Nek6 (NIMA-related kinase 6) - Rat Genome Database

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Gene: Nek6 (NIMA-related kinase 6) Rattus norvegicus
Analyze
Symbol: Nek6
Name: NIMA-related kinase 6
RGD ID: 727779
Description: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human NEK6 (NIMA related kinase 6); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: never in mitosis A-related kinase 6; NIMA (never in mitosis gene a)-related expressed kinase 6; NIMA (never in mitosis gene a)-related kinase 6; nimA-related protein kinase 6; serine/threonine-protein kinase Nek6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,693,994 - 42,766,026 (+)NCBIGRCr8
mRatBN7.2322,284,269 - 22,356,302 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,284,279 - 22,395,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,752,489 - 25,824,488 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,337,482 - 34,409,485 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0332,149,813 - 32,221,975 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,811,927 - 22,888,598 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,811,927 - 22,888,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,037,221 - 28,114,175 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,348,698 - 18,381,895 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,245,069 - 18,278,267 (+)NCBI
Celera320,719,448 - 20,791,246 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cefaloridine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
lead(0)  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriolar satellite  (IEA,ISO)
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
nuclear speck  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)
spindle pole  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Belham C, etal., Curr Biol. 2001 Aug 7;11(15):1155-67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:10964517   PMID:12054534   PMID:12477932   PMID:12761501   PMID:12840024   PMID:14563848   PMID:19001501   PMID:20873783  


Genomics

Comparative Map Data
Nek6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,693,994 - 42,766,026 (+)NCBIGRCr8
mRatBN7.2322,284,269 - 22,356,302 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,284,279 - 22,395,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,752,489 - 25,824,488 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,337,482 - 34,409,485 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0332,149,813 - 32,221,975 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,811,927 - 22,888,598 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,811,927 - 22,888,598 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,037,221 - 28,114,175 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,348,698 - 18,381,895 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,245,069 - 18,278,267 (+)NCBI
Celera320,719,448 - 20,791,246 (+)NCBICelera
Cytogenetic Map3q12NCBI
NEK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,257,606 - 124,353,307 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,257,606 - 124,353,307 (+)EnsemblGRCh38hg38GRCh38
GRCh379127,019,885 - 127,115,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,060,070 - 126,154,542 (+)NCBINCBI36Build 36hg18NCBI36
Build 349124,099,802 - 124,194,271NCBI
Celera997,667,169 - 97,761,958 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef996,633,275 - 96,727,666 (+)NCBIHuRef
CHM1_19127,169,017 - 127,263,737 (+)NCBICHM1_1
T2T-CHM13v2.09136,455,708 - 136,551,354 (+)NCBIT2T-CHM13v2.0
Nek6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,314,052 - 38,477,502 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,401,655 - 38,484,618 (+)EnsemblGRCm39 Ensembl
GRCm38238,483,863 - 38,587,490 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,511,643 - 38,594,606 (+)EnsemblGRCm38mm10GRCm38
MGSCv37238,367,396 - 38,443,010 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36238,333,709 - 38,410,050 (+)NCBIMGSCv36mm8
MGSCv36238,950,290 - 39,027,048 (+)NCBIMGSCv36mm8
Celera240,274,369 - 40,309,329 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.41NCBI
Nek6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,762,643 - 3,820,979 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,762,643 - 3,833,000 (-)NCBIChiLan1.0ChiLan1.0
NEK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,002,104 - 15,097,346 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1915,004,800 - 15,099,678 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0995,379,090 - 95,474,348 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19123,900,131 - 123,994,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9123,903,240 - 123,994,658 (+)Ensemblpanpan1.1panPan2
NEK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,594,026 - 58,677,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,594,045 - 58,674,274 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,790,942 - 57,874,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0959,513,709 - 59,597,117 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl959,513,709 - 59,594,207 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1958,271,493 - 58,354,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0958,588,052 - 58,671,089 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0958,678,689 - 58,761,888 (-)NCBIUU_Cfam_GSD_1.0
Nek6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,837,785 - 192,864,646 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648712,606,312 - 12,633,285 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648712,606,312 - 12,632,982 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,078,435 - 265,176,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,078,407 - 265,170,960 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21298,837,214 - 298,942,112 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11213,791,431 - 13,887,713 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1213,792,903 - 13,842,307 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660792,189,264 - 2,285,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476010,739,235 - 10,797,238 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476010,739,235 - 10,807,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek6
294 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:53
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000014630
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3612543751125437Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)33779691953640235Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)33779691947904329Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH144381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,329,649 - 22,330,836 (+)MAPPERmRatBN7.2
Rnor_6.0322,862,284 - 22,863,469NCBIRnor6.0
Rnor_5.0328,087,920 - 28,089,105UniSTSRnor5.0
RGSC_v3.4318,356,307 - 18,357,492UniSTSRGSC3.4
Celera320,764,773 - 20,765,958UniSTS
RH 3.4 Map3212.91UniSTS
Cytogenetic Map3q11UniSTS
RH141371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,355,925 - 22,356,143 (+)MAPPERmRatBN7.2
Rnor_6.0322,888,222 - 22,888,439NCBIRnor6.0
Rnor_5.0328,113,799 - 28,114,016UniSTSRnor5.0
RGSC_v3.4318,382,347 - 18,382,564UniSTSRGSC3.4
Celera320,790,870 - 20,791,087UniSTS
RH 3.4 Map3217.0UniSTS
Cytogenetic Map3q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014630   ⟹   ENSRNOP00000014631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,329,151 - 22,395,990 (+)Ensembl
Rnor_6.0 Ensembl322,854,768 - 22,887,770 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082561   ⟹   ENSRNOP00000069868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,321,948 - 22,395,990 (+)Ensembl
Rnor_6.0 Ensembl322,829,817 - 22,888,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086147   ⟹   ENSRNOP00000069207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,284,279 - 22,356,261 (+)Ensembl
Rnor_6.0 Ensembl322,811,927 - 22,888,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116855   ⟹   ENSRNOP00000083098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,284,299 - 22,357,196 (+)Ensembl
RefSeq Acc Id: NM_001277232   ⟹   NP_001264161
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,706,644 - 42,766,026 (+)NCBI
mRatBN7.2322,296,919 - 22,356,302 (+)NCBI
Rnor_6.0322,829,817 - 22,888,598 (+)NCBI
Rnor_5.0328,037,221 - 28,114,175 (+)NCBI
Celera320,732,051 - 20,791,246 (+)NCBI
Sequence:
RefSeq Acc Id: NM_182953   ⟹   NP_891998
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,693,994 - 42,766,026 (+)NCBI
mRatBN7.2322,284,269 - 22,356,302 (+)NCBI
Rnor_6.0322,811,927 - 22,888,598 (+)NCBI
Rnor_5.0328,037,221 - 28,114,175 (+)NCBI
RGSC_v3.4318,348,698 - 18,381,895 (+)RGD
Celera320,719,448 - 20,791,246 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234100   ⟹   XP_006234162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,097 - 42,765,985 (+)NCBI
mRatBN7.2322,284,367 - 22,356,294 (+)NCBI
Rnor_6.0322,812,020 - 22,888,557 (+)NCBI
Rnor_5.0328,037,221 - 28,114,175 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591866   ⟹   XP_017447355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,368 - 42,765,985 (+)NCBI
mRatBN7.2322,284,643 - 22,356,294 (+)NCBI
Rnor_6.0322,812,215 - 22,888,557 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105334   ⟹   XP_038961262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,697,285 - 42,765,985 (+)NCBI
mRatBN7.2322,287,555 - 22,356,294 (+)NCBI
RefSeq Acc Id: XM_039105335   ⟹   XP_038961263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,177 - 42,765,985 (+)NCBI
mRatBN7.2322,284,476 - 22,356,294 (+)NCBI
RefSeq Acc Id: XM_039105336   ⟹   XP_038961264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,177 - 42,765,985 (+)NCBI
mRatBN7.2322,284,547 - 22,356,294 (+)NCBI
RefSeq Acc Id: XM_039105337   ⟹   XP_038961265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,519 - 42,765,985 (+)NCBI
mRatBN7.2322,284,794 - 22,356,294 (+)NCBI
RefSeq Acc Id: NP_891998   ⟸   NM_182953
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264161   ⟸   NM_001277232
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234162   ⟸   XM_006234100
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447355   ⟸   XM_017591866
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069868   ⟸   ENSRNOT00000082561
Ensembl Acc Id: ENSRNOP00000014631   ⟸   ENSRNOT00000014630
Ensembl Acc Id: ENSRNOP00000069207   ⟸   ENSRNOT00000086147
RefSeq Acc Id: XP_038961263   ⟸   XM_039105335
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961264   ⟸   XM_039105336
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961265   ⟸   XM_039105337
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961262   ⟸   XM_039105334
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083098   ⟸   ENSRNOT00000116855
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59895-F1-model_v2 AlphaFold P59895 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692052
Promoter ID:EPDNEW_R2575
Type:initiation region
Name:Nek6_1
Description:NIMA-related kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0322,811,951 - 22,812,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727779 AgrOrtholog
BioCyc Gene G2FUF-49910 BioCyc
Ensembl Genes ENSRNOG00000010897 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086147 ENTREZGENE
  ENSRNOT00000116855 ENTREZGENE
  ENSRNOT00000116855.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7459041 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:360161 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187307 IMAGE-MGC_LOAD
NCBI Gene 360161 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED UniProtKB/Swiss-Prot
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Nek6 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010897 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2Q7T9_RAT UniProtKB/TrEMBL
  A0A8L2R0L5_RAT UniProtKB/TrEMBL
  A0A8L2R1R0 ENTREZGENE, UniProtKB/TrEMBL
  A6JEU5_RAT UniProtKB/TrEMBL
  B1H218 ENTREZGENE, UniProtKB/TrEMBL
  NEK6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-21 Nek6  NIMA-related kinase 6  Nek6  NIMA (never in mitosis gene a)-related kinase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nek6  NIMA (never in mitosis gene a)-related kinase 6  Nek6  NIMA (never in mitosis gene a)-related expressed kinase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Nek6  NIMA (never in mitosis gene a)-related expressed kinase 6      Symbol and Name status set to approved 1299863 APPROVED