Lrrk2<sup>em1Sage</sup> (leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Lrrk2em1Sage (leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Lrrk2em1Sage
Name: leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID: 7241045
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 10-bp frameshift deletion in exon 30 (CCCAGAGAGC)
ASSOCIATED WITH abnormal circulating aspartate transaminase level; decreased circulating alanine transaminase level; decreased circulating bilirubin level; ASSOCIATED WITH synucleinopathy
Type: allele  of Lrrk2  
Previously known as: Lrrk2^[em1Sage]; Lrrk2em1Sage
Is Marker For: Strains:   LE-Lrrk2em1Sage   LE-Lrrk2em1Sage-/-  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map7 RGD


References

References - curated
# Reference Title Reference Citation
1. Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs. Baptista MA, etal., PLoS One. 2013 Nov 14;8(11):e80705. doi: 10.1371/journal.pone.0080705. eCollection 2013.
2. Abrogation of a-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. Daher JP, etal., Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94. doi: 10.1073/pnas.1403215111. Epub 2014 Jun 9.
3. Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis. Miklavc P, etal., PLoS One. 2014 Jan 21;9(1):e84926. doi: 10.1371/journal.pone.0084926. eCollection 2014.
4. Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis. Ness D, etal., PLoS One. 2013 Jun 14;8(6):e66164. doi: 10.1371/journal.pone.0066164. Print 2013.
5. Data registered by Sigma Advanced Genetic Engineering Labs Personal communication with SAGE Labs and RGD curators

Genomics


Related Rat Strains
The following Strains have been annotated to Lrrk2em1Sage
LE-Lrrk2em1Sage-/-     LE-Lrrk2em1Sage    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information