Kcnip1 (potassium voltage-gated channel interacting protein 1) - Rat Genome Database

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Gene: Kcnip1 (potassium voltage-gated channel interacting protein 1) Rattus norvegicus
Analyze
Symbol: Kcnip1
Name: potassium voltage-gated channel interacting protein 1
RGD ID: 70886
Description: Enables calcium ion binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in positive regulation of action potential. Located in dendrite and neuronal cell body. Part of potassium channel complex. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-type potassium channel modulatory protein 1; A-type potassium channel modulatory protein KCNIP1; Kchip1; Kv channel-interacting protein 1; potassium channel interacting protein 1; potassium channel-interacting protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81018,723,726 - 19,093,025 (-)NCBIGRCr8
mRatBN7.21018,219,519 - 18,588,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1018,219,519 - 18,589,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1022,974,802 - 23,344,367 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01022,463,387 - 22,832,928 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01017,944,312 - 18,311,678 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,558,128 - 18,942,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,558,128 - 18,942,540 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01018,443,846 - 18,821,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,549,984 - 18,565,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1017,854,471 - 18,221,759 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels. Boland LM, etal., Am J Physiol Cell Physiol 2003 Jul;285(1):C161-70.
2. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J and Rainnie DG, Neuroscience. 2010 Dec 15;171(3):721-33. doi: 10.1016/j.neuroscience.2010.09.011. Epub 2010 Sep 16.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The diversity of calcium sensor proteins in the regulation of neuronal function. McCue HV, etal., Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a004085. doi: 10.1101/cshperspect.a004085. Epub 2010 Jul 28.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Ohya S, etal., Biochem Biophys Res Commun 2001 Mar 23;282(1):96-102.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Scannevin RH, etal., Neuron. 2004 Feb 19;41(4):587-98. doi: 10.1016/s0896-6273(04)00049-2.
13. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. Shibata R, etal., J Biol Chem 2003 Sep 19;278(38):36445-54. Epub 2003 Jun 26.
14. Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells. Strassle BW, etal., J Comp Neurol. 2005 Apr 4;484(2):144-55.
15. Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels. Zhou W, etal., Neuron. 2004 Feb 19;41(4):573-86.
Additional References at PubMed
PMID:10676964   PMID:11423117   PMID:12138168   PMID:15356203   PMID:17187064   PMID:17725712   PMID:19261906   PMID:19713751   PMID:19896980   PMID:24037673   PMID:25917026  


Genomics

Comparative Map Data
Kcnip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81018,723,726 - 19,093,025 (-)NCBIGRCr8
mRatBN7.21018,219,519 - 18,588,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1018,219,519 - 18,589,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1022,974,802 - 23,344,367 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01022,463,387 - 22,832,928 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01017,944,312 - 18,311,678 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,558,128 - 18,942,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,558,128 - 18,942,540 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01018,443,846 - 18,821,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,549,984 - 18,565,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1017,854,471 - 18,221,759 (-)NCBICelera
Cytogenetic Map10q12NCBI
KCNIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385170,353,487 - 170,736,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5170,353,487 - 170,736,632 (+)EnsemblGRCh38hg38GRCh38
GRCh375169,780,491 - 170,163,636 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365169,713,459 - 170,096,214 (+)NCBINCBI36Build 36hg18NCBI36
Build 345169,863,625 - 170,096,212NCBI
Celera5165,812,814 - 166,196,213 (+)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5164,879,389 - 165,261,398 (+)NCBIHuRef
CHM1_15169,213,393 - 169,596,144 (+)NCBICHM1_1
T2T-CHM13v2.05170,892,193 - 171,275,276 (+)NCBIT2T-CHM13v2.0
Kcnip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,579,339 - 33,943,854 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,579,339 - 33,943,152 (-)EnsemblGRCm39 Ensembl
GRCm381133,629,339 - 33,993,348 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,629,339 - 33,993,152 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,529,780 - 33,743,527 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,529,780 - 33,743,527 (-)NCBIMGSCv36mm8
Celera1136,039,564 - 36,254,398 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.21NCBI
Kcnip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540823,437,358 - 23,662,533 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540823,299,192 - 23,662,395 (+)NCBIChiLan1.0ChiLan1.0
KCNIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24165,508,638 - 165,892,400 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15163,648,181 - 164,031,942 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05165,711,110 - 166,095,049 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15172,470,524 - 172,853,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5172,622,331 - 172,853,992 (+)Ensemblpanpan1.1panPan2
KCNIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1441,220,128 - 41,566,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl441,223,369 - 41,431,510 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha441,172,875 - 41,519,111 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0441,602,547 - 41,942,922 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl441,602,549 - 41,942,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1441,416,697 - 41,625,830 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0441,607,074 - 41,947,032 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0442,117,879 - 42,457,557 (-)NCBIUU_Cfam_GSD_1.0
Kcnip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721395,445,808 - 95,758,308 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366094,168,480 - 4,361,586 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366094,168,487 - 4,481,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1653,267,523 - 53,653,730 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11653,272,652 - 53,694,974 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21657,545,284 - 57,558,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12372,555,329 - 72,934,425 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2372,910,263 - 72,934,422 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660345,723,126 - 5,957,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473319,255,587 - 19,464,938 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473319,255,938 - 19,625,087 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnip1
3033 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:69
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000007187, ENSRNOT00000040737
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101724551319388279Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat

Markers in Region
AU046920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21018,284,013 - 18,284,176 (+)MAPPERmRatBN7.2
Rnor_6.01018,629,143 - 18,629,305NCBIRnor6.0
Rnor_5.01018,514,094 - 18,514,256UniSTSRnor5.0
RGSC_v3.41018,623,429 - 18,623,591UniSTSRGSC3.4
Celera1017,918,049 - 17,918,211UniSTS
Cytogenetic Map10q12UniSTS
RH142383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21018,565,193 - 18,565,369 (+)MAPPERmRatBN7.2
Rnor_6.01018,919,035 - 18,919,210NCBIRnor6.0
Rnor_5.01018,797,692 - 18,797,867UniSTSRnor5.0
RGSC_v3.41018,911,999 - 18,912,174UniSTSRGSC3.4
Celera1018,196,301 - 18,196,476UniSTS
Cytogenetic Map10q12UniSTS
BF405894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21018,397,901 - 18,397,992 (+)MAPPERmRatBN7.2
Rnor_6.01018,746,739 - 18,746,829NCBIRnor6.0
Rnor_5.01018,625,945 - 18,626,035UniSTSRnor5.0
RGSC_v3.41018,743,401 - 18,743,491UniSTSRGSC3.4
Celera1018,030,228 - 18,030,318UniSTS
Cytogenetic Map10q12UniSTS
AA849706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21018,219,699 - 18,219,894 (+)MAPPERmRatBN7.2
Rnor_6.01018,558,309 - 18,558,503NCBIRnor6.0
Rnor_5.01018,444,027 - 18,444,221UniSTSRnor5.0
RGSC_v3.41018,549,360 - 18,549,554UniSTSRGSC3.4
Celera1017,854,652 - 17,854,846UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 25 113 57 56 25 17 25 6 149 62 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000007187   ⟹   ENSRNOP00000007187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1018,219,519 - 18,436,359 (-)Ensembl
Rnor_6.0 Ensembl1018,558,936 - 18,942,540 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000040737   ⟹   ENSRNOP00000046697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1018,219,519 - 18,588,696 (-)Ensembl
Rnor_6.0 Ensembl1018,558,128 - 18,579,632 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079031   ⟹   ENSRNOP00000071584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1018,219,519 - 18,270,788 (-)Ensembl
Rnor_6.0 Ensembl1018,558,128 - 18,574,710 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083090   ⟹   ENSRNOP00000074006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1018,219,519 - 18,436,359 (-)Ensembl
Rnor_6.0 Ensembl1018,558,129 - 18,574,909 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120110   ⟹   ENSRNOP00000094374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1018,219,519 - 18,589,045 (-)Ensembl
RefSeq Acc Id: NM_001261387   ⟹   NP_001248316
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81018,723,726 - 19,093,025 (-)NCBI
mRatBN7.21018,219,519 - 18,588,833 (-)NCBI
Rnor_6.01018,558,128 - 18,942,677 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Celera1017,854,471 - 18,221,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001261388   ⟹   NP_001248317
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81018,723,726 - 19,093,025 (-)NCBI
mRatBN7.21018,219,519 - 18,588,833 (-)NCBI
Rnor_6.01018,558,128 - 18,942,677 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Celera1017,854,471 - 18,221,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001261389   ⟹   NP_001248318
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81018,723,726 - 18,940,809 (-)NCBI
mRatBN7.21018,219,519 - 18,436,604 (-)NCBI
Rnor_6.01018,558,128 - 18,784,083 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Celera1017,854,471 - 18,068,210 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022929   ⟹   NP_075218
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81018,723,726 - 18,940,809 (-)NCBI
mRatBN7.21018,219,519 - 18,436,604 (-)NCBI
Rnor_6.01018,558,128 - 18,784,083 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
RGSC_v3.41018,549,984 - 18,565,789 (-)RGD
Celera1017,854,471 - 18,068,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246105   ⟹   XP_006246167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81018,723,726 - 18,775,105 (-)NCBI
mRatBN7.21018,219,519 - 18,272,740 (-)NCBI
Rnor_6.01018,558,132 - 18,616,322 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Sequence:
RefSeq Acc Id: NP_075218   ⟸   NM_022929
- Peptide Label: isoform 4
- UniProtKB: A6HDH0 (UniProtKB/TrEMBL),   A0A0G2K701 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001248317   ⟸   NM_001261388
- Peptide Label: isoform 2
- UniProtKB: A0A8I6ALG6 (UniProtKB/TrEMBL),   A0A0G2K701 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001248316   ⟸   NM_001261387
- Peptide Label: isoform 1
- UniProtKB: A0A0H2UHE0 (UniProtKB/TrEMBL),   A0A0H2UHY1 (UniProtKB/TrEMBL),   A0A0G2K701 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001248318   ⟸   NM_001261389
- Peptide Label: isoform 3
- UniProtKB: Q8CIR1 (UniProtKB/Swiss-Prot),   Q793P9 (UniProtKB/Swiss-Prot),   Q8R425 (UniProtKB/Swiss-Prot),   Q8R426 (UniProtKB/Swiss-Prot),   A0A0G2K701 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246167   ⟸   XM_006246105
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0U3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071584   ⟸   ENSRNOT00000079031
Ensembl Acc Id: ENSRNOP00000074006   ⟸   ENSRNOT00000083090
Ensembl Acc Id: ENSRNOP00000007187   ⟸   ENSRNOT00000007187
Ensembl Acc Id: ENSRNOP00000046697   ⟸   ENSRNOT00000040737
Ensembl Acc Id: ENSRNOP00000094374   ⟸   ENSRNOT00000120110
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R426-F1-model_v2 AlphaFold Q8R426 1-227 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70886 AgrOrtholog
BioCyc Gene G2FUF-25594 BioCyc
Ensembl Genes ENSRNOG00000005365 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055002929 UniProtKB/Swiss-Prot
  ENSRNOG00060002790 UniProtKB/Swiss-Prot
  ENSRNOG00065009508 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007187 UniProtKB/TrEMBL
  ENSRNOT00000007187.6 UniProtKB/Swiss-Prot
  ENSRNOT00000040737.3 UniProtKB/TrEMBL
  ENSRNOT00000079031.2 UniProtKB/TrEMBL
  ENSRNOT00000083090 UniProtKB/TrEMBL
  ENSRNOT00000083090.2 UniProtKB/Swiss-Prot
  ENSRNOT00000120110.1 UniProtKB/TrEMBL
  ENSRNOT00055004580 UniProtKB/Swiss-Prot
  ENSRNOT00060004491 UniProtKB/Swiss-Prot
  ENSRNOT00065015217 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recoverin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65023 UniProtKB/Swiss-Prot
NCBI Gene 65023 ENTREZGENE
PANTHER KV CHANNEL-INTERACTING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23055 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnip1 PhenoGen
PRINTS RECOVERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005365 RatGTEx
  ENSRNOG00055002929 RatGTEx
  ENSRNOG00060002790 RatGTEx
  ENSRNOG00065009508 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K701 ENTREZGENE, UniProtKB/TrEMBL
  A0A0H2UHE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0H2UHY1 ENTREZGENE
  A0A8I6ALG6 ENTREZGENE, UniProtKB/TrEMBL
  A6HDH0 ENTREZGENE, UniProtKB/TrEMBL
  A6HDH1_RAT UniProtKB/TrEMBL
  A6HDH2_RAT UniProtKB/TrEMBL
  A6HDH3_RAT UniProtKB/TrEMBL
  KCIP1_RAT UniProtKB/Swiss-Prot
  Q793P9 ENTREZGENE
  Q8CIR1 ENTREZGENE
  Q8R425 ENTREZGENE
  Q8R426 ENTREZGENE
UniProt Secondary A0A0H2UHY1 UniProtKB/TrEMBL
  Q793P9 UniProtKB/Swiss-Prot
  Q8CIR1 UniProtKB/Swiss-Prot
  Q8R425 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnip1  potassium voltage-gated channel interacting protein 1  Kcnip1  Kv channel-interacting protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Kcnip1  Kv channel-interacting protein 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process coexpression of the two splice variants with Kv4.2 channels in oocytes slows the K current decay and destabilizes the open-inactivated channel gating 724600
gene_product member of the rapidly inactivating K channels in brain and heart 724600