Lhx2 (LIM homeobox 2) - Rat Genome Database

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Gene: Lhx2 (LIM homeobox 2) Rattus norvegicus
Analyze
Symbol: Lhx2
Name: LIM homeobox 2
RGD ID: 71076
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in neuron differentiation. Predicted to be active in nucleus. Orthologous to human LHX2 (LIM homeobox 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein LH-2; Lh-2; LH2A; LIM homeobox protein 2; LIM/homeobox protein Lhx2; LOC296706
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,523,345 - 42,553,646 (+)NCBIGRCr8
mRatBN7.2322,113,619 - 22,143,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,126,007 - 22,143,908 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,594,877 - 25,612,777 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,179,870 - 34,197,771 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,991,800 - 32,009,717 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,628,674 - 22,658,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,640,545 - 22,658,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0327,870,008 - 27,887,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,129,455 - 18,147,357 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,025,179 - 18,043,730 (+)NCBI
Celera320,559,471 - 20,577,366 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amosite asbestos  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
dexamethasone  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flusilazole  (ISO)
fulvestrant  (ISO)
glyphosate  (EXP)
hydroxyurea  (ISO)
imidacloprid  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Gene Data Set MGD Curation, June 12, 2002
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Porter FD, etal., Development 1997 Aug;124(15):2935-44.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted. Vyas A, etal., J Comp Neurol 2003 Nov 24;466(4):545-53.
9. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Xu Y, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):227-31.
Additional References at PubMed
PMID:7513049   PMID:9697309   PMID:10431247   PMID:10482234   PMID:10593900   PMID:11165475   PMID:11719201   PMID:15173589   PMID:15295034   PMID:17005264   PMID:17493606   PMID:17991461  
PMID:18076286   PMID:18184563   PMID:19146846   PMID:19820705   PMID:21857657   PMID:22457488   PMID:22734700   PMID:24012369   PMID:26371318   PMID:28053041   PMID:34581932  


Genomics

Comparative Map Data
Lhx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,523,345 - 42,553,646 (+)NCBIGRCr8
mRatBN7.2322,113,619 - 22,143,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,126,007 - 22,143,908 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,594,877 - 25,612,777 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,179,870 - 34,197,771 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,991,800 - 32,009,717 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,628,674 - 22,658,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,640,545 - 22,658,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0327,870,008 - 27,887,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,129,455 - 18,147,357 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,025,179 - 18,043,730 (+)NCBI
Celera320,559,471 - 20,577,366 (+)NCBICelera
Cytogenetic Map3q12NCBI
LHX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,011,768 - 124,033,301 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,001,670 - 124,033,301 (+)EnsemblGRCh38hg38GRCh38
GRCh379126,774,047 - 126,795,580 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369125,813,710 - 125,835,263 (+)NCBINCBI36Build 36hg18NCBI36
Build 349123,853,442 - 123,874,996NCBI
Celera997,421,143 - 97,442,696 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef996,387,559 - 96,409,113 (+)NCBIHuRef
CHM1_19126,922,665 - 126,944,218 (+)NCBICHM1_1
T2T-CHM13v2.09136,209,686 - 136,231,219 (+)NCBIT2T-CHM13v2.0
Lhx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,229,282 - 38,259,747 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,229,293 - 38,259,745 (+)EnsemblGRCm39 Ensembl
GRCm38238,339,271 - 38,369,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,339,281 - 38,369,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37238,206,828 - 38,225,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36238,173,317 - 38,191,737 (+)NCBIMGSCv36mm8
Celera240,107,977 - 40,108,866 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.31NCBI
Lhx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,998,242 - 4,018,875 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,999,364 - 4,019,543 (-)NCBIChiLan1.0ChiLan1.0
LHX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,322,198 - 15,343,933 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1915,324,546 - 15,346,290 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0995,132,445 - 95,154,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19123,655,845 - 123,676,803 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9123,655,845 - 123,676,796 (+)Ensemblpanpan1.1panPan2
LHX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,825,505 - 58,859,311 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,825,492 - 58,845,883 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha958,022,250 - 58,042,687 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0959,745,814 - 59,766,310 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl959,745,801 - 59,766,240 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1958,502,870 - 58,523,325 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0958,819,702 - 58,840,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0958,910,400 - 58,930,871 (-)NCBIUU_Cfam_GSD_1.0
Lhx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,627,290 - 192,645,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648712,395,812 - 12,414,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648712,395,817 - 12,413,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1264,900,591 - 264,920,890 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11264,900,931 - 264,920,888 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21298,708,264 - 298,728,222 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LHX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11214,110,122 - 14,133,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1214,110,068 - 14,132,026 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660791,939,043 - 1,961,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476010,951,837 - 10,982,592 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lhx2
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:254
Count of miRNA genes:133
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000014452, ENSRNOT00000064507
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat

Markers in Region
D3Got17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,131,405 - 22,131,609 (+)MAPPERmRatBN7.2
Rnor_6.0322,645,944 - 22,646,147NCBIRnor6.0
Rnor_5.0327,875,426 - 27,875,629UniSTSRnor5.0
RGSC_v3.4318,134,854 - 18,135,057RGDRGSC3.4
RGSC_v3.4318,134,854 - 18,135,057UniSTSRGSC3.4
RGSC_v3.1318,031,226 - 18,031,429RGD
Celera320,564,870 - 20,565,073UniSTS
RH 3.4 Map3224.2RGD
RH 3.4 Map3224.2UniSTS
RH 2.0 Map3103.6RGD
Cytogenetic Map3q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 6 68 1
Low 22 35 35 5 35 3 5 4 31 3
Below cutoff 20 9 11 5 6 2 19 5 4 5

Sequence


RefSeq Acc Id: ENSRNOT00000014452   ⟹   ENSRNOP00000014452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl322,640,604 - 22,657,887 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000064507   ⟹   ENSRNOP00000061914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,126,007 - 22,143,908 (+)Ensembl
Rnor_6.0 Ensembl322,640,545 - 22,658,446 (+)Ensembl
RefSeq Acc Id: NM_001106571   ⟹   NP_001100041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,535,744 - 42,553,645 (+)NCBI
mRatBN7.2322,126,007 - 22,143,908 (+)NCBI
Rnor_6.0322,640,545 - 22,658,446 (+)NCBI
Rnor_5.0327,870,008 - 27,887,929 (+)NCBI
RGSC_v3.4318,129,455 - 18,147,357 (+)RGD
Celera320,559,471 - 20,577,366 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234072   ⟹   XP_006234134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,535,788 - 42,553,646 (+)NCBI
mRatBN7.2322,126,036 - 22,143,909 (+)NCBI
Rnor_6.0322,640,577 - 22,658,447 (+)NCBI
Rnor_5.0327,870,008 - 27,887,929 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234073   ⟹   XP_006234135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,537,347 - 42,553,646 (+)NCBI
mRatBN7.2322,127,610 - 22,143,909 (+)NCBI
Rnor_6.0322,642,148 - 22,658,447 (+)NCBI
Rnor_5.0327,870,008 - 27,887,929 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761742   ⟹   XP_008759964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,536,018 - 42,553,646 (+)NCBI
mRatBN7.2322,126,329 - 22,143,909 (+)NCBI
Rnor_6.0322,640,763 - 22,658,447 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591665   ⟹   XP_017447154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,523,345 - 42,553,646 (+)NCBI
mRatBN7.2322,113,619 - 22,143,909 (+)NCBI
Rnor_6.0322,628,674 - 22,658,447 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063283527   ⟹   XP_063139597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,538,696 - 42,553,646 (+)NCBI
RefSeq Acc Id: NP_001100041   ⟸   NM_001106571
- UniProtKB: P36198 (UniProtKB/Swiss-Prot),   A6JEU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234134   ⟸   XM_006234072
- Peptide Label: isoform X1
- UniProtKB: P36198 (UniProtKB/Swiss-Prot),   D4A380 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234135   ⟸   XM_006234073
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008759964   ⟸   XM_008761742
- Peptide Label: isoform X2
- UniProtKB: P36198 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447154   ⟸   XM_017591665
- Peptide Label: isoform X2
- UniProtKB: P36198 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014452   ⟸   ENSRNOT00000014452
RefSeq Acc Id: ENSRNOP00000061914   ⟸   ENSRNOT00000064507
RefSeq Acc Id: XP_063139597   ⟸   XM_063283527
- Peptide Label: isoform X4
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36198-F1-model_v2 AlphaFold P36198 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71076 AgrOrtholog
BioCyc Gene G2FUF-49914 BioCyc
Ensembl Genes ENSRNOG00000010551 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064507.4 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:296706 UniProtKB/TrEMBL
NCBI Gene Lhx2 ENTREZGENE
PANTHER LIM/HOMEOBOX PROTEIN LHX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM/HOMEOBOX PROTEIN LHX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lhx2 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010551 RatGTEx
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JEU2 ENTREZGENE, UniProtKB/TrEMBL
  D4A380 ENTREZGENE, UniProtKB/TrEMBL
  LHX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Lhx2  LIM homeobox 2  Lhx2  LIM homeobox protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-09 Lhx2  LIM homeobox protein 2  Lhx2_predicted  LIM homeobox protein 2 (predicted)  Data merged from RGD:1309617 737654 APPROVED
2005-01-12 Lhx2_predicted  LIM homeobox protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-07-09 Lhx2  LIM homeobox protein 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a homeodomain and two repeats of a LIM domain 70777
gene_protein 426 amino acids 70777