Rffl (ring finger and FYVE-like domain containing E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Rffl (ring finger and FYVE-like domain containing E3 ubiquitin protein ligase) Rattus norvegicus
Analyze
Symbol: Rffl (Ensembl: Rad51d)
Name: ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RGD ID: 727916
Description: Predicted to enable enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of signal transduction; and protein K48-linked ubiquitination. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in endosome membrane. Predicted to be active in cytoplasm and plasma membrane. Biomarker of hypertension. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase rififylin; fring; FYVE-RING finger protein Sakura; LOC282844; MGC94279; ring finger and FYVE like domain containing protein; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein SAKURA; RING-type E3 ubiquitin transferase rififylin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp301
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21067,740,711 - 67,803,694 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,740,712 - 67,824,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,360,780 - 72,423,716 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01071,866,156 - 71,929,095 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01067,327,967 - 67,393,247 (-)NCBIRnor_WKY
Rnor_6.01070,157,621 - 70,220,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,157,621 - 70,220,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,788,330 - 69,851,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,025,035 - 71,047,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,038,657 - 71,060,903 (-)NCBI
Celera1066,686,813 - 66,709,204 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
gallic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercaptoethanol  (ISO)
metformin  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
trichostatin A  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes. Araki K, etal., J Neurochem 2003 Aug;86(3):749-62.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension. Gopalakrishnan K, etal., Hypertension. 2011 Apr;57(4):764-71. doi: 10.1161/HYPERTENSIONAHA.110.165803. Epub 2011 Feb 28.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15069192   PMID:15229288   PMID:15489334   PMID:17121812   PMID:18382127   PMID:18450452   PMID:19946888   PMID:22609986   PMID:28827789  


Genomics

Comparative Map Data
Rffl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21067,740,711 - 67,803,694 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,740,712 - 67,824,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,360,780 - 72,423,716 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01071,866,156 - 71,929,095 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01067,327,967 - 67,393,247 (-)NCBIRnor_WKY
Rnor_6.01070,157,621 - 70,220,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,157,621 - 70,220,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,788,330 - 69,851,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,025,035 - 71,047,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,038,657 - 71,060,903 (-)NCBI
Celera1066,686,813 - 66,709,204 (-)NCBICelera
Cytogenetic Map10q26NCBI
RFFL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,005,990 - 35,089,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1735,005,990 - 35,089,319 (-)EnsemblGRCh38hg38GRCh38
GRCh371733,333,009 - 33,416,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,360,244 - 30,440,407 (-)NCBINCBI36Build 36hg18NCBI36
Celera1730,246,327 - 30,326,489 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,522,054 - 29,601,016 (-)NCBIHuRef
CHM1_11733,400,524 - 33,480,727 (-)NCBICHM1_1
T2T-CHM13v2.01735,953,906 - 36,037,140 (-)NCBIT2T-CHM13v2.0
Rffl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,694,645 - 82,762,065 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,693,275 - 82,762,036 (-)EnsemblGRCm39 Ensembl
GRCm381182,803,819 - 82,871,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,802,449 - 82,871,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,617,321 - 82,684,712 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,620,017 - 82,686,939 (-)NCBIMGSCv36mm8
Celera1192,423,191 - 92,490,746 (-)NCBICelera
Cytogenetic Map11CNCBI
Rffl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554819,718,369 - 9,765,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554819,718,369 - 9,788,048 (-)NCBIChiLan1.0ChiLan1.0
RFFL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11722,014,167 - 22,069,553 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,035,643 - 22,069,546 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01721,696,808 - 21,779,878 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RFFL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,271,419 - 38,346,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,222,051 - 38,365,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,495,000 - 37,573,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,083,074 - 39,162,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,054,329 - 39,156,002 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,866,520 - 37,945,113 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,151,818 - 38,231,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,239,649 - 38,318,516 (+)NCBIUU_Cfam_GSD_1.0
Rffl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,282,719 - 37,325,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538139,723 - 203,600 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936538139,690 - 203,600 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFFL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,075,337 - 40,151,043 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,075,259 - 40,151,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,676,668 - 41,712,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RFFL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,515,393 - 28,593,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1628,518,231 - 28,533,070 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660751,388,544 - 1,472,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rffl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248752,897,832 - 2,964,866 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248752,896,888 - 2,964,838 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rffl
358 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:829
Count of miRNA genes:257
Interacting mature miRNAs:321
Transcripts:ENSRNOT00000010015, ENSRNOT00000041389
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944767750281Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944767750281Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)106631944767750281Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944767750281Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944767750281Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944768164786Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944768164786Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944768164786Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944768164786Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
1579917Bp282Blood pressure QTL 2820.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106740031668164786Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
2292440Bp312Blood pressure QTL 312arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106775004968164786Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat

Markers in Region
D10Got87  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,765,546 - 67,765,709 (+)MAPPERmRatBN7.2
Rnor_6.01070,182,462 - 70,182,622NCBIRnor6.0
Rnor_5.01069,813,167 - 69,813,327UniSTSRnor5.0
Rnor_5.01070,947,551 - 70,947,711UniSTSRnor5.0
RGSC_v3.41071,048,033 - 71,048,194RGDRGSC3.4
RGSC_v3.41071,048,034 - 71,048,194UniSTSRGSC3.4
RGSC_v3.11071,061,656 - 71,061,817RGD
Celera1066,709,958 - 66,710,118UniSTS
RH 2.0 Map10689.8RGD
Cytogenetic Map10q26UniSTS
D10Chm171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,750,049 - 67,750,281 (+)MAPPERmRatBN7.2
Rnor_6.01070,166,960 - 70,167,191NCBIRnor6.0
Rnor_5.01069,797,667 - 69,797,898UniSTSRnor5.0
RGSC_v3.41071,032,534 - 71,032,765UniSTSRGSC3.4
Celera1066,694,510 - 66,694,687UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 42 34 19 34 38 32 35 10
Low 39 15 7 7 8 11 36 3 6 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY157969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010015   ⟹   ENSRNOP00000010015
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,740,981 - 67,824,434 (-)Ensembl
Rnor_6.0 Ensembl1070,159,607 - 70,172,739 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000038376   ⟹   ENSRNOP00000036257
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,810,289 - 67,824,354 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000041389   ⟹   ENSRNOP00000045245
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,740,884 - 67,779,898 (-)Ensembl
Rnor_6.0 Ensembl1070,157,621 - 70,220,558 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076089   ⟹   ENSRNOP00000068502
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1070,159,740 - 70,202,398 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076398   ⟹   ENSRNOP00000068077
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,740,981 - 67,803,751 (-)Ensembl
Rnor_6.0 Ensembl1070,157,626 - 70,220,560 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076509   ⟹   ENSRNOP00000093509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,805,799 - 67,824,434 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076596   ⟹   ENSRNOP00000068131
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,740,712 - 67,779,935 (-)Ensembl
Rnor_6.0 Ensembl1070,157,624 - 70,220,582 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076598   ⟹   ENSRNOP00000067950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,742,487 - 67,764,793 (-)Ensembl
Rnor_6.0 Ensembl1070,159,397 - 70,181,708 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117637   ⟹   ENSRNOP00000082234
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,810,289 - 67,824,354 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119950   ⟹   ENSRNOP00000096856
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,810,289 - 67,824,354 (-)Ensembl
RefSeq Acc Id: NM_001004068   ⟹   NP_001004068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,742,487 - 67,764,793 (-)NCBI
Rnor_6.01070,159,397 - 70,181,708 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
RGSC_v3.41071,025,035 - 71,047,280 (-)RGD
Celera1066,686,813 - 66,709,204 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246969   ⟹   XP_006247031
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,780,135 (-)NCBI
Rnor_6.01070,157,621 - 70,197,081 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246970   ⟹   XP_006247032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,780,129 (-)NCBI
Rnor_6.01070,157,621 - 70,197,081 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246973   ⟹   XP_006247035
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,765,102 (-)NCBI
Rnor_6.01070,157,621 - 70,182,016 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246974   ⟹   XP_006247036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,803,637 (-)NCBI
Rnor_6.01070,157,621 - 70,220,618 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246977   ⟹   XP_006247039
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,780,770 (-)NCBI
Rnor_6.01070,157,621 - 70,198,173 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246978   ⟹   XP_006247040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,764,833 (-)NCBI
Rnor_6.01070,157,621 - 70,182,015 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246979   ⟹   XP_006247041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,803,694 (-)NCBI
Rnor_6.01070,157,621 - 70,220,617 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085320   ⟹   XP_038941248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,755,831 (-)NCBI
RefSeq Acc Id: XM_039085321   ⟹   XP_038941249
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,780,131 (-)NCBI
RefSeq Acc Id: XM_039085322   ⟹   XP_038941250
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,803,466 (-)NCBI
RefSeq Acc Id: XM_039085323   ⟹   XP_038941251
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,740,711 - 67,779,748 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001004068   ⟸   NM_001004068
- UniProtKB: Q8CIN9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247036   ⟸   XM_006246974
- Peptide Label: isoform X4
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247041   ⟸   XM_006246979
- Peptide Label: isoform X5
- UniProtKB: Q8CIN9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247039   ⟸   XM_006246977
- Peptide Label: isoform X4
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247032   ⟸   XM_006246970
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QZU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247031   ⟸   XM_006246969
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006247040   ⟸   XM_006246978
- Peptide Label: isoform X5
- UniProtKB: Q6AY29 (UniProtKB/Swiss-Prot),   Q8CIN9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247035   ⟸   XM_006246973
- Peptide Label: isoform X4
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010015   ⟸   ENSRNOT00000010015
RefSeq Acc Id: ENSRNOP00000045245   ⟸   ENSRNOT00000041389
RefSeq Acc Id: ENSRNOP00000068077   ⟸   ENSRNOT00000076398
RefSeq Acc Id: ENSRNOP00000068502   ⟸   ENSRNOT00000076089
RefSeq Acc Id: ENSRNOP00000067950   ⟸   ENSRNOT00000076598
RefSeq Acc Id: ENSRNOP00000068131   ⟸   ENSRNOT00000076596
RefSeq Acc Id: XP_038941250   ⟸   XM_039085322
- Peptide Label: isoform X4
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941249   ⟸   XM_039085321
- Peptide Label: isoform X4
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941251   ⟸   XM_039085323
- Peptide Label: isoform X4
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941248   ⟸   XM_039085320
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000036257   ⟸   ENSRNOT00000038376
RefSeq Acc Id: ENSRNOP00000082234   ⟸   ENSRNOT00000117637
RefSeq Acc Id: ENSRNOP00000096856   ⟸   ENSRNOT00000119950
RefSeq Acc Id: ENSRNOP00000093509   ⟸   ENSRNOT00000076509
Protein Domains
RecA family profile   RING-type   SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIN9-F1-model_v2 AlphaFold Q8CIN9 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697516
Promoter ID:EPDNEW_R8040
Type:initiation region
Name:Rffl_2
Description:ring finger and FYVE-like domain containing E3 ubiquitin proteinligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8041  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,181,705 - 70,181,765EPDNEW
RGD ID:13697522
Promoter ID:EPDNEW_R8041
Type:initiation region
Name:Rffl_1
Description:ring finger and FYVE-like domain containing E3 ubiquitin proteinligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8040  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,220,578 - 70,220,638EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727916 AgrOrtholog
BioCyc Gene G2FUF-23918 BioCyc
Ensembl Genes ENSRNOG00000007596 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010015.5 UniProtKB/TrEMBL
  ENSRNOP00000045245 ENTREZGENE
  ENSRNOP00000045245.3 UniProtKB/TrEMBL
  ENSRNOP00000067950 ENTREZGENE
  ENSRNOP00000067950.1 UniProtKB/Swiss-Prot
  ENSRNOP00000068077 ENTREZGENE
  ENSRNOP00000068077.2 UniProtKB/TrEMBL
  ENSRNOP00000068131 ENTREZGENE
  ENSRNOP00000068131.2 UniProtKB/TrEMBL
  ENSRNOP00000082234.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010015.6 UniProtKB/TrEMBL
  ENSRNOT00000041389 ENTREZGENE
  ENSRNOT00000041389.5 UniProtKB/TrEMBL
  ENSRNOT00000076398 ENTREZGENE
  ENSRNOT00000076398.3 UniProtKB/TrEMBL
  ENSRNOT00000076596 ENTREZGENE
  ENSRNOT00000076596.3 UniProtKB/TrEMBL
  ENSRNOT00000076598 ENTREZGENE
  ENSRNOT00000076598.3 UniProtKB/Swiss-Prot
  ENSRNOT00000117637.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131890 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/TrEMBL
  DNA_recomb/repair_Rad51_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Rad51_DMC1_RadA UniProtKB/TrEMBL
  RecA_ATP-bd UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:282844 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94279 IMAGE-MGC_LOAD
NCBI Gene 282844 ENTREZGENE
PANTHER CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA REPAIR PROTEIN RAD51 HOMOLOG 4 UniProtKB/TrEMBL
  DNA REPAIR PROTEIN RAD51 HOMOLOG 4 UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rad51 UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rffl PhenoGen
PROSITE RECA_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF68906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUK5_RAT UniProtKB/TrEMBL
  A0A8L2Q4J8_RAT UniProtKB/TrEMBL
  A0A8L2QM30_RAT UniProtKB/TrEMBL
  A0A8L2QZU3 ENTREZGENE, UniProtKB/TrEMBL
  Q6AY29 ENTREZGENE
  Q8CIN9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6AY29 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Rffl  ring finger and FYVE-like domain containing E3 ubiquitin protein ligase  Rffl  ring finger and FYVE-like domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Rffl  ring finger and FYVE-like domain containing 1  Rffl  ring finger and FYVE like domain containing protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rffl  ring finger and FYVE like domain containing protein    fring  Name updated 1299863 APPROVED
2005-07-08 Rffl  fring  LOC282844    Symbol updated 1299863 APPROVED