Dnm3 (dynamin 3) - Rat Genome Database

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Gene: Dnm3 (dynamin 3) Rattus norvegicus
Analyze
Symbol: Dnm3
Name: dynamin 3
RGD ID: 727949
Description: Enables G protein-coupled glutamate receptor binding activity; GTPase activity; and enzyme binding activity. A structural constituent of postsynapse. Involved in several processes, including filopodium assembly; positive regulation of synaptic vesicle recycling; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including dendritic spine head; postsynaptic density; and synaptic cleft. Part of apical tubulobulbar complex and basal tubulobulbar complex. Is active in glutamatergic synapse and postsynaptic endocytic zone membrane. Orthologous to human DNM3 (dynamin 3); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dynamin, testicular; dynamin-2; dynamin-3; LOC171574; T-dynamin; testicular dynamin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,892,381 - 77,371,346 (-)NCBIGRCr8
mRatBN7.21374,359,043 - 74,838,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,359,213 - 74,838,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,937,177 - 77,413,346 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,244,410 - 78,721,423 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,504,269 - 75,981,283 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,906,711 - 80,379,967 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,910,382 - 80,379,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01384,796,219 - 85,272,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,688,376 - 78,165,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11377,702,567 - 78,179,370 (-)NCBI
Celera1374,120,681 - 74,589,220 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
carbon nanotube  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethylparaben  (ISO)
fenamidone  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
glyphosate  (EXP)
hydrogen sulfide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel sulfate  (ISO)
ozone  (ISO)
paraquat  (EXP)
PCB138  (EXP)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential distribution of dynamin isoforms in mammalian cells. Cao H, etal., Mol Biol Cell. 1998 Sep;9(9):2595-609.
2. Three dynamin-encoding genes are differentially expressed in developing rat brain. Cook T, etal., J Neurochem 1996 Sep;67(3):927-31.
3. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Gray NW, etal., Curr Biol. 2003 Mar 18;13(6):510-5.
6. A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines. Gray NW, etal., J Cell Sci. 2005 Mar 15;118(Pt 6):1279-90. Epub 2005 Mar 1.
7. Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
8. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Ikeuchi Y, etal., Cell Rep. 2013 Sep 12;4(5):879-89. doi: 10.1016/j.celrep.2013.07.042. Epub 2013 Aug 29.
9. Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. Lu J, etal., Neuron. 2007 Sep 20;55(6):874-89.
10. The cytosolic domain of APP induces the relocalization of dynamin 3 in hippocampal neurons. Meckler X, etal., Eur J Neurosci. 2006 Nov;24(9):2439-43.
11. A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis. Nakata T, etal., J Cell Sci 1993 May;105 ( Pt 1):1-5.
12. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
18. Dynamin isoforms decode action potential firing for synaptic vesicle recycling. Tanifuji S, etal., J Biol Chem. 2013 Jun 28;288(26):19050-9. doi: 10.1074/jbc.M112.445874. Epub 2013 May 16.
19. The role of dynamin 3 in the testis. Vaid KS, etal., J Cell Physiol. 2007 Mar;210(3):644-54.
20. Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
Additional References at PubMed
PMID:10908605   PMID:12850060   PMID:14651853   PMID:14760703   PMID:16903783   PMID:19032944   PMID:21689597   PMID:21700703   PMID:23410488   PMID:23533145   PMID:23746204   PMID:26302298  
PMID:32357304  


Genomics

Comparative Map Data
Dnm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,892,381 - 77,371,346 (-)NCBIGRCr8
mRatBN7.21374,359,043 - 74,838,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,359,213 - 74,838,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,937,177 - 77,413,346 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,244,410 - 78,721,423 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,504,269 - 75,981,283 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,906,711 - 80,379,967 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,910,382 - 80,379,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01384,796,219 - 85,272,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,688,376 - 78,165,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11377,702,567 - 78,179,370 (-)NCBI
Celera1374,120,681 - 74,589,220 (-)NCBICelera
Cytogenetic Map13q22NCBI
DNM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,841,498 - 172,418,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,817,887 - 172,418,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,810,638 - 172,387,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,077,261 - 170,648,480 (+)NCBINCBI36Build 36hg18NCBI36
Build 341168,542,294 - 169,113,513NCBI
Celera1144,920,019 - 145,491,322 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1143,034,379 - 143,605,830 (+)NCBIHuRef
CHM1_11173,232,859 - 173,803,974 (+)NCBICHM1_1
T2T-CHM13v2.01171,198,091 - 171,775,179 (+)NCBIT2T-CHM13v2.0
Dnm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,810,022 - 162,305,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,810,022 - 162,305,603 (-)EnsemblGRCm39 Ensembl
GRCm381161,982,450 - 162,478,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,982,453 - 162,478,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,917,433 - 164,408,165 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361163,823,979 - 164,314,705 (-)NCBIMGSCv36mm8
Celera1164,442,411 - 164,918,051 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
Dnm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540612,345,693 - 12,881,269 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540612,345,483 - 12,881,182 (+)NCBIChiLan1.0ChiLan1.0
DNM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2177,327,604 - 77,910,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1177,007,605 - 77,584,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,339,773 - 147,916,513 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11151,049,215 - 151,626,289 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1151,049,346 - 151,615,808 (+)Ensemblpanpan1.1panPan2
DNM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,569,708 - 27,024,939 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,574,453 - 27,024,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha726,095,554 - 26,643,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0726,315,840 - 26,863,371 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl726,315,837 - 26,863,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1726,226,439 - 26,773,966 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0726,297,008 - 26,844,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0726,447,294 - 26,995,113 (-)NCBIUU_Cfam_GSD_1.0
Dnm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934497,125,192 - 97,564,504 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648114,971,947 - 15,411,288 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648114,971,977 - 15,411,253 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9114,262,791 - 114,797,674 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19114,262,782 - 114,805,252 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,088,358 - 126,400,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12556,735,877 - 57,285,557 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2556,746,215 - 57,285,498 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605558,341,839 - 58,908,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247719,247,218 - 9,838,254 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247719,247,463 - 9,838,276 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnm3
2842 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:848
Count of miRNA genes:172
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000041058, ENSRNOT00000047799, ENSRNOT00000064219, ENSRNOT00000067653, ENSRNOT00000068490
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat

Markers in Region
D13Mit5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,741,916 - 74,742,160 (+)MAPPERmRatBN7.2
Rnor_6.01380,285,619 - 80,285,862NCBIRnor6.0
Rnor_5.01385,176,659 - 85,176,902UniSTSRnor5.0
RGSC_v3.41378,070,513 - 78,070,756UniSTSRGSC3.4
RGSC_v3.41378,070,512 - 78,070,756RGDRGSC3.4
RGSC_v3.11378,084,701 - 78,084,944RGD
Celera1374,492,227 - 74,492,470UniSTS
RH 3.4 Map13460.4UniSTS
RH 3.4 Map13460.4RGD
RH 2.0 Map13528.0RGD
SHRSP x BN Map1329.4998RGD
FHH x ACI Map1330.36RGD
Cytogenetic Map13q22UniSTS
D13Mit3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,741,854 - 74,742,070 (+)MAPPERmRatBN7.2
Rnor_6.01380,285,557 - 80,285,772NCBIRnor6.0
Rnor_5.01385,176,597 - 85,176,812UniSTSRnor5.0
RGSC_v3.41378,070,450 - 78,070,666RGDRGSC3.4
RGSC_v3.41378,070,451 - 78,070,666UniSTSRGSC3.4
RGSC_v3.11378,084,630 - 78,084,951RGD
Celera1374,492,165 - 74,492,380UniSTS
RH 3.4 Map13455.5RGD
RH 3.4 Map13455.5UniSTS
RH 2.0 Map13520.3RGD
Cytogenetic Map13q22UniSTS
BE116196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,583,374 - 74,583,535 (+)MAPPERmRatBN7.2
Rnor_6.01380,125,908 - 80,126,068NCBIRnor6.0
Rnor_5.01385,019,818 - 85,019,978UniSTSRnor5.0
RGSC_v3.41377,911,188 - 77,911,348UniSTSRGSC3.4
Celera1374,335,013 - 74,335,173UniSTS
RH 3.4 Map13452.7UniSTS
Cytogenetic Map13q22UniSTS
AW534587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,586,257 - 74,586,455 (+)MAPPERmRatBN7.2
Rnor_6.01380,128,791 - 80,128,988NCBIRnor6.0
Rnor_5.01385,022,701 - 85,022,898UniSTSRnor5.0
RGSC_v3.41377,914,071 - 77,914,268UniSTSRGSC3.4
Celera1374,337,896 - 74,338,093UniSTS
RH 3.4 Map13452.8UniSTS
Cytogenetic Map13q22UniSTS
AA800783  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,379,993 - 74,380,135 (+)MAPPERmRatBN7.2
Rnor_6.01379,923,151 - 79,923,292NCBIRnor6.0
Rnor_5.01384,817,022 - 84,817,163UniSTSRnor5.0
RGSC_v3.41377,700,644 - 77,700,785UniSTSRGSC3.4
Celera1374,132,732 - 74,132,873UniSTS
RH 3.4 Map13470.3UniSTS
Cytogenetic Map13q22UniSTS
BQ200675  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,398,937 - 74,399,133 (+)MAPPERmRatBN7.2
Rnor_6.01379,942,093 - 79,942,288NCBIRnor6.0
Rnor_5.01384,835,963 - 84,836,158UniSTSRnor5.0
RGSC_v3.41377,719,587 - 77,719,782UniSTSRGSC3.4
Celera1374,151,687 - 74,151,882UniSTS
RH 3.4 Map13470.2UniSTS
Cytogenetic Map13q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 87 86 55 25 55 6 214 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_138538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC144674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF201839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067653   ⟹   ENSRNOP00000063767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,367,731 - 74,838,108 (-)Ensembl
Rnor_6.0 Ensembl1379,910,382 - 80,379,929 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075938   ⟹   ENSRNOP00000068044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,379,880 - 74,838,108 (-)Ensembl
Rnor_6.0 Ensembl1379,923,000 - 80,379,929 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098479   ⟹   ENSRNOP00000085302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,384,473 - 74,838,108 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102382   ⟹   ENSRNOP00000084111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,359,213 - 74,838,108 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104847   ⟹   ENSRNOP00000088404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,384,000 - 74,838,108 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106497   ⟹   ENSRNOP00000088872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,379,843 - 74,572,337 (-)Ensembl
RefSeq Acc Id: NM_138538   ⟹   NP_612547
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,900,999 - 77,371,346 (-)NCBI
mRatBN7.21374,367,726 - 74,838,104 (-)NCBI
Rnor_6.01379,910,883 - 80,379,925 (-)NCBI
Rnor_5.01384,796,219 - 85,272,032 (-)NCBI
RGSC_v3.41377,688,376 - 78,165,178 (-)RGD
Celera1374,120,681 - 74,589,220 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250141   ⟹   XP_006250203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,896,827 - 77,371,218 (-)NCBI
mRatBN7.21374,363,532 - 74,838,134 (-)NCBI
Rnor_6.01379,906,711 - 80,379,966 (-)NCBI
Rnor_5.01384,796,219 - 85,272,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250142   ⟹   XP_006250204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,913,116 - 77,371,218 (-)NCBI
mRatBN7.21374,379,843 - 74,838,134 (-)NCBI
Rnor_6.01379,923,000 - 80,379,966 (-)NCBI
Rnor_5.01384,796,219 - 85,272,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090312   ⟹   XP_038946240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,034,326 - 77,371,218 (-)NCBI
mRatBN7.21374,501,053 - 74,838,133 (-)NCBI
RefSeq Acc Id: XM_039090313   ⟹   XP_038946241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,130,508 - 77,371,218 (-)NCBI
mRatBN7.21374,597,237 - 74,838,133 (-)NCBI
RefSeq Acc Id: XM_039090316   ⟹   XP_038946244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,130,509 - 77,371,218 (-)NCBI
mRatBN7.21374,597,237 - 74,838,131 (-)NCBI
RefSeq Acc Id: XM_063272013   ⟹   XP_063128083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,913,116 - 77,371,218 (-)NCBI
RefSeq Acc Id: XM_063272014   ⟹   XP_063128084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,892,381 - 77,371,218 (-)NCBI
RefSeq Acc Id: XM_063272015   ⟹   XP_063128085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,892,388 - 77,371,218 (-)NCBI
RefSeq Acc Id: XM_063272016   ⟹   XP_063128086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,943,162 - 77,371,218 (-)NCBI
RefSeq Acc Id: XM_063272017   ⟹   XP_063128087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81376,943,162 - 77,371,218 (-)NCBI
RefSeq Acc Id: NP_612547   ⟸   NM_138538
- UniProtKB: Q9QXL9 (UniProtKB/Swiss-Prot),   Q08877 (UniProtKB/Swiss-Prot),   A0A8I6A9X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250203   ⟸   XM_006250141
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250204   ⟸   XM_006250142
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A9X4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063767   ⟸   ENSRNOT00000067653
Ensembl Acc Id: ENSRNOP00000068044   ⟸   ENSRNOT00000075938
RefSeq Acc Id: XP_038946240   ⟸   XM_039090312
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038946241   ⟸   XM_039090313
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038946244   ⟸   XM_039090316
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000088404   ⟸   ENSRNOT00000104847
Ensembl Acc Id: ENSRNOP00000085302   ⟸   ENSRNOT00000098479
Ensembl Acc Id: ENSRNOP00000084111   ⟸   ENSRNOT00000102382
Ensembl Acc Id: ENSRNOP00000088872   ⟸   ENSRNOT00000106497
RefSeq Acc Id: XP_063128084   ⟸   XM_063272014
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063128085   ⟸   XM_063272015
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063128083   ⟸   XM_063272013
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128087   ⟸   XM_063272017
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063128086   ⟸   XM_063272016
- Peptide Label: isoform X6
Protein Domains
Dynamin-type G   GED   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08877-F1-model_v2 AlphaFold Q08877 1-869 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698940
Promoter ID:EPDNEW_R9464
Type:single initiation site
Name:Dnm3_1
Description:dynamin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01380,379,968 - 80,380,028EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727949 AgrOrtholog
BioCyc Gene G2FUF-17683 BioCyc
Ensembl Genes ENSRNOG00000026490 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055017816 UniProtKB/Swiss-Prot
  ENSRNOG00060008697 UniProtKB/Swiss-Prot
  ENSRNOG00065020069 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067653.4 UniProtKB/Swiss-Prot
  ENSRNOT00000075938.2 UniProtKB/Swiss-Prot
  ENSRNOT00000098479.1 UniProtKB/TrEMBL
  ENSRNOT00000102382.1 UniProtKB/TrEMBL
  ENSRNOT00000104847.1 UniProtKB/TrEMBL
  ENSRNOT00000106497.1 UniProtKB/TrEMBL
  ENSRNOT00055030146 UniProtKB/Swiss-Prot
  ENSRNOT00060014690 UniProtKB/Swiss-Prot
  ENSRNOT00065033930 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin, middle domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dynamin UniProtKB/TrEMBL
  Dynamin_central UniProtKB/Swiss-Prot
  Dynamin_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/Swiss-Prot
  Dynamin_stalk UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171574 UniProtKB/Swiss-Prot
NCBI Gene 171574 ENTREZGENE
PANTHER DYNAMIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnm3 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026490 RatGTEx
  ENSRNOG00055017816 RatGTEx
  ENSRNOG00060008697 RatGTEx
  ENSRNOG00065020069 RatGTEx
SMART DYNc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZYS4_RAT UniProtKB/TrEMBL
  A0A8I6A8P1_RAT UniProtKB/TrEMBL
  A0A8I6A9X4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GCQ8_RAT UniProtKB/TrEMBL
  A6ID88_RAT UniProtKB/TrEMBL
  A6ID90_RAT UniProtKB/TrEMBL
  A6ID91_RAT UniProtKB/TrEMBL
  DYN3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QXL9 ENTREZGENE
UniProt Secondary Q9QXL9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Dnm3  dynamin 3  LOC171574  testicular dynamin  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in seminferous tubules of testis, in Sertoli cells 1299610