Kynu (kynureninase) - Rat Genome Database

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Gene: Kynu (kynureninase) Rattus norvegicus
Analyze
Symbol: Kynu
Name: kynureninase
RGD ID: 71061
Description: Enables kynureninase activity and pyridoxal phosphate binding activity. Involved in tryptophan catabolic process to acetyl-CoA. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in cytoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kynureninase (L-kynurenine hydrolase); L-kynurenine hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp140  
Candidate Gene For: Bp140
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8348,188,286 - 48,338,996 (+)NCBIGRCr8
mRatBN7.2327,778,646 - 27,929,470 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl327,778,772 - 27,929,488 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx331,169,534 - 31,320,227 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0339,754,563 - 39,905,257 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0337,572,172 - 37,723,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0328,416,926 - 28,566,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl328,416,954 - 28,566,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0333,622,141 - 33,770,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4324,046,242 - 24,195,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1323,942,613 - 24,092,267 (+)NCBI
Celera326,096,675 - 26,244,576 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bromuconazole  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
estrone  (ISO)
etoposide  (ISO)
fenvalerate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-linolenic acid  (ISO)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
kynurenine  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
mestranol  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methomyl  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
Nutlin-3  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (ISO)
mitochondrion  (ISO)
nucleoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats. Comai S, etal., Clin Chim Acta. 2005 Oct;360(1-2):67-80. doi: 10.1016/j.cccn.2005.04.013.
2. Expression of kynurenine aminotransferase in the subplate of the rat and its possible role in the regulation of programmed cell death. Csillik AE, etal., Cereb Cortex 2002 Nov;12(11):1193-201.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats. Kwok JB, etal., J Biol Chem 2002 Sep 27;277(39):35779-82.
6. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats. Mizutan K, etal., Hypertens Res 2002 Jan;25(1):135-40.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The metabolism of L-tryptophan by isolated rat liver cells. Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism. Smith SA, etal., Biochem J. 1980 Nov 15;192(2):673-86.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection. Takeuchi F and Shibata Y, Biochem J. 1984 Jun 15;220(3):693-9.
21. Purification and properties of kynureninase from rat liver. Takeuchi F, etal., J Biochem. 1980 Oct;88(4):987-94.
22. Cloning and recombinant expression of rat and human kynureninase. Toma S, etal., FEBS Lett 1997 May 12;408(1):5-10.
Additional References at PubMed
PMID:1939450   PMID:6468727   PMID:7578221   PMID:8706755   PMID:9291104   PMID:11985583   PMID:15489334   PMID:17334708   PMID:18614015   PMID:28792876  


Genomics

Comparative Map Data
Kynu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8348,188,286 - 48,338,996 (+)NCBIGRCr8
mRatBN7.2327,778,646 - 27,929,470 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl327,778,772 - 27,929,488 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx331,169,534 - 31,320,227 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0339,754,563 - 39,905,257 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0337,572,172 - 37,723,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0328,416,926 - 28,566,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl328,416,954 - 28,566,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0333,622,141 - 33,770,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4324,046,242 - 24,195,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1323,942,613 - 24,092,267 (+)NCBI
Celera326,096,675 - 26,244,576 (+)NCBICelera
Cytogenetic Map3q12NCBI
KYNU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,877,664 - 143,055,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,877,657 - 143,055,833 (+)EnsemblGRCh38hg38GRCh38
GRCh372143,635,233 - 143,813,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,351,665 - 143,516,355 (+)NCBINCBI36Build 36hg18NCBI36
Build 342143,468,950 - 143,633,606NCBI
Celera2137,347,656 - 137,512,293 (+)NCBICelera
Cytogenetic Map2q22.2NCBI
HuRef2135,626,307 - 135,791,074 (+)NCBIHuRef
CHM1_12143,640,202 - 143,804,900 (+)NCBICHM1_1
T2T-CHM13v2.02143,325,958 - 143,504,091 (+)NCBIT2T-CHM13v2.0
Kynu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39243,445,270 - 43,572,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl243,445,341 - 43,572,734 (+)EnsemblGRCm39 Ensembl
GRCm38243,555,258 - 43,683,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl243,555,329 - 43,682,715 (+)EnsemblGRCm38mm10GRCm38
MGSCv37243,410,849 - 43,538,235 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36243,377,338 - 43,504,724 (+)NCBIMGSCv36mm8
Celera245,275,609 - 45,403,071 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map225.64NCBI
Kynu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554409,420,009 - 9,536,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554409,420,141 - 9,536,767 (+)NCBIChiLan1.0ChiLan1.0
KYNU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21331,861,346 - 32,151,868 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B31,876,156 - 32,166,772 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B16,792,401 - 16,947,766 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B146,976,053 - 147,131,298 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B146,975,995 - 147,132,634 (+)Ensemblpanpan1.1panPan2
KYNU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11945,022,450 - 45,150,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1945,022,072 - 45,149,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1945,274,902 - 45,404,061 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01946,479,473 - 46,607,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1946,479,626 - 46,607,752 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11945,139,690 - 45,268,624 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01945,269,758 - 45,399,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01946,664,690 - 46,794,435 (+)NCBIUU_Cfam_GSD_1.0
Kynu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303107,812,529 - 107,984,835 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646933,632,892 - 33,734,433 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646933,632,885 - 33,805,158 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KYNU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl158,850,544 - 8,982,891 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1158,847,335 - 8,982,951 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2159,760,379 - 9,821,853 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KYNU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11028,230,129 - 28,394,103 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1028,230,508 - 28,394,076 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040171,182,800 - 171,346,370 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kynu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473242,627,715 - 42,753,165 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473242,627,789 - 42,751,037 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kynu
1227 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:24
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000043533
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
RH140553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2327,859,860 - 27,860,058 (+)MAPPERmRatBN7.2
Rnor_6.0328,497,302 - 28,497,499NCBIRnor6.0
Rnor_5.0333,700,461 - 33,700,658UniSTSRnor5.0
RGSC_v3.4324,125,532 - 24,125,729UniSTSRGSC3.4
Celera326,175,593 - 26,175,790UniSTS
Cytogenetic Map3q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 19 72 90 89 59 25 59 6 184 63 52 45 59 30

Sequence


Ensembl Acc Id: ENSRNOT00000043533   ⟹   ENSRNOP00000050947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl327,778,772 - 27,929,488 (+)Ensembl
Rnor_6.0 Ensembl328,416,954 - 28,566,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097426   ⟹   ENSRNOP00000084707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl327,778,772 - 27,929,488 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113563   ⟹   ENSRNOP00000082004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl327,778,772 - 27,929,488 (+)Ensembl
RefSeq Acc Id: NM_053902   ⟹   NP_446354
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8348,188,286 - 48,338,996 (+)NCBI
mRatBN7.2327,778,755 - 27,929,470 (+)NCBI
Rnor_6.0328,416,989 - 28,566,919 (+)NCBI
Rnor_5.0333,622,141 - 33,770,793 (+)NCBI
RGSC_v3.4324,046,242 - 24,195,898 (+)RGD
Celera326,096,675 - 26,244,576 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446354 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53206 (Get FASTA)   NCBI Sequence Viewer  
  AAH78762 (Get FASTA)   NCBI Sequence Viewer  
  EDM00489 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050947.4
  ENSRNOP00000082004.1
  ENSRNOP00000084707.1
GenBank Protein P70712 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446354   ⟸   NM_053902
- UniProtKB: Q9QW90 (UniProtKB/Swiss-Prot),   Q7M0D0 (UniProtKB/Swiss-Prot),   Q68G25 (UniProtKB/Swiss-Prot),   P70712 (UniProtKB/Swiss-Prot),   A0A8L2QQS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050947   ⟸   ENSRNOT00000043533
Ensembl Acc Id: ENSRNOP00000082004   ⟸   ENSRNOT00000113563
Ensembl Acc Id: ENSRNOP00000084707   ⟸   ENSRNOT00000097426
Protein Domains
Aminotransferase class V

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70712-F1-model_v2 AlphaFold P70712 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692061
Promoter ID:EPDNEW_R2586
Type:initiation region
Name:Kynu_1
Description:kynureninase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0328,417,003 - 28,417,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71061 AgrOrtholog
BioCyc Gene G2FUF-49851 BioCyc
BioCyc Pathway PWY-5651 [L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde] BioCyc
BioCyc Pathway Image PWY-5651 BioCyc
Ensembl Genes ENSRNOG00000029993 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043533.5 UniProtKB/TrEMBL
  ENSRNOT00000097426.1 UniProtKB/TrEMBL
  ENSRNOT00000113563.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128911 IMAGE-MGC_LOAD
InterPro Aminotrans_V_dom UniProtKB/TrEMBL
  Kynureninase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
KEGG Report rno:116682 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93273 IMAGE-MGC_LOAD
NCBI Gene 116682 ENTREZGENE
PANTHER KYNURENINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14084 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aminotran_5 UniProtKB/TrEMBL
  KYNU_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kynu PhenoGen
PIRSF KYNU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029993 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZW86_RAT UniProtKB/TrEMBL
  A0A8I6A2I1_RAT UniProtKB/TrEMBL
  A0A8L2QQS0 ENTREZGENE, UniProtKB/TrEMBL
  A6JEX1_RAT UniProtKB/TrEMBL
  KYNU_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G25 ENTREZGENE
  Q7M0D0 ENTREZGENE
  Q9QW90 ENTREZGENE
UniProt Secondary Q68G25 UniProtKB/Swiss-Prot
  Q7M0D0 UniProtKB/Swiss-Prot
  Q9QW90 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Kynu  kynureninase  Kynu  kynureninase (L-kynurenine hydrolase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Kynu  kynureninase (L-kynurenine hydrolase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression level in the brainstem higher in the spontaneously hypertensive rats (SHR) than in the WKY 631322
gene_function metabolizes kynurenine into anthranilic acid 631322
gene_function has cysteine-conjugate beta-lyase activity 70787
gene_protein consists of 464 amino acids 70787