Serpinb7 (serpin family B member 7) - Rat Genome Database

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Gene: Serpinb7 (serpin family B member 7) Rattus norvegicus
Analyze
Symbol: Serpinb7
Name: serpin family B member 7
RGD ID: 71063
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in positive regulation of biosynthetic process and positive regulation of glomerular mesangial cell proliferation. Predicted to be active in extracellular space. Biomarker of nephritis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINB7 (serpin family B member 7); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Megsin; serine (or cysteine) peptidase inhibitor, clade B, member 7; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin B7; serpin peptidase inhibitor, clade B (ovalbumin), member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,884,466 - 23,956,834 (+)NCBIGRCr8
mRatBN7.21323,369,830 - 23,442,205 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,395,671 - 23,442,205 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,770,062 - 23,811,605 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01325,054,524 - 25,096,071 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01323,740,244 - 23,781,790 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01327,282,456 - 27,354,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,312,498 - 27,354,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01332,431,704 - 32,503,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41313,464,818 - 13,506,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11313,464,817 - 13,506,372 (+)NCBI
Celera1323,245,098 - 23,286,663 (+)NCBICelera
Cytogenetic Map13p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice. Inagi R, etal., Diabetes. 2006 Feb;55(2):356-66.
4. Megsin 2093T-2180C haplotype at the 3' untranslated region is associated with poor renal survival in Korean IgA nephropathy patients. Lim CS, etal., Clin Nephrol. 2008 Aug;70(2):101-9.
5. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. McDonough CW, etal., Hum Genet. 2009 Dec;126(6):805-17. doi: 10.1007/s00439-009-0732-8.
6. Gene Data Set MGD Curation, June 12, 2002
7. Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis. Nangaku M, etal., Kidney Int 2001 Aug;60(2):641-52.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies). Takano K, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):1040-7. Epub 2006 Jun 12.
15. [Association of single nucleotide polymorphism of megsin gene with IgA nephropathy]. Wang ZH, etal., Zhonghua Yi Xue Za Zhi. 2006 May 23;86(19):1337-41.
16. Overexpression of megsin induces mesangial cell proliferation and excretion of type IV collagen in vitro. Xia Y, etal., Cell Immunol. 2011;271(2):413-7. doi: 10.1016/j.cellimm.2011.08.009. Epub 2011 Sep 5.
17. A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population. Xia YF, etal., Clin Nephrol. 2006 Mar;65(3):153-9.
Additional References at PubMed
PMID:18580857  


Genomics

Comparative Map Data
Serpinb7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,884,466 - 23,956,834 (+)NCBIGRCr8
mRatBN7.21323,369,830 - 23,442,205 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,395,671 - 23,442,205 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,770,062 - 23,811,605 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01325,054,524 - 25,096,071 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01323,740,244 - 23,781,790 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01327,282,456 - 27,354,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,312,498 - 27,354,052 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01332,431,704 - 32,503,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41313,464,818 - 13,506,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11313,464,817 - 13,506,372 (+)NCBI
Celera1323,245,098 - 23,286,663 (+)NCBICelera
Cytogenetic Map13p11NCBI
SERPINB7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,753,057 - 63,805,370 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1863,752,935 - 63,805,376 (+)EnsemblGRCh38hg38GRCh38
GRCh371861,420,291 - 61,472,604 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361859,571,257 - 59,623,584 (+)NCBINCBI36Build 36hg18NCBI36
Build 341859,593,623 - 59,623,590NCBI
Celera1858,140,787 - 58,193,062 (+)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1858,121,598 - 58,173,856 (+)NCBIHuRef
CHM1_11861,416,473 - 61,468,833 (+)NCBICHM1_1
T2T-CHM13v2.01863,958,110 - 64,010,475 (+)NCBIT2T-CHM13v2.0
Serpinb7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391107,350,418 - 107,380,419 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1107,327,385 - 107,380,419 (+)EnsemblGRCm39 Ensembl
GRCm381107,422,689 - 107,452,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1107,399,655 - 107,452,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv371109,319,266 - 109,349,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361109,250,236 - 109,280,235 (+)NCBIMGSCv36mm8
Celera1110,260,443 - 110,291,388 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map150.34NCBI
Serpinb7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540247,599,150 - 47,649,885 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540247,599,503 - 47,649,537 (+)NCBIChiLan1.0ChiLan1.0
SERPINB7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21781,269,142 - 81,315,895 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11866,956,410 - 67,008,506 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01857,112,242 - 57,164,213 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11860,423,119 - 60,475,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1860,445,135 - 60,475,165 (+)Ensemblpanpan1.1panPan2
SERPINB7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,336,067 - 13,392,674 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,336,837 - 13,358,125 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,296,781 - 14,353,408 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,191,171 - 13,247,792 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,191,169 - 13,218,577 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,229,696 - 13,286,210 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,158,947 - 13,215,544 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,408,033 - 13,464,630 (-)NCBIUU_Cfam_GSD_1.0
Serpinb7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494426,626,496 - 26,678,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364971,866,166 - 1,887,690 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364971,865,540 - 1,887,695 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINB7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1157,953,877 - 157,998,842 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11157,953,872 - 157,999,242 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,390,325 - 175,435,317 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINB7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11815,992,154 - 16,020,001 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1815,992,186 - 16,044,650 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660609,672,358 - 9,700,689 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinb7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247929,730,223 - 9,794,673 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpinb7
531 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:13
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000003466
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 4 9 7 11
Below cutoff 2 15 28 16 10 16 3 3 17 18 23 3

Sequence


RefSeq Acc Id: ENSRNOT00000003466   ⟹   ENSRNOP00000003466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1323,395,671 - 23,442,205 (+)Ensembl
Rnor_6.0 Ensembl1327,312,498 - 27,354,052 (+)Ensembl
RefSeq Acc Id: NM_130404   ⟹   NP_569088
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,910,306 - 23,956,834 (+)NCBI
mRatBN7.21323,395,670 - 23,442,205 (+)NCBI
Rnor_6.01327,312,498 - 27,354,052 (+)NCBI
Rnor_5.01332,431,704 - 32,503,907 (+)NCBI
RGSC_v3.41313,464,818 - 13,506,372 (+)RGD
Celera1323,245,098 - 23,286,663 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249629   ⟹   XP_006249691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,884,466 - 23,956,834 (+)NCBI
mRatBN7.21323,369,830 - 23,442,205 (+)NCBI
Rnor_6.01327,282,456 - 27,354,775 (+)NCBI
Rnor_5.01332,431,704 - 32,503,907 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_569088 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249691 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL16769 (Get FASTA)   NCBI Sequence Viewer  
  EDL91756 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003466
  ENSRNOP00000003466.4
RefSeq Acc Id: NP_569088   ⟸   NM_130404
- UniProtKB: G3V6B5 (UniProtKB/TrEMBL),   A6JSV8 (UniProtKB/TrEMBL),   Q920J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249691   ⟸   XM_006249629
- Peptide Label: isoform X1
- UniProtKB: G3V6B5 (UniProtKB/TrEMBL),   A6JSV8 (UniProtKB/TrEMBL),   Q920J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003466   ⟸   ENSRNOT00000003466
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6B5-F1-model_v2 AlphaFold G3V6B5 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71063 AgrOrtholog
BioCyc Gene G2FUF-18582 BioCyc
Ensembl Genes ENSRNOG00000002555 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003466 ENTREZGENE
  ENSRNOT00000003466.5 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:117092 UniProtKB/TrEMBL
NCBI Gene 117092 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  SERPIN B7 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb7 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002555 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A6JSV8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6B5 ENTREZGENE, UniProtKB/TrEMBL
  Q920J5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpinb7  serpin family B member 7  Serpinb7  serpin peptidase inhibitor, clade B (ovalbumin), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-19 Serpinb7  serpin peptidase inhibitor, clade B (ovalbumin), member 7  Serpinb7  serine (or cysteine) peptidase inhibitor, clade B, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Serpinb7  serine (or cysteine) peptidase inhibitor, clade B, member 7  Serpinb7  serine (or cysteine) proteinase inhibitor, clade B, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Serpinb7  serine (or cysteine) proteinase inhibitor, clade B, member 7      Name updated 1299863 APPROVED
2002-07-09 Serpinb7  serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression upregulated in mesangial cells during proliferative stage in the nephron 70611