Folr1 (folate receptor alpha) - Rat Genome Database

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Gene: Folr1 (folate receptor alpha) Rattus norvegicus
Analyze
Symbol: Folr1
Name: folate receptor alpha
RGD ID: 71032
Description: Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Predicted to be involved in several processes, including circulatory system development; nervous system development; and regulation of signal transduction. Predicted to act upstream of or within folic acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fbp1; folate binding protein 1; folate receptor 1; folate receptor 1 (adult)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,631,462 - 165,650,430 (-)NCBIGRCr8
mRatBN7.21156,219,460 - 156,238,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,219,460 - 156,230,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,209,769 - 164,220,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,389,863 - 171,401,069 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,267,520 - 164,278,567 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,934,457 - 166,945,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,934,460 - 166,943,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,124,242 - 173,135,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,315,191 - 159,324,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,394,208 - 159,403,158 (-)NCBI
Celera1154,298,870 - 154,310,077 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
diallyl trisulfide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diiodine  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
gallic acid  (ISO)
genistein  (ISO)
glucose  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
ICI D1694  (ISO)
lead diacetate  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule. Birn H, etal., Am J Physiol. 1993 Feb;264(2 Pt 1):C302-10.
2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3. Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules. da Costa M, etal., Am J Physiol Cell Physiol 2000 Apr;278(4):C812-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Coding sequence, genomic organization and expression of a folate binding protein gene in the rat. Sadasivan E, etal., Gene 2000 Aug 22;254(1-2):219-28.
13. Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos. Spiegelstein O, etal., Neurochem Res 2004 Jun;29(6):1105-12.
14. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
Additional References at PubMed
PMID:2527252   PMID:8033114   PMID:10787414   PMID:12477932   PMID:12854656   PMID:14722620   PMID:17286298   PMID:19116913   PMID:19199708   PMID:19581412   PMID:20424322   PMID:21649587  
PMID:23243496   PMID:23376485   PMID:23533145   PMID:23851396   PMID:26667416   PMID:27011008   PMID:30113208   PMID:36675153  


Genomics

Comparative Map Data
Folr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,631,462 - 165,650,430 (-)NCBIGRCr8
mRatBN7.21156,219,460 - 156,238,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,219,460 - 156,230,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,209,769 - 164,220,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,389,863 - 171,401,069 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,267,520 - 164,278,567 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,934,457 - 166,945,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,934,460 - 166,943,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,124,242 - 173,135,651 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,315,191 - 159,324,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,394,208 - 159,403,158 (-)NCBI
Celera1154,298,870 - 154,310,077 (-)NCBICelera
Cytogenetic Map1q32NCBI
FOLR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,189,709 - 72,196,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,189,558 - 72,196,323 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,900,753 - 71,907,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,578,250 - 71,585,014 (+)NCBINCBI36Build 36hg18NCBI36
Build 341171,580,855 - 71,585,014NCBI
Celera1169,202,176 - 69,208,941 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,193,609 - 68,200,378 (+)NCBIHuRef
CHM1_11171,784,063 - 71,790,828 (+)NCBICHM1_1
T2T-CHM13v2.01172,116,250 - 72,122,864 (+)NCBIT2T-CHM13v2.0
Folr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,507,551 - 101,519,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,507,538 - 101,519,995 (-)EnsemblGRCm39 Ensembl
GRCm387101,858,331 - 101,870,788 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,858,331 - 101,870,788 (-)EnsemblGRCm38mm10GRCm38
MGSCv377109,006,845 - 109,019,197 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,732,152 - 101,744,504 (-)NCBIMGSCv36mm8
Celera7102,230,147 - 102,242,481 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.67NCBI
Folr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,187,388 - 19,197,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,188,830 - 19,197,728 (-)NCBIChiLan1.0ChiLan1.0
LOC100994139
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2973,138,207 - 73,144,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,180,529 - 74,188,172 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,268,721 - 67,275,498 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11170,492,039 - 70,498,665 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,492,039 - 70,498,665 (+)Ensemblpanpan1.1panPan2
LOC609612
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,944,350 - 25,951,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,714,017 - 25,720,656 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,153,187 - 26,159,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,153,297 - 26,159,800 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12125,944,449 - 25,951,109 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,160,593 - 26,167,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,062,191 - 26,068,851 (-)NCBIUU_Cfam_GSD_1.0
Folr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,892,012 - 59,897,666 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,491,547 - 1,497,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,489,916 - 1,497,200 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOLR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,757,040 - 6,760,402 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,753,513 - 6,760,433 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,515,002 - 7,521,923 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOLR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,405,513 - 63,413,372 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,406,597 - 63,413,352 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604362,470,494 - 62,476,997 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Folr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,820,163 - 4,851,339 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248174,830,164 - 4,850,565 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Folr1
94 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:83
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000026962
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat

Markers in Region
D1Bda29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,220,011 - 156,220,359 (+)MAPPERmRatBN7.2
Rnor_6.01166,935,009 - 166,935,356NCBIRnor6.0
Rnor_5.01173,124,794 - 173,125,141UniSTSRnor5.0
RGSC_v3.41159,315,739 - 159,316,086UniSTSRGSC3.4
Celera1154,299,422 - 154,299,769UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17 14 14 23 35 32
Low 3 14 23 10 19 10 8 11 47 9 11 8
Below cutoff 25 12 12 12 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF219904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF219905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF219906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC157811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM060472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU095827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000026962   ⟹   ENSRNOP00000026962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,219,460 - 156,230,667 (-)Ensembl
Rnor_6.0 Ensembl1166,934,462 - 166,943,592 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079675   ⟹   ENSRNOP00000071311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1166,934,460 - 166,939,541 (-)Ensembl
RefSeq Acc Id: NM_133527   ⟹   NP_598211
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,462 - 165,642,669 (-)NCBI
mRatBN7.21156,219,460 - 156,230,667 (-)NCBI
Rnor_6.01166,934,457 - 166,945,845 (-)NCBI
Rnor_5.01173,124,242 - 173,135,651 (-)NCBI
RGSC_v3.41159,315,191 - 159,324,141 (-)RGD
Celera1154,298,870 - 154,310,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229842   ⟹   XP_006229904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,639,634 (-)NCBI
mRatBN7.21156,219,574 - 156,227,508 (-)NCBI
Rnor_6.01166,934,457 - 166,942,684 (-)NCBI
Rnor_5.01173,124,242 - 173,135,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588710   ⟹   XP_017444199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,641,291 (-)NCBI
mRatBN7.21156,219,464 - 156,229,294 (-)NCBI
Rnor_6.01166,934,457 - 166,944,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588711   ⟹   XP_017444200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,641,288 (-)NCBI
mRatBN7.21156,219,464 - 156,229,293 (-)NCBI
Rnor_6.01166,934,457 - 166,945,864 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085665   ⟹   XP_038941593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,430 (-)NCBI
mRatBN7.21156,219,460 - 156,238,435 (-)NCBI
RefSeq Acc Id: XM_039085707   ⟹   XP_038941635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,430 (-)NCBI
mRatBN7.21156,219,574 - 156,238,436 (-)NCBI
RefSeq Acc Id: XM_039085757   ⟹   XP_038941685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,428 (-)NCBI
mRatBN7.21156,219,464 - 156,238,434 (-)NCBI
RefSeq Acc Id: XM_063273293   ⟹   XP_063129363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,639,566 (-)NCBI
RefSeq Acc Id: XM_063273361   ⟹   XP_063129431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,428 (-)NCBI
RefSeq Acc Id: XM_063273405   ⟹   XP_063129475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,642,650 (-)NCBI
RefSeq Acc Id: NP_598211   ⟸   NM_133527
- Peptide Label: precursor
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229904   ⟸   XM_006229842
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444200   ⟸   XM_017588711
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444199   ⟸   XM_017588710
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071311   ⟸   ENSRNOT00000079675
RefSeq Acc Id: ENSRNOP00000026962   ⟸   ENSRNOT00000026962
RefSeq Acc Id: XP_038941593   ⟸   XM_039085665
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941685   ⟸   XM_039085757
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941635   ⟸   XM_039085707
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129431   ⟸   XM_063273361
- Peptide Label: isoform X1
- UniProtKB: Q9JL02 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   G3V8M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129475   ⟸   XM_063273405
- Peptide Label: isoform X1
- UniProtKB: Q9JL02 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   G3V8M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129363   ⟸   XM_063273293
- Peptide Label: isoform X2
- UniProtKB: Q9JL02 (UniProtKB/TrEMBL)
Protein Domains
Folate receptor-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8M6-F1-model_v2 AlphaFold G3V8M6 1-255 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690263
Promoter ID:EPDNEW_R786
Type:multiple initiation site
Name:Folr1_1
Description:folate receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01166,943,650 - 166,943,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71032 AgrOrtholog
BioCyc Gene G2FUF-58272 BioCyc
Ensembl Genes ENSRNOG00000019902 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026962 ENTREZGENE
  ENSRNOT00000026962.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9088301 IMAGE-MGC_LOAD
InterPro Folate_rcpt UniProtKB/TrEMBL
  Folate_rcpt-like UniProtKB/TrEMBL
KEGG Report rno:171049 UniProtKB/TrEMBL
MGC_CLONE MGC:187337 IMAGE-MGC_LOAD
NCBI Gene 171049 ENTREZGENE
PANTHER Folt_rcpt UniProtKB/TrEMBL
  PTHR10517:SF15 UniProtKB/TrEMBL
Pfam Folate_rec UniProtKB/TrEMBL
PhenoGen Folr1 PhenoGen
RatGTEx ENSRNOG00000019902 RatGTEx
UniProt A6I6X2 ENTREZGENE, UniProtKB/TrEMBL
  A6I6X6_RAT UniProtKB/TrEMBL
  A9UMV5_RAT UniProtKB/TrEMBL
  G3V8M6 ENTREZGENE, UniProtKB/TrEMBL
  Q9JL02 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-23 Folr1  folate receptor alpha  Folr1  folate receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-29 Folr1  folate receptor 1  Folr1  folate receptor 1 (adult)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Folr1  folate receptor 1 (adult)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein found on the brush borders of kidney tubules 1358236
gene_function reabsorbs folate from the renal tubular fluid 1358236
gene_homology 72-92% homology with Folr1 cDNAs from mouse, human and pig; high amino acid sequence homology among known members of the folate receptor family 70742
gene_regulation the shorter of the two mRNA species in the kidney may be transcribed from a second promoter immediately upstream of exon 3, possibly located within the second intron 70742
gene_regulation protein levels increase in tissue culture cells under conditions of low folate concentration 1358236
gene_regulation in vivo under conditions of low folate concentration, levels of Folr1 protein but not mRNA are decreased in kidney, apparently due to the proteolysis of unsaturated receptor resulting from decreased levels of folate in the glomerular filtrate; levels of protein in liver and brain are essentially unaffected under the same conditions 1358236
gene_transcript approximately 10 kb in size and has 7 exons and 6 introns 70742
gene_transcript kidney expresses two transcripts which differ in the length of their 5' untranslated regions by 311 nucleotides; the mRNA expressed in brain is intermediate in length between the two kidney transcripts 70742