Gk (glycerol kinase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gk (glycerol kinase) Rattus norvegicus
Analyze
Symbol: Gk
Name: glycerol kinase
RGD ID: 70893
Description: Enables histone binding activity. Involved in response to ethanol; response to norepinephrine; and response to xenobiotic stimulus. Predicted to be located in cytosol and nucleus. Predicted to be active in mitochondrion. Used to study familial hypercholesterolemia. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to several human genes including GK (glycerol kinase); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (R)-noradrenaline; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ASTP; ATP-stimulated glucocorticoid-receptor translocation promoter; ATP-stimulated glucocorticoid-receptor translocaton promoter; ATP:glycerol 3-phosphotransferase; glycerokinase; Gyk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X54,106,708 - 54,189,940 (-)NCBIGRCr8
GRCr8 EnsemblX54,112,214 - 54,196,701 (-)EnsemblGRCr8 Ensembl
mRatBN7.2X50,162,089 - 50,238,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX50,163,123 - 50,238,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX51,492,275 - 51,568,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X54,992,657 - 55,069,083 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X52,623,653 - 52,700,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X54,227,291 - 54,303,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,227,397 - 54,303,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X54,426,876 - 54,503,386 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X72,416,872 - 72,493,296 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,789,241 - 50,865,448 (-)NCBICelera
RGSC_v3.1X72,491,081 - 72,566,588 (-)NCBI
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
CL316243  (EXP)
clofibrate  (EXP)
clorgyline  (ISO)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
difenoconazole  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylselenide  (ISO)
diuron  (ISO)
dobutamine  (EXP)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
Ganoderic acid A  (ISO)
glafenine  (EXP)
glycerol  (EXP,ISO)
glycerol 1-phosphate  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydroquinone  (ISO)
hydroxyl  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lovastatin  (ISO)
malathion  (EXP)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propranolol  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulindac sulfide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
Torularhodin  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)
membrane  (IEA)
mitochondrial outer membrane  (IEA)
mitochondrion  (IBA,IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Chronic ethanol administration alters hepatic rates of glycerol phosphorylation and glycerol 3-phosphate oxidation: a dynamic in vivo 31P magnetic resonance spectroscopy study. Brauer M, etal., Biochem Cell Biol. 1998;76(2-3):542-52.
2. Expression of glycerokinase in brown adipose tissue is stimulated by the sympathetic nervous system. Festuccia WT, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1536-41.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Glycerol kinase and dihydroxyacetone kinase in rat brain. Jenkins BT and Hajra AK, J Neurochem. 1976 Feb;26(2):377-85.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats. Lee DH, etal., Metabolism. 2005 Oct;54(10):1282-9.
7. Gene Data Set MGD Curation, June 12, 2002
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Molecular cloning of rat liver glucocorticoid-receptor translocation promoter. Okamoto K, etal., Biochem Biophys Res Commun 1993 Jun 30;193(3):848-54.
11. Properties of an adenosine triphosphate-stimulated factor that enhances the nuclear binding of activated glucocorticoid-receptor complex: binding to histone-agarose. Okamoto K, etal., Endocrinology. 1989 Feb;124(2):675-80.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Human and rat adrenal glycerol kinase: subcellular distribution and bisubstrate kinetics. Seltzer WK and McCabe ER, Mol Cell Biochem. 1984 Apr;62(1):43-50.
20. Clinical heterogeneity and novel mutations in the glycerol kinase gene in three families with isolated glycerol kinase deficiency. Sjarif DR, etal., J Med Genet. 1998 Aug;35(8):650-6.
21. Lipid and glucose utilization in hypercholesterolemic rats fed a diet containing heated chickpea (Cicer aretinum L.): a potential functional food. Zulet MA, etal., Int J Vitam Nutr Res. 1999 Nov;69(6):403-11. doi: 10.1024/0300-9831.69.6.403.
Additional References at PubMed
PMID:8499898   PMID:8651297   PMID:8884278   PMID:9302256   PMID:14651853   PMID:15845384   PMID:16105550   PMID:18614015   PMID:19056867   PMID:20399282   PMID:21536471   PMID:22871113  
PMID:23376485   PMID:29960856   PMID:34800366  


Genomics

Comparative Map Data
Gk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X54,106,708 - 54,189,940 (-)NCBIGRCr8
GRCr8 EnsemblX54,112,214 - 54,196,701 (-)EnsemblGRCr8 Ensembl
mRatBN7.2X50,162,089 - 50,238,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX50,163,123 - 50,238,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX51,492,275 - 51,568,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X54,992,657 - 55,069,083 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X52,623,653 - 52,700,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X54,227,291 - 54,303,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX54,227,397 - 54,303,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X54,426,876 - 54,503,386 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X72,416,872 - 72,493,296 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX50,789,241 - 50,865,448 (-)NCBICelera
RGSC_v3.1X72,491,081 - 72,566,588 (-)NCBI
Cytogenetic MapXq21NCBI
GK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X30,653,423 - 30,731,462 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX30,653,359 - 30,731,462 (+)EnsemblGRCh38hg38GRCh38
GRCh37X30,671,540 - 30,749,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X30,581,461 - 30,658,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X30,431,196 - 30,508,381NCBI
CeleraX34,794,970 - 34,872,746 (+)NCBICelera
Cytogenetic MapXp21.2NCBI
HuRefX28,409,908 - 28,487,802 (+)NCBIHuRef
CHM1_1X30,702,368 - 30,780,409 (+)NCBICHM1_1
T2T-CHM13v2.0X30,247,310 - 30,325,392 (+)NCBIT2T-CHM13v2.0
Gk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X84,745,543 - 84,820,425 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX84,745,543 - 84,820,425 (-)EnsemblGRCm39 Ensembl
GRCm38X85,701,937 - 85,776,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX85,701,937 - 85,776,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X82,947,276 - 83,022,158 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X81,954,656 - 82,029,402 (-)NCBIMGSCv36mm8
CeleraX76,897,628 - 76,973,181 (-)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX39.32NCBI
Gk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955531106,761 - 183,347 (-)NCBIChiLan1.0ChiLan1.0
GK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X32,451,539 - 32,528,605 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X32,454,918 - 32,531,984 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X23,250,290 - 23,327,373 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X30,806,950 - 30,876,075 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX30,806,950 - 30,877,131 (+)Ensemblpanpan1.1panPan2
GK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X25,748,060 - 25,834,462 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX30,724,675 - 30,810,642 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X25,779,221 - 25,865,989 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX25,788,453 - 25,865,989 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X25,824,618 - 25,911,312 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X25,818,511 - 25,904,987 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X25,914,905 - 26,001,706 (+)NCBIUU_Cfam_GSD_1.0
Gk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X18,614,780 - 18,776,739 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365536,707,148 - 6,787,245 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X26,470,422 - 26,558,892 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X28,788,865 - 28,872,354 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X29,043,390 - 29,119,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX29,043,571 - 29,118,646 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605631,026,654 - 31,105,211 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476225,270,270 - 25,357,167 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476225,268,398 - 25,357,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gk
153 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1133
Count of miRNA genes:322
Interacting mature miRNAs:437
Transcripts:ENSRNOT00000051249, ENSRNOT00000064340
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
AA945076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X50,162,299 - 50,162,493 (+)MAPPERmRatBN7.2
Rnor_6.0X54,227,492 - 54,227,685NCBIRnor6.0
Rnor_5.0X54,426,978 - 54,427,171UniSTSRnor5.0
RGSC_v3.4X72,416,967 - 72,417,160UniSTSRGSC3.4
CeleraX50,789,336 - 50,789,529UniSTS
RH 3.4 MapX662.32UniSTS
Cytogenetic MapXq22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000051249   ⟹   ENSRNOP00000048795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,114,229 - 54,189,731 (-)Ensembl
mRatBN7.2 EnsemblX50,163,123 - 50,238,631 (-)Ensembl
Rnor_6.0 EnsemblX54,228,315 - 54,303,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000064340   ⟹   ENSRNOP00000059825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,114,229 - 54,189,731 (-)Ensembl
mRatBN7.2 EnsemblX50,163,123 - 50,238,631 (-)Ensembl
Rnor_6.0 EnsemblX54,227,397 - 54,303,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087547   ⟹   ENSRNOP00000074103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,114,746 - 54,189,731 (-)Ensembl
mRatBN7.2 EnsemblX50,163,669 - 50,238,631 (-)Ensembl
Rnor_6.0 EnsemblX54,227,399 - 54,303,864 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087919   ⟹   ENSRNOP00000075227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,117,579 - 54,170,127 (-)Ensembl
mRatBN7.2 EnsemblX50,165,694 - 50,219,023 (-)Ensembl
Rnor_6.0 EnsemblX54,233,646 - 54,303,729 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125155   ⟹   ENSRNOP00000102393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,113,167 - 54,189,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137012   ⟹   ENSRNOP00000103355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,119,052 - 54,189,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153646   ⟹   ENSRNOP00000108996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,117,095 - 54,189,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155314   ⟹   ENSRNOP00000100840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,112,214 - 54,189,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158613   ⟹   ENSRNOP00000102933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX54,121,384 - 54,196,701 (-)Ensembl
RefSeq Acc Id: NM_024381   ⟹   NP_077357
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,311 - 54,189,731 (-)NCBI
mRatBN7.2X50,162,205 - 50,238,631 (-)NCBI
Rnor_6.0X54,227,397 - 54,303,825 (-)NCBI
Rnor_5.0X54,426,876 - 54,503,386 (-)NCBI
RGSC_v3.4X72,416,872 - 72,493,296 (-)RGD
CeleraX50,789,241 - 50,865,448 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256987   ⟹   XP_006257049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,304 - 54,189,940 (-)NCBI
mRatBN7.2X50,162,200 - 50,238,705 (-)NCBI
Rnor_6.0X54,227,390 - 54,303,896 (-)NCBI
Rnor_5.0X54,426,876 - 54,503,386 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256988   ⟹   XP_006257050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,304 - 54,189,809 (-)NCBI
mRatBN7.2X50,162,200 - 50,238,703 (-)NCBI
Rnor_6.0X54,227,390 - 54,303,895 (-)NCBI
Rnor_5.0X54,426,876 - 54,503,386 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773274   ⟹   XP_008771496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,304 - 54,189,809 (-)NCBI
mRatBN7.2X50,162,200 - 50,238,707 (-)NCBI
Rnor_6.0X54,227,390 - 54,303,897 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773275   ⟹   XP_008771497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,304 - 54,189,809 (-)NCBI
mRatBN7.2X50,162,200 - 50,238,705 (-)NCBI
Rnor_6.0X54,227,390 - 54,303,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773276   ⟹   XP_008771498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,106,708 - 54,189,809 (-)NCBI
mRatBN7.2X50,162,089 - 50,238,707 (-)NCBI
Rnor_6.0X54,227,291 - 54,303,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773278   ⟹   XP_008771500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,304 - 54,189,809 (-)NCBI
mRatBN7.2X50,162,200 - 50,238,705 (-)NCBI
Rnor_6.0X54,227,390 - 54,303,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100087   ⟹   XP_038956015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,117,671 - 54,189,809 (-)NCBI
mRatBN7.2X50,166,565 - 50,238,707 (-)NCBI
RefSeq Acc Id: XM_063280321   ⟹   XP_063136391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,304 - 54,189,809 (-)NCBI
RefSeq Acc Id: XM_063280322   ⟹   XP_063136392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X54,113,304 - 54,189,809 (-)NCBI
RefSeq Acc Id: NP_077357   ⟸   NM_024381
- UniProtKB: A6IPW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257049   ⟸   XM_006256987
- Peptide Label: isoform X5
- UniProtKB: Q63060 (UniProtKB/Swiss-Prot),   A0A0G2K785 (UniProtKB/TrEMBL),   A6IPW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257050   ⟸   XM_006256988
- Peptide Label: isoform X7
- UniProtKB: A6IPW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771498   ⟸   XM_008773276
- Peptide Label: isoform X4
- UniProtKB: A6IPW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771497   ⟸   XM_008773275
- Peptide Label: isoform X2
- UniProtKB: A6IPW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771496   ⟸   XM_008773274
- Peptide Label: isoform X1
- UniProtKB: A6IPW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771500   ⟸   XM_008773278
- Peptide Label: isoform X6
- UniProtKB: A6IPW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074103   ⟸   ENSRNOT00000087547
Ensembl Acc Id: ENSRNOP00000075227   ⟸   ENSRNOT00000087919
Ensembl Acc Id: ENSRNOP00000048795   ⟸   ENSRNOT00000051249
Ensembl Acc Id: ENSRNOP00000059825   ⟸   ENSRNOT00000064340
RefSeq Acc Id: XP_038956015   ⟸   XM_039100087
- Peptide Label: isoform X3
- UniProtKB: A6IPW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136392   ⟸   XM_063280322
- Peptide Label: isoform X9
- UniProtKB: D3ZCI0 (UniProtKB/TrEMBL),   F1LSY6 (UniProtKB/TrEMBL),   A6IPW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136391   ⟸   XM_063280321
- Peptide Label: isoform X8
- UniProtKB: A0A8J8YI12 (UniProtKB/TrEMBL),   A6IPW2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100840   ⟸   ENSRNOT00000155314
Ensembl Acc Id: ENSRNOP00000108996   ⟸   ENSRNOT00000153646
Ensembl Acc Id: ENSRNOP00000103355   ⟸   ENSRNOT00000137012
Ensembl Acc Id: ENSRNOP00000102933   ⟸   ENSRNOT00000158613
Ensembl Acc Id: ENSRNOP00000102393   ⟸   ENSRNOT00000125155
Protein Domains
Carbohydrate kinase FGGY C-terminal   Carbohydrate kinase FGGY N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63060-F1-model_v2 AlphaFold Q63060 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701836
Promoter ID:EPDNEW_R12356
Type:multiple initiation site
Name:Gk_1
Description:glycerol kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X54,303,843 - 54,303,903EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70893 AgrOrtholog
BioCyc Gene G2FUF-2347 BioCyc
Ensembl Genes ENSRNOG00000034116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051249 ENTREZGENE
  ENSRNOT00000064340 ENTREZGENE
  ENSRNOT00000087547 ENTREZGENE
  ENSRNOT00000087547.2 UniProtKB/Swiss-Prot
  ENSRNOT00000137012 ENTREZGENE
  ENSRNOT00000153646 ENTREZGENE
  ENSRNOT00000158613 ENTREZGENE
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Carb_kinase_FGGY UniProtKB/Swiss-Prot
  Carb_kinase_FGGY_C UniProtKB/Swiss-Prot
  Carb_kinase_FGGY_CS UniProtKB/Swiss-Prot
  Carb_kinase_FGGY_N UniProtKB/Swiss-Prot
  GK1-3_metazoa UniProtKB/Swiss-Prot
  Glycerol_kin UniProtKB/Swiss-Prot
KEGG Report rno:79223 UniProtKB/Swiss-Prot
NCBI Gene 79223 ENTREZGENE
PANTHER GLYCEROL KINASE UniProtKB/Swiss-Prot
  SUGAR KINASE UniProtKB/Swiss-Prot
Pfam FGGY_C UniProtKB/Swiss-Prot
  FGGY_N UniProtKB/Swiss-Prot
PhenoGen Gk PhenoGen
PIRSF GlpK UniProtKB/Swiss-Prot
PROSITE FGGY_KINASES_1 UniProtKB/Swiss-Prot
  FGGY_KINASES_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000034116 RatGTEx
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt A0A0G2K785 ENTREZGENE
  A0A0G2KA23_RAT UniProtKB/TrEMBL
  A0A8J8YI12 ENTREZGENE, UniProtKB/TrEMBL
  A6IPW2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCI0 ENTREZGENE, UniProtKB/TrEMBL
  F1LSY6 ENTREZGENE
  GLPK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2K785 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Gk  glycerol kinase  Gyk  glycerol kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Gyk  glycerol kinase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology middle portion of the amino acid sequence has 48% homology to E. coli glycerol kinase 70643