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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Gmpr | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GMPR mRNA | CTD | PMID:22079256 | Gmpr | Rat | 1,1-dichloroethene | decreases expression | ISO | Gmpr (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of GMPR mRNA | CTD | PMID:26682919 | Gmpr | Rat | 1-chloro-2,4-dinitrobenzene | increases methylation | ISO | Gmpr (Mus musculus) | 6480464 | Dinitrochlorobenzene results in increased methylation of GMPR gene | CTD | PMID:26732893 | Gmpr | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Gmpr (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of GMPR mRNA | CTD | PMID:17942748 | Gmpr | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Gmpr (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GMPR mRNA | CTD | PMID:17942748 | Gmpr | Rat | 17beta-estradiol | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of GMPR mRNA | CTD | PMID:30165855 | Gmpr | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Gmpr (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GMPR mRNA | CTD | PMID:17942748 | Gmpr | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GMPR mRNA | CTD | PMID:34747641 | Gmpr | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GMPR mRNA | CTD | PMID:32109520 and PMID:33387578 | Gmpr | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Gmpr (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of GMPR mRNA | CTD | PMID:21570461 | Gmpr | Rat | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 | Gmpr | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Gmpr (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of GMPR mRNA | CTD | PMID:25172293 | Gmpr | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Gmpr (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of GMPR mRNA | CTD | PMID:20188158 | Gmpr | Rat | 3H-1,2-dithiole-3-thione | increases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in increased expression of GMPR mRNA | CTD | PMID:19162173 | Gmpr | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Gmpr (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of GMPR exon | CTD | PMID:33297965 | Gmpr | Rat | aconitine | decreases expression | EXP | | 6480464 | Aconitine results in decreased expression of GMPR protein | CTD | PMID:33236894 | Gmpr | Rat | aflatoxin B1 | increases methylation | ISO | GMPR (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of GMPR intron | CTD | PMID:30157460 | Gmpr | Rat | all-trans-retinoic acid | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | Tretinoin results in increased expression of GMPR mRNA | CTD | PMID:33167477 | Gmpr | Rat | alpha-Zearalanol | decreases expression | EXP | | 6480464 | Zeranol results in decreased expression of GMPR mRNA | CTD | PMID:35163327 | Gmpr | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of GMPR mRNA | CTD | PMID:35163327 | Gmpr | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GMPR mRNA | CTD | PMID:16483693 | Gmpr | Rat | arsane | affects methylation | ISO | GMPR (Homo sapiens) | 6480464 | Arsenic affects the methylation of GMPR gene | CTD | PMID:25304211 | Gmpr | Rat | arsenic atom | affects methylation | ISO | GMPR (Homo sapiens) | 6480464 | Arsenic affects the methylation of GMPR gene | CTD | PMID:25304211 | Gmpr | Rat | benzo[a]pyrene | decreases methylation | ISO | GMPR (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of GMPR promoter | CTD | PMID:27901495 | Gmpr | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GMPR mRNA | CTD | PMID:25181051 | Gmpr | Rat | bisphenol A | increases expression | ISO | Gmpr (Mus musculus) | 6480464 | bisphenol A results in increased expression of GMPR mRNA | CTD | PMID:32156529 | Gmpr | Rat | bisphenol A | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of GMPR mRNA | CTD | PMID:33670352 | Gmpr | Rat | bisphenol A | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | bisphenol A results in increased expression of GMPR mRNA | CTD | PMID:29275510 | Gmpr | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GMPR mRNA | CTD | PMID:30816183 | Gmpr | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of GMPR gene | CTD | PMID:28505145 | Gmpr | Rat | butanal | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of GMPR mRNA | CTD | PMID:26079696 | Gmpr | Rat | cadmium atom | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GMPR mRNA | CTD | PMID:35301059 | Gmpr | Rat | cadmium dichloride | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of GMPR mRNA | CTD | PMID:21457566 | Gmpr | Rat | cadmium dichloride | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GMPR mRNA | CTD | PMID:35301059 | Gmpr | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of GMPR mRNA | CTD | PMID:33453195 | Gmpr | Rat | chromium(6+) | affects expression | ISO | GMPR (Homo sapiens) | 6480464 | chromium hexavalent ion affects the expression of GMPR mRNA | CTD | PMID:30690063 | Gmpr | Rat | copper(II) chloride | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | cupric chloride results in decreased expression of GMPR mRNA | CTD | PMID:38568856 | Gmpr | Rat | cyclosporin A | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of GMPR mRNA | CTD | PMID:20106945 | Gmpr | Rat | dexamethasone | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [Dexamethasone co-treated with Genistein] results in increased expression of GMPR mRNA | CTD | PMID:25136773 | Gmpr | Rat | dexamethasone | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | Dexamethasone results in increased expression of GMPR mRNA | CTD | PMID:25136773 | Gmpr | Rat | dextran sulfate | increases expression | ISO | Gmpr (Mus musculus) | 6480464 | Dextran Sulfate results in increased expression of GMPR protein | CTD | PMID:35362542 | Gmpr | Rat | dextran sulfate | multiple interactions | ISO | Gmpr (Mus musculus) | 6480464 | evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GMPR protein] | CTD | PMID:35362542 | Gmpr | Rat | dibutyl phthalate | decreases expression | ISO | Gmpr (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of GMPR mRNA | CTD | PMID:21266533 | Gmpr | Rat | entinostat | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | entinostat results in increased expression of GMPR mRNA | CTD | PMID:27188386 | Gmpr | Rat | erlotinib hydrochloride | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | Erlotinib Hydrochloride results in decreased expression of GMPR mRNA | CTD | PMID:27720938 | Gmpr | Rat | ethanol | increases expression | ISO | Gmpr (Mus musculus) | 6480464 | Ethanol results in increased expression of GMPR mRNA | CTD | PMID:30319688 | Gmpr | Rat | Evodiamine | multiple interactions | ISO | Gmpr (Mus musculus) | 6480464 | evodiamine inhibits the reaction [Dextran Sulfate results in increased expression of GMPR protein] | CTD | PMID:35362542 | Gmpr | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of GMPR mRNA | CTD | PMID:27387713 | Gmpr | Rat | genistein | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | Genistein results in increased expression of GMPR mRNA | CTD | PMID:25136773 | Gmpr | Rat | genistein | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [Dexamethasone co-treated with Genistein] results in increased expression of GMPR mRNA | CTD | PMID:25136773 | Gmpr | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of GMPR mRNA | CTD | PMID:33387578 | Gmpr | Rat | hydroquinone | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | hydroquinone results in decreased expression of GMPR mRNA | CTD | PMID:31256213 | Gmpr | Rat | hydroquinone O-beta-D-glucopyranoside | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | Arbutin results in decreased expression of GMPR mRNA | CTD | PMID:17103032 | Gmpr | Rat | kojic acid | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | kojic acid results in decreased expression of GMPR mRNA | CTD | PMID:16595896 | Gmpr | Rat | lipopolysaccharide | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of GMPR mRNA | CTD | PMID:35811015 | Gmpr | Rat | Mesaconitine | increases expression | EXP | | 6480464 | mesaconitine results in increased expression of GMPR protein | CTD | PMID:37182599 | Gmpr | Rat | metformin | decreases expression | ISO | Gmpr (Mus musculus) | 6480464 | Metformin results in decreased expression of GMPR mRNA | CTD | PMID:23457588 | Gmpr | Rat | N-methyl-4-phenylpyridinium | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of GMPR mRNA | CTD | PMID:24810058 | Gmpr | Rat | nickel atom | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | Nickel results in increased expression of GMPR mRNA | CTD | PMID:23195993 | Gmpr | Rat | nickel sulfate | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of GMPR mRNA | CTD | PMID:22714537 | Gmpr | Rat | nitrates | multiple interactions | ISO | Gmpr (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of GMPR mRNA | CTD | PMID:35964746 | Gmpr | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of GMPR mRNA | CTD | PMID:25729387 | Gmpr | Rat | ozone | multiple interactions | ISO | Gmpr (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of GMPR mRNA | CTD | PMID:34911549 | Gmpr | Rat | paracetamol | affects response to substance | ISO | GMPR (Homo sapiens) | 6480464 | GMPR gene polymorphism affects the susceptibility to Acetaminophen | CTD | PMID:26104854 | Gmpr | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of GMPR mRNA | CTD | PMID:33387578 | Gmpr | Rat | pentanal | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | pentanal results in increased expression of GMPR mRNA | CTD | PMID:26079696 | Gmpr | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of GMPR mRNA | CTD | PMID:35163327 | Gmpr | Rat | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of GMPR protein | CTD | PMID:34958885 | Gmpr | Rat | potassium chromate | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of GMPR mRNA | CTD | PMID:22079256 | Gmpr | Rat | potassium chromate | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of GMPR mRNA | CTD | PMID:22714537 | Gmpr | Rat | potassium chromate | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GMPR mRNA | CTD | PMID:22079256 | Gmpr | Rat | progesterone | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | Progesterone results in decreased expression of GMPR mRNA | CTD | PMID:21540246 | Gmpr | Rat | propanal | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of GMPR mRNA | CTD | PMID:26079696 | Gmpr | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | GMPR (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of GMPR mRNA | CTD | PMID:35811015 | Gmpr | Rat | sodium arsenite | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of GMPR mRNA | CTD | PMID:22714537 | Gmpr | Rat | sodium arsenite | decreases expression | ISO | Gmpr (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of GMPR mRNA | CTD | PMID:37682722 | Gmpr | Rat | sodium arsenite | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of GMPR mRNA | CTD | PMID:38568856 | Gmpr | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of GMPR mRNA | CTD | PMID:19281266 | Gmpr | Rat | sunitinib | decreases expression | ISO | GMPR (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of GMPR mRNA | CTD | PMID:31533062 | Gmpr | Rat | temozolomide | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | Temozolomide results in increased expression of GMPR mRNA | CTD | PMID:31758290 | Gmpr | Rat | testosterone | increases expression | ISO | Gmpr (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of GMPR mRNA | CTD | PMID:33848595 | Gmpr | Rat | testosterone | multiple interactions | ISO | Gmpr (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:33848595 | Gmpr | Rat | tetrachloromethane | affects expression | ISO | Gmpr (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of GMPR mRNA | CTD | PMID:17484886 | Gmpr | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of GMPR mRNA | CTD | PMID:16239168 | Gmpr | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of GMPR mRNA | CTD | PMID:34492290 | Gmpr | Rat | titanium dioxide | increases methylation | ISO | Gmpr (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of GMPR gene | CTD | PMID:35295148 | Gmpr | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of GMPR mRNA | CTD | PMID:25729387 | Gmpr | Rat | trichloroethene | affects expression | ISO | Gmpr (Mus musculus) | 6480464 | Trichloroethylene affects the expression of GMPR mRNA | CTD | PMID:21135412 | Gmpr | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of GMPR mRNA | CTD | PMID:33387578 | Gmpr | Rat | trichostatin A | affects expression | ISO | GMPR (Homo sapiens) | 6480464 | trichostatin A affects the expression of GMPR mRNA | CTD | PMID:28542535 | Gmpr | Rat | trimellitic acid | decreases methylation | ISO | Gmpr (Mus musculus) | 6480464 | trimellitic acid results in decreased methylation of GMPR gene | CTD | PMID:26732893 | Gmpr | Rat | triphenyl phosphate | affects expression | ISO | GMPR (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of GMPR mRNA | CTD | PMID:37042841 | Gmpr | Rat | valproic acid | increases methylation | ISO | GMPR (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of GMPR gene | CTD | PMID:29154799 | Gmpr | Rat | valproic acid | increases expression | ISO | GMPR (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of GMPR mRNA | CTD | PMID:19101580 more ... | Gmpr | Rat | valproic acid | affects expression | ISO | GMPR (Homo sapiens) | 6480464 | Valproic Acid affects the expression of GMPR mRNA | CTD | PMID:25979313 | |