Rag1<sup>em1Ang</sup> (recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon) - Rat Genome Database

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Gene: Rag1em1Ang (recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon) Rattus norvegicus
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Symbol: Rag1em1Ang
Name: recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon
RGD ID: 7204135
Description: This mutant allele was made by zinc finger nuclease mutagenesis using meganucleases recognizing the 22-bp DNA sequence (nt731â¿¿752) in exon 2 of the Rag1 gene. This allele showed a 5-bp deletion due to the deletion of 8-bp and insertion of 3-bp that predicts a protein with a normal sequence up to aa 245, followed by 5 aa from the insertions and mutations, followed by a stop codon in position 751.
ASSOCIATED WITH decreased B cell number; decreased bone marrow cell number; decreased CD4-positive, alpha beta T cell number; ASSOCIATED WITH Immune Deficiency Disease; severe combined immunodeficiency
Type: allele  of Rag1  
Previously known as: Rag1em1Ang
Is Marker For: Strains:   SD-Rag1em1Ang  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map3 RGD


References

References - curated
# Reference Title Reference Citation
1. Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases. Menoret S, etal., FASEB J. 2012 Nov 12.
2. Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models. Ménoret S, etal., Transplantation. 2018 Apr 24. doi: 10.1097/TP.0000000000002251.

Genomics


Related Rat Strains
The following Strains have been annotated to Rag1em1Ang


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information