Srebf1_v2 (sterol regulatory element binding factor 1, variant 2) - Rat Genome Database

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Gene: Srebf1_v2 (sterol regulatory element binding factor 1, variant 2) Rattus norvegicus
Symbol: Srebf1_v2
Name: sterol regulatory element binding factor 1, variant 2
RGD ID: 728328
Description: a chromatin binding protein involved in cholesterol metabolism; associated with diabetes and fetal growth retardation
ENCODES an splice that exhibits chromatin binding; protein-containing complex binding; INVOLVED IN cellular response to insulin stimulus; cholesterol metabolic process; lung development; ASSOCIATED WITH decreased cholesterol level; ASSOCIATED WITH Fetal Growth Retardation; Insulin Resistance; type 2 diabetes mellitus; FOUND IN protein-containing complex
Type: splice  of Srebf1  
Previously known as: Srebp1-c; Srebp1c
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
RGSC_v3.11046,476,924 - 46,487,123 (-)NCBI

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. Bonzon-Kulichenko E, etal., Endocrinology. 2009 Jan;150(1):169-78. Epub 2008 Sep 18.
2. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. Botolin D, etal., J Lipid Res. 2006 Jan;47(1):181-92. Epub 2005 Oct 12.
3. Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring. Desai M, etal., Reprod Sci. 2008 Oct;15(8):785-96.
4. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Foretz M, etal., Mol Cell Biol. 1999 May;19(5):3760-8.
5. Involvement of glomerular SREBP-1c in diabetic nephropathy. Ishigaki N, etal., Biochem Biophys Res Commun. 2007 Dec 21;364(3):502-8. Epub 2007 Oct 16.
6. Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue. Lacasa D, etal., J Biol Chem. 2001 Apr 13;276(15):11512-6. Epub 2001 Jan 16.
7. Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population. Liu JX, etal., Diabetes Res Clin Pract. 2008 Oct;82(1):42-7. Epub 2008 Aug 8.
8. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Ota T, etal., Gastroenterology. 2007 Jan;132(1):282-93. Epub 2006 Oct 12.
9. Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat. Pravenec M, etal., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10.
10. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Proctor G, etal., Diabetes. 2006 Sep;55(9):2502-9.
11. Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance. Sajan MP, etal., Diabetologia. 2009 Jun;52(6):1197-207. Epub 2009 Apr 9.
12. Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.PG - Sun L, etal., J Biol Chem 2002 May 24;277(21):18919-27.
13. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. Tamehiro N, etal., J Biol Chem. 2007 Jul 20;282(29):21090-9. Epub 2007 May 27.
14. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. Yellaturu CR, etal., J Biol Chem. 2009 Mar 20;284(12):7518-32. Epub 2009 Jan 21.
15. Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. Yin HQ, et al., Toxicol Appl Pharmacol. 2009 Apr 1;236(1):124-30. doi: 10.1016/j.taap.2008.12.030. Epub 2009 Jan 24.
16. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Zhang F, etal., Am J Respir Cell Mol Biol 2004 Feb;30(2):174-83. Epub 2003 Aug 01.




Nucleotide Sequences
GenBank Nucleotide AF286470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Srebf1_v2  sterol regulatory element binding factor 1, variant 2      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript produced through the use of alternative transcription start sites that result in alternate form of exon 1 625517
gene_transcript predominant in vivo form 625517