Ddah1 (dimethylarginine dimethylaminohydrolase 1)

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Gene: Ddah1 (dimethylarginine dimethylaminohydrolase 1) Rattus norvegicus

Analyze

Symbol:

Ddah1

Name:

dimethylarginine dimethylaminohydrolase 1

RGD ID:

70968

Description:

Enables amino acid binding activity and dimethylargininase activity. Involved in arginine metabolic process; positive regulation of angiogenesis; and positive regulation of nitric oxide biosynthetic process. Human ortholog(s) of this gene implicated in cardiovascular system disease and hypertension. Orthologous to human DDAH1 (dimethylarginine dimethylaminohydrolase 1); INTERACTS WITH 1-nitropropane; 17alpha-ethynylestradiol; 2,3,4,7,8-Pentachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DDAH-1; DDAHI; dimethylargininase-1; n(G),N(G)-dimethylarginine dimethylaminohydrolase 1; NG,NG dimethylarginine dimethylaminohydrolase; NGNG dimethylarginine dimethylaminohydrolase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Ddah1^em1Ywxu

Genetic Models:

SD-Ddah1^em1Ywxu

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	234,667,499 - 234,800,322 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	234,667,491 - 234,799,339 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	242,465,212 - 242,597,798 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	240,356,099 - 240,488,167 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	235,222,839 - 235,355,419 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	251,634,368 - 251,766,009 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	251,634,431 - 251,766,014 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	270,160,842 - 270,289,319 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	243,932,221 - 244,069,832 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	243,918,960 - 244,056,573 (+)	NCBI
Celera	2	226,655,820 - 226,787,619 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cardiovascular system disease (ISO)

genetic disease (ISO)

hypertension (ISO)

liver disease (ISO)

Pulmonary Arterial Hypertension (IMP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1-nitropropane (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,4,7,8-Pentachlorodibenzofuran (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-diaminotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-acetamidofluorene (EXP)

2-nitro-p-phenylenediamine (EXP)

2-nitrofluorene (EXP)

2-nitropropane (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

4-acetylaminofluorene (EXP)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

4-nitro-1,2-phenylenediamine (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

Allylamine (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butan-1-ol (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chromium trinitrate (ISO)

chromium(6+) (ISO)

chrysene (ISO)

cisplatin (ISO)

clofibrate (EXP)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

hydroquinone (ISO)

indometacin (EXP)

inulin (ISO)

irbesartan (EXP)

ivermectin (ISO)

lead diacetate (EXP,ISO)

lead(0) (ISO)

lead(2+) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

methamphetamine (EXP)

methapyrilene (EXP)

methylmercury chloride (ISO)

N-nitrosodimethylamine (EXP)

N-nitrosomorpholine (EXP)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

nitrobenzenes (EXP)

p-toluidine (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

paroxetine (ISO)

perfluorododecanoic acid (EXP)

perfluorooctane-1-sulfonic acid (EXP,ISO)

phenobarbital (EXP,ISO)

phenylmercury acetate (ISO)

pioglitazone (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propiconazole (ISO)

ranitidine (EXP)

rotenone (EXP)

sarin (EXP)

SB 431542 (ISO)

simvastatin (EXP)

sodium arsenite (EXP,ISO)

sulforaphane (ISO)

taurine (ISO)

temozolomide (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (EXP)

valproic acid (ISO)

venlafaxine hydrochloride (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arginine catabolic process (ISO)

arginine metabolic process (IBA,IDA)

citrulline metabolic process (IBA,ISO,ISS)

negative regulation of cell population proliferation (ISO)

negative regulation of cellular response to hypoxia (ISO)

negative regulation of vascular permeability (ISO)

positive regulation of angiogenesis (IMP)

positive regulation of nitric oxide biosynthetic process (IBA,IMP,ISO)

regulation of systemic arterial blood pressure (ISO)

Molecular Function

amino acid binding (IBA,IDA)

dimethylargininase activity (IBA,IDA,ISO,ISS,TAS)

metal ion binding (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased aorta wall thickness (IMP)

increased heart right ventricle weight (IMP)

increased right ventricle systolic pressure (IMP)

oxidative stress (IMP)

pulmonary fibrosis (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cloning and sequencing of cDNA encoding NG,NG-dimethylarginine dimethylaminohydrolase from rat kidney.	Kimoto M, etal., Biochim Biophys Acta 1997 Jan 4;1337(1):6-10.
4.	Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis.	Kostourou V, etal., Br J Cancer 2002 Sep 9;87(6):673-80.
5.	Gene Data Set	MGD Curation, June 12, 2002
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats.	Sasaki A, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1480-7. Epub 2007 Feb 23.
11.	DDAH gene and cardiovascular risk.	Valkonen VP, etal., Vasc Med. 2005 Jul;10 Suppl 1:S45-8.
12.	Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats.	Wang D, etal., Int J Cardiol. 2019 Nov 15;295:14-20. doi: 10.1016/j.ijcard.2019.07.078. Epub 2019 Jul 27.

Additional References at PubMed

PMID:14766200	PMID:15256062	PMID:16533509	PMID:16959216	PMID:17409314	PMID:17673667	PMID:17909098	PMID:18614015	PMID:19056867	PMID:19156866	PMID:19481782	PMID:19528264
PMID:19663506	PMID:21408057	PMID:21493890	PMID:21590769	PMID:22785485	PMID:22995517	PMID:23376485	PMID:23533145	PMID:24455716	PMID:24895913	PMID:25013773	PMID:26375520
PMID:29263339	PMID:29513072	PMID:29721731	PMID:31870966	PMID:33574439	PMID:35509834

Genomics

Comparative Map Data

Ddah1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	234,667,499 - 234,800,322 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	234,667,491 - 234,799,339 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	242,465,212 - 242,597,798 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	240,356,099 - 240,488,167 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	235,222,839 - 235,355,419 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	251,634,368 - 251,766,009 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	251,634,431 - 251,766,014 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	270,160,842 - 270,289,319 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	243,932,221 - 244,069,832 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	243,918,960 - 244,056,573 (+)	NCBI
Celera	2	226,655,820 - 226,787,619 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

DDAH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	85,318,485 - 85,578,200 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	85,318,481 - 85,578,363 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	85,784,168 - 86,043,883 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	85,556,756 - 85,703,411 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	85,496,189 - 85,642,844	NCBI
Celera	1	84,028,261 - 84,288,153 (-)	NCBI		Celera
Cytogenetic Map	1	p22.3	NCBI
HuRef	1	83,894,842 - 84,154,833 (-)	NCBI		HuRef
CHM1_1	1	85,899,643 - 86,159,483 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	85,159,290 - 85,419,019 (-)	NCBI		T2T-CHM13v2.0

Ddah1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	145,464,447 - 145,600,032 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	145,464,430 - 145,600,032 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	145,758,692 - 145,894,277 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	145,758,675 - 145,894,277 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	145,421,656 - 145,557,241 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	145,696,113 - 145,829,059 (+)	NCBI		MGSCv36	mm8
Celera	3	152,212,383 - 152,347,807 (+)	NCBI		Celera
Cytogenetic Map	3	H2	NCBI

Ddah1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	8,636,756 - 8,676,790 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	8,637,116 - 8,673,881 (+)	NCBI	ChiLan1.0	ChiLan1.0

DDAH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	140,509,872 - 140,770,243 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	117,875,875 - 118,136,304 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	86,732,327 - 86,991,596 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

DDAH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	62,548,852 - 62,683,687 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	62,549,152 - 62,683,729 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	65,198,038 - 65,332,811 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	63,091,600 - 63,223,617 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	63,092,081 - 63,223,617 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	62,619,548 - 62,750,820 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	62,587,035 - 62,721,493 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	63,093,978 - 63,228,831 (+)	NCBI		UU_Cfam_GSD_1.0

Ddah1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	95,908,280 - 96,043,352 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936608	262,445 - 397,762 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936608	262,653 - 397,753 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDAH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	130,579,729 - 130,617,531 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	130,485,305 - 130,617,534 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	143,081,555 - 143,209,100 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DDAH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	47,788,410 - 48,031,868 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	47,891,289 - 48,032,343 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	69,777,494 - 70,020,724 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ddah1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	12,026,248 - 12,170,147 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	12,027,450 - 12,170,003 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ddah1
941 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	191
Count of miRNA genes:	130
Interacting mature miRNAs:	158
Transcripts:	ENSRNOT00000045016
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	229059610	249053267	Rat

Markers in Region

D2Got166

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	234,670,004 - 234,670,280 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	251,636,874 - 251,637,149	NCBI	Rnor6.0
Rnor_5.0	2	270,163,348 - 270,163,623	UniSTS	Rnor5.0
RGSC_v3.4	2	243,934,775 - 243,935,051	RGD	RGSC3.4
RGSC_v3.4	2	243,934,776 - 243,935,051	UniSTS	RGSC3.4
RGSC_v3.1	2	243,921,515 - 243,921,791	RGD
Celera	2	226,658,326 - 226,658,601	UniSTS
Cytogenetic Map	2	q44	UniSTS

RH140029

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	234,798,808 - 234,799,010 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	251,764,496 - 251,764,697	NCBI	Rnor6.0
Rnor_5.0	2	270,288,789 - 270,288,990	UniSTS	Rnor5.0
RGSC_v3.4	2	244,069,535 - 244,069,736	UniSTS	RGSC3.4
Celera	2	226,787,089 - 226,787,290	UniSTS
Cytogenetic Map	2	q44	UniSTS

Genetic Models

This gene Ddah1 is modified in the following models/strains

SD-Ddah1^em1Ywxu

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	33	40	39		39		1	74	35	32	11
Low	1	10	17	2	19	2	8	10			9		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000045016 ⟹ ENSRNOP00000044971

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	234,667,491 - 234,799,339 (+)	Ensembl
Rnor_6.0 Ensembl	2	251,634,431 - 251,766,014 (+)	Ensembl

RefSeq Acc Id:

NM_022297 ⟹ NP_071633

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	234,667,499 - 234,799,339 (+)	NCBI
Rnor_6.0	2	251,634,368 - 251,765,026 (+)	NCBI
Rnor_5.0	2	270,160,842 - 270,289,319 (+)	NCBI
RGSC_v3.4	2	243,932,221 - 244,069,832 (+)	RGD
Celera	2	226,655,820 - 226,787,619 (+)	RGD

Sequence:

show sequence

GGAGCCGCCGGGCGCTCGCAGGCTCGCAGGCTCGCAGGTTGGGCGCGCGCTGCTCTCGGGAAGA
CCCGGCCACCGAGCCAAACCCCGCCGCCGCCTCTCCGCGCGAGCCATGGCCGGCCTCAGCCACC
CCTCGGTCTTCGGCCGGGCCACCCACGCCGTGGTGCGGGCTCCGCCCGAGTCCCTGTGCCGCCA
CGCGCTGAGGCGCTCCCAGGGCGAAGAGGTGGATTTCGCTCGCGCTGAGCGCCAGCACCAGCTC
TACGTGGGCGTGCTGGGCAGCAAGCTGGGGCTGCAGGTGGTGCAGCTGCCGGCCGACGAGAGCC
TGCCTGACTGCGTGTTCGTGGAGGACGTGGCCGTGGTGTGCGAGGAGACCGCCCTCATCACCCG
CCCCGGGGCGCCTAGCCGCAGGAAGGAGGTTGACATGATGAAAGAGGCTTTGGAAAAACTTCAG
CTCAACATAGTAGAGATGAAAGATGAAAATGCAACCTTAGATGGTGGGGACGTCCTATTCACAG
GCAGAGAGTTTTTTGTGGGCCTTTCCAAAAGGACAAATCAACGAGGTGCTGAGATCTTGGCTGA
TACTTTCAAGGACTACGCAGTTTCCACAGTCCCCGTGGCCGATTCTTTGCATTTAAAGAGTTTC
TGCAGCATGGCTGGCCCCAACCTGATCGCAATAGGGTCCAGTGAATCTGCGCAGAAGGCCCTCA
AGATCATGCAACAGATGAGTGACCACCGTTATGACAAGCTCACTGTACCGGACGACATGGCCGC
CAACTGTATATATTTAAATATCCCCAGCAAAGGGCATGTCTTGCTGCACCGAACCCCAGAAGAG
TACCCAGAAAGCGCAAAGGTTTATGAGAAGCTCAAGGACCATCTACTGATCCCTGTGAGCAATT
CTGAGATGGAAAAGGTGGACGGCTTGCTCACCTGCTGCTCCGTTTTTATTAACAAGAAGACAGA
CTCTTGAGCGGAAGAGTCCCTCCCGAGCGGCCGGCGAGTGGCCTAGGCCAGGCTGATGATGGCT
CTGTACCCATTCCTCCTGTTTCCTTTGACAATCTACTGTGCCACTAACTCTTGTTTACAAAGAA
TTCCAATCTTAATCGCCTCATTTCCCCACACCCCCCTCTTCCTCACGGGGCCCCCTAACCTGTG
CACACATTTGCTCAATGAACTAAGCAACCTAGGAAATACAGAACTAACGAATCATTGGAATGTG
ATTGATAGCGTGGAGGCACTCACTCCAGCCTCTGTGTCCTTAGTGTGGGAATAGTTTAGATGCA
GGGCATCCTGAAGGACTGACCTCCTGGGCAGACAGATAAACAAGCAAGGGACTTTCTTTGCTTC
ATGAGTTGCGTTTGGTTCCTGTGAGAGTCCTGAGAACGTGGATTTTTTCCCATTCCCCTCTCTT
CTCACCTCTAAAACACTTTCTTCCAGGTCTTCCTTTGGCCTTCCTCACTTCTTTCGTAATCACC
TTGAACCTGGATTTATCCAAGGTCTCGAACTCTGGATACCCTCCTAACGTCCACCCTGTCTACG
TGCAGTCCTCTCCTCCTCACAGCCACAACTTCTGCCACCACCAGCAAATCAGAGTGGCTGGTTG
GAGACGAGGAACCTCACAGAGGCACATCCTGACAGGGTTTCCCATTAGCACACCTAGGAAGGTA
AATTCAGGTGGTTGATACAGGATGTTAGATACAGAAGCCTAGAAACACCCCCATGGGTACATCT
CAGAGAGACTGAGTCACTGCCATGATTTTGCCTCATGACTGGTCCTATAGGAGCGTGGAGGAAA
GTCTTTCTCCACCCCACCACCTCCCCCTTTTTCAGCTTCCTTCTGACTCAACCTTGTATCTACC
CCCTTAGAATCACCATGATTTTGAAAAGTCATTTCCTTCAAAAGAGGCAGAACATCTAATGATT
GTTGACGGTCTGGTAAGAGCTAGAGGGAACTGCCTCCACCCAAGGCCTAGGAGCACAATCAGGA
AATGGTTCCTAAAGTCAACTTCAAACAATGTGTGAGTCTCCTTTGAAATATCCATGACTGTTTA
CTGTGGAATTCAACCGAAACTTCAAATTACACAACTTTCANNAGACGCAGGTCTCTCACAGGGA
ACAATACCACAGCAAAGGAATTCCTTTCTTGAAAGCTGAAACAGGCCAAGGACATGGTACCTTA
CAAGGCACGGTGACCCAGCCAGGCATCTCATCAAACTTCTGGTCACTTCTACCTTGGCTGTATA
GCCTGCAGTCTGTCATTCGATATTTAAAGTTGGGGAGACAAAGGCTATGTCAGCTCTAGCTCTC
CTTACCTCTCTTTGTGATCAGTGTTTCTTCTAGTGAAGGCAAGAGAGACTGGGCCTCATCTCGT
CCCCCTCAGTGGCCGGAAGTGAGAAAATCAAGACTTCCTTTACCGCCCTTCTCTTAGTTGGCAA
CCTCTCTGAAGAGGTCTCCATCTCTCCCTTGCTGTCTAACTCTAGACTCATATCGCATGCCAAT
ATCTAACTGTACACCCTGTGAATGAACCATATCCTGGTCACTGTCACATTTCACAGCGTATCAC
AGGTGAACAGTTATGCCTTCTCCAGGGCAAGGGAATATGAGACAGTTGCCTAAATTCATAAAGA
AAAATTGTTCTCAGCCATTATGGTTGCCTTGAGGGGTTAAAGTTGACCCCACCTACACTAGC

hide sequence

RefSeq Acc Id:

XM_017591068 ⟹ XP_017446557

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	234,684,993 - 234,800,322 (+)	NCBI
Rnor_6.0	2	251,651,493 - 251,766,009 (+)	NCBI

Sequence:

show sequence

CCCGCTGTCGGGACAGAAATGCCCTAGTTGCACTCTAGTTGAAACCGCAAAATCCTCAGGACTA
TGGAGTCTGACCTCCCTCCCCTCCTCTCTCTGGGGATCTCTATGGTCTCCCTGCCCATTTATCT
ATAAGTTAAGCTGATAACAACTTGTGGTCAACCTGAGTCTCATGGGCCTAGATTAATTTGTTGA
GCCAAGCAAACACCTCGAGCCATCAGTAGCTGGGCAGACGTAGCACACCGGGTTTAGCACGGTT
CCCCAGTCTGGATTCTGTCGGGTTAGTTTCAGGGTTCAAAGGCCAAGTTGGTTTTCTTAGAGTG
GCGAGTCAGCACAGAGGCATGGTTTTGAACGTAGTCAGACAGTGCCTCACGCATTTCTGGCCCC
TTCCTGCTGTGCAAATCCAAACACCCAAGAGTTGTGTAAGACAAAGAGACCACAGTATCGCCGT
CTTCTTTCTTGAAACTCAACAATGATGTCCTTTCTCTCCCTCCTGTTAAAAGCTGGGCCGCCCC
CTGGTGAAATATTGTTATCTAAAACCACTGCTGTAGGGAGAGTGGACATAAACGAAGGAAAGGG
ACAAAGGGAAGGCAGAAGAAGAGAGGAGAGGGACCCGCTAAAAGAAACCCTGACAGTGTCTACT
CAGAAACGTGGTTGACATGATGAAAGAGGCTTTGGAAAAACTTCAGCTCAACATAGTAGAGATG
AAAGATGAAAATGCAACCTTAGATGGTGGGGACGTCCTATTCACAGGCAGAGAGTTTTTTGTGG
GCCTTTCCAAAAGGACAAATCAACGAGGTGCTGAGATCTTGGCTGATACTTTCAAGGACTACGC
AGTTTCCACAGTCCCCGTGGCCGATTCTTTGCATTTAAAGAGTTTCTGCAGCATGGCTGGCCCC
AACCTGATCGCAATAGGGTCCAGTGAATCTGCGCAGAAGGCCCTCAAGATCATGCAACAGATGA
GTGACCACCGTTATGACAAGCTCACTGTACCGGACGACATGGCCGCCAACTGTATATATTTAAA
TATCCCCAGCAAAGGGCATGTCTTGCTGCACCGAACCCCAGAAGAGTACCCAGAAAGCGCAAAG
GTTTATGAGAAGCTCAAGGACCATCTACTGATCCCTGTGAGCAATTCTGAGATGGAAAAGGTGG
ACGGCTTGCTCACCTGCTGCTCCGTTTTTATTAACAAGAAGACAGACTCTTGAGCGGAAGAGTC
CCTCCCGAGCGGCCGGCGAGTGGCCTAGGCCAGGCTGATGATGGCTCTGTACCCATTCCTCCTG
TTTCCTTTGACAATCTACTGTGCCACTAACTCTTGTTTACAAAGAATTCCAATCTTAATCGCCT
CATTTCCCCACACCCCCCTCTTCCTCACGGGGCCCCCTAACCTGTGCACACATTTGCTCAATGA
ACTAAGCAACCTAGGAAATACAGAACTAACGAATCATTGGAATGTGATTGATAGCGTGGAGGCA
CTCACTCCAGCCTCTGTGTCCTTAGTGTGGGAATAGTTTAGATGCAGGGCATCCTGAAGGACTG
ACCTCCTGGGCAGACAGATAAACAAGCAAGGGACTTTCTTTGCTTCATGAGTTGCGTTTGGTTC
CTGTGAGAGTCCTGAGAACGTGGATTTTTTCCCATTCCCCTCTCTTCTCACCTCTAAAACACTT
TCTTCCAGGTCTTCCTTTGGCCTTCCTCACTTCTTTCGTAATCACCTTGAACCTGGATTTATCC
AAGGTCTCGAACTCTGGATACCCTCCTAACGTCCACCCTGTCTACGTGCAGTCCTCTCCTCCTC
ACAGCCACAACTTCTGCCACCACCAGCAAATCAGAGTGGCTGGTTGGAGACGAGGGACCTCACA
GAGGCACATCCTGACAGGGTTTCCCATTAGCACACCTAGGAAGGTAAATTCAGGTGGTTGATAC
AGGATGTTAGATACAGAAGCCTAGAAACACCCCCATGGGTACATCTCAGAGAGACTGAGTCACT
GCCATGATTTTGCCTCATGACTGGTCCTATAGGAGCGTGGAGGAAAGTCTTTCTCCACCCCACC
ACCTCCCCCTTTTTCAGCTTCCTTCTGACTCAACCTTGTATCTACCCCCTTAGAATCACCATGA
TTTTGAAAAGTCATTTCCTTCAAAAAAAGGCAGAACATCTAATGATTGTTGACGGTCTGGTAAG
AGCTAGAGGGAACTGCCTCCACCCAAGGCCTAGGAGCACAATCAGGAAATGGTTCCTAAAGTCA
ACTTCAAACAATGTGTGAGTCTCCTTTGAAATATCCATGACTGTTTACTGTGGAATTCAACCGA
AACTTCAAATTACACAACTTTCAGCAGACGCAGGTCTCTCACAGGGAACAATACCACAGCAAAG
GAATTCCTTTCTTGAAAGCTGAAACAGGCCAAGGACATGGTACCTTACAAGGCACGGTGACCCA
GCCAGGCATCTCATCAAACTTCTGGTCACTTCTACCTTGGCTGTATAGCCTGCAGTCTGTCATT
CGATATTTAAAGTTGGGGAGACAAAGGCTATGTCAGCTCTAGCTCTCCTTACCTCTCTTTGTGA
TCAGTGTTTCTTCTAGTGAAGGCAAGAGAGACTGGGCCTCATCTCGTCCCCCTCAGTGGCCGGA
AGTGAGAAAATCAAGACTTCCTTTACCGCCCTTCTCTTAGTTGGCAACCTCTCTGAAGAGGTCT
CCATCTCTCCCTTGCTGTCTAACTCTAGACTCATATCGCATGCCAATATCTAACTGTACACCCT
GTGAATGAACCATATCCTGGTCACTGTCACATTTCACAGCGTATCACAGGTGAACAGTTATGCC
TTCTCCAGGGCAAGGGAATATGAGACAGTTGCCTAAATTCATAAAGAAAAATTGTTCTCAGCCA
TTATGGTTGCCTTGAGGGGTTAAAGTTGACCCCACCTACACTAGCAAAAAAAAAAAATTCTTAA
TTGTGGGAAGTGACCATCTCAAAATCAACCACAGGAAAAACAGCCCACTCTACACATACCAGCA
TATAATTGTCACTGACGCCTCTTCTATCATCCCGGTTCCAGAACTGTCCTCAATGATATTTAGT
CAATTACAAGGGATTAGGTTTCTTTCATGGTGACAGTTTCTTCTACCAAAGGTGGCTTTCCATT
CCCCTTTCCTTTTGCATCCCTCTTTCCTTGTTTGTCCTGAGAAATTGACGAGAGTCCCTGCCTC
CTCCCCATCTTATTCTGCTCTTGGACTCCCTGTGTGATACAGTGATGTGAAAACTCAAAATACA
TGCAGCACGGCTCCTGTGAGGTCCTCATCAGCGTGATGAAAGGGAAAGATGTCTTTACCCAAGT
TCCCTTTGTGTCTCACGGAGACGGGAAGACTAACAAGAAGGCTTCTTAACATCGTAAAGACATG
AGTTCCGTTGAACTAAGTATATAGGTTGGGTTAGAATGAACGGGTCCATGTGGGTTGGTCTAGT
GAAGAGATGAGCTAGATGCAATGTGTCATTTAGCGTTATGTCTTTAACCGGTGGGCTGCTGTAA
GAATCGGTGGCAGTTCTCTCTCTGCCGTGTGTTAATTGCTCTGGAACGCTACTAGGACCCGAAT
ACTAAGGCCACATCTCTACGTCTCTAAGAAGGGGAAATAAGATAGGCTTTAGTCTCACAGTGTG
GCCTAGGTGGGGTTGCATGTTACTCCCTAACACGCTACAGAATTCAGACATAGTTTCTGTGTGG
TGGTAGGTCTGTGCTTTTTTTATCGTCTTGCCTGCCATCTTCCAGCCAGTGTATGGTTTATCCA
GTCTGTGTGCCAAAGCCAGCCATGTCTCCCACGACCCGTTAGTCCAGAGGAGTTCTGCCCCAAC
ACTAGTTTCCAGCTGCCCACTCCTAATGTACACCAATCAAGACAGAATAAAATTTGAGTTGTTC
GGTG

hide sequence

RefSeq Acc Id:

XM_039103038 ⟹ XP_038958966

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	234,755,361 - 234,800,322 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071633	(Get FASTA)	NCBI Sequence Viewer
	XP_017446557	(Get FASTA)	NCBI Sequence Viewer
	XP_038958966	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82408	(Get FASTA)	NCBI Sequence Viewer
	EDL82409	(Get FASTA)	NCBI Sequence Viewer
	O08557	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_071633 ⟸ NM_022297

- UniProtKB:

O08557 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAGLSHPSVFGRATHAVVRAPPESLCRHALRRSQGEEVDFARAERQHQLYVGVLGSKLGLQVVQ
LPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDG
GDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADSLHLKSFCSMAGPNLIAIGSSE
SAQKALKIMQQMSDHRYDKLTVPDDMAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHL
LIPVSNSEMEKVDGLLTCCSVFINKKTDS

hide sequence

RefSeq Acc Id:	XP_017446557 ⟸ XM_017591068
- Peptide Label:	isoform X1
- Sequence:	show sequence MMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVP VADSLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDMAANCIYLNIPSKG HVLLHRTPEEYPESAKVYEKLKDHLLIPVSNSEMEKVDGLLTCCSVFINKKTDS hide sequence

RefSeq Acc Id:

ENSRNOP00000044971 ⟸ ENSRNOT00000045016

RefSeq Acc Id:	XP_038958966 ⟸ XM_039103038
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08557-F1-model_v2	AlphaFold	O08557	1-285	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691809

Promoter ID:

EPDNEW_R2334

Type:

initiation region

Name:

Ddah1_1

Description:

dimethylarginine dimethylaminohydrolase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	251,634,348 - 251,634,408	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70968	AgrOrtholog
BioCyc Gene	G2FUF-50919	BioCyc
Ensembl Genes	ENSRNOG00000014613	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000044971	ENTREZGENE
	ENSRNOP00000044971.3	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000045016	ENTREZGENE
	ENSRNOT00000045016.5	UniProtKB/Swiss-Prot
InterPro	DDAH	UniProtKB/Swiss-Prot
KEGG Report	rno:64157	UniProtKB/Swiss-Prot
NCBI Gene	64157	ENTREZGENE
PANTHER	PTHR12737	UniProtKB/Swiss-Prot
	PTHR12737:SF17	UniProtKB/Swiss-Prot
Pfam	ADI	UniProtKB/Swiss-Prot
PhenoGen	Ddah1	PhenoGen
Superfamily-SCOP	Pentein	UniProtKB/Swiss-Prot
UniProt	DDAH1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-07-09	Ddah1	dimethylarginine dimethylaminohydrolase 1			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	catalyzes the conversion of N(G), N(G)-dimethyl-L-arginine and H(2)O to dimethylamine and L-citrulline	70711
gene_mutations_overexpression	overexpression induces increased nitric oxide synthesis and angiogenesis	727432
gene_protein	protein is 285 amino acids with a M(r) of 3,1414	727432

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Mammalian Phenotype