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Gene: Cilk1 (ciliogenesis associated kinase 1) Rattus norvegicus

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Symbol:

Cilk1

Name:

ciliogenesis associated kinase 1

RGD ID:

71050

Description:

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome and juvenile myoclonic epilepsy 10. Orthologous to human CILK1 (ciliogenesis associated kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

heart serine-threonine protein kinase; Ick; intestinal cell (MAK-like) kinase; intestinal cell kinase; MAK-related kinase; MRK; serine/threonine-protein kinase ICK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CILK1 (ciliogenesis associated kinase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cilk1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cilk1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CILK1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CILK1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cilk1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CILK1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CILK1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cilk1 (ciliogenesis associated kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	C6orf118 (chromosome 6 open reading frame 118)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Cilk1 (ciliogenesis associated kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CILK1 (ciliogenesis associated kinase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IME2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG42366	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dyf-5	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cilk1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	87,868,294 - 87,922,995 (+)	NCBI		GRCr8
mRatBN7.2	8	78,984,075 - 79,042,695 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	78,984,258 - 79,042,691 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	84,474,767 - 84,530,110 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	82,751,418 - 82,806,761 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	80,574,141 - 80,629,484 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	85,413,998 - 85,473,374 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	85,413,537 - 85,472,694 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	84,982,701 - 85,037,684 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	83,086,346 - 83,140,977 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	83,105,399 - 83,160,031 (+)	NCBI
Celera	8	78,732,894 - 78,787,000 (+)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	asphyxiating thoracic dystrophy		ISO	RGD:1345110	8554872	ClinVar Annotator: match by term: Short rib-polydactyly syndrome	ClinVar	PMID:27466187
Cilk1	Rat	coloboma		ISO	RGD:1345110	8554872	ClinVar Annotator: match by term: Congenital ocular coloboma	ClinVar	PMID:25741868
Cilk1	Rat	cranioectodermal dysplasia		ISO	RGD:1345110	8554872	ClinVar Annotator: match by term: Cranioectodermal dysplasia	ClinVar	PMID:25741868
Cilk1	Rat	endocrine-cerebro-osteodysplasia syndrome		ISO	RGD:1345110	8554872	ClinVar Annotator: match by term: Endocrine-cerebro-osteodysplasia syndrome	ClinVar	PMID:19185282\|PMID:25741868\|PMID:25741883\|PMID:27069622\|PMID:28492532
Cilk1	Rat	Idiopathic Generalized Epilepsy		ISO	RGD:1345110	8554872	ClinVar Annotator: match by term: Epilepsy, juvenile myoclonic, susceptibility to, 10 \| ClinVar Annotator: match more ...	ClinVar	PMID:25741868\|PMID:28492532\|PMID:29539279\|PMID:32178256
Cilk1	Rat	juvenile myoclonic epilepsy 10		ISO	RGD:1345110	8554872	ClinVar Annotator: match by term: CILK1-related condition	ClinVar	PMID:25741868\|PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	endocrine-cerebro-osteodysplasia syndrome		ISO	RGD:1345110	11554173	CTD Direct Evidence: marker/mechanism	CTD

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	endocrine-cerebro-osteodysplasia syndrome		ISS	RGD:737218	13592920	OMIM:612651	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	endocrine-cerebro-osteodysplasia syndrome		ISO	RGD:1345110	7240710		OMIM
Cilk1	Rat	juvenile myoclonic epilepsy 10		ISO	RGD:1345110	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:737218	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CILK1 mRNA	CTD	PMID:22206623
Cilk1	Rat	17beta-estradiol	increases expression	ISO	RGD:737218	6480464	Estradiol results in increased expression of CILK1 mRNA	CTD	PMID:39298647
Cilk1	Rat	17beta-hydroxy-17-methylestra-4,9,11-trien-3-one	increases expression	ISO	RGD:1345110	6480464	Metribolone results in increased expression of CILK1 mRNA	CTD	PMID:17010196
Cilk1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:737218	6480464	Tetrachlorodibenzodioxin affects the expression of CILK1 mRNA	CTD	PMID:21570461
Cilk1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of CILK1 mRNA	CTD	PMID:34747641
Cilk1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of CILK1 mRNA	CTD	PMID:32109520
Cilk1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:737218	6480464	Tetrachlorodibenzodioxin results in decreased expression of CILK1 mRNA	CTD	PMID:26290441
Cilk1	Rat	2,4,6-trinitrotoluene	affects expression	EXP		6480464	Trinitrotoluene affects the expression of CILK1 mRNA	CTD	PMID:21346803
Cilk1	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2,6-dinitrotoluene affects the expression of CILK1 mRNA	CTD	PMID:21346803
Cilk1	Rat	2-hydroxypropanoic acid	decreases expression	ISO	RGD:1345110	6480464	Lactic Acid results in decreased expression of CILK1 mRNA	CTD	PMID:30851411
Cilk1	Rat	3-methylcholanthrene	multiple interactions	ISO	RGD:1345110	6480464	Methylcholanthrene promotes the reaction [AHR protein binds to CILK1 promoter]	CTD	PMID:20348232
Cilk1	Rat	4,4'-sulfonyldiphenol	decreases methylation	ISO	RGD:737218	6480464	bisphenol S results in decreased methylation of CILK1 promoter	CTD	PMID:33297965
Cilk1	Rat	4-hydroxynon-2-enal	increases expression	ISO	RGD:737218	6480464	4-hydroxy-2-nonenal results in increased expression of CILK1 mRNA	CTD	PMID:19191707
Cilk1	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of CILK1 mRNA	CTD	PMID:24780913
Cilk1	Rat	aflatoxin B1	increases expression	ISO	RGD:737218	6480464	Aflatoxin B1 results in increased expression of CILK1 mRNA	CTD	PMID:19770486
Cilk1	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1345110	6480464	Aflatoxin B1 results in decreased methylation of CILK1 gene	CTD	PMID:27153756
Cilk1	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of CILK1 mRNA	CTD	PMID:16483693
Cilk1	Rat	arsane	multiple interactions	ISO	RGD:1345110	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Cilk1	Rat	arsenic atom	multiple interactions	ISO	RGD:1345110	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Cilk1	Rat	arsenous acid	increases expression	ISO	RGD:1345110	6480464	Arsenic Trioxide results in increased expression of CILK1 mRNA	CTD	PMID:27829220
Cilk1	Rat	atrazine	decreases expression	ISO	RGD:1345110	6480464	Atrazine results in decreased expression of CILK1 mRNA	CTD	PMID:22378314
Cilk1	Rat	benzo[a]pyrene	increases expression	ISO	RGD:737218	6480464	Benzo(a)pyrene results in increased expression of CILK1 mRNA	CTD	PMID:22228805
Cilk1	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:737218	6480464	Benzo(a)pyrene results in decreased expression of CILK1 mRNA	CTD	PMID:19770486
Cilk1	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of CILK1 mRNA	CTD	PMID:25181051
Cilk1	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of CILK1 gene	CTD	PMID:28505145
Cilk1	Rat	bortezomib	increases expression	ISO	RGD:1345110	6480464	Bortezomib results in increased expression of CILK1 mRNA	CTD	PMID:20977926
Cilk1	Rat	cadmium atom	multiple interactions	ISO	RGD:1345110	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CILK1 more ...	CTD	PMID:35301059
Cilk1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1345110	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CILK1 more ...	CTD	PMID:35301059
Cilk1	Rat	capsaicin	increases expression	EXP		6480464	Capsaicin results in increased expression of CILK1 protein	CTD	PMID:22150557
Cilk1	Rat	capsaicin	multiple interactions	EXP		6480464	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; more ...	CTD	PMID:22150557
Cilk1	Rat	carbon nanotube	increases expression	ISO	RGD:737218	6480464	Nanotubes, Carbon results in increased expression of CILK1 mRNA	CTD	PMID:25554681
Cilk1	Rat	chloroprene	increases expression	ISO	RGD:737218	6480464	Chloroprene results in increased expression of CILK1 mRNA	CTD	PMID:23125180
Cilk1	Rat	chlorpyrifos	decreases expression	ISO	RGD:737218	6480464	Chlorpyrifos results in decreased expression of CILK1 mRNA	CTD	PMID:37019170
Cilk1	Rat	chromium(6+)	affects expression	ISO	RGD:737218	6480464	chromium hexavalent ion affects the expression of CILK1 mRNA	CTD	PMID:28472532
Cilk1	Rat	cisplatin	decreases expression	ISO	RGD:1345110	6480464	Cisplatin results in decreased expression of CILK1 mRNA	CTD	PMID:27594783
Cilk1	Rat	cisplatin	increases expression	ISO	RGD:1345110	6480464	Cisplatin results in increased expression of CILK1 mRNA	CTD	PMID:27392435
Cilk1	Rat	cobalt dichloride	increases expression	ISO	RGD:1345110	6480464	cobaltous chloride results in increased expression of CILK1 mRNA	CTD	PMID:19320972
Cilk1	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of CILK1 mRNA	CTD	PMID:26577399
Cilk1	Rat	cyclosporin A	decreases expression	ISO	RGD:1345110	6480464	Cyclosporine results in decreased expression of CILK1 mRNA	CTD	PMID:25562108
Cilk1	Rat	diarsenic trioxide	increases expression	ISO	RGD:1345110	6480464	Arsenic Trioxide results in increased expression of CILK1 mRNA	CTD	PMID:27829220
Cilk1	Rat	diuron	increases expression	EXP		6480464	Diuron results in increased expression of CILK1 mRNA	CTD	PMID:21551480
Cilk1	Rat	doxorubicin	decreases expression	ISO	RGD:1345110	6480464	Doxorubicin results in decreased expression of CILK1 mRNA	CTD	PMID:29803840
Cilk1	Rat	ethyl methanesulfonate	increases expression	ISO	RGD:1345110	6480464	Ethyl Methanesulfonate results in increased expression of CILK1 mRNA	CTD	PMID:23649840
Cilk1	Rat	fenthion	decreases expression	ISO	RGD:737218	6480464	Fenthion results in decreased expression of CILK1 mRNA	CTD	PMID:34813904
Cilk1	Rat	flavonoids	decreases expression	EXP		6480464	Flavonoids results in decreased expression of CILK1 mRNA	CTD	PMID:18035473
Cilk1	Rat	folic acid	multiple interactions	ISO	RGD:737218	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CILK1 mRNA	CTD	PMID:22206623
Cilk1	Rat	formaldehyde	increases expression	ISO	RGD:1345110	6480464	Formaldehyde results in increased expression of CILK1 mRNA	CTD	PMID:23649840
Cilk1	Rat	FR900359	increases phosphorylation	ISO	RGD:1345110	6480464	FR900359 results in increased phosphorylation of CILK1 protein	CTD	PMID:37730182
Cilk1	Rat	GSK-J4	increases expression	ISO	RGD:1345110	6480464	GSK-J4 results in increased expression of CILK1 mRNA	CTD	PMID:29301935
Cilk1	Rat	manganese atom	multiple interactions	ISO	RGD:1345110	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Cilk1	Rat	manganese(0)	multiple interactions	ISO	RGD:1345110	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Cilk1	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:1345110	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Cilk1	Rat	methidathion	decreases expression	ISO	RGD:737218	6480464	methidathion results in decreased expression of CILK1 mRNA	CTD	PMID:34813904
Cilk1	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1345110	6480464	Methyl Methanesulfonate results in increased expression of CILK1 mRNA	CTD	PMID:23649840
Cilk1	Rat	naphthalene	increases expression	ISO	RGD:737218	6480464	naphthalene results in increased expression of CILK1 mRNA	CTD	PMID:18978301
Cilk1	Rat	naproxen	multiple interactions	EXP		6480464	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; more ...	CTD	PMID:22150557
Cilk1	Rat	paracetamol	decreases expression	ISO	RGD:1345110	6480464	Acetaminophen results in decreased expression of CILK1 mRNA	CTD	PMID:21420995\|PMID:22230336
Cilk1	Rat	paracetamol	affects expression	ISO	RGD:737218	6480464	Acetaminophen affects the expression of CILK1 mRNA	CTD	PMID:17562736
Cilk1	Rat	perfluorooctane-1-sulfonic acid	decreases expression	EXP		6480464	perfluorooctane sulfonic acid results in decreased expression of CILK1 mRNA	CTD	PMID:19162173
Cilk1	Rat	phenobarbital	affects expression	ISO	RGD:737218	6480464	Phenobarbital affects the expression of CILK1 mRNA	CTD	PMID:19136022
Cilk1	Rat	pirinixic acid	affects expression	ISO	RGD:737218	6480464	pirinixic acid affects the expression of CILK1 mRNA	CTD	PMID:19136022
Cilk1	Rat	pirinixic acid	decreases expression	ISO	RGD:737218	6480464	pirinixic acid results in decreased expression of CILK1 mRNA	CTD	PMID:17950772
Cilk1	Rat	pirinixic acid	multiple interactions	ISO	RGD:737218	6480464	NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of CILK1 mRNA]	CTD	PMID:17950772
Cilk1	Rat	rac-lactic acid	decreases expression	ISO	RGD:1345110	6480464	Lactic Acid results in decreased expression of CILK1 mRNA	CTD	PMID:30851411
Cilk1	Rat	silicon dioxide	decreases expression	ISO	RGD:1345110	6480464	Silicon Dioxide analog results in decreased expression of CILK1 mRNA; Silicon Dioxide results in decreased more ...	CTD	PMID:25351596\|PMID:25895662
Cilk1	Rat	sodium arsenate	decreases expression	ISO	RGD:737218	6480464	sodium arsenate results in decreased expression of CILK1 mRNA	CTD	PMID:30953684
Cilk1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1345110	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Cilk1	Rat	sodium fluoride	increases expression	ISO	RGD:737218	6480464	Sodium Fluoride results in increased expression of CILK1 mRNA	CTD	PMID:27862939
Cilk1	Rat	Soman	decreases expression	EXP		6480464	Soman results in decreased expression of CILK1 mRNA	CTD	PMID:19281266
Cilk1	Rat	sumatriptan	multiple interactions	EXP		6480464	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; more ...	CTD	PMID:22150557
Cilk1	Rat	temozolomide	increases expression	ISO	RGD:1345110	6480464	Temozolomide results in increased expression of CILK1 mRNA	CTD	PMID:31758290
Cilk1	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of CILK1 mRNA	CTD	PMID:34492290
Cilk1	Rat	titanium dioxide	decreases expression	ISO	RGD:737218	6480464	titanium dioxide results in decreased expression of CILK1 mRNA	CTD	PMID:23557971
Cilk1	Rat	triptonide	decreases expression	ISO	RGD:737218	6480464	triptonide results in decreased expression of CILK1 mRNA	CTD	PMID:33045310
Cilk1	Rat	tunicamycin	increases expression	ISO	RGD:737218	6480464	Tunicamycin results in increased expression of CILK1 mRNA	CTD	PMID:17127020
Cilk1	Rat	valproic acid	decreases methylation	ISO	RGD:1345110	6480464	Valproic Acid results in decreased methylation of CILK1 gene	CTD	PMID:29154799

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	cell projection organization	involved_in	IEA	UniProtKB-KW:KW-0970	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	cilium assembly	involved_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	cilium assembly	involved_in	IBA	MGI:1934157\|MGI:96913\|PANTHER:PTN001172286\|UniProtKB:Q9UPZ9\|WB:WBGene00001121\|ZFIN:ZDB-GENE-030131-7279	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cilk1	Rat	cilium assembly	involved_in	ISO	RGD:737218	1624291	PMID:24797473	RGD	PMID:24797473
Cilk1	Rat	cilium assembly	involved_in	ISO	RGD:1345110	1624291	PMID:24797473	RGD	PMID:24797473
Cilk1	Rat	cilium assembly	involved_in	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	cilium assembly	involved_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	intracellular signal transduction	involved_in	IDA		70769	PMID:8570168	UniProt
Cilk1	Rat	intracellular signal transduction	involved_in	IBA	CGD:CAL0000176774\|CGD:CAL0000183747\|CGD:CAL0000197240\|FB:FBgn0000229\|FB:FBgn0003256\|FB:FBgn0015765\|FB:FBgn0024846\|FB:FBgn0267339\|MGI:1201387\|MGI:1338024\|MGI:1346347\|MGI:1346858\|MGI:1346859\|MGI:1346861\|MGI:1346863\|MGI:1346865\|PANTHER:PTN000622075\|PomBase:SPAC24B11.06c\|PomBase:SPAC31G5.09c\|PomBase:SPBC119.08\|RGD:3046\|RGD:3663\|RGD:621505\|RGD:621506\|RGD:628847\|RGD:70496\|RGD:70500\|RGD:71050\|SGD:S000000112\|SGD:S000001072\|SGD:S000004103\|UniProtKB:C8VFS8\|UniProtKB:O15264\|UniProtKB:P27361\|UniProtKB:P28482\|UniProtKB:P45983\|UniProtKB:P45984\|UniProtKB:Q15759\|UniProtKB:Q16539\|UniProtKB:Q9P419\|UniProtKB:Q9UPZ9\|WB:WBGene00002178\|WB:WBGene00002187\|WB:WBGene00003401\|WB:WBGene00004055\|WB:WBGene00004056\|WB:WBGene00004057\|ZFIN:ZDB-GENE-010202-1\|ZFIN:ZDB-GENE-010202-2\|dictyBase:DDB_G0270218\|dictyBase:DDB_G0283903\|dictyBase:DDB_G0286353	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cilk1	Rat	intracellular signal transduction	involved_in	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	intracellular signal transduction	involved_in	ISO	RGD:1345110	1624291	PMID:10699974	RGD	PMID:10699974
Cilk1	Rat	intraciliary anterograde transport	involved_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	intraciliary anterograde transport	involved_in	ISO	RGD:737218	1624291	PMID:25243405	RGD	PMID:25243405
Cilk1	Rat	intraciliary anterograde transport	involved_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	intraciliary retrograde transport	involved_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	intraciliary retrograde transport	involved_in	ISO	RGD:737218	1624291	PMID:25243405	RGD	PMID:25243405
Cilk1	Rat	intraciliary retrograde transport	involved_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	intraciliary transport	involved_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	intraciliary transport	involved_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	intraciliary transport	involved_in	IBA	MGI:1934157\|PANTHER:PTN001172286\|WB:WBGene00001121	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cilk1	Rat	intraciliary transport	involved_in	ISO	RGD:737218	1624291	PMID:24797473	RGD	PMID:24797473
Cilk1	Rat	protein phosphorylation	involved_in	ISO	RGD:737218	1624291	PMID:24797473	RGD	PMID:24797473
Cilk1	Rat	protein phosphorylation	involved_in	ISO	RGD:1345110	1624291	PMID:10699974	RGD	PMID:10699974
Cilk1	Rat	protein phosphorylation	involved_in	IDA		70769	PMID:8570168	UniProt

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	cell projection	located_in	IEA	UniProtKB-KW:KW-0966	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	ciliary basal body	located_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	ciliary basal body	located_in	ISO	RGD:737218	1624291	PMID:24853502	RGD	PMID:24853502
Cilk1	Rat	ciliary basal body	located_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	ciliary base	located_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	ciliary base	located_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	ciliary base	located_in	ISO	RGD:737218	1624291	PMID:25243405	RGD	PMID:25243405
Cilk1	Rat	ciliary tip	located_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	ciliary tip	located_in	ISO	RGD:737218	1624291	PMID:24797473	RGD	PMID:24797473
Cilk1	Rat	ciliary tip	located_in	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	ciliary tip	located_in	ISO	RGD:1345110	1624291	PMID:24797473	RGD	PMID:24797473
Cilk1	Rat	ciliary tip	located_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	cilium	located_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	cilium	located_in	IEA	UniProtKB-SubCell:SL-0066	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Cilk1	Rat	cilium	located_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	cilium	located_in	ISO	RGD:737218	1624291	PMID:25243405	RGD	PMID:25243405
Cilk1	Rat	cilium	is_active_in	IBA	MGI:1934157\|MGI:96913\|PANTHER:PTN001172286\|UniProtKB:Q9UPZ9\|WB:WBGene00001121	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cilk1	Rat	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Cilk1	Rat	cytoplasm	is_active_in	IBA	CGD:CAL0000197240\|FB:FBgn0003256\|FB:FBgn0052703\|FB:FBgn0267339\|MGI:1338024\|MGI:1346347\|MGI:1346858\|MGI:1346859\|MGI:1346861\|MGI:1346862\|MGI:1346863\|MGI:1346865\|MGI:1354946\|MGI:2444559\|MGI:96913\|PANTHER:PTN000622075\|PomBase:SPAC24B11.06c\|PomBase:SPBC119.08\|RGD:3046\|RGD:3663\|RGD:621506\|RGD:628847\|RGD:70500\|RGD:70975\|RGD:71050\|SGD:S000000112\|SGD:S000001072\|SGD:S000004103\|TAIR:locus:2024887\|TAIR:locus:2043904\|TAIR:locus:2085632\|TAIR:locus:2092717\|TAIR:locus:2124943\|UniProtKB:A0A0A7R535\|UniProtKB:A0A1L8FXY5\|UniProtKB:A9T142\|UniProtKB:P28482\|UniProtKB:P45984\|UniProtKB:Q10N20\|UniProtKB:Q13164\|UniProtKB:Q16539\|UniProtKB:Q16659\|UniProtKB:Q586V3\|UniProtKB:Q8TD08\|WB:WBGene00002178\|WB:WBGene00002187\|WB:WBGene00003048\|WB:WBGene00003401\|WB:WBGene00004055\|WB:WBGene00004056\|WB:WBGene00004057\|WB:WBGene00015478\|dictyBase:DDB_G0283903\|dictyBase:DDB_G0286353	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cilk1	Rat	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	cytoplasm	located_in	IDA		70769	PMID:8570168	UniProt
Cilk1	Rat	cytoskeleton	located_in	IEA	UniProtKB-KW:KW-0206	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	nucleus	is_active_in	IBA	CGD:CAL0000197240\|FB:FBgn0000229\|FB:FBgn0003256\|FB:FBgn0015765\|FB:FBgn0052703\|MGI:1201387\|MGI:1336881\|MGI:1346347\|MGI:1346858\|MGI:1346859\|MGI:1346861\|MGI:1346865\|MGI:1354946\|MGI:1934157\|MGI:2444559\|PANTHER:PTN000622075\|PomBase:SPAC24B11.06c\|PomBase:SPAC31G5.09c\|PomBase:SPBC119.08\|RGD:3046\|RGD:628675\|RGD:70500\|SGD:S000000112\|SGD:S000001072\|SGD:S000003272\|SGD:S000003642\|SGD:S000004103\|TAIR:locus:2024887\|TAIR:locus:2062897\|TAIR:locus:2092717\|TAIR:locus:2124943\|UniProtKB:A9T142\|UniProtKB:C8V7D1\|UniProtKB:P20794\|UniProtKB:P27361\|UniProtKB:P28482\|UniProtKB:P45983\|UniProtKB:P45984\|UniProtKB:P53779\|UniProtKB:Q10N20\|UniProtKB:Q13164\|UniProtKB:Q16539\|UniProtKB:Q5AZN7\|UniProtKB:Q7KQK7\|UniProtKB:Q8TD08\|UniProtKB:Q9P419\|UniProtKB:Q9UPZ9\|WB:WBGene00002178\|WB:WBGene00003048\|WB:WBGene00003401\|WB:WBGene00004055\|WB:WBGene00004057\|dictyBase:DDB_G0283903\|dictyBase:DDB_G0286353	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cilk1	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	nucleus	located_in	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	nucleus	located_in	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Cilk1	Rat	nucleus	located_in	ISO	RGD:1345110	1624291	PMID:19185282	RGD	PMID:19185282
Cilk1	Rat	nucleus	located_in	ISS	UniProtKB:Q9UPZ9	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	nucleus	located_in	ISS	UniProtKB:Q9JKV2	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Cilk1	Rat	nucleus	located_in	ISO	RGD:737218	1624291	PMID:25243405	RGD	PMID:25243405

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cilk1	Rat	ATP binding	enables	IEA	UniRule:UR001503341	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Cilk1	Rat	ATP binding	enables	IEA	InterPro:IPR000719\|InterPro:IPR017441	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cilk1	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	ATP binding	enables	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	ATP binding	enables	ISO	RGD:1345110	1624291	PMID:10699974	RGD	PMID:10699974
Cilk1	Rat	ATP binding	enables	IDA		70769	PMID:8570168	UniProt
Cilk1	Rat	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	magnesium ion binding	enables	ISO	RGD:1345110	1624291	PMID:10699974	RGD	PMID:10699974
Cilk1	Rat	magnesium ion binding	enables	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	nucleotide binding	enables	IEA	UniRule:UR001503341	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Cilk1	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	protein binding	enables	ISO	RGD:1345110	1624291	UniProtKB:P08238\|UniProtKB:Q13451\|UniProtKB:Q9NRG4 PMID:22939624, PMID:27173435, PMID:32707033, PMID:33961781	RGD	PMID:22939624\|PMID:27173435\|PMID:32707033\|PMID:33961781
Cilk1	Rat	protein kinase activity	enables	IEA	InterPro:IPR000719\|InterPro:IPR008271	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Cilk1	Rat	protein kinase activity	enables	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	protein kinase activity	enables	ISO	RGD:1345110	1624291	PMID:19185282	RGD	PMID:19185282
Cilk1	Rat	protein serine kinase activity	enables	IEA	RHEA:17989	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Cilk1	Rat	protein serine/threonine kinase activity	enables	IDA		70769	PMID:8570168	UniProt
Cilk1	Rat	protein serine/threonine kinase activity	enables	IEA	UniProtKB-KW:KW-0723	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Cilk1	Rat	protein serine/threonine kinase activity	enables	IEA	EC:2.7.11.1	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Cilk1	Rat	protein serine/threonine kinase activity	enables	ISO	RGD:737218	1624291	PMID:10699974	RGD	PMID:10699974
Cilk1	Rat	protein serine/threonine kinase activity	enables	IBA	CGD:CAL0000183747\|CGD:CAL0000196384\|CGD:CAL0000200092\|CGD:CAL0000201386\|FB:FBgn0003256\|FB:FBgn0011817\|FB:FBgn0015765\|FB:FBgn0024846\|FB:FBgn0267339\|MGI:1201387\|MGI:1338024\|MGI:1346347\|MGI:1346859\|MGI:1346861\|MGI:1346862\|MGI:1346865\|MGI:1354946\|MGI:1934157\|PANTHER:PTN000622075\|PomBase:SPAC24B11.06c\|PomBase:SPAC31G5.09c\|PomBase:SPBC119.08\|RGD:3046\|RGD:3663\|RGD:621505\|RGD:621506\|RGD:628847\|RGD:70496\|RGD:70500\|RGD:70975\|SGD:S000000112\|SGD:S000003272\|SGD:S000004103\|TAIR:locus:2012808\|TAIR:locus:2043904\|TAIR:locus:2080457\|TAIR:locus:2124943\|UniProtKB:A9S9Q8\|UniProtKB:O15264\|UniProtKB:P27361\|UniProtKB:P28482\|UniProtKB:P45984\|UniProtKB:P46196\|UniProtKB:P53778\|UniProtKB:Q15759\|UniProtKB:Q16539\|UniProtKB:Q8ILF0\|UniProtKB:Q8TD08\|UniProtKB:Q9UBE8\|UniProtKB:Q9UPZ9\|WB:WBGene00001121\|WB:WBGene00002178\|WB:WBGene00002187\|WB:WBGene00003048\|WB:WBGene00003401\|WB:WBGene00004055\|WB:WBGene00004056\|WB:WBGene00004057\|ZFIN:ZDB-GENE-010202-2\|dictyBase:DDB_G0283903\|dictyBase:DDB_G0286353	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Cilk1	Rat	protein serine/threonine kinase activity	enables	IEA	UniProtKB:Q9UPZ9\|ensembl:ENSP00000501692	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	protein serine/threonine kinase activity	enables	ISO	RGD:1345110	1624291	PMID:10699974	RGD	PMID:10699974
Cilk1	Rat	protein serine/threonine kinase activity	enables	IEA	UniProtKB:Q9JKV2\|ensembl:ENSMUSP00000048234	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Cilk1	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Disease Annotations Click to see Annotation Detail View

asphyxiating thoracic dystrophy (ISO)

coloboma (ISO)

cranioectodermal dysplasia (ISO)

endocrine-cerebro-osteodysplasia syndrome (ISO,ISS)

Idiopathic Generalized Epilepsy (ISO)

juvenile myoclonic epilepsy 10 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bortezomib (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

capsaicin (EXP)

carbon nanotube (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diuron (EXP)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

GSK-J4 (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

naphthalene (ISO)

naproxen (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

Soman (EXP)

sumatriptan (EXP)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell projection organization (IEA)

cilium assembly (IBA,IEA,ISO,ISS)

intracellular signal transduction (IBA,IDA,IEA,ISO)

intraciliary anterograde transport (IEA,ISO,ISS)

intraciliary retrograde transport (IEA,ISO,ISS)

intraciliary transport (IBA,IEA,ISO,ISS)

protein phosphorylation (IDA,ISO)

Cellular Component

cell projection (IEA)

ciliary basal body (IEA,ISO,ISS)

ciliary base (IEA,ISO,ISS)

ciliary tip (IEA,ISO,ISS)

cilium (IBA,IEA,ISO,ISS)

cytoplasm (IBA,IDA,IEA)

cytoskeleton (IEA)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

ATP binding (IDA,IEA,ISO)

kinase activity (IEA)

magnesium ion binding (IEA,ISO)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,IEA,ISO)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning of a novel serine/threonine kinase, MRK, possibly involved in cardiac development.	Abe S, etal., Oncogene 1995 Dec 7;11(11):2187-95.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Gene Data Set	MGD Curation, June 12, 2002
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10699974	PMID:19185282	PMID:24797473	PMID:24853502	PMID:25243405

Genomics

Comparative Map Data

Cilk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	87,868,294 - 87,922,995 (+)	NCBI		GRCr8
mRatBN7.2	8	78,984,075 - 79,042,695 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	78,984,258 - 79,042,691 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	84,474,767 - 84,530,110 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	82,751,418 - 82,806,761 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	80,574,141 - 80,629,484 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	85,413,998 - 85,473,374 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	85,413,537 - 85,472,694 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	84,982,701 - 85,037,684 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	83,086,346 - 83,140,977 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	83,105,399 - 83,160,031 (+)	NCBI
Celera	8	78,732,894 - 78,787,000 (+)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

CILK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	53,001,303 - 53,061,824 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	53,001,279 - 53,061,824 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	52,866,101 - 52,926,622 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	52,974,057 - 53,034,559 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	52,974,056 - 53,034,549	NCBI
Celera	6	54,527,872 - 54,588,397 (-)	NCBI		Celera
Cytogenetic Map	6	p12.1	NCBI
HuRef	6	52,697,571 - 52,758,090 (-)	NCBI		HuRef
CHM1_1	6	52,867,865 - 52,928,390 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	52,840,881 - 52,901,428 (-)	NCBI		T2T-CHM13v2.0

Cilk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	78,016,425 - 78,079,396 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	78,016,474 - 78,079,389 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	78,109,080 - 78,172,114 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	78,109,192 - 78,172,107 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	77,956,999 - 78,019,917 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	77,899,093 - 77,953,626 (+)	NCBI		MGSCv36	mm8
Celera	9	75,286,395 - 75,349,194 (+)	NCBI		Celera
Cytogenetic Map	9	E1	NCBI
cM Map	9	43.56	NCBI

Cilk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	3,019,525 - 3,068,090 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	2,997,726 - 3,065,106 (+)	NCBI	ChiLan1.0	ChiLan1.0

CILK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	67,472,436 - 67,512,442 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	63,348,948 - 63,388,827 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	52,556,272 - 52,617,199 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	54,198,594 - 54,255,449 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	54,198,594 - 54,255,435 (-)	Ensembl	panpan1.1		panPan2

CILK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	20,453,322 - 20,511,463 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	20,450,834 - 20,511,673 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	20,347,814 - 20,405,500 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	20,950,443 - 21,008,297 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	20,952,122 - 21,008,325 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	20,455,977 - 20,513,492 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	20,560,568 - 20,618,196 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	20,698,567 - 20,755,529 (-)	NCBI		UU_Cfam_GSD_1.0

Cilk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	56,090,665 - 56,129,505 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	7,813,064 - 7,869,545 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	7,830,714 - 7,869,533 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CILK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	46,658,681 - 46,723,585 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	46,658,671 - 46,723,286 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	134,404,039 - 134,465,673 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CILK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	19,509,955 - 19,572,011 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	19,510,106 - 19,572,002 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	52,849,509 - 52,911,320 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cilk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624850	218,958 - 278,199 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624850	219,042 - 286,756 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cilk1
404 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	41
Count of miRNA genes:	30
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000012257
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	58991697	91341052	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	58991697	91341052	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	58991697	91341052	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat

Markers in Region

RH140960

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	79,041,350 - 79,042,505 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	85,471,354 - 85,472,508	NCBI	Rnor6.0
Rnor_5.0	8	85,036,344 - 85,037,498	UniSTS	Rnor5.0
RGSC_v3.4	8	83,139,637 - 83,140,791	UniSTS	RGSC3.4
Celera	8	78,785,660 - 78,786,814	UniSTS
Cytogenetic Map	8	q31	UniSTS

BF390953

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	78,999,474 - 78,999,627 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	85,429,321 - 85,429,473	NCBI	Rnor6.0
Rnor_5.0	8	84,994,184 - 84,994,336	UniSTS	Rnor5.0
RGSC_v3.4	8	83,097,829 - 83,097,981	UniSTS	RGSC3.4
Celera	8	78,744,383 - 78,744,535	UniSTS
RH 3.4 Map	8	924.2	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D26178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012257 ⟹ ENSRNOP00000012257

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	78,987,991 - 79,042,691 (+)	Ensembl
Rnor_6.0 Ensembl	8	85,417,838 - 85,472,694 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078159 ⟹ ENSRNOP00000068950

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	78,984,258 - 79,042,690 (+)	Ensembl
Rnor_6.0 Ensembl	8	85,413,537 - 85,472,670 (+)	Ensembl

RefSeq Acc Id:

NM_138886 ⟹ NP_620241

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	87,868,294 - 87,922,995 (+)	NCBI
mRatBN7.2	8	78,987,991 - 79,042,691 (+)	NCBI
Rnor_6.0	8	85,417,838 - 85,472,694 (+)	NCBI
Rnor_5.0	8	84,982,701 - 85,037,684 (+)	NCBI
RGSC_v3.4	8	83,086,346 - 83,140,977 (+)	RGD
Celera	8	78,732,894 - 78,787,000 (+)	RGD

Sequence:

show sequence

GGGTTCCTGCTGGATGCCACGCGCTGCCGGGTGTGGACTTGCCGGGTTCGCCCGCTCGGATCCC
ACTGCCCTTGCCTGCCGGGCCCGCTCGGGTGCACGCGCCGCCCGGCTGTGATCGCCGCCAGCAG
AAGACTGATCTTTGAAAATATGTATTTGGGAGATAATCACGTTCTGTTGAATACTTTGTGCTGG
TGCTGCCATCGAAAAATCTGGTTACAGTCCGGGGAGGCCTGCTACCATTGCAGGACTGAACCGC
CTCGGCCCTGAGATGAGTGTCCCGACAGAGCAGGCGCACCATGAATAGATACACAACGATCAAA
CAGCTTGGGGATGGGACCTATGGTTCTGTCCTGCTGGGGAGAAGCATTGAATCTGGAGAACTAA
TTGCCATTAAAAAAATGAAAAGAAAGTTTTACTCCTGGGAAGAATGCATGAACCTTCGGGAGGT
TAAGTCTTTAAAGAAGCTCAACCATGCCAATATAGTGAAGTTAAAAGAGGTTATCAGGGAGAAC
GACCATCTCTATTTCATCTTCGAGTACATGAAGGAAAACCTTTACCAGCTCATTAAAGAAAGAA
ATAAGTTGTTCCCAGAGTCTGCAATAAGGAATATAATGTATCAGATATTGCAAGGACTGGCGTT
CATTCACAAACATGGTTTCTTCCACCGGGACTTAAAGCCTGAGAACCTCCTCTGCATGGGACCA
GAACTTGTGAAAATCGCGGACTTCGGATTGGCCCGAGAAATCCGATCAAGACCTCCATACACAG
ACTATGTGTCTACTAGATGGTATAGGGCTCCAGAAGTACTCCTGAGATCTACCAACTACAGCTC
CCCCATTGATGTCTGGGCCGTGGGCTGCATCATGGCAGAGGTGTACACCCTCCGGCCTCTTTTC
CCTGGGGCCAGTGAAATTGACACGATTTTCAAAATTTGCCAAGTGTTGGGAACACCGAAGAAGA
CTGACTGGCCTGAAGGCTACCAGCTGTCAAGTGCTATGAATTTCATCTGGCCCCAGTGCATACC
CAATAACTTAAAGACACTAATTCCAAATGCTAGCAGCGAAGCAATTCAGCTCCTGAGAGACTTG
CTTCAGTGGGATCCCAAGAAACGACCAACTGCTAGTCAGGCACTTCGATACCCTTACTTCCAGA
TCGGACACCCACTGGGCATCAGCACACAGGACTCGGGAAAGCCACAGAAAGATGTCCAAGACAA
GACAGGCCCACCTCCTTACGTCAAGCCAGCCCCTCCTGCCCAGGCCCCAACCAAGGCGCATACA
CTGATTTCTTCACGACCAAACCAAGCCAGTCAACCCCATCAGCATTTTGTATATCCCTACAAGG
GCGAAGCCTCTAGGACAGAGCAGCTGAGCCACGTGCAGGAGGGCCAGCCAAACCCACCATTCTT
CCCGTCCCTCCACAACAAGAATCTCCCGCCAAAAATCCTAGCTGGCCTGGAACAGAAAAGCGGT
GACATGAAACCAAAGAGCAGGAGAAGATGGGGTCTCATTTCCAGGTCAACCAAGGGTTCTGATG
ATTGGGCCGACTTGGCTGACTTAGATTTCAGTTCCTCTCTCACCAGAATAGATGTCAAAAACAA
GAAGAGACAGAGTGACGACCCCCTCTGCAGGTTTGAAAGTGTTTTGGACCTGAAGCCATCTGAG
CCGGTGGGTACAGGAACTAGTGTCTCCACCCAGGCTTCCTCCCAGAGGAGAGACACGCCGACCC
TGCAGTCCACAGCAAAGCAGCACTACTTGAAGCACTCTCGCTACCTGCCTGGAATAAATATAAG
AAATGGCGTGCTCCCAAATCCAGGCAAGGACTTTCTTCCATCAAGTTCATGGTCCAGTTCTGGT
TTGTCTGGAAAATCTTCAGGAACGGTATCAGTAGTGAGCAAAATAACTTCAGTTGGCTCAGGCT
CCACGAGCTCTACTGGACTGACTGGAAGCTACATCCCTTCCTTTCTGAAGAAGGAAGTCGGCTC
TGTCATGCAGAGGGTCCAGCTGGCGCCTCTCGCAGCCCCTTCCCCCGGCTACTCTTCCCTCAAG
GCCGTGAGACCTCACCCAGGGAGGCCATTCTTTCACACCCAGCCTAGGAGCACGCCTGGCTTGA
TTCCACGACCTCCAGCTGTGCAGCCTGTGCACGGCAGGATAGACTGGTCTTCCAAGTACCCATC
TCGGCGGTGACTGTCCCAGCTGACTCCGTTGTACCCCCACAACCACGTGGCGGTGTAAAAGCAC
CCACACTTACAGCAGTTCTGAACTAACACATTTCAATATTTCTTTTAAATGTTTTTTTAAACAT
TGATTTGAATGCAATACCCTCTTTTTGTATAAAATTATTTTATTCT

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Protein Sequences


Protein RefSeqs	NP_620241	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA05166	(Get FASTA)	NCBI Sequence Viewer
	EDL77748	(Get FASTA)	NCBI Sequence Viewer
	EDL77749	(Get FASTA)	NCBI Sequence Viewer
	EDL77750	(Get FASTA)	NCBI Sequence Viewer
	EDL77751	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012257
GenBank Protein	Q62726	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_620241 ⟸ NM_138886

- UniProtKB:

Q62726 (UniProtKB/Swiss-Prot), A6I1H7 (UniProtKB/TrEMBL), G3V760 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVK
LKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKP
ENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAE
VYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWPQCIPNNLKTLIPNASSE
AIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGISTQDSGKPQKDVQDKTGPPPYVKPAPPA
QAPTKAHTLISSRPNQASQPHQHFVYPYKGEASRTEQLSHVQEGQPNPPFFPSLHNKNLPPKIL
AGLEQKSGDMKPKSRRRWGLISRSTKGSDDWADLADLDFSSSLTRIDVKNKKRQSDDPLCRFES
VLDLKPSEPVGTGTSVSTQASSQRRDTPTLQSTAKQHYLKHSRYLPGINIRNGVLPNPGKDFLP
SSSWSSSGLSGKSSGTVSVVSKITSVGSGSTSSTGLTGSYIPSFLKKEVGSVMQRVQLAPLAAP
SPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAVQPVHGRIDWSSKYPSRR

hide sequence

Ensembl Acc Id:

ENSRNOP00000012257 ⟸ ENSRNOT00000012257

Ensembl Acc Id:

ENSRNOP00000068950 ⟸ ENSRNOT00000078159

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62726-F1-model_v2	AlphaFold	Q62726	1-629	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696139

Promoter ID:

EPDNEW_R6664

Type:

initiation region

Name:

Ick_2

Description:

intestinal cell kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R6665

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	85,414,049 - 85,414,109	EPDNEW

RGD ID:

13696140

Promoter ID:

EPDNEW_R6665

Type:

initiation region

Name:

Ick_1

Description:

intestinal cell kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R6664

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	85,417,794 - 85,417,854	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:71050	AgrOrtholog
BioCyc Gene	G2FUF-29771	BioCyc
Ensembl Genes	ENSRNOG00000008691	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000012257	ENTREZGENE
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	Kinase-like_dom	UniProtKB/Swiss-Prot
	MAP_kinase	UniProtKB/Swiss-Prot
	Prot_kinase_cat_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_prot_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:84411	UniProtKB/Swiss-Prot
NCBI Gene	84411	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Cilk1	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008691	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	Kinase_like	UniProtKB/Swiss-Prot
UniProt	A0A0G2JU35_RAT	UniProtKB/TrEMBL
	A6I1H7	ENTREZGENE, UniProtKB/TrEMBL
	G3V760	ENTREZGENE, UniProtKB/TrEMBL
	ICK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-30	Cilk1	ciliogenesis associated kinase 1	Ick	intestinal cell kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-25	Ick	intestinal cell kinase	Ick	intestinal cell (MAK-like) kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-25	Ick	intestinal cell (MAK-like) kinase	Ick	intestinal cell kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Ick	intestinal cell kinase			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	has an C-terminal non-catalytic and an N-terminal catalytic domain	70769
gene_expression	isolated from the heart	70769
gene_product	member of the serine/threonine kinase family	70769
gene_protein	encoded protein is 629 amino acid in size	70769

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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