Pax8 (paired box 8) - Rat Genome Database

Name: Pax8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pax8 (paired box 8) Mus musculus

Analyze

Symbol:

Pax8

Name:

paired box 8

RGD ID:

730850

MGI Page

MGI

Description:

Enables transcription cis-regulatory region binding activity. Involved in several processes, including kidney development; negative regulation of apoptotic process; and regulation of epithelial cell differentiation involved in kidney development. Acts upstream of or within epithelial cell differentiation; metanephros development; and thyroid gland development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; inner ear; and thyroid gland. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

paired box gene 8; paired box protein Pax-8; Pax; Pax-8

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PAX8 (paired box 8)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PAX8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PAX8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PAX8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pax8 (paired box 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Pax8 (paired box 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PAX8 (paired box 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pax8 (paired box 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	egl-38	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sv	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	pax8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	24,310,563 - 24,365,611 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	24,310,572 - 24,365,611 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	24,420,551 - 24,475,599 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	24,420,560 - 24,475,599 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	24,276,080 - 24,331,086 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	24,242,569 - 24,297,575 (-)	NCBI		MGSCv36	mm8
Celera	2	24,140,049 - 24,195,191 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	16.43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colorectal Neoplasms (ISO)

congenital hypothyroidism (IAGP,ISO)

congenital nongoitrous hypothyroidism 2 (ISO)

COVID-19 (ISO)

Follicular Thyroid Cancer (ISO)

genetic disease (ISO)

obesity (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-amphetamine (EXP)

(S)-nicotine (ISO)

1,2-dichloroethane (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (EXP)

5-aza-2'-deoxycytidine (ISO)

acetamide (ISO)

all-trans-retinoic acid (EXP,ISO)

ammonium chloride (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

bathocuproine disulfonic acid (ISO)

benzo[a]pyrene (EXP)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

bromobenzene (ISO)

cadmium dichloride (ISO)

calcium atom (ISO)

calcium(0) (ISO)

cannabidiol (ISO)

carmustine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cocaine (ISO)

colforsin daropate hydrochloride (ISO)

decabromodiphenyl ether (ISO)

endosulfan (ISO)

flavonoids (ISO)

folic acid (EXP,ISO)

furan (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lipopolysaccharide (EXP)

nicotine (ISO)

paracetamol (ISO)

perchlorate (ISO)

perfluorobutanesulfonic acid (ISO)

perfluorobutyric acid (ISO)

perfluorododecanoic acid (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorohexanoic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

perfluoroundecanoic acid (ISO)

pyrrolidine dithiocarbamate (ISO)

quercetin (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sirolimus (ISO)

sodium dichromate (EXP)

sodium perchlorate (ISO)

streptozocin (EXP)

thioacetamide (ISO)

trichloroethene (ISO)

triptonide (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure development (IBA)

animal organ morphogenesis (TAS)

branching involved in ureteric bud morphogenesis (ISO)

cell differentiation (IEA)

cellular response to gonadotropin stimulus (ISO)

central nervous system development (IEP)

DNA-templated transcription (ISO)

epithelial cell differentiation (IMP)

inner ear morphogenesis (IGI)

kidney development (ISO)

kidney epithelium development (IEP)

mesenchymal to epithelial transition involved in metanephros morphogenesis (ISO)

mesonephric tubule development (IEP)

mesonephros development (IEP,IMP)

metanephric comma-shaped body morphogenesis (ISO)

metanephric distal convoluted tubule development (IMP)

metanephric epithelium development (ISO)

metanephric nephron tubule formation (IMP)

metanephric S-shaped body morphogenesis (ISO)

metanephros development (IEP,IGI)

negative regulation of apoptotic process involved in metanephric collecting duct development (IMP)

negative regulation of apoptotic process involved in metanephric nephron tubule development (IMP)

negative regulation of cardiac muscle cell apoptotic process (IMP)

negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis (IMP)

negative regulation of mesenchymal cell apoptotic process involved in metanephros development (IMP)

otic vesicle development (ISO)

positive regulation of branching involved in ureteric bud morphogenesis (IMP)

positive regulation of DNA-templated transcription (IDA,IGI,IMP,ISO)

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (IMP)

positive regulation of metanephric DCT cell differentiation (IMP)

positive regulation of thyroid hormone generation (IMP,ISO)

positive regulation of transcription by RNA polymerase II (ISO)

pronephric field specification (IEP)

pronephros development (IMP)

regulation of apoptotic process (IMP)

regulation of DNA-templated transcription (ISO,TAS)

regulation of metanephric nephron tubule epithelial cell differentiation (IMP)

regulation of thyroid-stimulating hormone secretion (ISO)

regulation of transcription by RNA polymerase II (IBA)

S-shaped body morphogenesis (IEP)

sulfur compound metabolic process (ISO)

thyroid gland development (IEP,IGI,IMP,ISO)

urogenital system development (IGI)

ventricular septum development (IMP)

Cellular Component

nucleoplasm (ISO)

nucleus (IDA,ISO)

transcription regulator complex (TAS)

Molecular Function

DNA binding (ISO,ISS)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO,TAS)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (IPI)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (IDA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

thyroid cancer pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal action potential (IAGP)

abnormal adenohypophysis morphology (IAGP)

abnormal auditory bulla morphology (IAGP)

abnormal bone remodeling (IAGP)

abnormal bone trabecula morphology (IAGP)

abnormal caput epididymis morphology (IAGP)

abnormal cochlear hair cell morphology (IAGP)

abnormal cochlear hair cell stereociliary bundle morphology (IAGP)

abnormal cochlear IHC efferent innervation pattern (IAGP)

abnormal cochlear inner hair cell physiology (IAGP)

abnormal corpus epididymis morphology (IAGP)

abnormal epididymis epithelium morphology (IAGP)

abnormal epiphyseal plate morphology (IAGP)

abnormal external auditory canal morphology (IAGP)

abnormal inner hair cell synaptic ribbon morphology (IAGP)

abnormal kidney collecting duct epithelium morphology (IAGP)

abnormal kidney development (IAGP)

abnormal kidney medulla morphology (IAGP)

abnormal kidney morphology (IAGP)

abnormal kidney papilla morphology (IAGP)

abnormal kinocilium morphology (IAGP)

abnormal metanephric mesenchyme morphology (IAGP)

abnormal middle ear morphology (IAGP)

abnormal middle ear ossicle morphology (IAGP)

abnormal Mullerian duct morphology (IAGP)

abnormal organ of Corti morphology (IAGP)

abnormal outer ear morphology (IAGP)

abnormal outer hair cell stereociliary bundle morphology (IAGP)

abnormal pillar cell morphology (IAGP)

abnormal proximal convoluted tubule morphology (IAGP)

abnormal renal corpuscle morphology (IAGP)

abnormal renal glomerulus morphology (IAGP)

abnormal renal tubule epithelial cell primary cilium morphology (IAGP)

abnormal renal tubule epithelium morphology (IAGP)

abnormal renal tubule morphology (IAGP)

abnormal stapedial artery morphology (IAGP)

abnormal stapes crus morpholgy (IAGP)

abnormal stapes morphology (IAGP)

abnormal thyroid diverticulum morphology (IAGP)

abnormal thyroid follicle morphology (IAGP)

abnormal thyroid follicular cell morphology (IAGP)

abnormal thyroid gland development (IAGP)

abnormal thyroid gland morphology (IAGP)

abnormal urine homeostasis (IAGP)

abnormal uterus development (IAGP)

absent efferent ductules of testis (IAGP)

absent endometrium (IAGP)

absent epididymis (IAGP)

absent metanephros (IAGP)

absent outer ear (IAGP)

absent round window (IAGP)

absent stapedial artery (IAGP)

absent thyroid follicular cells (IAGP)

absent thyroid gland (IAGP)

absent ureter (IAGP)

absent uterine horn (IAGP)

absent vas deferens (IAGP)

albuminuria (IAGP)

arrest of spermatogenesis (IAGP)

blind vagina (IAGP)

cochlear outer hair cell degeneration (IAGP)

deafness (IAGP)

decreased activity of thyroid gland (IAGP)

decreased body size (IAGP)

decreased body weight (IAGP)

decreased bone mineral density of femur (IAGP)

decreased bone mineral density of humerus (IAGP)

decreased bone mineralization (IAGP)

decreased bone volume (IAGP)

decreased circulating thyroxine level (IAGP)

decreased circulating triiodothyronine level (IAGP)

decreased compact bone thickness (IAGP)

decreased femur compact bone thickness (IAGP)

decreased kidney collecting duct number (IAGP)

decreased kidney weight (IAGP)

decreased lactotroph cell number (IAGP)

decreased nephron number (IAGP)

decreased renal glomerular filtration rate (IAGP)

decreased renal glomerulus number (IAGP)

decreased somatotroph cell number (IAGP)

decreased testis weight (IAGP)

decreased urine ammonia level (IAGP)

decreased urine creatinine level (IAGP)

decreased urine glucose level (IAGP)

decreased urine osmolality (IAGP)

decreased urine pH (IAGP)

decreased urine phosphate level (IAGP)

decreased urine potassium level (IAGP)

decreased urine protein level (IAGP)

decreased urine sodium level (IAGP)

delayed bone ossification (IAGP)

delayed ear emergence (IAGP)

delayed endochondral bone ossification (IAGP)

delayed eyelid opening (IAGP)

delayed inner ear development (IAGP)

dilated oviduct (IAGP)

dilated renal glomerular capsule (IAGP)

dilated renal tubule (IAGP)

dilated uterine cervix (IAGP)

elongated kidney papilla (IAGP)

enlarged tectorial membrane (IAGP)

external auditory canal stenosis (IAGP)

female infertility (IAGP)

hydronephrosis (IAGP)

hypertension (IAGP)

increased angiotensin II level (IAGP)

increased apoptosis (IAGP)

increased circulating thyroid-stimulating hormone level (IAGP)

increased fluid intake (IAGP)

increased kidney apoptosis (IAGP)

increased kidney cell proliferation (IAGP)

increased or absent threshold for auditory brainstem response (IAGP)

increased susceptibility to kidney reperfusion injury (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

increased thyroid-stimulating hormone level (IAGP)

increased thyrotroph cell number (IAGP)

increased urine calcium level (IAGP)

increased urine chloride ion level (IAGP)

increased urine glucose level (IAGP)

increased urine potassium level (IAGP)

increased urine protein level (IAGP)

isosthenuria (IAGP)

kidney cortex cyst (IAGP)

lethality at weaning, complete penetrance (IAGP)

male infertility (IAGP)

metabolic acidosis (IAGP)

oliguria (IAGP)

pale kidney (IAGP)

polyuria (IAGP)

postnatal growth retardation (IAGP)

postnatal lethality, complete penetrance (IAGP)

premature death (IAGP)

reduced male fertility (IAGP)

renal hypoplasia (IAGP)

renal interstitial fibrosis (IAGP)

short limbs (IAGP)

small ears (IAGP)

small epididymis (IAGP)

small metanephros (IAGP)

small round window (IAGP)

small thyroid gland (IAGP)

testicular atrophy (IAGP)

thin myometrium (IAGP)

uterus hypoplasia (IAGP)

vagina atresia (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.	Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2.	PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis.	Macchia PE, etal., Nat Genet. 1998 May;19(1):83-6.
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	MGD IEA	MGD IEA
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.	Zannini M, etal., EMBO J 1997 Jun 2;16(11):3185-97.

Additional References at PubMed

PMID:1283313	PMID:1337742	PMID:1485966	PMID:1508216	PMID:1516825	PMID:1685142	PMID:1723950	PMID:7590254	PMID:7737192	PMID:7883790	PMID:7906966	PMID:7981748
PMID:7990960	PMID:8071351	PMID:8099544	PMID:8126546	PMID:8318736	PMID:8413205	PMID:8431641	PMID:8575294	PMID:8625814	PMID:8652674	PMID:8751373	PMID:8786137
PMID:8861958	PMID:9049629	PMID:9205117	PMID:9271117	PMID:9590297	PMID:9671580	PMID:9878254	PMID:9916856	PMID:9986727	PMID:9989404	PMID:10197584	PMID:10349636
PMID:10471511	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11453662	PMID:11500373	PMID:11704761	PMID:11773436	PMID:11786385	PMID:12070080	PMID:12117823	PMID:12231626
PMID:12432093	PMID:12435636	PMID:12441357	PMID:12466851	PMID:12477932	PMID:12538634	PMID:12586753	PMID:12591240	PMID:12810586	PMID:12815622	PMID:12874121	PMID:14531730
PMID:14617574	PMID:14731361	PMID:14981357	PMID:15048807	PMID:15172686	PMID:15231702	PMID:15328022	PMID:15525602	PMID:15581879	PMID:15618518	PMID:15673575	PMID:15741321
PMID:15802493	PMID:16054034	PMID:16138831	PMID:16141072	PMID:16141073	PMID:16150900	PMID:16319112	PMID:16331648	PMID:16418214	PMID:16452098	PMID:16803873	PMID:16916509
PMID:17036046	PMID:17047028	PMID:17082261	PMID:17166926	PMID:17210747	PMID:17300925	PMID:17314325	PMID:17318265	PMID:17376978	PMID:17376979	PMID:17495424	PMID:17693601
PMID:17900554	PMID:17932107	PMID:18287559	PMID:18346943	PMID:18377888	PMID:18495817	PMID:18703040	PMID:18985716	PMID:19010321	PMID:19235715	PMID:19389367	PMID:19477936
PMID:19501082	PMID:19715689	PMID:19797117	PMID:19834026	PMID:19924770	PMID:20040500	PMID:20059953	PMID:20160132	PMID:20211142	PMID:20470391	PMID:20702572	PMID:20727173
PMID:20843830	PMID:20851479	PMID:20978353	PMID:21267068	PMID:21303848	PMID:21308996	PMID:21345181	PMID:21354128	PMID:21362415	PMID:21364918	PMID:21491542	PMID:21512107
PMID:21731775	PMID:21784065	PMID:21873635	PMID:21924257	PMID:21952241	PMID:22028439	PMID:22076439	PMID:22132122	PMID:22135066	PMID:22167068	PMID:22242190	PMID:22249313
PMID:22432025	PMID:22453009	PMID:22511595	PMID:22526732	PMID:22912798	PMID:23051751	PMID:23078112	PMID:23307789	PMID:23384425	PMID:23511952	PMID:23555292	PMID:23707896
PMID:23716689	PMID:23892084	PMID:23920117	PMID:23974041	PMID:24045698	PMID:24265449	PMID:24550112	PMID:24598167	PMID:24909663	PMID:24952961	PMID:25127920	PMID:25274613
PMID:25287489	PMID:25389909	PMID:25458011	PMID:25490145	PMID:25587709	PMID:25617721	PMID:25647637	PMID:25799508	PMID:25892012	PMID:25925253	PMID:26035382	PMID:26047795
PMID:26439621	PMID:26550799	PMID:26658320	PMID:26776520	PMID:26781745	PMID:26786105	PMID:26988119	PMID:27068110	PMID:27090781	PMID:27129161	PMID:27287879	PMID:27341756
PMID:27699213	PMID:27820600	PMID:27827435	PMID:28160066	PMID:28373486	PMID:28385297	PMID:28473526	PMID:28760814	PMID:28923959	PMID:28993399	PMID:29361553	PMID:29377931
PMID:29449451	PMID:29705331	PMID:29712641	PMID:29742982	PMID:29941522	PMID:30061411	PMID:30237523	PMID:30271355	PMID:30352879	PMID:30397221	PMID:30427222	PMID:30446499
PMID:30753823	PMID:31166707	PMID:31296958	PMID:31412026	PMID:31534052	PMID:31575647	PMID:31582725	PMID:31673025	PMID:32325033	PMID:32402291	PMID:32541007	PMID:32554463
PMID:32852840	PMID:32968282	PMID:32998907	PMID:33192541	PMID:33711282	PMID:33795231	PMID:34321664	PMID:34496237	PMID:34502288	PMID:34605272	PMID:34789765	PMID:34906895
PMID:35001662	PMID:35017633	PMID:35289766	PMID:35613264	PMID:35645295	PMID:35794482	PMID:36165446	PMID:36260124	PMID:36521641	PMID:36543770

Genomics

Comparative Map Data

Pax8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	24,310,563 - 24,365,611 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	24,310,572 - 24,365,611 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	24,420,551 - 24,475,599 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	24,420,560 - 24,475,599 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	24,276,080 - 24,331,086 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	24,242,569 - 24,297,575 (-)	NCBI		MGSCv36	mm8
Celera	2	24,140,049 - 24,195,191 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	16.43	NCBI

PAX8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	113,215,997 - 113,278,921 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	113,215,997 - 113,278,921 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	113,973,574 - 114,036,498 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	113,690,045 - 113,752,968 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	113,691,170 - 113,752,728	NCBI
Celera	2	107,358,161 - 107,421,066 (-)	NCBI		Celera
Cytogenetic Map	2	q14.1	NCBI
HuRef	2	106,427,614 - 106,522,962 (-)	NCBI		HuRef
CHM1_1	2	113,977,965 - 114,040,915 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	113,642,573 - 113,705,473 (-)	NCBI		T2T-CHM13v2.0

Pax8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	7,185,721 - 7,242,363 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	7,185,723 - 7,242,363 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	10,289,591 - 10,345,823 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	18,875,838 - 18,932,068 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	17,065,649 - 17,121,886 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	1,527,316 - 1,586,019 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	1,527,279 - 1,584,946 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	1,520,144 - 1,576,052 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	2,671,478 - 2,726,801 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	2,672,153 - 2,726,345 (-)	NCBI
Celera	3	2,022,899 - 2,078,650 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Pax8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	1,016,289 - 1,073,796 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	1,016,226 - 1,072,643 (+)	NCBI	ChiLan1.0	ChiLan1.0

PAX8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2A	14,936,160 - 14,974,705 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	88,845,877 - 88,905,266 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	114,162,110 - 114,222,865 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	114,162,110 - 114,222,865 (-)	Ensembl	panpan1.1		panPan2

PAX8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	37,307,130 - 37,331,729 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	37,306,033 - 37,363,178 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	37,077,650 - 37,133,660 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	38,084,443 - 38,141,710 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	38,085,541 - 38,141,710 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	37,220,866 - 37,276,852 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	37,277,373 - 37,333,166 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	37,490,112 - 37,546,218 (-)	NCBI		UU_Cfam_GSD_1.0

Pax8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	82,629,178 - 82,682,663 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936783	1,523,661 - 1,576,568 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936783	1,523,658 - 1,553,464 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAX8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	16,236,074 - 16,299,650 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	16,233,378 - 16,297,365 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666080	3,382,976 - 3,450,250 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pax8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	13,300,606 - 13,357,903 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	13,291,880 - 13,358,066 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pax8
1807 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1441
Count of miRNA genes:	652
Interacting mature miRNAs:	774
Transcripts:	ENSMUST00000028355, ENSMUST00000133746, ENSMUST00000136228, ENSMUST00000149294, ENSMUST00000149860, ENSMUST00000152614, ENSMUST00000153535, ENSMUST00000153601
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4141836	Tgq11_m	triglyceride QTL 11 (mouse)			Not determined			1	25324559	Mouse
4142333	Tgq10_m	triglyceride QTL 10 (mouse)			Not determined			1	25324559	Mouse
1301838	Sluc16_m	susceptibility to lung cancer 16 (mouse)			Not determined		2	1	26529589	Mouse
12904743	Carcdq3_m	cardiac collagen deposition QTL 3 (mouse)					2	3234940	28179150	Mouse
1301769	Orgwq2_m	organ weight QTL 2 (mouse)			Not determined		2	3887126	93421651	Mouse
1301980	Fcsa5_m	femoral cross-sectional area 5 (mouse)			Not determined		2	7679115	41679261	Mouse
1301790	Pcfm1_m	periosteal circumference and femur length 1 (mouse)			Not determined		2	8236296	42236396	Mouse
10043876	Adip22_m	adiposity 22 (mouse)			Not determined		2	8308051	42308240	Mouse
1300624	Insq7_m	insulin QTL 7 (mouse)			Not determined		2	9384446	43384575	Mouse
10755513	Amzn4_m	anatomical modifier of Zfp423 4 (mouse)					2	9384446	43384575	Mouse
12903993	Opfaq1_m	open field activity QTL 1 (mouse)					2	9676691	27022642	Mouse
8552707	Cia23_m	collagen induced arthritis QTL 23 (mouse)			Not determined		2	12129537	66556453	Mouse
1301641	Sbmd2_m	spinal bone mineral density 2 (mouse)			Not determined		2	14214567	48214713	Mouse
1357881	Estoq1_m	embryo survival total QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357454	Kidq1_m	kidney weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357436	Splq1_m	spleen weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
39128209	Lwq14_m	liver weight QTL 14 (mouse)					2	20897778	118894840	Mouse
1558899	Egq1_m	early growth QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1558966	W10q9_m	weight 10 weeks QTL 9 (mouse)			Not determined		2	20897778	118894840	Mouse
1558915	W3q1_m	weight 3 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1558738	W6q1_m	weight 6 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357681	Hrtq1_m	heart weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1301376	Etohc1_m	ethanol consumption 1 (mouse)			Not determined		2	21129725	55129871	Mouse
4141708	Pbwg1.2_m	postnatal body weight growth 1.2 (mouse)			Not determined			21129725	55129871	Mouse
13463470	Tubisq1_m	tubulointerstitial injury severity, QTL 1 (mouse)					2	23689145	57689269	Mouse
1302174	Dssc2_m	dextran sodium sulfate induced colitis QTL2 (mouse)			Not determined		2	24224632	148700377	Mouse

Markers in Region

PMC187478P1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	24,444,703 - 24,445,091	UniSTS	GRCm38
MGSCv37	2	24,300,223 - 24,300,611	UniSTS	GRCm37
Celera	2	24,164,273 - 24,164,661	UniSTS
Cytogenetic Map	2	B	UniSTS
cM Map	2	13.5	UniSTS

D11Bir2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	19	44,761,686 - 44,761,823	UniSTS	GRCm38
GRCm38	2	24,443,002 - 24,443,139	UniSTS	GRCm38
MGSCv37	2	24,298,522 - 24,298,659	UniSTS	GRCm37
MGSCv37	19	44,836,176 - 44,836,313	UniSTS	GRCm37
Celera	2	24,162,572 - 24,162,709	UniSTS
Celera	19	45,532,280 - 45,532,417	UniSTS
Cytogenetic Map	2	B	UniSTS
Cytogenetic Map	19	C3	UniSTS
cM Map	2	13.5	UniSTS
cM Map	4		UniSTS
cM Map	2	24.0	UniSTS
cM Map	7	61.0	UniSTS
cM Map	11	6.0	UniSTS
cM Map	1	86.6	UniSTS
cM Map	17	43.5	UniSTS
cM Map	14	48.0	UniSTS
cM Map	1	102.8	UniSTS
cM Map	11	25.0	UniSTS
cM Map	2	39.0	UniSTS

Pax8

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	2	B	UniSTS
cM Map	2	13.5	UniSTS

Pax8

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	24,421,088 - 24,421,284	UniSTS	GRCm38
MGSCv37	2	24,276,608 - 24,276,804	UniSTS	GRCm37
Celera	2	24,140,577 - 24,140,773	UniSTS
Cytogenetic Map	2	B	UniSTS
cM Map	2	13.5	UniSTS

Pax8

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	2	B	UniSTS
cM Map	2	13.5	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_011040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK032920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK050717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK052610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL732528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY157583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC020526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY442465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X57487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000028355 ⟹ ENSMUSP00000028355

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,310,572 - 24,365,611 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,420,560 - 24,475,599 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000133746

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,333,010 - 24,335,912 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,442,998 - 24,445,900 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000136228 ⟹ ENSMUSP00000133316

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,319,539 - 24,365,586 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,429,527 - 24,475,574 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000149294 ⟹ ENSMUSP00000115194

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,311,532 - 24,365,109 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,421,520 - 24,475,097 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000149860

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,311,406 - 24,313,094 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,421,394 - 24,423,082 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000152614

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,361,897 - 24,365,586 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,471,885 - 24,475,574 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000153535 ⟹ ENSMUSP00000120319

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,331,189 - 24,365,227 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,441,177 - 24,475,215 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000153601 ⟹ ENSMUSP00000134343

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	24,311,543 - 24,365,576 (-)	Ensembl
GRCm38.p6 Ensembl	2	24,421,531 - 24,475,564 (-)	Ensembl

RefSeq Acc Id:

NM_011040 ⟹ NP_035170

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	24,310,563 - 24,365,611 (-)	NCBI
GRCm38	2	24,420,551 - 24,475,599 (-)	NCBI
MGSCv37	2	24,276,080 - 24,331,086 (-)	RGD
Celera	2	24,140,040 - 24,195,224 (-)	NCBI
cM Map	2		ENTREZGENE

Sequence:

show sequence

AACTGGCTGGCGATGCCAGGTGGATGGGAGCAAACTTCAGAAGGAAGAGACGCCTGGGCCTTGG
GCACCCTCAGGGGCAGACCCAGGCAGAAAGGGCCTGAGGCCAGCCGGCCAGGGTAGCTGCGTGG
CAGCCAGAGCTGCCAGGACCTGCGTAGGAAAGCTGCGAGTGTCCCTCAGTCTGTGAGCGACTCC
CCGGCGATGCCTCACAACTCGATCAGATCCGGCCATGGAGGGCTGAATCAACTAGGAGGGGCCT
TTGTGAATGGCAGGCCTCTGCCAGAAGTTGTACGTCAACGCATTGTGGACTTGGCCCACCAGGG
CGTGAGGCCCTGTGATATTTCTCGCCAGCTCCGTGTCAGCCATGGCTGTGTAAGCAAGATCCTT
GGCAGGTACTACGAGACTGGCAGCATCCGGCCTGGAGTGATAGGGGGCTCCAAGCCCAAGGTGG
CCACCCCCAAGGTGGTGGAGAAGATAGGAGACTACAAGCGGCAGAACCCTACCATGTTTGCTTG
GGAGATCCGGGACCGGCTCCTGGCAGAAGGCGTTTGTGACAATGACACTGTCCCCAGTGTCAGC
TCCATCAACAGAATCATCCGGACCAAAGTGCAGCAGCCATTCAACCTCCCCATGGATAGCTGTG
TGGCCACCAAGTCTCTGAGCCCAGGACACACACTGATCCCCAGCTCAGCTGTAACACCCCCAGA
GTCACCCCAGTCGGATTCCTTGGGCTCTACCTACTCTATCAACGGGCTCCTAGGAATTGCTCAG
CCTGGCAATGACAACAAGAGAAAGATGGATGATAGTGACCAGGACAGCTGTCGGCTAAGCATCG
ACTCACAGAGCAGCAGCAGTGGTCCTCGAAAGCACCTTCGTACGGACACCTTCAGCCAGCACCA
TCTCGAGGCCCTTGAGTGCCCGTTTGAGCGGCAGCATTACCCGGAGGCCTATGCCTCCCCCAGC
CACACCAAAGGGGAGCAGGGGCTGTACCCACTGCCCTTACTCAACAGTGCCCTGGATGATGGGA
AGGCCACCCTGACATCTTCCAATACACCTCTGGGACGCAACCTCTCGACTCACCAGACCTACCC
TGTGGTGGCAGATCCTCATTCACCCTTCGCCATAAAGCAGGAAACCCCAGAGCTCTCCAGTTCT
AGCTCCACCCCTTCCTCTTTATCTAGCTCCGCCTTTTTGGATCTGCAGCAAGTCGGCTCTGGGG
GCCCAGCAGGTGCCTCGGTCCCACCCTTCAATGCCTTTCCCCATGCTGCCTCCGTGTATGGGCA
GTTCACGGGCCAGGCCCTCCTCTCAGGGCGAGAGATGGTGGGGCCCACGCTGCCTGGATACCCA
CCCCACATCCCCACCAGTGGACAGGGCAGCTATGCCTCTTCTGCTATCGCAGGCATGGTGGCAG
GAAGTGAATATTCTGGCAATGCCTACAGCCACACCCCGTATTCCTCCTACAGTGAGGCCTGGCG
CTTCCCCAACTCCAGCCTGCTGAGTTCTCCATATTATTACAGCTCTACATCAAGGCCAAGCGCA
CCACCCACCTCTGCCACAGCCTTTGACCATCTGTAGTTGTCATGGGGACAGTGGGAAGAACCAG
GCAAGAATCAGGAGGACTTGGCCTGAGACAGGCCCCAGAGAGTCACACAAAGGAATCTTTATTT
ATTACATGAAAAATAACCACAATTCCAGCATTGCCGCTCACTCCCTGTGTGGTCAATTAAATGA
ACCATGAAAGTCAGGATGACCTTGGAGAAGGCCAAACTGTCCTCCAGGATTCATTTTGTGAGTG
ACAGGAGTTCCAGGAAACAAGAACCACCCATTTCAAAAGAGACACAGAGGAGAAATGTACCGAA
GCTGGCACCCACCAAAGGAGAGAAAAGGGGTTCACGAAGAACTTAGAGGGAGATGAGTCTGAGG
GTGTACAGGGCCACCTGTTTGGTCTTCATCTAGACAACTCCAGCAATTATGAACAGTATGCAAG
TCCTTCTGGCCTACAATCACAGCCTAGGGCCAAGGCTCTACGTGTCAGTCATCCTAGCAGTTAC
CACCTTGAGCCTCTACTACCTGCATCTTTCTGGGGATTCAGCTGACCTTCTATTTCCAGTTGCT
GTGCATTTACAAGCACCCCTTAGCCTCTCAACCAGTGGCTACCCCTTTGGCAGCAGCGAACCTG
TCCCCTGGAAAGTTCAGTGAGGCTCTACGTAGAACATAGGAAGACACAACAGATGGGACCAGCC
ATGTCCTCTCCTCAACAGCCTTGCCAATTCAAGTGTGCTTTCTGCAGTTCCAGCCCGCGCAGCC
ACTGAAGAGACCCCCAAGGCCAGCAACAAGATTCCCTCTCTGGCTCCTCAGCTCTTTCCCCACA
TACAACCTCACTGTAAATACCGTAAATGAAACTCTGTTTCGGTCAAGCTTTCCTCTTTCCATCC
CCCAGTCTTTGGTCTCTGAAATATCTCCCTACTATGTTGGGGTTTTCTCCTTCATACTTTTTTT
TTTTAAAAAAAAAAAAAAAGACAACCCACCATTACCACATGACTCAATAAACCATTACTCTTGG
TCTCAGGTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_035170	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH20526	(Get FASTA)	NCBI Sequence Viewer
	AAN72308	(Get FASTA)	NCBI Sequence Viewer
	CAA40725	(Get FASTA)	NCBI Sequence Viewer
	CAA67904	(Get FASTA)	NCBI Sequence Viewer
	EDL08172	(Get FASTA)	NCBI Sequence Viewer
	Q00288	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_035170 ⟸ NM_011040

- UniProtKB:

Q6GU20 (UniProtKB/Swiss-Prot), Q00288 (UniProtKB/Swiss-Prot), A0A6P5P8M0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGR
YYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSI
NRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPG
NDNKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDTFSQHHLEALECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSALDDGKATLTSSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSSS
TPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPH
IPTSGQGSYASSAIAGMVAGSEYSGNAYSHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPP
TSATAFDHL

hide sequence

RefSeq Acc Id:

ENSMUSP00000028355 ⟸ ENSMUST00000028355

RefSeq Acc Id:

ENSMUSP00000115194 ⟸ ENSMUST00000149294

RefSeq Acc Id:

ENSMUSP00000134343 ⟸ ENSMUST00000153601

RefSeq Acc Id:

ENSMUSP00000120319 ⟸ ENSMUST00000153535

RefSeq Acc Id:

ENSMUSP00000133316 ⟸ ENSMUST00000136228

Protein Domains

Paired

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q00288-F1-model_v2	AlphaFold	Q00288	1-457	view protein structure

Promoters

RGD ID:

6832007

Promoter ID:

MM_KWN:28045

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney

Transcripts:

OTTMUST00000028467

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	24,278,481 - 24,278,981 (-)	MPROMDB

RGD ID:

6832004

Promoter ID:

MM_KWN:28048

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney

Transcripts:

OTTMUST00000028466

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	24,301,081 - 24,302,132 (-)	MPROMDB

RGD ID:

6832005

Promoter ID:

MM_KWN:28050

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney

Transcripts:

ENSMUST00000102940, OTTMUST00000028458, OTTMUST00000028459, OTTMUST00000028460, OTTMUST00000028461, OTTMUST00000028462, OTTMUST00000028463, OTTMUST00000028464, OTTMUST00000028465

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	24,330,831 - 24,331,331 (-)	MPROMDB

RGD ID:

6876520

Promoter ID:

EPDNEW_M1710

Type:

multiple initiation site

Name:

Pax8_1

Description:

Mus musculus paired box 8 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	24,475,574 - 24,475,634	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:97492	AgrOrtholog
Ensembl Genes	ENSMUSG00000026976	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000028355	ENTREZGENE
	ENSMUSP00000028355.5	UniProtKB/Swiss-Prot
	ENSMUSP00000115194.3	UniProtKB/TrEMBL
	ENSMUSP00000120319.2	UniProtKB/TrEMBL
	ENSMUSP00000133316.3	UniProtKB/TrEMBL
	ENSMUSP00000134343.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000028355	ENTREZGENE
	ENSMUST00000028355.11	UniProtKB/Swiss-Prot
	ENSMUST00000136228.10	UniProtKB/TrEMBL
	ENSMUST00000149294.8	UniProtKB/TrEMBL
	ENSMUST00000153535.2	UniProtKB/TrEMBL
	ENSMUST00000153601.8	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAIRED_DNA_bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Paired_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pax2_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAX_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:18510	UniProtKB/Swiss-Prot
MGD	MGI:97492	ENTREZGENE
NCBI Gene	18510	ENTREZGENE
PANTHER	PAIRED BOX PROTEIN PAX-8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45636	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PAX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pax2_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pax8	PhenoGen
PRINTS	PAIREDBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PAIRED_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAIRED_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	PAX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A6P5P8M0	ENTREZGENE
	A2AIU6_MOUSE	UniProtKB/TrEMBL
	A2AIU7_MOUSE	UniProtKB/TrEMBL
	A2AIU8_MOUSE	UniProtKB/TrEMBL
	G3UZ49_MOUSE	UniProtKB/TrEMBL
	PAX8_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6GU20	ENTREZGENE
UniProt Secondary	P97342	UniProtKB/Swiss-Prot
	Q6GU20	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-11-26	Pax8	paired box 8		paired box gene 8	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype