Pax8 (paired box 8) - Rat Genome Database

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Gene: Pax8 (paired box 8) Mus musculus
Analyze
Symbol: Pax8
Name: paired box 8
RGD ID: 730850
MGI Page MGI
Description: Enables transcription cis-regulatory region binding activity. Involved in several processes, including kidney development; negative regulation of apoptotic process; and regulation of epithelial cell differentiation involved in kidney development. Acts upstream of or within epithelial cell differentiation; metanephros development; and thyroid gland development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; gut; and sensory organ. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: paired box gene 8; paired box protein Pax-8; Pax; Pax-8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,310,563 - 24,365,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,310,572 - 24,365,611 (-)EnsemblGRCm39 Ensembl
GRCm38224,420,551 - 24,475,599 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,420,560 - 24,475,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv37224,276,080 - 24,331,086 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,242,569 - 24,297,575 (-)NCBIMGSCv36mm8
Celera224,140,049 - 24,195,191 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
corn oil  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
endosulfan  (ISO)
ethylparaben  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
glyphosate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nicotine  (ISO)
paracetamol  (ISO)
perchlorate  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
potassium iodide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium dichromate  (EXP)
sodium perchlorate  (ISO)
streptozocin  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (TAS)
branching involved in ureteric bud morphogenesis  (ISO)
cell differentiation  (IEA)
cellular response to gonadotropin stimulus  (ISO)
central nervous system development  (IEP)
DNA-templated transcription  (ISO)
epithelial cell differentiation  (IMP)
inner ear morphogenesis  (IGI)
kidney development  (ISO)
kidney epithelium development  (IEP)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
mesonephric tubule development  (IEP)
mesonephros development  (IEP,IMP)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric distal convoluted tubule development  (IMP)
metanephric epithelium development  (ISO)
metanephric nephron tubule formation  (IMP)
metanephric S-shaped body morphogenesis  (ISO)
metanephros development  (IEP,IGI)
negative regulation of apoptotic process involved in metanephric collecting duct development  (IMP)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (IMP)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (IMP)
otic vesicle development  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of DNA-templated transcription  (IDA,IGI,IMP,ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IMP)
positive regulation of metanephric DCT cell differentiation  (IMP)
positive regulation of thyroid hormone generation  (IMP,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
pronephric field specification  (IEP)
pronephros development  (IMP)
regulation of apoptotic process  (IMP)
regulation of DNA-templated transcription  (ISO,TAS)
regulation of metanephric nephron tubule epithelial cell differentiation  (IMP)
regulation of thyroid-stimulating hormone secretion  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
S-shaped body morphogenesis  (IEP)
sulfur compound metabolic process  (ISO)
thyroid gland development  (IEP,IGI,IMP,ISO)
urogenital system development  (IGI)
ventricular septum development  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal adenohypophysis morphology  (IAGP)
abnormal auditory bulla morphology  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal caput epididymis morphology  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear hair cell stereociliary bundle morphology  (IAGP)
abnormal cochlear IHC efferent innervation pattern  (IAGP)
abnormal cochlear inner hair cell physiology  (IAGP)
abnormal corpus epididymis morphology  (IAGP)
abnormal epididymis epithelium morphology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal external auditory canal morphology  (IAGP)
abnormal inner hair cell synaptic ribbon morphology  (IAGP)
abnormal kidney collecting duct epithelium morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney papilla morphology  (IAGP)
abnormal kinocilium morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal Mullerian duct morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal outer hair cell stereociliary bundle morphology  (IAGP)
abnormal pillar cell morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal corpuscle morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule epithelial cell primary cilium morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal stapedial artery morphology  (IAGP)
abnormal stapes crus morpholgy  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal thyroid diverticulum morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid follicular cell morphology  (IAGP)
abnormal thyroid gland development  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal uterus development  (IAGP)
absent efferent ductules of testis  (IAGP)
absent endometrium  (IAGP)
absent epididymis  (IAGP)
absent metanephros  (IAGP)
absent outer ear  (IAGP)
absent round window  (IAGP)
absent stapedial artery  (IAGP)
absent thyroid follicular cells  (IAGP)
absent thyroid gland  (IAGP)
absent ureter  (IAGP)
absent uterine horn  (IAGP)
absent vas deferens  (IAGP)
albuminuria  (IAGP)
arrest of spermatogenesis  (IAGP)
blind vagina  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
deafness  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased bone mineral density of humerus  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone volume  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased circulating triiodothyronine level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased femur compact bone thickness  (IAGP)
decreased kidney collecting duct number  (IAGP)
decreased kidney weight  (IAGP)
decreased lactotroph cell number  (IAGP)
decreased nephron number  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased round window size  (IAGP)
decreased somatotroph cell number  (IAGP)
decreased testis weight  (IAGP)
decreased urine ammonia level  (IAGP)
decreased urine creatinine level  (IAGP)
decreased urine glucose level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine pH  (IAGP)
decreased urine phosphate level  (IAGP)
decreased urine potassium level  (IAGP)
decreased urine protein level  (IAGP)
decreased urine sodium level  (IAGP)
delayed bone ossification  (IAGP)
delayed ear emergence  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed eyelid opening  (IAGP)
delayed inner ear development  (IAGP)
dilated oviduct  (IAGP)
dilated renal glomerular capsule  (IAGP)
dilated renal tubule  (IAGP)
dilated uterine cervix  (IAGP)
elongated kidney papilla  (IAGP)
enlarged tectorial membrane  (IAGP)
external auditory canal stenosis  (IAGP)
female infertility  (IAGP)
hydronephrosis  (IAGP)
hypertension  (IAGP)
increased angiotensin II level  (IAGP)
increased apoptosis  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased fluid intake  (IAGP)
increased kidney apoptosis  (IAGP)
increased kidney cell proliferation  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased susceptibility to kidney reperfusion injury  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased thyroid-stimulating hormone level  (IAGP)
increased thyrotroph cell number  (IAGP)
increased urine calcium level  (IAGP)
increased urine chloride ion level  (IAGP)
increased urine glucose level  (IAGP)
increased urine potassium level  (IAGP)
increased urine protein level  (IAGP)
isosthenuria  (IAGP)
kidney cortex cyst  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
male infertility  (IAGP)
metabolic acidosis  (IAGP)
no abnormal phenotype detected  (IAGP)
oliguria  (IAGP)
pale kidney  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
reduced male fertility  (IAGP)
renal hypoplasia  (IAGP)
renal interstitial fibrosis  (IAGP)
short limbs  (IAGP)
small ears  (IAGP)
small epididymis  (IAGP)
small metanephros  (IAGP)
small thyroid gland  (IAGP)
testicular atrophy  (IAGP)
thin myometrium  (IAGP)
uterus hypoplasia  (IAGP)
vagina atresia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2. PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Macchia PE, etal., Nat Genet. 1998 May;19(1):83-6.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. Zannini M, etal., EMBO J 1997 Jun 2;16(11):3185-97.
Additional References at PubMed
PMID:1283313   PMID:1337742   PMID:1485966   PMID:1508216   PMID:1516825   PMID:1685142   PMID:1723950   PMID:7590254   PMID:7737192   PMID:7883790   PMID:7906966   PMID:7981748  
PMID:7990960   PMID:8071351   PMID:8099544   PMID:8126546   PMID:8318736   PMID:8413205   PMID:8431641   PMID:8575294   PMID:8625814   PMID:8652674   PMID:8751373   PMID:8786137  
PMID:8861958   PMID:9049629   PMID:9205117   PMID:9271117   PMID:9590297   PMID:9671580   PMID:9878254   PMID:9916856   PMID:9986727   PMID:9989404   PMID:10197584   PMID:10349636  
PMID:10471511   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11453662   PMID:11500373   PMID:11704761   PMID:11773436   PMID:11786385   PMID:12070080   PMID:12117823   PMID:12231626  
PMID:12432093   PMID:12435636   PMID:12441357   PMID:12466851   PMID:12477932   PMID:12538634   PMID:12586753   PMID:12591240   PMID:12810586   PMID:12815622   PMID:12874121   PMID:14531730  
PMID:14617574   PMID:14731361   PMID:14981357   PMID:15048807   PMID:15172686   PMID:15231702   PMID:15328022   PMID:15525602   PMID:15581879   PMID:15618518   PMID:15673575   PMID:15741321  
PMID:15802493   PMID:16054034   PMID:16138831   PMID:16141072   PMID:16141073   PMID:16150900   PMID:16319112   PMID:16331648   PMID:16418214   PMID:16452098   PMID:16803873   PMID:16916509  
PMID:17036046   PMID:17047028   PMID:17082261   PMID:17166926   PMID:17210747   PMID:17300925   PMID:17314325   PMID:17318265   PMID:17376978   PMID:17376979   PMID:17495424   PMID:17693601  
PMID:17900554   PMID:17932107   PMID:18287559   PMID:18346943   PMID:18377888   PMID:18495817   PMID:18703040   PMID:18985716   PMID:19010321   PMID:19235715   PMID:19389367   PMID:19477936  
PMID:19501082   PMID:19715689   PMID:19797117   PMID:19834026   PMID:19924770   PMID:20040500   PMID:20059953   PMID:20160132   PMID:20211142   PMID:20470391   PMID:20702572   PMID:20727173  
PMID:20843830   PMID:20851479   PMID:20978353   PMID:21267068   PMID:21303848   PMID:21308996   PMID:21345181   PMID:21354128   PMID:21362415   PMID:21364918   PMID:21491542   PMID:21512107  
PMID:21731775   PMID:21784065   PMID:21873635   PMID:21924257   PMID:21952241   PMID:22028439   PMID:22076439   PMID:22132122   PMID:22135066   PMID:22167068   PMID:22242190   PMID:22249313  
PMID:22432025   PMID:22453009   PMID:22511595   PMID:22526732   PMID:22912798   PMID:23051751   PMID:23078112   PMID:23307789   PMID:23384425   PMID:23511952   PMID:23555292   PMID:23707896  
PMID:23716689   PMID:23892084   PMID:23920117   PMID:23974041   PMID:24045698   PMID:24265449   PMID:24440154   PMID:24550112   PMID:24598167   PMID:24909663   PMID:24952961   PMID:25127920  
PMID:25274613   PMID:25287489   PMID:25389909   PMID:25458011   PMID:25490145   PMID:25587709   PMID:25617721   PMID:25647637   PMID:25799508   PMID:25892012   PMID:25925253   PMID:26035382  
PMID:26047795   PMID:26439621   PMID:26550799   PMID:26658320   PMID:26776520   PMID:26781745   PMID:26786105   PMID:26988119   PMID:27068110   PMID:27090781   PMID:27129161   PMID:27287879  
PMID:27341756   PMID:27699213   PMID:27820600   PMID:27827435   PMID:28160066   PMID:28373486   PMID:28385297   PMID:28473526   PMID:28760814   PMID:28923959   PMID:28993399   PMID:29361553  
PMID:29377931   PMID:29449451   PMID:29705331   PMID:29712641   PMID:29742982   PMID:29941522   PMID:30061411   PMID:30237523   PMID:30271355   PMID:30352879   PMID:30397221   PMID:30427222  
PMID:30446499   PMID:30753823   PMID:31166707   PMID:31296958   PMID:31412026   PMID:31534052   PMID:31575647   PMID:31582725   PMID:31673025   PMID:32325033   PMID:32402291   PMID:32541007  
PMID:32554463   PMID:32852840   PMID:32968282   PMID:32998907   PMID:33192541   PMID:33711282   PMID:33795231   PMID:34321664   PMID:34496237   PMID:34502288   PMID:34605272   PMID:34789765  
PMID:34906895   PMID:35001662   PMID:35017633   PMID:35289766   PMID:35613264   PMID:35645295   PMID:35794482   PMID:35858415   PMID:35982894   PMID:36130202   PMID:36165446   PMID:36205075  
PMID:36260124   PMID:36357396   PMID:36521641   PMID:36543770   PMID:37102687   PMID:37141145   PMID:37191061   PMID:37298722   PMID:37345578   PMID:37714160   PMID:37964961   PMID:37977366  
PMID:38078651   PMID:38426493   PMID:38724885   PMID:38750011  


Genomics

Comparative Map Data
Pax8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,310,563 - 24,365,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,310,572 - 24,365,611 (-)EnsemblGRCm39 Ensembl
GRCm38224,420,551 - 24,475,599 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,420,560 - 24,475,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv37224,276,080 - 24,331,086 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,242,569 - 24,297,575 (-)NCBIMGSCv36mm8
Celera224,140,049 - 24,195,191 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.43NCBI
PAX8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,215,997 - 113,278,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2113,215,997 - 113,278,921 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,973,574 - 114,036,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,690,045 - 113,752,968 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,691,170 - 113,752,728NCBI
Celera2107,358,161 - 107,421,066 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,427,614 - 106,522,962 (-)NCBIHuRef
CHM1_12113,977,965 - 114,040,915 (-)NCBICHM1_1
T2T-CHM13v2.02113,642,573 - 113,705,473 (-)NCBIT2T-CHM13v2.0
Pax8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,584,000 - 27,641,094 (-)NCBIGRCr8
mRatBN7.237,185,721 - 7,242,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,185,723 - 7,242,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,289,591 - 10,345,823 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,875,838 - 18,932,068 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,065,649 - 17,121,886 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,527,316 - 1,586,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,527,279 - 1,584,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,520,144 - 1,576,052 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,671,478 - 2,726,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,672,153 - 2,726,345 (-)NCBI
Celera32,022,899 - 2,078,650 (-)NCBICelera
Cytogenetic Map3p13NCBI
Pax8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,016,289 - 1,073,796 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,016,226 - 1,072,643 (+)NCBIChiLan1.0ChiLan1.0
PAX8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21214,933,395 - 14,971,937 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A14,936,160 - 14,974,705 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A88,845,877 - 88,905,266 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A114,162,110 - 114,222,865 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,162,110 - 114,222,865 (-)Ensemblpanpan1.1panPan2
PAX8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,307,130 - 37,331,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,306,033 - 37,363,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,077,650 - 37,133,660 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,084,443 - 38,141,710 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,085,541 - 38,141,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,220,866 - 37,276,852 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,277,373 - 37,333,166 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,490,112 - 37,546,218 (-)NCBIUU_Cfam_GSD_1.0
Pax8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,629,178 - 82,682,663 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,523,661 - 1,576,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,523,658 - 1,553,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,236,074 - 16,299,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,233,378 - 16,297,365 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,382,976 - 3,450,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pax8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474913,300,606 - 13,357,903 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474913,291,880 - 13,358,066 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pax8
1807 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1441
Count of miRNA genes:652
Interacting mature miRNAs:774
Transcripts:ENSMUST00000028355, ENSMUST00000133746, ENSMUST00000136228, ENSMUST00000149294, ENSMUST00000149860, ENSMUST00000152614, ENSMUST00000153535, ENSMUST00000153601
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse

Markers in Region
PMC187478P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38224,444,703 - 24,445,091UniSTSGRCm38
MGSCv37224,300,223 - 24,300,611UniSTSGRCm37
Celera224,164,273 - 24,164,661UniSTS
Cytogenetic Map2BUniSTS
cM Map213.5UniSTS
D11Bir2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,761,686 - 44,761,823UniSTSGRCm38
GRCm38224,443,002 - 24,443,139UniSTSGRCm38
MGSCv37224,298,522 - 24,298,659UniSTSGRCm37
MGSCv371944,836,176 - 44,836,313UniSTSGRCm37
Celera224,162,572 - 24,162,709UniSTS
Celera1945,532,280 - 45,532,417UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map19C3UniSTS
cM Map213.5UniSTS
cM Map4 UniSTS
cM Map224.0UniSTS
cM Map761.0UniSTS
cM Map116.0UniSTS
cM Map186.6UniSTS
cM Map1743.5UniSTS
cM Map1448.0UniSTS
cM Map1102.8UniSTS
cM Map1125.0UniSTS
cM Map239.0UniSTS
Pax8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2BUniSTS
cM Map213.5UniSTS
Pax8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38224,421,088 - 24,421,284UniSTSGRCm38
MGSCv37224,276,608 - 24,276,804UniSTSGRCm37
Celera224,140,577 - 24,140,773UniSTS
Cytogenetic Map2BUniSTS
cM Map213.5UniSTS
Pax8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2BUniSTS
cM Map213.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK032920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY157583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY442465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X57487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X99598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000028355   ⟹   ENSMUSP00000028355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,310,572 - 24,365,611 (-)Ensembl
GRCm38.p6 Ensembl224,420,560 - 24,475,599 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,333,010 - 24,335,912 (-)Ensembl
GRCm38.p6 Ensembl224,442,998 - 24,445,900 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136228   ⟹   ENSMUSP00000133316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,319,539 - 24,365,586 (-)Ensembl
GRCm38.p6 Ensembl224,429,527 - 24,475,574 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149294   ⟹   ENSMUSP00000115194
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,311,532 - 24,365,109 (-)Ensembl
GRCm38.p6 Ensembl224,421,520 - 24,475,097 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,311,406 - 24,313,094 (-)Ensembl
GRCm38.p6 Ensembl224,421,394 - 24,423,082 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,361,897 - 24,365,586 (-)Ensembl
GRCm38.p6 Ensembl224,471,885 - 24,475,574 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153535   ⟹   ENSMUSP00000120319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,331,189 - 24,365,227 (-)Ensembl
GRCm38.p6 Ensembl224,441,177 - 24,475,215 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153601   ⟹   ENSMUSP00000134343
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,311,543 - 24,365,576 (-)Ensembl
GRCm38.p6 Ensembl224,421,531 - 24,475,564 (-)Ensembl
RefSeq Acc Id: NM_011040   ⟹   NP_035170
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39224,310,563 - 24,365,611 (-)NCBI
GRCm38224,420,551 - 24,475,599 (-)NCBI
MGSCv37224,276,080 - 24,331,086 (-)RGD
Celera224,140,040 - 24,195,224 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035170   ⟸   NM_011040
- UniProtKB: P97342 (UniProtKB/Swiss-Prot),   Q6GU20 (UniProtKB/Swiss-Prot),   Q00288 (UniProtKB/Swiss-Prot),   A2AIU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028355   ⟸   ENSMUST00000028355
RefSeq Acc Id: ENSMUSP00000115194   ⟸   ENSMUST00000149294
RefSeq Acc Id: ENSMUSP00000134343   ⟸   ENSMUST00000153601
RefSeq Acc Id: ENSMUSP00000120319   ⟸   ENSMUST00000153535
RefSeq Acc Id: ENSMUSP00000133316   ⟸   ENSMUST00000136228
Protein Domains
Paired

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00288-F1-model_v2 AlphaFold Q00288 1-457 view protein structure

Promoters
RGD ID:6832007
Promoter ID:MM_KWN:28045
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000028467
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36224,278,481 - 24,278,981 (-)MPROMDB
RGD ID:6832004
Promoter ID:MM_KWN:28048
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000028466
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36224,301,081 - 24,302,132 (-)MPROMDB
RGD ID:6832005
Promoter ID:MM_KWN:28050
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000102940,   OTTMUST00000028458,   OTTMUST00000028459,   OTTMUST00000028460,   OTTMUST00000028461,   OTTMUST00000028462,   OTTMUST00000028463,   OTTMUST00000028464,   OTTMUST00000028465
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36224,330,831 - 24,331,331 (-)MPROMDB
RGD ID:6876520
Promoter ID:EPDNEW_M1710
Type:multiple initiation site
Name:Pax8_1
Description:Mus musculus paired box 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38224,475,574 - 24,475,634EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97492 AgrOrtholog
Ensembl Genes ENSMUSG00000026976 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028355 ENTREZGENE
  ENSMUST00000028355.11 UniProtKB/Swiss-Prot
  ENSMUST00000136228.10 UniProtKB/TrEMBL
  ENSMUST00000149294.8 UniProtKB/TrEMBL
  ENSMUST00000153535.2 UniProtKB/TrEMBL
  ENSMUST00000153601.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIRED_DNA_bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paired_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pax2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAX_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18510 UniProtKB/Swiss-Prot
MGD MGI:97492 ENTREZGENE
NCBI Gene 18510 ENTREZGENE
PANTHER PAIRED BOX PROTEIN PAX-8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45636 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pax2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pax8 PhenoGen
PRINTS PAIREDBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PAIRED_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AIU6_MOUSE UniProtKB/TrEMBL
  A2AIU7 ENTREZGENE, UniProtKB/TrEMBL
  A2AIU8_MOUSE UniProtKB/TrEMBL
  G3UZ49_MOUSE UniProtKB/TrEMBL
  P97342 ENTREZGENE
  PAX8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6GU20 ENTREZGENE
UniProt Secondary P97342 UniProtKB/Swiss-Prot
  Q6GU20 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Pax8  paired box 8    paired box gene 8  Symbol and/or name change 5135510 APPROVED