Htr7 (5-hydroxytryptamine receptor 7) - Rat Genome Database

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Gene: Htr7 (5-hydroxytryptamine receptor 7) Rattus norvegicus
Symbol: Htr7
Name: 5-hydroxytryptamine receptor 7
RGD ID: 71034
Description: Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including axon terminus; neuronal cell body; and synaptic vesicle. Is active in postsynaptic membrane and presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
Previously known as: 5-HT-7; 5-HT-X; 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5Ht7; GPRFO; high affinity serotonin receptor (5HT7); high affinity serotonin receptor (5HT7) gene; LOC103694905; serotonin receptor 7
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Htr7em1Geh   Htr7em1Msu  
Genetic Models: SD-Htr7em1Msu WI-Htr7em1Geh
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81243,049,064 - 243,173,636 (-)NCBIGRCr8
mRatBN7.21233,636,442 - 233,761,063 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,636,452 - 233,760,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,035,877 - 242,157,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,959,213 - 249,074,281 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,797,382 - 241,912,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01254,547,964 - 254,671,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,547,620 - 254,671,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01261,759,122 - 261,879,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,136,279 - 240,260,620 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11240,308,574 - 240,434,503 (-)NCBI
Celera1230,737,463 - 230,859,847 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-carboxamidotryptamine  (ISO)
5-fluorouracil  (ISO)
5-methoxytryptamine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromocriptine  (ISO)
buta-1,3-diene  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clozapine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyproheptadine  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dioxygen  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
glycidol  (EXP)
ketanserin  (ISO)
L-methionine  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lisuride  (ISO)
lurasidone hydrochloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesulergine  (ISO)
metergoline  (ISO)
methiothepin  (ISO)
mianserin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
paliperidone palmitate  (ISO)
PD 0325901  (ISO)
risperidone  (ISO)
ritanserin  (ISO)
rotenone  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
spiperone  (ISO)
tamoxifen  (ISO)
testosterone undecanoate  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
vortioxetine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. null null
2. Blockade of 5-HT7 receptors reduces tactile allodynia in the rat. Amaya-Castellanos E, etal., Pharmacol Biochem Behav. 2011 Oct;99(4):591-7. Epub 2011 Jun 15.
3. Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions. Brenchat A, etal., Eur J Pain. 2012 Jan;16(1):72-81. doi: 10.1016/j.ejpain.2011.07.004.
4. Creation of the 5-hydroxytryptamine receptor 7 knockout rat as a tool for cardiovascular research. Demireva EY, etal., Physiol Genomics. 2019 Jul 1;51(7):290-301. doi: 10.1152/physiolgenomics.00030.2019. Epub 2019 May 24.
5. Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal spinal cord: immunocytochemical evidence. Doly S, etal., J Comp Neurol. 2005 Sep 26;490(3):256-69.
6. Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity. Galici R, etal., Behav Pharmacol. 2008 Mar;19(2):153-9.
7. Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat. Gasbarri A, etal., Behav Brain Res. 2008 Dec 16;195(1):164-70. Epub 2008 Jan 9.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum. Geurts FJ, etal., J Chem Neuroanat 2002 Jun;24(1):65-74.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy. Graf M, etal., Neurosci Lett. 2004 Apr 8;359(1-2):45-8.
12. A 5-HT7 heteroreceptor-mediated inhibition of serotonin release in raphe nuclei slices of the rat: evidence for a serotonergic-glutamatergic interaction. Harsing LG Jr, etal., Neurochem Res. 2004 Aug;29(8):1487-97.
13. The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder. Hedlund PB and Sutcliffe JG, Neurosci Lett. 2007 Mar 13;414(3):247-51. Epub 2007 Jan 11.
14. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. Heidmann DE, etal., J Neurochem 1997 Apr;68(4):1372-81.
15. The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. Horiguchi M, etal., J Pharmacol Exp Ther. 2011 Aug;338(2):605-14. Epub 2011 May 10.
16. Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. Lenglet S, etal., Endocrinology 2002 May;143(5):1748-60.
17. Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology. Leo D, etal., Genes Brain Behav. 2009 Apr;8(3):356-68. Epub 2009 Feb 19.
18. Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model. Liy-Salmeron G and Meneses A, Hippocampus. 2008;18(9):965-74.
19. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Lovenberg TW, etal., Neuron 1993 Sep;11(3):449-58.
20. Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties. Matott MP and Kline DD, Brain Res. 2016 Mar 15;1635:12-26. doi: 10.1016/j.brainres.2016.01.017. Epub 2016 Jan 15.
21. Gene Data Set MGD Curation, June 12, 2002
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Monti JM, etal., Behav Brain Res. 2008 Aug 22;191(2):184-9. Epub 2008 Mar 25.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors. Parga J, etal., Dev Neurobiol. 2007 Jan;67(1):10-22.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. Effects of repetitive administration of tianeptine, zinc hydroaspartate and electroconvulsive shock on the reactivity of 5-HT(7) receptors in rat hippocampus. Pitra P, etal., Pharmacol Rep. 2007 Nov-Dec;59(6):627-35.
29. Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats. Read KE, etal., Br J Pharmacol. 2003 Sep;140(1):53-60. Epub 2003 Jul 29.
30. 5-Hydroxytryptamine potentiates neurogenic contractions of rat isolated urinary bladder through both 5-HT(7) and 5-HT(2C) receptors. Rekik M, etal., Eur J Pharmacol. 2011 Jan 10;650(1):403-10. Epub 2010 Oct 20.
31. GOA pipeline RGD automated data pipeline
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test. Rocha-Gonzalez HI, etal., Pain. 2005 Sep;117(1-2):182-92.
34. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Ruat M, etal., Proc Natl Acad Sci U S A 1993 Sep 15;90(18):8547-51.
35. 5-HT does not lower blood pressure in the 5-HT7 knockout rat. Seitz BM, etal., Physiol Genomics. 2019 Jul 1;51(7):302-310. doi: 10.1152/physiolgenomics.00031.2019. Epub 2019 May 24.
36. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. Shen Y, etal., J Biol Chem 1993 Aug 25;268(24):18200-4.
37. Imipramine counteracts corticosterone-induced alterations in the effects of the activation of 5-HT(7) receptors in rat hippocampus. Tokarski K, etal., J Physiol Pharmacol. 2009 Jun;60(2):83-8.
38. The 5-HT(7) receptor antagonist SB 269970 counteracts restraint stress-induced attenuation of long-term potentiation in rat frontal cortex. Tokarski K, etal., J Physiol Pharmacol. 2011 Dec;62(6):663-7.
39. Selective inhibition of 5-HT7 receptor reduces CGRP release in an experimental model for migraine. Wang X, etal., Headache. 2010 Apr;50(4):579-87. Epub 2010 Mar 5.
40. Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression. Wesolowska A, etal., Neuropharmacology. 2006 Sep;51(3):578-86. Epub 2006 Jul 7.
41. Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. Witkin JM, etal., Epilepsy Res. 2007 Jun;75(1):39-45. Epub 2007 May 7.
42. Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury. Yelleswarapu NK, etal., Neurosci Lett. 2012 Mar 21.
43. Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. Zlojutro M, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):44-58. doi: 10.1002/ajmg.b.31136. Epub 2010 Nov 2.
44. Expression and role of 5-HT7 receptor in brain and intestine in rats with irritable bowel syndrome. Zou BC, etal., Chin Med J (Engl). 2007 Dec 5;120(23):2069-74.
Additional References at PubMed
PMID:8517926   PMID:15707674   PMID:16759802   PMID:16901936   PMID:17543469   PMID:17853773   PMID:18996171   PMID:19302555   PMID:19447286   PMID:19629447   PMID:19805745   PMID:20071609  
PMID:21248402   PMID:21403818   PMID:21538661   PMID:22543085   PMID:22922122   PMID:23164613   PMID:23542440   PMID:23603557   PMID:23672716   PMID:23694713   PMID:23742863   PMID:24129596  
PMID:24162801   PMID:24603678   PMID:24709857   PMID:26470809   PMID:26773257   PMID:26979176   PMID:27178363   PMID:27393215   PMID:28987281   PMID:29384698   PMID:29730242   PMID:31846086  
PMID:32329363   PMID:34199392   PMID:36344870  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81243,049,064 - 243,173,636 (-)NCBIGRCr8
mRatBN7.21233,636,442 - 233,761,063 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,636,452 - 233,760,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,035,877 - 242,157,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,959,213 - 249,074,281 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,797,382 - 241,912,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01254,547,964 - 254,671,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,547,620 - 254,671,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01261,759,122 - 261,879,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,136,279 - 240,260,620 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11240,308,574 - 240,434,503 (-)NCBI
Celera1230,737,463 - 230,859,847 (-)NCBICelera
Cytogenetic Map1q53NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381090,740,823 - 90,858,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1090,740,823 - 90,858,039 (-)EnsemblGRCh38hg38GRCh38
GRCh371092,500,580 - 92,617,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361092,490,555 - 92,607,651 (-)NCBINCBI36Build 36hg18NCBI36
Build 341092,490,557 - 92,607,651NCBI
Celera1086,247,007 - 86,364,124 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1086,129,586 - 86,246,677 (-)NCBIHuRef
CHM1_11092,778,457 - 92,895,518 (-)NCBICHM1_1
T2T-CHM13v2.01091,624,488 - 91,741,713 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391935,935,815 - 36,035,533 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1935,936,134 - 36,034,907 (-)EnsemblGRCm39 Ensembl
GRCm381935,958,415 - 36,058,133 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1935,958,734 - 36,057,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv371936,033,217 - 36,131,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361936,025,416 - 36,122,486 (-)NCBIMGSCv36mm8
Celera1936,736,456 - 36,835,310 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1930.3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554252,321,420 - 2,420,530 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554252,321,420 - 2,420,420 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v28102,745,099 - 102,888,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110102,751,872 - 102,893,463 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01087,480,970 - 87,598,212 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11091,008,278 - 91,125,416 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1091,009,941 - 91,125,158 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1285,438,872 - 5,524,385 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl285,440,388 - 5,524,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha285,605,815 - 5,691,701 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,658,606 - 5,744,502 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,660,149 - 5,744,487 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1285,415,879 - 5,501,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0285,454,660 - 5,540,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0285,588,358 - 5,595,285 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721341,937,016 - 42,106,548 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366013,569,544 - 3,626,797 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366013,569,626 - 3,626,782 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl14102,444,588 - 102,548,907 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114102,443,312 - 102,548,894 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214111,526,055 - 111,660,097 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1984,081,713 - 84,191,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl984,083,396 - 84,190,876 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604844,783,137 - 44,901,015 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247371,960,057 - 2,067,038 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247371,960,985 - 2,067,086 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Htr7
1056 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:193
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000025450, ENSRNOT00000025493
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,689,317 - 233,689,502 (+)MAPPERmRatBN7.2
Rnor_6.01254,600,468 - 254,600,652NCBIRnor6.0
Rnor_5.01261,812,236 - 261,812,420UniSTSRnor5.0
RGSC_v3.41240,187,535 - 240,187,719UniSTSRGSC3.4
Celera1230,788,543 - 230,788,727UniSTS
Cytogenetic Map1q53UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,647,144 - 233,647,284 (+)MAPPERmRatBN7.2
Rnor_6.01254,558,311 - 254,558,450NCBIRnor6.0
Rnor_5.01261,769,469 - 261,769,608UniSTSRnor5.0
RGSC_v3.41240,145,378 - 240,145,517UniSTSRGSC3.4
Celera1230,746,558 - 230,746,697UniSTS
Cytogenetic Map1q53UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,759,790 - 233,760,331 (+)MAPPERmRatBN7.2
Rnor_6.01254,670,943 - 254,671,483NCBIRnor6.0
Rnor_5.01261,879,084 - 261,879,624UniSTSRnor5.0
RGSC_v3.41240,259,967 - 240,260,507UniSTSRGSC3.4
Celera1230,859,194 - 230,859,734UniSTS
Cytogenetic Map1q53UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,636,861 - 233,636,980 (+)MAPPERmRatBN7.2
Rnor_6.01254,548,030 - 254,548,148NCBIRnor6.0
Rnor_5.01261,759,188 - 261,759,306UniSTSRnor5.0
RGSC_v3.41240,135,095 - 240,135,213UniSTSRGSC3.4
Celera1230,736,279 - 230,736,397UniSTS
RH 3.4 Map11585.11UniSTS
Cytogenetic Map1q53UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,759,890 - 233,759,981 (+)MAPPERmRatBN7.2
Rnor_6.01254,671,043 - 254,671,133NCBIRnor6.0
Rnor_5.01261,879,184 - 261,879,274UniSTSRnor5.0
RGSC_v3.41240,260,067 - 240,260,157UniSTSRGSC3.4
Celera1230,859,294 - 230,859,384UniSTS
Cytogenetic Map1q53UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,638,000 - 233,638,107 (+)MAPPERmRatBN7.2
Rnor_6.01254,549,169 - 254,549,275NCBIRnor6.0
Rnor_5.01261,760,327 - 261,760,433UniSTSRnor5.0
RGSC_v3.41240,136,234 - 240,136,340UniSTSRGSC3.4
Celera1230,737,418 - 230,737,524UniSTS
Cytogenetic Map1q53UniSTS

Genetic Models
This gene Htr7 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 5
Low 8 2 2 2 53 24 19
Below cutoff 20 35 28 19 28 1 1 27 7 14 1 1


RefSeq Acc Id: ENSRNOT00000025450   ⟹   ENSRNOP00000025450
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,636,459 - 233,760,444 (-)Ensembl
Rnor_6.0 Ensembl1254,547,627 - 254,671,596 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000025493   ⟹   ENSRNOP00000025493
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,636,452 - 233,760,436 (-)Ensembl
Rnor_6.0 Ensembl1254,547,937 - 254,671,778 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078150   ⟹   ENSRNOP00000071410
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,646,241 - 233,760,626 (-)Ensembl
Rnor_6.0 Ensembl1254,547,620 - 254,671,588 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082732   ⟹   ENSRNOP00000074238
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,646,062 - 233,760,626 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089855   ⟹   ENSRNOP00000073500
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,638,103 - 233,760,626 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111885   ⟹   ENSRNOP00000082600
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,636,769 - 233,760,626 (-)Ensembl
RefSeq Acc Id: NM_022938   ⟹   NP_075227
Rat AssemblyChrPosition (strand)Source
GRCr81243,050,668 - 243,173,048 (-)NCBI
mRatBN7.21233,638,046 - 233,760,444 (-)NCBI
Rnor_6.01254,549,214 - 254,671,596 (-)NCBI
Rnor_5.01261,759,122 - 261,879,914 (-)NCBI
RGSC_v3.41240,136,279 - 240,260,620 (-)RGD
Celera1230,737,463 - 230,859,847 (-)RGD
RefSeq Acc Id: XM_006231307   ⟹   XP_006231369
Rat AssemblyChrPosition (strand)Source
GRCr81243,049,064 - 243,173,629 (-)NCBI
mRatBN7.21233,636,442 - 233,761,056 (-)NCBI
Rnor_6.01254,547,964 - 254,671,811 (-)NCBI
Rnor_5.01261,759,122 - 261,879,914 (-)NCBI
RefSeq Acc Id: XM_039089833   ⟹   XP_038945761
Rat AssemblyChrPosition (strand)Source
GRCr81243,049,064 - 243,090,072 (-)NCBI
mRatBN7.21233,636,442 - 233,680,229 (-)NCBI
RefSeq Acc Id: XM_039089840   ⟹   XP_038945768
Rat AssemblyChrPosition (strand)Source
GRCr81243,050,757 - 243,173,636 (-)NCBI
mRatBN7.21233,639,589 - 233,761,063 (-)NCBI
RefSeq Acc Id: NP_075227   ⟸   NM_022938
- UniProtKB: A6I144 (UniProtKB/TrEMBL),   A0A0G2K0E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231369   ⟸   XM_006231307
- Peptide Label: isoform X1
- UniProtKB: P97936 (UniProtKB/Swiss-Prot),   P32305 (UniProtKB/Swiss-Prot),   A0A8L2R8K1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071410   ⟸   ENSRNOT00000078150
RefSeq Acc Id: ENSRNOP00000025493   ⟸   ENSRNOT00000025493
RefSeq Acc Id: ENSRNOP00000025450   ⟸   ENSRNOT00000025450
RefSeq Acc Id: XP_038945761   ⟸   XM_039089833
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038945768   ⟸   XM_039089840
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K5P0 (UniProtKB/TrEMBL),   P97842 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082600   ⟸   ENSRNOT00000111885
RefSeq Acc Id: ENSRNOP00000073500   ⟸   ENSRNOT00000089855
RefSeq Acc Id: ENSRNOP00000074238   ⟸   ENSRNOT00000082732
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32305-F1-model_v2 AlphaFold P32305 1-448 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71034 AgrOrtholog
BioCyc Gene G2FUF-55834 BioCyc
Ensembl Genes ENSRNOG00000018827 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030434 UniProtKB/Swiss-Prot
  ENSRNOG00060030044 UniProtKB/Swiss-Prot
  ENSRNOG00065030344 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025450.8 UniProtKB/Swiss-Prot
  ENSRNOT00000025493.8 UniProtKB/TrEMBL
  ENSRNOT00000078150.3 UniProtKB/TrEMBL
  ENSRNOT00000082732.2 UniProtKB/TrEMBL
  ENSRNOT00000089855.2 UniProtKB/TrEMBL
  ENSRNOT00000111885.1 UniProtKB/Swiss-Prot
  ENSRNOT00055052855 UniProtKB/Swiss-Prot
  ENSRNOT00060052273 UniProtKB/Swiss-Prot
  ENSRNOT00065052373 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5HT_7_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65032 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Htr7 PhenoGen
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018827 RatGTEx
  ENSRNOG00055030434 RatGTEx
  ENSRNOG00060030044 RatGTEx
  ENSRNOG00065030344 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT7R_RAT UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2K5P0 UniProtKB/TrEMBL
  P97936 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Htr7  5-hydroxytryptamine receptor 7  LOC103694905  5-hydroxytryptamine receptor 7  Data merged from RGD:9265298 737654 PROVISIONAL
2016-02-11 Htr7  5-hydroxytryptamine receptor 7  Htr7  5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694905  5-hydroxytryptamine receptor 7      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-06 Htr7  5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled  Htr7  5-hydroxytryptamine (serotonin) receptor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Htr7  5-hydroxytryptamine (serotonin) receptor 7      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in Purkinje cells 727384
gene_process activation results in aldosterone secretion via the adenylyl cyclase/PKA pathway and the calcium influx 729310