Rag1<sup>em1Ztm</sup> (recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover) - Rat Genome Database

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Gene: Rag1em1Ztm (recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover) Rattus norvegicus
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Symbol: Rag1em1Ztm
Name: recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover
RGD ID: 7204132
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is a 4-bp deletion in exon 2 (del 5246-5249).
ASSOCIATED WITH decreased B cell number; decreased T cell number; small thymus; ASSOCIATED WITH severe combined immunodeficiency
Type: allele  of Rag1  
Previously known as: Rag1em1Ztm
Is Marker For: Strains:   LEW-Rag1em1Ztm  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map3 RGD


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat. Zschemisch NH, etal., BMC Immunol. 2012 Nov 8;13:60. doi: 10.1186/1471-2172-13-60.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Rag1em1Ztm-var1 chr3 87922910 87922913 TTCC - deletion mRatBN7.2
Rag1em1Ztm-var1 chr3 91212243 91212246 TTCC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Rag1em1Ztm


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information