Cnn3 (calponin 3) - Rat Genome Database

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Gene: Cnn3 (calponin 3) Rattus norvegicus
Analyze
Symbol: Cnn3
Name: calponin 3
RGD ID: 71044
Description: Enables microtubule binding activity. Involved in negative regulation of ATP-dependent activity. Located in dendritic spine and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Orthologous to human CNN3 (calponin 3); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acidic calponin; acidic calponin h3; calponin 3, acidic; calponin, acidic isoform; calponin, non-muscle isoform; calponin-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,203,661 - 212,234,772 (+)NCBIGRCr8
GRCr8 Ensembl2212,226,640 - 212,234,815 (+)EnsemblGRCr8 Ensembl
mRatBN7.22209,518,948 - 209,550,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,518,948 - 209,550,104 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2217,181,924 - 217,213,028 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,089,643 - 215,120,749 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02209,931,377 - 209,962,475 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,005,069 - 225,036,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,005,019 - 225,036,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,044,080 - 243,075,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,044,803 - 218,075,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2201,950,953 - 201,982,114 (+)NCBICelera
RGSC_v3.12218,007,864 - 218,038,976 (+)NCBI
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-bromohexadecanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
diuron  (EXP)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-toluidine  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
rotenone  (EXP,ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Subcellular distribution of calponin and caldesmon in rat hippocampus. Agassandian C, etal., Brain Res. 2000 Dec 29;887(2):444-9.
2. Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
3. Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle. Applegate D, etal., J Biol Chem 1994 Apr 8;269(14):10683-90.
4. Mapping the microtubule binding regions of calponin. Fattoum A, etal., Biochemistry 2003 Feb 11;42(5):1274-82.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Distribution of caldesmon and of the acidic isoform of calponin in cultured cerebellar neurons and in different regions of the rat brain: an immunofluorescence and confocal microscopy study. Represa A, etal., Exp Cell Res. 1995 Dec;221(2):333-43.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:16358313   PMID:20181831   PMID:21423176   PMID:21492153   PMID:25468996  


Genomics

Comparative Map Data
Cnn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,203,661 - 212,234,772 (+)NCBIGRCr8
GRCr8 Ensembl2212,226,640 - 212,234,815 (+)EnsemblGRCr8 Ensembl
mRatBN7.22209,518,948 - 209,550,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,518,948 - 209,550,104 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2217,181,924 - 217,213,028 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,089,643 - 215,120,749 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02209,931,377 - 209,962,475 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,005,069 - 225,036,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,005,019 - 225,036,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,044,080 - 243,075,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,044,803 - 218,075,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2201,950,953 - 201,982,114 (+)NCBICelera
RGSC_v3.12218,007,864 - 218,038,976 (+)NCBI
Cytogenetic Map2q42NCBI
CNN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,896,957 - 94,927,110 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,896,949 - 94,927,223 (-)EnsemblGRCh38hg38GRCh38
GRCh37195,362,513 - 95,392,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,135,095 - 95,165,289 (-)NCBINCBI36Build 36hg18NCBI36
Build 34195,074,529 - 95,104,722NCBI
Celera193,616,973 - 93,647,200 (-)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef193,484,336 - 93,514,531 (-)NCBIHuRef
CHM1_1195,477,311 - 95,507,534 (-)NCBICHM1_1
T2T-CHM13v2.0194,745,314 - 94,775,463 (-)NCBIT2T-CHM13v2.0
Cnn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,220,190 - 121,251,854 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3121,220,146 - 121,251,856 (+)EnsemblGRCm39 Ensembl
GRCm383121,426,541 - 121,458,205 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,426,497 - 121,458,207 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,129,459 - 121,161,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363121,418,564 - 121,450,228 (+)NCBIMGSCv36mm8
Celera3127,782,383 - 127,824,521 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
Cnn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543580,185 - 89,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543580,185 - 89,216 (-)NCBIChiLan1.0ChiLan1.0
CNN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21132,096,906 - 132,127,207 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11131,251,606 - 131,281,812 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,558,652 - 97,588,791 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,286,015 - 96,316,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,286,015 - 96,316,249 (-)Ensemblpanpan1.1panPan2
CNN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,378,031 - 54,405,009 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,368,162 - 54,404,201 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,077,741 - 57,105,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0654,751,458 - 54,778,564 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl654,743,775 - 54,778,564 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,425,310 - 54,453,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,409,986 - 54,438,043 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0654,862,633 - 54,890,718 (+)NCBIUU_Cfam_GSD_1.0
Cnn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,609,983 - 104,638,951 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365374,308,951 - 4,337,998 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365374,308,951 - 4,337,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,504,433 - 122,528,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14122,504,450 - 122,528,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,245,269 - 134,269,263 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,325,810 - 38,356,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,325,848 - 38,356,760 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603379,710,142 - 79,740,641 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247422,737,057 - 2,767,273 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247422,737,131 - 2,767,026 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnn3
155 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:437
Count of miRNA genes:233
Interacting mature miRNAs:262
Transcripts:ENSRNOT00000015579
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2209350500221678003Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat

Markers in Region
RH128022  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,549,320 - 209,549,521 (+)MAPPERmRatBN7.2
Rnor_6.02225,035,437 - 225,035,637NCBIRnor6.0
Rnor_5.02243,074,448 - 243,074,648UniSTSRnor5.0
RGSC_v3.42218,075,172 - 218,075,372UniSTSRGSC3.4
Celera2201,981,372 - 201,981,572UniSTS
RH 3.4 Map21501.4UniSTS
Cytogenetic Map2q41UniSTS
RH127599  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,549,845 - 209,550,031 (+)MAPPERmRatBN7.2
Rnor_6.02225,035,962 - 225,036,147NCBIRnor6.0
Rnor_5.02243,074,973 - 243,075,158UniSTSRnor5.0
RGSC_v3.42218,075,697 - 218,075,882UniSTSRGSC3.4
Celera2201,981,897 - 201,982,082UniSTS
RH 3.4 Map21500.9UniSTS
Cytogenetic Map2q41UniSTS
RH129426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,549,874 - 209,550,055 (+)MAPPERmRatBN7.2
Rnor_6.02225,035,991 - 225,036,171NCBIRnor6.0
Rnor_5.02243,075,002 - 243,075,182UniSTSRnor5.0
RGSC_v3.42218,075,726 - 218,075,906UniSTSRGSC3.4
Celera2201,981,926 - 201,982,106UniSTS
RH 3.4 Map21518.7UniSTS
Cytogenetic Map2q41UniSTS
RH142485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,527,968 - 209,528,142 (+)MAPPERmRatBN7.2
Rnor_6.02225,014,087 - 225,014,260NCBIRnor6.0
Rnor_5.02243,053,098 - 243,053,271UniSTSRnor5.0
RGSC_v3.42218,053,822 - 218,053,995UniSTSRGSC3.4
Celera2201,960,073 - 201,960,246UniSTS
RH 3.4 Map21517.6UniSTS
Cytogenetic Map2q41UniSTS
RH143859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22209,542,595 - 209,542,725 (+)MAPPERmRatBN7.2
Rnor_6.02225,028,712 - 225,028,841NCBIRnor6.0
Rnor_5.02243,067,723 - 243,067,852UniSTSRnor5.0
RGSC_v3.42218,068,447 - 218,068,576UniSTSRGSC3.4
Celera2201,974,647 - 201,974,776UniSTS
RH 3.4 Map21517.6UniSTS
Cytogenetic Map2q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015579   ⟹   ENSRNOP00000015579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2209,518,948 - 209,550,104 (+)Ensembl
Rnor_6.0 Ensembl2225,005,019 - 225,036,188 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104611   ⟹   ENSRNOP00000093982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2212,226,640 - 212,234,815 (+)Ensembl
mRatBN7.2 Ensembl2209,541,826 - 209,550,104 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114771   ⟹   ENSRNOP00000077681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2209,518,948 - 209,549,860 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119824   ⟹   ENSRNOP00000092181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2209,518,948 - 209,549,860 (+)Ensembl
RefSeq Acc Id: NM_019359   ⟹   NP_062232
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,203,661 - 212,234,772 (+)NCBI
mRatBN7.22209,518,948 - 209,550,063 (+)NCBI
Rnor_6.02225,005,069 - 225,036,179 (+)NCBI
Rnor_5.02243,044,080 - 243,075,234 (+)NCBI
RGSC_v3.42218,044,803 - 218,075,914 (+)RGD
Celera2201,950,953 - 201,982,114 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102991   ⟹   XP_038958919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82212,224,913 - 212,234,570 (+)NCBI
mRatBN7.22209,541,367 - 209,550,107 (+)NCBI
Protein Sequences
Protein RefSeqs NP_062232 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958919 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18590 (Get FASTA)   NCBI Sequence Viewer  
  AAH62020 (Get FASTA)   NCBI Sequence Viewer  
  EDL82075 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092181.1
  ENSRNOP00000093982
GenBank Protein P37397 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062232   ⟸   NM_019359
- UniProtKB: P37397 (UniProtKB/Swiss-Prot),   A6HVE0 (UniProtKB/TrEMBL),   A0A8I6AJV8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015579   ⟸   ENSRNOT00000015579
RefSeq Acc Id: XP_038958919   ⟸   XM_039102991
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AJV8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077681   ⟸   ENSRNOT00000114771
Ensembl Acc Id: ENSRNOP00000093982   ⟸   ENSRNOT00000104611
Ensembl Acc Id: ENSRNOP00000092181   ⟸   ENSRNOT00000119824
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37397-F1-model_v2 AlphaFold P37397 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691718
Promoter ID:EPDNEW_R2243
Type:initiation region
Name:Cnn3_1
Description:calponin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02225,005,039 - 225,005,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71044 AgrOrtholog
BioCyc Gene G2FUF-51413 BioCyc
Ensembl Genes ENSRNOG00000011559 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000104611 ENTREZGENE
  ENSRNOT00000119824.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623281 IMAGE-MGC_LOAD
InterPro Calponin-like UniProtKB/Swiss-Prot
  Calponin/LIMCH1 UniProtKB/Swiss-Prot
  Calponin_repeat UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  SM22_calponin UniProtKB/Swiss-Prot
KEGG Report rno:54321 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72485 IMAGE-MGC_LOAD
NCBI Gene 54321 ENTREZGENE
PANTHER CALPONIN UniProtKB/Swiss-Prot
  MUSCLE-SPECIFIC PROTEIN 20 UniProtKB/Swiss-Prot
Pfam Calponin UniProtKB/Swiss-Prot
  PF00307 UniProtKB/Swiss-Prot
PhenoGen Cnn3 PhenoGen
PRINTS CALPONIN UniProtKB/Swiss-Prot
  SM22CALPONIN UniProtKB/Swiss-Prot
PROSITE CALPONIN_1 UniProtKB/Swiss-Prot
  CALPONIN_2 UniProtKB/Swiss-Prot
  PS50021 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011559 RatGTEx
SMART SM00033 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot
UniProt A0A8I5YBZ5_RAT UniProtKB/TrEMBL
  A0A8I6AJV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q7M2_RAT UniProtKB/TrEMBL
  A6HVE0 ENTREZGENE, UniProtKB/TrEMBL
  CNN3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Cnn3  calponin 3  Cnn3  calponin 3, acidic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cnn3  calponin 3, acidic      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds F-actin and microtubule filaments 727577