Cpb2 (carboxypeptidase B2) - Rat Genome Database

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Gene: Cpb2 (carboxypeptidase B2) Rattus norvegicus
Analyze
Symbol: Cpb2
Name: carboxypeptidase B2
RGD ID: 71035
Description: Enables carboxypeptidase activity. Involved in several processes, including liver regeneration; negative regulation of hepatocyte proliferation; and regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (carboxypeptidase B2); PARTICIPATES IN fibrinolysis pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxypeptidase B2 (plasma); carboxypeptidase R; carboxypeptidase U; CPR; CPU; LOC684726; similar to carboxypeptidase B2 (plasma); TAFI; thrombin-activable fibrinolysis inhibitor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81556,967,128 - 57,015,964 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1556,966,839 - 57,015,962 (+)EnsemblGRCr8
mRatBN7.21550,557,722 - 50,606,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1550,557,717 - 50,606,556 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1554,699,866 - 54,748,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,818,184 - 55,867,090 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,650,058 - 52,698,853 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01557,290,849 - 57,339,762 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1557,290,849 - 57,339,760 (+)Ensemblrn6Rnor6.0
Rnor_5.01561,001,889 - 61,050,732 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41556,104,920 - 56,154,321 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1550,189,675 - 50,237,544 (+)NCBICelera
RGSC_v3.11556,120,686 - 56,170,027 (+)NCBI
Cytogenetic Map15q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
azathioprine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
desogestrel  (ISO)
dextran sulfate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
furan  (EXP)
hydroxyurea  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
nefazodone  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omega-6 fatty acid  (ISO)
orlistat  (ISO)
p-anisidine  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quartz  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Metabolic syndrome accompanied by hypercholesterolemia is strongly associated with proinflammatory state and impairment of fibrinolysis in patients with type 2 diabetes: synergistic effects of plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor. Aso Y, etal., Diabetes Care. 2005 Sep;28(9):2211-6.
2. An inhibitor of thrombin activated fibrinolysis inhibitor (TAFI) can reduce extracellular matrix accumulation in an in vitro model of glucose induced ECM expansion. Atkinson JM, etal., Matrix Biol. 2013 Jan 29. pii: S0945-053X(13)00007-3. doi: 10.1016/j.matbio.2013.01.006.
3. Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis. Bruno NE, etal., J Thromb Haemost. 2008 Jan;6(1):139-46. Epub 2007 Nov 5.
4. Immune complex-mediated glomerulonephritis is ameliorated by thrombin-activatable fibrinolysis inhibitor deficiency. Bruno NE, etal., Thromb Haemost. 2008 Jul;100(1):90-100. doi: 10.1160/TH08-02-0092.
5. Thrombin activatable fibrinolysis inhibitor in Behcet's disease. Donmez A, etal., Thromb Res. 2005;115(4):287-92.
6. Thrombin-activatable fibrinolysis inhibitor and the risk for recurrent venous thromboembolism. Eichinger S, etal., Blood. 2004 May 15;103(10):3773-6. Epub 2004 Jan 22.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Enhancement of endogenous plasminogen activator-induced thrombolysis by argatroban and APC and its control by TAFI, measured in an arterial thrombolysis model in vivo using rat mesenteric arterioles. Hashimoto M, etal., Thromb Haemost 2002 Jan;87(1):110-3.
9. Characterization of rat thrombin-activatable fibrinolysis inhibitor (TAFI)--a comparative study assessing the biological equivalence of rat, murine and human TAFI. Hillmayer K, etal., J Thromb Haemost. 2006 Nov;4(11):2470-7. Epub 2006 Sep 21.
10. Insulin resistance is associated with increased circulating level of thrombin-activatable fibrinolysis inhibitor in type 2 diabetic patients. Hori Y, etal., J Clin Endocrinol Metab. 2002 Feb;87(2):660-5.
11. Plasma levels of thrombin-activatable fibrinolysis inhibitor in primary and secondary thrombocytosis. Kaftan O, etal., Clin Appl Thromb Hemost. 2005 Oct;11(4):449-54.
12. Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N. Kato T, etal., Microbiol Immunol 2000;44(8):719-28.
13. A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease. Kremer Hovinga JA, etal., J Thromb Haemost. 2004 Jan;2(1):54-7.
14. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
15. Markers of endothelial cell injury and thrombin activatable fibrinolysis inhibitor in nephrotic syndrome. Malyszko J, etal., Blood Coagul Fibrinolysis. 2002 Oct;13(7):615-21.
16. Thrombin activatable fibrinolysis inhibitor (TAFI) and markers of endothelial cell injury in dialyzed patients with diabetic nephropathy. Malyszko J, etal., Thromb Haemost. 2004 Mar;91(3):480-6.
17. Gene Data Set MGD Curation, June 12, 2002
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Association between TAFI antigen and Ala147Thr polymorphism of the TAFI gene and the angina pectoris incidence. The PRIME Study (Prospective Epidemiological Study of MI). Morange PE, etal., Thromb Haemost. 2003 Mar;89(3):554-60.
20. EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats. Muto Y, etal., Crit Care Med. 2009 May;37(5):1744-9. doi: 10.1097/CCM.0b013e31819ffc14.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture. Okumura N, etal., J Biol Chem. 2009 Jun 12;284(24):16553-61. doi: 10.1074/jbc.M109.011452. Epub 2009 Apr 22.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Tissue factor pathway inhibitor and thrombin activatable fibrinolytic inhibitor plasma levels following burn and septic injuries in rats. Ravindranath TM, etal., Clin Appl Thromb Hemost. 2004 Oct;10(4):379-85.
25. Plasma thrombin activatable fibrinolysis inhibitor and tissue factor pathway inhibitor changes following sepsis. Ravindranath TM, etal., Clin Appl Thromb Hemost. 2007 Oct;13(4):362-8.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Minocycline effects on the cerebrospinal fluid proteome of experimental autoimmune encephalomyelitis rats. Stoop MP, etal., J Proteome Res. 2012 Aug 3;11(8):4315-25. doi: 10.1021/pr300428e. Epub 2012 Jul 25.
30. Association of genotypes of thrombin-activatable fibrinolysis inhibitors with thrombotic microangiopathies--a pilot study. Sucker C, etal., Nephrol Dial Transplant. 2007 May;22(5):1347-50. Epub 2007 Feb 27.
31. Genetic variation in thrombin-activatable fibrinolysis inhibitor is associated with the risk of diabetic nephropathy. Xu CW, etal., J Endocrinol Invest. 2012 Jul;35(7):620-4.
32. Increased plasma thrombin-activatable fibrinolysis inhibitor levels in normotensive type 2 diabetic patients with microalbuminuria. Yano Y, etal., J Clin Endocrinol Metab. 2003 Feb;88(2):736-41.
33. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. Yoshida T, etal., Genomics. 2009 Mar;93(3):221-6. doi: 10.1016/j.ygeno.2008.11.001. Epub 2008 Dec 6.
Additional References at PubMed
PMID:10739389   PMID:12477932   PMID:12958609   PMID:18513211   PMID:23533145   PMID:24188431   PMID:28289017   PMID:37978153  


Genomics

Comparative Map Data
Cpb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81556,967,128 - 57,015,964 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1556,966,839 - 57,015,962 (+)EnsemblGRCr8
mRatBN7.21550,557,722 - 50,606,569 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1550,557,717 - 50,606,556 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1554,699,866 - 54,748,774 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,818,184 - 55,867,090 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,650,058 - 52,698,853 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01557,290,849 - 57,339,762 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1557,290,849 - 57,339,760 (+)Ensemblrn6Rnor6.0
Rnor_5.01561,001,889 - 61,050,732 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41556,104,920 - 56,154,321 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1550,189,675 - 50,237,544 (+)NCBICelera
RGSC_v3.11556,120,686 - 56,170,027 (+)NCBI
Cytogenetic Map15q11NCBI
CPB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381346,053,186 - 46,105,033 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1346,053,186 - 46,105,033 (-)Ensemblhg38GRCh38
GRCh371346,627,321 - 46,679,168 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361345,525,323 - 45,577,212 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341345,525,322 - 45,577,169NCBI
Celera1327,682,037 - 27,734,241 (-)NCBICelera
Cytogenetic Map13q14.13NCBI
HuRef1327,424,287 - 27,477,016 (-)NCBIHuRef
CHM1_11346,596,461 - 46,648,341 (-)NCBICHM1_1
T2T-CHM13v2.01345,274,576 - 45,326,411 (-)NCBIT2T-CHM13v2.0
Cpb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391475,479,727 - 75,520,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1475,479,727 - 75,520,995 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381475,242,287 - 75,283,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1475,242,287 - 75,283,555 (+)Ensemblmm10GRCm38
MGSCv371475,642,094 - 75,683,362 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361473,976,443 - 74,017,701 (+)NCBIMGSCv36mm8
Celera1472,744,408 - 72,785,554 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.73NCBI
Cpb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555183,740,348 - 3,803,539 (-)Ensembl
ChiLan1.0NW_0049555183,740,348 - 3,803,540 (-)NCBIChiLan1.0ChiLan1.0
CPB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21445,285,438 - 45,339,238 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11336,339,651 - 36,393,445 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01326,926,788 - 26,979,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CPB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1225,074,805 - 5,126,635 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl225,074,816 - 5,126,170 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha225,060,946 - 5,113,389 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0225,190,115 - 5,242,228 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl225,190,159 - 5,241,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1224,972,456 - 5,024,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0225,035,678 - 5,087,765 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0225,040,873 - 5,092,730 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cpb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945156,155,086 - 156,203,983 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936857577,585 - 626,267 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936857577,067 - 609,855 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,234,447 - 21,298,241 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11121,234,447 - 21,298,250 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21121,696,077 - 21,757,686 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1324,108,854 - 24,161,669 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl324,109,416 - 24,161,408 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605719,855,294 - 19,907,245 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247488,849,900 - 8,928,853 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247488,850,128 - 8,927,986 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpb2
309 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:106
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000014909
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 10 16 64 84 87 59 32 59 3 184 66 2 50 40 68 28 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000014909   ⟹   ENSRNOP00000014909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1556,966,839 - 57,015,962 (+)Ensembl
mRatBN7.2 Ensembl1550,557,717 - 50,606,556 (+)Ensembl
Rnor_6.0 Ensembl1557,290,849 - 57,339,760 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170550   ⟹   ENSRNOP00000103314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1556,967,117 - 57,015,961 (+)Ensembl
RefSeq Acc Id: NM_053617   ⟹   NP_446069
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81556,967,128 - 57,015,964 (+)NCBI
mRatBN7.21550,557,722 - 50,606,563 (+)NCBI
Rnor_6.01557,290,849 - 57,339,762 (+)NCBI
Rnor_5.01561,001,889 - 61,050,732 (+)NCBI
RGSC_v3.41556,104,920 - 56,154,321 (+)RGD
Celera1550,189,675 - 50,237,544 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092945   ⟹   XP_038948873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81556,967,238 - 57,015,964 (+)NCBI
mRatBN7.21550,557,737 - 50,606,569 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446069 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948873 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91133 (Get FASTA)   NCBI Sequence Viewer  
  AAI07448 (Get FASTA)   NCBI Sequence Viewer  
  EDM02289 (Get FASTA)   NCBI Sequence Viewer  
  EDM02290 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014909
  ENSRNOP00000014909.4
GenBank Protein Q9EQV9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446069   ⟸   NM_053617
- Peptide Label: precursor
- UniProtKB: Q3B7V3 (UniProtKB/Swiss-Prot),   Q5BKB8 (UniProtKB/Swiss-Prot),   Q9EQV9 (UniProtKB/Swiss-Prot),   A6HTS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014909   ⟸   ENSRNOT00000014909
RefSeq Acc Id: XP_038948873   ⟸   XM_039092945
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103314   ⟸   ENSRNOT00000170550
Protein Domains
Peptidase M14

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQV9-F1-model_v2 AlphaFold Q9EQV9 1-422 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699831
Promoter ID:EPDNEW_R10353
Type:initiation region
Name:Cpb2_1
Description:carboxypeptidase B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01557,290,838 - 57,290,898EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71035 AgrOrtholog
BioCyc Gene G2FUF-13131 BioCyc
Ensembl Genes ENSRNOG00000010935 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014909 ENTREZGENE
  ENSRNOT00000014909.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.340 UniProtKB/Swiss-Prot
  Zn peptidases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7323668 IMAGE-MGC_LOAD
  IMAGE:7323735 IMAGE-MGC_LOAD
InterPro CPB2 UniProtKB/Swiss-Prot
  M14A-like_propep UniProtKB/Swiss-Prot
  M14A_act_pep UniProtKB/Swiss-Prot
  Peptidase_M14 UniProtKB/Swiss-Prot
KEGG Report rno:113936 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108633 IMAGE-MGC_LOAD
  MGC:124950 IMAGE-MGC_LOAD
NCBI Gene 113936 ENTREZGENE
PANTHER CARBOXYPEPTIDASE B2 UniProtKB/Swiss-Prot
  PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B UniProtKB/Swiss-Prot
Pfam Peptidase_M14 UniProtKB/Swiss-Prot
  Propep_M14 UniProtKB/Swiss-Prot
PhenoGen Cpb2 PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/Swiss-Prot
PROSITE PEPTIDASE_M14 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010935 RatGTEx
SMART Zn_pept UniProtKB/Swiss-Prot
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot
UniProt A6HTS6 ENTREZGENE, UniProtKB/TrEMBL
  A6HTS7_RAT UniProtKB/TrEMBL
  CBPB2_RAT UniProtKB/Swiss-Prot
  Q3B7V3 ENTREZGENE
  Q5BKB8 ENTREZGENE
  Q9EQV9 ENTREZGENE
UniProt Secondary Q3B7V3 UniProtKB/Swiss-Prot
  Q5BKB8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Cpb2  carboxypeptidase B2  Cpb2  carboxypeptidase B2 (plasma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Cpb2  carboxypeptidase B2 (plasma)  LOC684726  similar to carboxypeptidase B2 (plasma)  Data merged from RGD:1586767 737654 PROVISIONAL
2006-11-19 LOC684726  similar to carboxypeptidase B2 (plasma)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Cpb2  carboxypeptidase B2 (plasma)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference