by provirus insertional mutagenesis, is the cyclin D2. Hanna Z, etal., Oncogene 1993 Jun;8(6):1661-6.
12. miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2). He X, etal., J Exp Clin Cancer Res. 2018 Sep 18;37(1):230. doi: 10.1186/s13046-018-0882-4.
13. Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer. Henrique R, etal., J Mol Med. 2006 Nov;84(11):911-8. Epub 2006 Sep 22.
14. Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target. Hung CS, etal., Int J Mol Sci. 2018 Oct 10;19(10). pii: ijms19103096. doi: 10.3390/ijms19103096.
15. Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. Ito M, etal., Clin Immunol. 2010 Jun;135(3):459-65. doi: 10.1016/j.clim.2010.02.002. Epub 2010 Mar 1.
16. Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions. Jeronimo C, etal., Breast Cancer Res Treat. 2007 Jun 5;.
17. Long non-coding RNA JPX correlates with poor prognosis and tumor progression in non-small-cell lung cancer by interacting with miR-145-5p and CCND2. Jin M, etal., Carcinogenesis. 2020 Jul 10;41(5):634-645. doi: 10.1093/carcin/bgz125.
18. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
19. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
20. Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung. Mehrotra J, etal., Clin Cancer Res. 2004 May 1;10(9):3104-9.
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
24. Promoter methylation of cyclin D2 gene in gastric carcinoma. Oshimo Y, etal., Int J Oncol. 2003 Dec;23(6):1663-70.
25. The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance. Park SY, etal., J Exp Clin Cancer Res. 2019 Sep 11;38(1):399. doi: 10.1186/s13046-019-1405-7.
26. CCND2 polymorphisms associated with clearance of HBV infection. Park TJ, etal., J Hum Genet. 2010 Jul;55(7):416-20. doi: 10.1038/jhg.2010.36. Epub 2010 Apr 23.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. Methylation profiling of urothelial carcinoma in bladder biopsy and urine. Pu RT, etal., Acta Cytol. 2006 Sep-Oct;50(5):499-506.
29. Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma. Qian Y, etal., Med Sci Monit. 2020 Dec 15;26:e927444. doi: 10.12659/MSM.927444.
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy. Rosenbaum E, etal., Clin Cancer Res. 2005 Dec 1;11(23):8321-5. doi: 10.1158/1078-0432.CCR-05-1183.
33. Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. Sakuma M, etal., Cancer Sci. 2007 Mar;98(3):380-6.
34. Expression of cyclin D2 is an independent predictor of the development of hepatic metastasis in colorectal cancer. Sarkar R, etal., Colorectal Dis. 2010 Apr;12(4):316-23. doi: 10.1111/j.1463-1318.2009.01829.x. Epub 2009 Mar 11.
35. Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. Schmidt BA, etal., Cancer Res. 2001 May 15;61(10):4214-21.
36. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
37. Prognostic significance of combined microRNA-206 and CyclinD2 in gastric cancer patients after curative surgery: A retrospective cohort study. Shi H, etal., Biomed Pharmacother. 2015 Apr;71:210-5. doi: 10.1016/j.biopha.2014.12.037. Epub 2015 Jan 9.
38. Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes. Skotheim RI, etal., Cell Oncol. 2006;28(5-6):315-26.
39. Localization of increased insulin-like growth factor binding protein-3 in diabetic rat penis: implications for erectile dysfunction. Soh J, etal., Urology. 2007 Nov;70(5):1019-23.
40. Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases. Takano Y, etal., Am J Pathol. 2000 Feb;156(2):585-94. doi: 10.1016/S0002-9440(10)64763-3.
41. CyPA-CD147-ERK1/2-cyclin D2 signaling pathway is upregulated during rat left ventricular hypertrophy. Tang FC, etal., Sheng Li Xue Bao. 2015 Aug 25;67(4):393-400.
42. Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. Tomoda T, etal., J Gastroenterol Hepatol. 2012 Apr;27(4):797-804. doi: 10.1111/j.1440-1746.2011.06948.x.
43. Gene expression profile changes and possible molecular subtypes in differentiated-type nonkeratinizing nasopharyngeal carcinoma. Wang S, etal., Int J Cancer. 2011 Feb 15;128(4):753-62. doi: 10.1002/ijc.25392.
44. microRNA-1297 Inhibits the Growth and Metastasis of Colorectal Cancer by Suppressing Cyclin D2 Expression. Wang Y, etal., DNA Cell Biol. 2017 Nov;36(11):991-999. doi: 10.1089/dna.2017.3829. Epub 2017 Sep 21.
45. Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma. Yamada S, etal., DNA Res. 2004 Oct 31;11(5):335-44.
46. Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms. Yang Z, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5539-48.
47. The 5D4 antibody (anti-cyclin D1/D2) related antigen: cytoplasmic staining is correlated to the progression of gastric cancer. Yasogawa Y, etal., Pathol Int. 1998 Sep;48(9):717-22. doi: 10.1111/j.1440-1827.1998.tb03972.x.
48. Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia. Yu J, etal., Aliment Pharmacol Ther. 2001 Sep;15(9):1505-11. doi: 10.1046/j.1365-2036.2001.01038.x.
49. Expression of cyclin genes in human gastric cancer and in first degree relatives. Yu J, etal., Chin Med J (Engl). 2002 May;115(5):710-5.
Additional References at PubMed
PMID:1372445   PMID:1386335   PMID:1386336   PMID:1738193   PMID:1827757   PMID:7537638   PMID:7603984   PMID:7624053   PMID:7628699   PMID:7671812   PMID:7739547   PMID:7965043  
PMID:8033213   PMID:8543804   PMID:8552401   PMID:8575777   PMID:8613787   PMID:8889548   PMID:8945475   PMID:8954727   PMID:9021147   PMID:9076683   PMID:9099742   PMID:9339900  
PMID:9584157   PMID:9603423   PMID:9784491   PMID:10101126   PMID:10349636   PMID:10352021   PMID:10380928   PMID:10441735   PMID:10457012   PMID:10528151   PMID:10652342   PMID:10784609  
PMID:10839359   PMID:10922068   PMID:10980142   PMID:10995841   PMID:11042159   PMID:11076861   PMID:11090462   PMID:11095619   PMID:11134518   PMID:11239426   PMID:11284963   PMID:11544199  
PMID:11557891   PMID:11748145   PMID:11756505   PMID:11809706   PMID:11823472   PMID:11872634   PMID:12147685   PMID:12205107   PMID:12381668   PMID:12466851   PMID:12477808   PMID:12477932  
PMID:12502747   PMID:12533516   PMID:12591240   PMID:12700661   PMID:12718939   PMID:12801993   PMID:12852854   PMID:12855747   PMID:12884287   PMID:12941628   PMID:14522949   PMID:14612431  
PMID:14651920   PMID:14660677   PMID:14681479   PMID:14975719   PMID:15003506   PMID:15031102   PMID:15037319   PMID:15105286   PMID:15136151   PMID:15155580   PMID:15156143   PMID:15159393  
PMID:15226823   PMID:15314163   PMID:15315760   PMID:15367660   PMID:15378605   PMID:15464586   PMID:15467835   PMID:15489334   PMID:15504908   PMID:15576649   PMID:15591534   PMID:15657434  
PMID:15680361   PMID:15716345   PMID:15735755   PMID:15782199   PMID:15800025   PMID:15831479   PMID:15843481   PMID:15902305   PMID:15970507   PMID:16054035   PMID:16107646   PMID:16141072  
PMID:16141073   PMID:16237170   PMID:16368932   PMID:16396903   PMID:16413468   PMID:16443763   PMID:16513252   PMID:16537919   PMID:16582912   PMID:16602821   PMID:16627858   PMID:16651541  
PMID:16672344   PMID:16782087   PMID:16790481   PMID:16818732   PMID:16840533   PMID:16902412   PMID:16914743   PMID:16943274   PMID:16954383   PMID:16983339   PMID:17151017   PMID:17177285  
PMID:17309103   PMID:17329594   PMID:17362983   PMID:17367776   PMID:17452458   PMID:17475776   PMID:17519332   PMID:17553984   PMID:17560576   PMID:17576928   PMID:17585069   PMID:17596282  
PMID:17687036   PMID:17699765   PMID:17873913   PMID:17919533   PMID:17965053   PMID:18023262   PMID:18079102   PMID:18165280   PMID:18287559   PMID:18311721   PMID:18312615   PMID:18374658  
PMID:18420946   PMID:18455718   PMID:18462697   PMID:18539113   PMID:18585919   PMID:18588871   PMID:18591257   PMID:18603407   PMID:18799693   PMID:18948418   PMID:19015276   PMID:19030180  
PMID:19139274   PMID:19144649   PMID:19208763   PMID:19265663   PMID:19286674   PMID:19287388   PMID:19304890   PMID:19386638   PMID:19401331   PMID:19449303   PMID:19515997   PMID:19541765  
PMID:19553382   PMID:19574535   PMID:19623612   PMID:19628581   PMID:19641124   PMID:19723764   PMID:19769959   PMID:19780901   PMID:19854167   PMID:19877281   PMID:19889636   PMID:19929250  
PMID:20080568   PMID:20090754   PMID:20103709   PMID:20105280   PMID:20368361   PMID:20433897   PMID:20436479   PMID:20506362   PMID:20545763   PMID:20736363   PMID:20831799   PMID:20833366  
PMID:21074523   PMID:21108844   PMID:21300888   PMID:21308864   PMID:21421844   PMID:21429093   PMID:21430164   PMID:21440680   PMID:21490060   PMID:21521747   PMID:21636786   PMID:21652635  
PMID:21654808   PMID:21690261   PMID:21690373   PMID:21709239   PMID:21731673   PMID:21743007   PMID:21768366   PMID:21771816   PMID:21862448   PMID:21873635   PMID:21880902   PMID:21935430  
PMID:22101301   PMID:22154697   PMID:22173065   PMID:22241836   PMID:22289519   PMID:22395070   PMID:22412967   PMID:22438573   PMID:22438823   PMID:22564330   PMID:22589735   PMID:22820645  
PMID:22896639   PMID:22923619   PMID:22929040   PMID:22945632   PMID:22972697   PMID:22996691   PMID:23063798   PMID:23079656   PMID:23109711   PMID:23193000   PMID:23244288   PMID:23326442  
PMID:23341776   PMID:23342106   PMID:23416452   PMID:23482492   PMID:23612904   PMID:23622063   PMID:23673159   PMID:23674600   PMID:23680462   PMID:23714078   PMID:23989931   PMID:24055172  
PMID:24073291   PMID:24154525   PMID:24155149   PMID:24192035   PMID:24194600   PMID:24204824   PMID:24248465   PMID:24474767   PMID:24602283   PMID:24661562   PMID:24680892   PMID:24705253  
PMID:24792116   PMID:24794528   PMID:24876127   PMID:24876129   PMID:24928431   PMID:25087893   PMID:25131634   PMID:25196150   PMID:25422376   PMID:25450615   PMID:25467980   PMID:25652406  
PMID:25668206   PMID:25784544   PMID:25807280   PMID:25848055   PMID:25852735   PMID:25912685   PMID:25972168   PMID:25986147   PMID:26020770   PMID:26021489   PMID:26091038   PMID:26238256  
PMID:26410627   PMID:26441343   PMID:26493106   PMID:26554594   PMID:26567220   PMID:26678830   PMID:26744331   PMID:26818545   PMID:26826126   PMID:26868297   PMID:27003939   PMID:27129404  
PMID:27196371   PMID:27416896   PMID:27458709   PMID:27541004   PMID:27736991   PMID:27862528   PMID:27957530   PMID:28009286   PMID:28031476   PMID:28107452   PMID:28164238   PMID:28167794  
PMID:28192421   PMID:28276606   PMID:28433741   PMID:28694260   PMID:28780306   PMID:28790015   PMID:28901173   PMID:29170629   PMID:29445069   PMID:29513653   PMID:29662889   PMID:29761490  
PMID:29878134   PMID:30059908   PMID:30085028   PMID:30134070   PMID:30146317   PMID:30300583   PMID:30428088   PMID:30674440   PMID:30679264   PMID:30699346   PMID:30979723   PMID:31024075  
PMID:31042497   PMID:31138536   PMID:31260508   PMID:31345937   PMID:31604927   PMID:31708014   PMID:31806625   PMID:32212902   PMID:32274496   PMID:32366272   PMID:32424171   PMID:32439755  
PMID:32703236   PMID:32760291   PMID:33010000   PMID:33020501   PMID:33332554   PMID:33580754   PMID:33821423   PMID:33846290   PMID:34133916   PMID:34246625   PMID:34321999   PMID:34406363  
PMID:34440873   PMID:34609043   PMID:34746147   PMID:34851661   PMID:34851821   PMID:35011697   PMID:35084365   PMID:35175194   PMID:35951005   PMID:36220812   PMID:36225391   PMID:36280202  
PMID:36351424   PMID:36880417   PMID:37000627   PMID:37171286   PMID:37566909   PMID:37751417   PMID:38177500   PMID:38191655   PMID:38355793   PMID:39106860  


Genomics

Comparative Map Data
Ccnd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,102,125 - 127,131,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,102,125 - 127,129,156 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386127,125,162 - 127,152,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,125,162 - 127,152,193 (-)Ensemblmm10GRCm38
MGSCv376127,075,726 - 127,101,066 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366127,091,327 - 127,116,667 (-)NCBIMGSCv36mm8
Celera6128,802,274 - 128,827,610 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
CCND2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,273,762 - 4,305,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,269,771 - 4,305,353 (+)Ensemblhg38GRCh38
GRCh37124,382,928 - 4,414,519 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,253,199 - 4,284,777 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34124,253,198 - 4,284,777NCBI
Celera126,004,961 - 6,036,590 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,239,192 - 4,271,184 (+)NCBIHuRef
CHM1_1124,382,561 - 4,414,148 (+)NCBICHM1_1
T2T-CHM13v2.0124,280,521 - 4,312,135 (+)NCBIT2T-CHM13v2.0
Ccnd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,653,048 - 161,675,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4161,653,048 - 161,680,301 (-)EnsemblGRCr8
GRCr8 Ensembl4161,648,530 - 161,652,344 (-)EnsemblGRCr8
mRatBN7.24159,966,883 - 159,989,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,962,363 - 159,989,495 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4166,196,679 - 166,219,054 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,979,585 - 162,001,961 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,613,640 - 160,636,015 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,674,885 - 159,697,207 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,674,885 - 159,697,207 (-)Ensemblrn6Rnor6.0
Rnor_5.04231,905,449 - 231,927,999 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44163,523,817 - 163,546,501 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4148,681,937 - 148,704,301 (-)NCBICelera
RGSC_v3.14163,768,752 - 163,791,437 (-)NCBI
Cytogenetic Map4q42NCBI
Ccnd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,083,351 - 2,103,430 (+)Ensembl
ChiLan1.0NW_0049554132,083,351 - 2,108,450 (+)NCBIChiLan1.0ChiLan1.0
CCND2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2109,816,882 - 9,848,545 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,813,657 - 9,845,303 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0124,385,957 - 4,417,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,309,272 - 4,340,893 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,309,272 - 4,335,551 (+)EnsemblpanPan2panpan1.1
CCND2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,563,306 - 40,593,362 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,564,921 - 40,594,255 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha276,088,998 - 6,119,026 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02740,919,385 - 40,949,416 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,919,385 - 40,950,262 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,857,202 - 40,887,247 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,832,370 - 40,862,362 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,499,635 - 5,529,695 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccnd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,687,978 - 104,709,380 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,474,749 - 4,496,810 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,474,801 - 4,496,158 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCND2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,087,379 - 66,114,571 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1566,092,483 - 66,114,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,314,784 - 68,331,944 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCND2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,307,419 - 4,339,003 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,307,401 - 4,333,661 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660633,904,650 - 3,936,230 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccnd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,382,948 - 1,405,107 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248601,383,015 - 1,405,107 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccnd2
1600 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1976
Count of miRNA genes:731
Interacting mature miRNAs:984
Transcripts:ENSMUST00000000188
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse

Markers in Region
C86853  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386127,129,491 - 127,129,713UniSTSGRCm38
MGSCv376127,079,509 - 127,079,731UniSTSGRCm37
Celera6128,806,049 - 128,806,271UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.1UniSTS
Whitehead/MRC_RH61251.71UniSTS
RH136101  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386127,126,662 - 127,126,953UniSTSGRCm38
MGSCv376127,076,680 - 127,076,971UniSTSGRCm37
Celera6128,803,224 - 128,803,515UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.1UniSTS
Ccnd2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386127,146,029 - 127,146,182UniSTSGRCm38
MGSCv376127,098,722 - 127,098,869UniSTSGRCm37
Celera6128,822,588 - 128,822,741UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.1UniSTS
cM Map661.1UniSTS
cM Map661.1UniSTS
cM Map661.1UniSTS
UniSTS:235558  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386127,126,302 - 127,126,410UniSTSGRCm38
MGSCv376127,076,320 - 127,076,428UniSTSGRCm37
Celera6128,802,864 - 128,802,972UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.1UniSTS
Ccnd2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F3UniSTS
Ccnd2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F3UniSTS
cM Map661.1UniSTS
Ccnd2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F3UniSTS
cM Map661.1UniSTS
Ccnd2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386127,148,704 - 127,148,851UniSTSGRCm38
MGSCv376127,098,722 - 127,098,869UniSTSGRCm37
Celera6128,825,264 - 128,825,411UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC163683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF015788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY161742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01200960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000188   ⟹   ENSMUSP00000000188
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,102,125 - 127,128,023 (-)Ensembl
GRCm38.p6 Ensembl6127,125,162 - 127,151,060 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201066   ⟹   ENSMUSP00000144095
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,125,246 - 127,127,996 (-)Ensembl
GRCm38.p6 Ensembl6127,148,283 - 127,151,033 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201564
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,107,472 - 127,116,115 (-)Ensembl
GRCm38.p6 Ensembl6127,130,509 - 127,139,152 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201637   ⟹   ENSMUSP00000144245
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,125,263 - 127,127,970 (-)Ensembl
GRCm38.p6 Ensembl6127,148,300 - 127,151,007 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,127,744 - 127,127,924 (-)Ensembl
GRCm38.p6 Ensembl6127,150,781 - 127,150,961 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201902   ⟹   ENSMUSP00000144006
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,122,986 - 127,129,156 (-)Ensembl
GRCm38.p6 Ensembl6127,146,023 - 127,152,193 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201985
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,116,056 - 127,123,651 (-)Ensembl
GRCm38.p6 Ensembl6127,139,093 - 127,146,688 (-)Ensembl
Ensembl Acc Id: ENSMUST00000202363
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,124,465 - 127,127,970 (-)Ensembl
GRCm38.p6 Ensembl6127,147,502 - 127,151,007 (-)Ensembl
RefSeq Acc Id: NM_009829   ⟹   NP_033959
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,102,671 - 127,128,011 (-)NCBI
GRCm386127,125,708 - 127,151,048 (-)NCBI
MGSCv376127,075,726 - 127,101,066 (-)RGD
Celera6128,802,274 - 128,827,610 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505459   ⟹   XP_006505522
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,102,125 - 127,128,074 (-)NCBI
GRCm386127,125,162 - 127,151,111 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505460   ⟹   XP_006505523
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,102,125 - 127,129,151 (-)NCBI
GRCm386127,125,162 - 127,152,188 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165785   ⟹   XP_036021678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,102,125 - 127,131,814 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165786   ⟹   XP_036021679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,102,125 - 127,131,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165787   ⟹   XP_036021680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,102,125 - 127,131,825 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165788   ⟹   XP_036021681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,129,127 - 127,131,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165789   ⟹   XP_036021682
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,129,127 - 127,131,913 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033959   ⟸   NM_009829
- UniProtKB: P30280 (UniProtKB/Swiss-Prot),   Q4FK45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505523   ⟸   XM_006505460
- Peptide Label: isoform X3
- UniProtKB: P30280 (UniProtKB/Swiss-Prot),   Q4FK45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505522   ⟸   XM_006505459
- Peptide Label: isoform X3
- UniProtKB: P30280 (UniProtKB/Swiss-Prot),   Q4FK45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000000188   ⟸   ENSMUST00000000188
Ensembl Acc Id: ENSMUSP00000144095   ⟸   ENSMUST00000201066
Ensembl Acc Id: ENSMUSP00000144006   ⟸   ENSMUST00000201902
Ensembl Acc Id: ENSMUSP00000144245   ⟸   ENSMUST00000201637
RefSeq Acc Id: XP_036021680   ⟸   XM_036165787
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036021678   ⟸   XM_036165785
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036021679   ⟸   XM_036165786
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036021681   ⟸   XM_036165788
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036021682   ⟸   XM_036165789
- Peptide Label: isoform X5
Protein Domains
Cyclin C-terminal   Cyclin N-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30280-F1-model_v2 AlphaFold P30280 1-289 view protein structure

Promoters
RGD ID:6838908
Promoter ID:MM_KWN:47688
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009829,   UC009DVS.1,   UC009DVV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366127,100,626 - 127,102,002 (-)MPROMDB
RGD ID:6848839
Promoter ID:MM_TRO:8536
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   MEF_B4,   MEF_B6
Transcripts:MTR001291.6.2422.0
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366127,102,161 - 127,102,917 (-)MPROMDB
RGD ID:6891106
Promoter ID:EPDNEW_M9004
Type:initiation region
Name:Ccnd2_1
Description:Mus musculus cyclin D2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386127,151,006 - 127,151,066EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88314 AgrOrtholog
Ensembl Genes ENSMUSG00000000184 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000188 ENTREZGENE
  ENSMUST00000000188.12 UniProtKB/Swiss-Prot
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot
InterPro Cyclin UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  Cyclin_C-dom UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
  Cyclins_cyclin-box UniProtKB/Swiss-Prot
KEGG Report mmu:12444 UniProtKB/Swiss-Prot
MGD MGI:88314 ENTREZGENE
NCBI Gene 12444 ENTREZGENE
PANTHER PTHR10177 UniProtKB/Swiss-Prot
Pfam Cyclin_C UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
PhenoGen Ccnd2 PhenoGen
PROSITE CYCLINS UniProtKB/Swiss-Prot
SMART CYCLIN UniProtKB/Swiss-Prot
  Cyclin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt A0A0J9YU51_MOUSE UniProtKB/TrEMBL
  CCND2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FK45 ENTREZGENE, UniProtKB/TrEMBL
  Q9D8L9_MOUSE UniProtKB/TrEMBL