Prkab1 (protein kinase AMP-activated non-catalytic subunit beta 1) - Rat Genome Database

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Gene: Prkab1 (protein kinase AMP-activated non-catalytic subunit beta 1) Rattus norvegicus
Analyze
Symbol: Prkab1
Name: protein kinase AMP-activated non-catalytic subunit beta 1
RGD ID: 71057
Description: Enables protein kinase binding activity. Predicted to be involved in cellular response to nutrient levels; positive regulation of cold-induced thermogenesis; and signal transduction. Predicted to act upstream of or within nail development. Part of nucleotide-activated protein kinase complex. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5'-AMP-activated protein kinase 40 kDa subunit; 5'-AMP-activated protein kinase subunit beta-1; 5'-AMP-activated protein kinase, beta subunit; 5'-AMP-activatedproteinkinase,betasubunit; 5'-AMP-activatedproteinkinasebetasubunit; 5-AMP-activated protein kinase beta subunit; 5-AMP-activatedproteinkinasebetasubunit; AMPK beta-1 chain; AMPK subunit beta-1; AMPKb; protein kinase, AMP-activated, beta 1 non-catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,248,971 - 46,259,487 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,249,010 - 46,259,482 (+)EnsemblGRCr8
mRatBN7.21240,588,140 - 40,598,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,588,211 - 40,598,661 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1241,761,540 - 41,771,903 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,375,265 - 42,385,628 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,435,725 - 41,446,088 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,316,298 - 46,326,789 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,316,236 - 46,326,790 (+)Ensemblrn6Rnor6.0
Rnor_5.01248,117,478 - 48,127,960 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,840,866 - 41,851,241 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,217,411 - 42,227,786 (+)NCBICelera
RGSC_v3.11241,704,253 - 41,714,629 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP,ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocin-1  (EXP)
Curcumol  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diethyl maleate  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
hydrogen sulfide  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
leflunomide  (EXP)
levonorgestrel  (ISO)
lycopene  (ISO)
methyl methanesulfonate  (ISO)
morin  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
Nutlin-3  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
quercetin  (EXP,ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
valproic acid  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Christensen M, etal., Sci Rep. 2016 Oct 26;6:35952. doi: 10.1038/srep35952.
2. Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. Gao G, etal., J Biol Chem 1996 Apr 12;271(15):8675-81.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
6. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
7. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Hawley SA, etal., J Biol. 2003;2(4):28. Epub 2003 Sep 24.
8. AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). Iseli TJ, etal., J Biol Chem. 2005 Apr 8;280(14):13395-400. Epub 2005 Jan 28.
9. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Li J, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1927-34. Epub 2006 Apr 28.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Mottillo EP, etal., Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. Woods A, etal., J Biol Chem 1996 Apr 26;271(17):10282-90.
Additional References at PubMed
PMID:7961907   PMID:9091312   PMID:9305909   PMID:10098881   PMID:11171104   PMID:15489334   PMID:16396499   PMID:16508085   PMID:16849326   PMID:17028174   PMID:17525164   PMID:18247380  
PMID:21481774   PMID:24625528   PMID:25340873   PMID:28576646  


Genomics

Comparative Map Data
Prkab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,248,971 - 46,259,487 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,249,010 - 46,259,482 (+)EnsemblGRCr8
mRatBN7.21240,588,140 - 40,598,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,588,211 - 40,598,661 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1241,761,540 - 41,771,903 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,375,265 - 42,385,628 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,435,725 - 41,446,088 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,316,298 - 46,326,789 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,316,236 - 46,326,790 (+)Ensemblrn6Rnor6.0
Rnor_5.01248,117,478 - 48,127,960 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,840,866 - 41,851,241 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,217,411 - 42,227,786 (+)NCBICelera
RGSC_v3.11241,704,253 - 41,714,629 (+)NCBI
Cytogenetic Map12q16NCBI
PRKAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812119,667,952 - 119,681,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12119,667,864 - 119,681,624 (+)Ensemblhg38GRCh38
GRCh3712120,105,938 - 120,119,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612118,590,144 - 118,603,812 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412118,568,480 - 118,582,148NCBI
Celera12119,738,816 - 119,752,482 (+)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12117,113,891 - 117,127,561 (+)NCBIHuRef
CHM1_112120,073,269 - 120,086,937 (+)NCBICHM1_1
T2T-CHM13v2.012119,655,225 - 119,668,903 (+)NCBIT2T-CHM13v2.0
Prkab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395116,151,654 - 116,162,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5116,151,645 - 116,162,567 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385116,013,586 - 116,024,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5116,013,586 - 116,024,508 (-)Ensemblmm10GRCm38
MGSCv375116,463,599 - 116,474,437 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365116,274,589 - 116,285,427 (-)NCBIMGSCv36mm8
Celera5113,114,056 - 113,125,788 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
Prkab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,876,661 - 11,890,069 (-)Ensembl
ChiLan1.0NW_00495545511,877,407 - 11,889,987 (-)NCBIChiLan1.0ChiLan1.0
PRKAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210127,733,557 - 127,747,256 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112127,729,754 - 127,743,635 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012117,246,691 - 117,260,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112120,624,004 - 120,637,585 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12120,624,004 - 120,637,585 (+)EnsemblpanPan2panpan1.1
PRKAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12615,706,583 - 15,716,612 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2615,706,678 - 15,715,314 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2615,711,405 - 15,721,444 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02615,974,145 - 15,984,177 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2615,974,172 - 15,984,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12615,944,207 - 15,954,235 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,012,374 - 16,022,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,053,316 - 16,063,357 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prkab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,654,905 - 146,666,590 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366681,152,929 - 1,165,576 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366681,153,791 - 1,165,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1433,201,669 - 33,217,539 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11433,201,359 - 33,217,641 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21435,147,989 - 35,163,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,008,306 - 115,021,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,008,313 - 115,023,373 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037130,084,721 - 130,097,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,922,685 - 13,935,912 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474713,923,315 - 13,935,397 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkab1
60 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:640
Count of miRNA genes:285
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000001508
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

Markers in Region
RH136885  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21240,598,362 - 40,598,561 (+)MAPPERmRatBN7.2
Rnor_6.01246,326,479 - 46,326,677NCBIRnor6.0
Rnor_5.01248,127,650 - 48,127,848UniSTSRnor5.0
RGSC_v3.41241,850,944 - 41,851,142UniSTSRGSC3.4
Celera1242,227,489 - 42,227,687UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001508   ⟹   ENSRNOP00000001508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,249,032 - 46,259,481 (+)Ensembl
mRatBN7.2 Ensembl1240,588,211 - 40,598,661 (+)Ensembl
Rnor_6.0 Ensembl1246,316,236 - 46,326,790 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134208   ⟹   ENSRNOP00000101213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,249,010 - 46,259,482 (+)Ensembl
RefSeq Acc Id: NM_031976   ⟹   NP_114182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,249,095 - 46,259,470 (+)NCBI
mRatBN7.21240,588,283 - 40,598,660 (+)NCBI
Rnor_6.01246,316,401 - 46,326,776 (+)NCBI
Rnor_5.01248,117,478 - 48,127,960 (+)NCBI
RGSC_v3.41241,840,866 - 41,851,241 (+)RGD
Celera1242,217,411 - 42,227,786 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249481   ⟹   XP_006249543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,248,971 - 46,259,487 (+)NCBI
mRatBN7.21240,588,140 - 40,598,673 (+)NCBI
Rnor_6.01246,316,298 - 46,326,789 (+)NCBI
Rnor_5.01248,117,478 - 48,127,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271713   ⟹   XP_063127783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,249,032 - 46,258,153 (+)NCBI
RefSeq Acc Id: NP_114182   ⟸   NM_031976
- UniProtKB: P80386 (UniProtKB/Swiss-Prot),   Q63048 (UniProtKB/Swiss-Prot),   A6J1R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249543   ⟸   XM_006249481
- Peptide Label: isoform X1
- UniProtKB: Q63048 (UniProtKB/Swiss-Prot),   P80386 (UniProtKB/Swiss-Prot),   A6J1R4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001508   ⟸   ENSRNOT00000001508
RefSeq Acc Id: XP_063127783   ⟸   XM_063271713
- Peptide Label: isoform X2
- UniProtKB: A6J1R5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101213   ⟸   ENSRNOT00000134208
Protein Domains
AMP-activated protein kinase glycogen-binding   Association with the SNF1 complex (ASC)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80386-F1-model_v2 AlphaFold P80386 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698682
Promoter ID:EPDNEW_R9207
Type:initiation region
Name:Prkab1_1
Description:protein kinase AMP-activated non-catalytic subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01246,316,387 - 46,316,447EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71057 AgrOrtholog
BioCyc Gene G2FUF-19026 BioCyc
Ensembl Genes ENSRNOG00000001142 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001508 ENTREZGENE
  ENSRNOT00000001508.4 UniProtKB/Swiss-Prot
  ENSRNOT00000134208 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  6.20.250.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599996 IMAGE-MGC_LOAD
InterPro AMPK1_CBM UniProtKB/Swiss-Prot
  ASC_dom UniProtKB/Swiss-Prot
  ASC_dom_sf UniProtKB/Swiss-Prot
  CRP1_MDG1_kinase UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:83803 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72378 IMAGE-MGC_LOAD
NCBI Gene 83803 ENTREZGENE
PANTHER 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT UniProtKB/Swiss-Prot
  5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 UniProtKB/Swiss-Prot
Pfam AMPK1_CBM UniProtKB/Swiss-Prot
  AMPKBI UniProtKB/Swiss-Prot
PhenoGen Prkab1 PhenoGen
RatGTEx ENSRNOG00000001142 RatGTEx
SMART AMPKBI UniProtKB/Swiss-Prot
Superfamily-SCOP SSF160219 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A6J1R4 ENTREZGENE, UniProtKB/TrEMBL
  A6J1R5 ENTREZGENE, UniProtKB/TrEMBL
  AAKB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63048 ENTREZGENE
UniProt Secondary Q63048 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkab1  protein kinase AMP-activated non-catalytic subunit beta 1  Prkab1  protein kinase, AMP-activated, beta 1 non-catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Prkab1  protein kinase, AMP-activated, beta 1 non-catalytic subunit      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associates with AMPKalpha and with AMPKgamma 729494