Klre1 (killer cell lectin like receptor E1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Klre1 (killer cell lectin like receptor E1) Rattus norvegicus
Analyze
Symbol: Klre1
Name: killer cell lectin like receptor E1 (Ensembl:killer cell lectin-like receptor, family E, member 1)
RGD ID: 727903
Description: Enables identical protein binding activity and protein phosphatase binding activity. Involved in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target. Located in cell surface; INTERACTS WITH bisphenol A (ortholog); lipopolysaccharide (ortholog); S-(1,2-dichlorovinyl)-L-cysteine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: killer cell lectin-like receptor subfamily E member 1; killer cell lectin-like receptor, family E, member 1; killer cell lectin-like receptor, subfamily E, member 1; NK cell lectin-like receptor family E, member 1
RGD Orthologs
Human
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,719,307 - 164,727,664 (+)NCBIGRCr8
mRatBN7.24163,033,581 - 163,041,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4163,033,563 - 163,041,638 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,270,513 - 169,276,372 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04165,053,473 - 165,059,328 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,687,521 - 163,693,376 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,346,684 - 163,355,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,349,125 - 163,354,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,989,389 - 211,997,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,857,685 - 166,864,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14167,102,620 - 167,109,157 (+)NCBI
Celera4151,715,553 - 151,721,408 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Westgaard IH, etal., J Exp Med 2003 Jun 2;197(11):1551-61.
Additional References at PubMed
PMID:18713988  


Genomics

Comparative Map Data
Klre1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,719,307 - 164,727,664 (+)NCBIGRCr8
mRatBN7.24163,033,581 - 163,041,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4163,033,563 - 163,041,638 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,270,513 - 169,276,372 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04165,053,473 - 165,059,328 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,687,521 - 163,693,376 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,346,684 - 163,355,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,349,125 - 163,354,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,989,389 - 211,997,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,857,685 - 166,864,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14167,102,620 - 167,109,157 (+)NCBI
Celera4151,715,553 - 151,721,408 (+)NCBICelera
Cytogenetic Map4q42NCBI
KLRC4-KLRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,372,353 - 10,410,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,372,353 - 10,391,874 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,372,353 - 10,410,146 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,524,952 - 10,562,745 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12p13.2NCBI
HuRef1210,267,379 - 10,305,170 (-)NCBIHuRef
CHM1_11210,494,385 - 10,532,177 (-)NCBICHM1_1
T2T-CHM13v2.01210,259,174 - 10,296,963 (-)NCBIT2T-CHM13v2.0
LOC102005691
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554137,489,127 - 7,504,956 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554137,489,158 - 7,503,014 (+)NCBIChiLan1.0ChiLan1.0
LOC100687968
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,059,707 - 36,068,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,555,689 - 10,564,069 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02736,406,096 - 36,414,471 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12736,293,162 - 36,301,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,316,965 - 36,325,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,077,763 - 10,086,143 (-)NCBIUU_Cfam_GSD_1.0
LOC101976242
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,084,874 - 97,099,433 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936902216,495 - 229,141 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936902216,495 - 229,150 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100519314
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1561,724,744 - 61,736,667 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,653,296 - 64,665,221 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,207,066 - 10,223,922 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,207,211 - 10,223,899 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660892,283,754 - 2,301,143 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Klre1
222 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6
Count of miRNA genes:6
Interacting mature miRNAs:6
Transcripts:ENSRNOT00000010669
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat


Sequence


Ensembl Acc Id: ENSRNOT00000084823   ⟹   ENSRNOP00000074069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4163,033,563 - 163,041,638 (+)Ensembl
Rnor_6.0 Ensembl4163,349,125 - 163,354,976 (+)Ensembl
RefSeq Acc Id: NM_001418987   ⟹   NP_001405916
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,719,604 - 164,727,664 (+)NCBI
mRatBN7.24163,033,581 - 163,041,641 (+)NCBI
RefSeq Acc Id: NM_181372   ⟹   NP_852037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,719,604 - 164,727,664 (+)NCBI
mRatBN7.24163,033,581 - 163,041,641 (+)NCBI
Rnor_6.04163,349,113 - 163,354,976 (+)NCBI
Rnor_5.04211,989,389 - 211,997,747 (+)NCBI
RGSC_v3.44166,857,685 - 166,864,221 (+)RGD
Celera4151,715,553 - 151,721,408 (+)RGD
Sequence:
RefSeq Acc Id: XM_063285915   ⟹   XP_063141985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,719,307 - 164,727,664 (+)NCBI
RefSeq Acc Id: NP_852037   ⟸   NM_181372
- Peptide Label: isoform 1
- UniProtKB: Q80ST4 (UniProtKB/Swiss-Prot),   Q80ZC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074069   ⟸   ENSRNOT00000084823
RefSeq Acc Id: NP_001405916   ⟸   NM_001418987
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063141985   ⟸   XM_063285915
- Peptide Label: isoform X1
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80ZC8-F1-model_v2 AlphaFold Q80ZC8 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727903 AgrOrtholog
BioCyc Gene G2FUF-42772 BioCyc
Ensembl Genes ENSRNOG00000058714 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084823.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKG2/CD94_NK_receptors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot
KEGG Report rno:297645 UniProtKB/Swiss-Prot
NCBI Gene 297645 ENTREZGENE
PANTHER C-TYPE LECTIN PROTEINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY E MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klre1 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058714 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP C-type lectin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IM62_RAT UniProtKB/TrEMBL
  A6IM64_RAT UniProtKB/TrEMBL
  A6IM65_RAT UniProtKB/TrEMBL
  KLRE1_RAT UniProtKB/Swiss-Prot
  Q80ST4 ENTREZGENE
  Q80ZC8 ENTREZGENE
UniProt Secondary Q80ST4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-30 Klre1  killer cell lectin like receptor E1  Klre1  killer cell lectin-like receptor, family E, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Klre1  killer cell lectin-like receptor, family E, member 1    killer cell lectin-like receptor, subfamily E, member 1  Name updated 1299863 APPROVED
2005-02-24   killer cell lectin-like receptor, subfamily E, member 1  Klre1  NK cell lectin-like receptor family E, member 1  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED