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Gene: Htr7 (5-hydroxytryptamine receptor 7) Rattus norvegicus
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Symbol: Htr7
Name: 5-hydroxytryptamine receptor 7
RGD ID: 71034
Description: Exhibits G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; generation of neurons; and modulation of chemical synaptic transmission. Localizes to several cellular components, including integral component of presynaptic membrane; rough endoplasmic reticulum; and synaptic vesicle. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-HT-7; 5-HT-X; 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5Ht7; GPRFO; high affinity serotonin receptor (5HT7); high affinity serotonin receptor (5HT7) gene; serotonin receptor 7
Orthologs:
Homo sapiens (human) : HTR7 (5-hydroxytryptamine receptor 7)  HGNC  Alliance
Mus musculus (house mouse) : Htr7 (5-hydroxytryptamine (serotonin) receptor 7)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr7 (5-hydroxytryptamine receptor 7)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR7 (5-hydroxytryptamine receptor 7)
Canis lupus familiaris (dog) : HTR7 (5-hydroxytryptamine receptor 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr7 (5-hydroxytryptamine receptor 7)
Sus scrofa (pig) : HTR7 (5-hydroxytryptamine receptor 7)
Chlorocebus sabaeus (African green monkey) : HTR7 (5-hydroxytryptamine receptor 7)
Heterocephalus glaber (naked mole-rat) : Htr7 (5-hydroxytryptamine receptor 7)
more info ...
Allele / Splice: Htr7em1Geh   Htr7em1Msu  
Genetic Models: SD-Htr7em1Msu WI-Htr7em1Geh
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01254,547,964 - 254,671,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,547,620 - 254,671,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01261,759,122 - 261,879,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,136,279 - 240,260,620 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11240,308,574 - 240,434,503 (-)NCBI
Celera1230,737,463 - 230,859,847 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Htr7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 71034
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.