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Gene: MMP2 (matrix metallopeptidase 2) Homo sapiens

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Symbol:

MMP2

Name:

matrix metallopeptidase 2

RGD ID:

730821

HGNC Page

HGNC:7166

Description:

Enables metallopeptidase activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; endodermal cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in extracellular space. Implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Biomarker of several diseases, including artery disease (multiple); carcinoma (multiple); cardiomyopathy (multiple); cholesteatoma (multiple); and neurodegenerative disease (multiple).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

72 kDa gelatinase; 72 kDa type IV collagenase; CLG4; CLG4A; collagenase type IV-A; gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP-2; MMP-II; MONA; neutrophil gelatinase; TBE-1

RGD Orthologs

Alliance Orthologs

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Mmp2 (matrix metallopeptidase 2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Mmp2 (matrix metallopeptidase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Mmp2 (matrix metallopeptidase 2)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	MMP2 (matrix metallopeptidase 2)	NCBI	Ortholog
Canis lupus familiaris (dog):	MMP2 (matrix metallopeptidase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mmp2 (matrix metallopeptidase 2)	NCBI	Ortholog
Sus scrofa (pig):	MMP2 (matrix metallopeptidase 2)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	MMP2 (matrix metallopeptidase 2)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Mmp2 (matrix metallopeptidase 2)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Srpk2 (SRSF protein kinase 2)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Mmp2 (matrix metallopeptidase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mmp2 (matrix metallopeptidase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mmp2 (matrix metallopeptidase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	zmp-4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	Y50D7A.13	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	W01F3.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	K03B8.6	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus laevis (African clawed frog):	mmp2.S	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	mmp2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	55,478,830 - 55,506,691 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	55,389,700 - 55,506,691 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	55,512,742 - 55,540,603 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	54,070,589 - 54,098,104 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	54,070,603 - 54,097,652	NCBI
Celera	16	40,027,315 - 40,054,814 (+)	NCBI		Celera
Cytogenetic Map	16	q12.2	NCBI
HuRef	16	41,400,533 - 41,427,983 (+)	NCBI		HuRef
CHM1_1	16	56,920,344 - 56,947,845 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	61,276,956 - 61,304,813 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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