Dbn1 (drebrin 1) - Rat Genome Database

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Gene: Dbn1 (drebrin 1) Rattus norvegicus
Analyze
Symbol: Dbn1
Name: drebrin 1
RGD ID: 70885
Description: Enables actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in several processes, including regulation of nervous system process; regulation of organelle organization; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including actin filament; axon; and dendrite. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic membrane. Biomarker of Parkinson's disease; cognitive disorder; sciatic neuropathy; temporal lobe epilepsy; and transient cerebral ischemia. Orthologous to human DBN1 (drebrin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: developmentally-regulated brain protein; drebrin; drebrin E
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,155,729 - 9,170,121 (+)NCBIGRCr8
mRatBN7.2179,150,608 - 9,164,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,150,659 - 9,164,984 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,166,818 - 9,180,807 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,696,845 - 10,710,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,163,206 - 9,177,195 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,679,511 - 9,693,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,679,628 - 9,693,820 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,788,527 - 11,802,863 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,194,687 - 15,208,660 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,194,686 - 15,208,660 (+)NCBI
Celera179,229,222 - 9,243,194 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flavonoids  (EXP)
FR900359  (ISO)
furan  (EXP)
gallic acid  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 415286  (EXP)
sevoflurane  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO,ISS)
cell communication by chemical coupling  (IEA,ISO)
cell communication by electrical coupling  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IDA)
cellular response to tumor necrosis factor  (IDA)
cellular response to X-ray  (IEP)
cytoplasmic sequestering of protein  (IEA,ISO,ISS)
generation of neurons  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lung alveolus development  (IEP)
maintenance of protein location in cell  (IEA,ISO)
modulation of inhibitory postsynaptic potential  (IMP)
negative regulation of actin filament bundle assembly  (IDA)
negative regulation of locomotion involved in locomotory behavior  (IMP)
negative regulation of muscle filament sliding  (IDA)
nervous system development  (IEP)
neural precursor cell proliferation  (IEA,ISO)
neuron projection morphogenesis  (IBA)
positive regulation of axon extension  (IBA,IMP)
positive regulation of cell-substrate adhesion  (IDA)
positive regulation of dendritic spine morphogenesis  (IBA,IEA,IMP,ISO,ISS)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of neuron projection development  (IDA,IMP)
positive regulation of receptor localization to synapse  (IEA,ISO,ISS)
positive regulation of substrate adhesion-dependent cell spreading  (IDA)
positive regulation of synaptic plasticity  (IEA,ISO,ISS)
postsynaptic actin cytoskeleton organization  (IBA,IDA,IMP)
prepulse inhibition  (IMP)
regulation of actin filament polymerization  (IBA,IMP)
regulation of filopodium assembly  (IMP)
regulation of postsynaptic density protein 95 clustering  (IMP)
response to activity  (IEP)
response to xenobiotic stimulus  (IEP)
spermatogenesis  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1. Ambrosi C, etal., PLoS One. 2016 Jun 9;11(6):e0157073. doi: 10.1371/journal.pone.0157073. eCollection 2016.
2. Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. Aoki C, etal., J Comp Neurol. 2005 Mar 21;483(4):383-402.
3. Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice. Aoki C, etal., J Comp Neurol. 2007 Dec 1;505(4):352-62.
4. Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. Counts SE, etal., J Neuropathol Exp Neurol. 2006 Jun;65(6):592-601.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
8. Guided motor training induces dendritic spine plastic changes in adult rat cerebellar purkinje cells. Gonzalez-Burgos I, etal., Neurosci Lett. 2011 Mar 24;491(3):216-20. doi: 10.1016/j.neulet.2011.01.043. Epub 2011 Jan 22.
9. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. Harigaya Y, etal., J Neurosci Res. 1996 Jan 1;43(1):87-92.
10. Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons. Hayashi K and Shirao T, J Neurosci. 1999 May 15;19(10):3918-25.
11. Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. Hayashi K, etal., J Neurosci. 1996 Nov 15;16(22):7161-70.
12. Effect of a neuron-specific actin-binding protein, drebrin A, on cell-substratum adhesion. Ikeda K, etal., Neurosci Lett. 1995 Jul 21;194(3):197-200.
13. Drebrin attenuates the interaction between actin and myosin-V. Ishikawa R, etal., Biochem Biophys Res Commun. 2007 Jul 27;359(2):398-401. Epub 2007 May 25.
14. Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons. Ivanov A, etal., J Cell Sci. 2009 Feb 15;122(Pt 4):524-34. doi: 10.1242/jcs.033464. Epub 2009 Jan 27.
15. Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology. Julien C, etal., J Neurosci Res. 2008 Aug 1;86(10):2292-302. doi: 10.1002/jnr.21667.
16. Antisense knockdown of drebrin A, a dendritic spine protein, causes stronger preference, impaired pre-pulse inhibition, and an increased sensitivity to psychostimulant. Kobayashi R, etal., Neurosci Res. 2004 Jun;49(2):205-17.
17. Drebrin expression is increased in spinal motoneurons of rats after axotomy. Kobayashi S, etal., Neurosci Lett. 2001 Oct 5;311(3):165-8.
18. Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Kojima N, etal., Neuroscience. 2010 Jan 13;165(1):138-50. doi: 10.1016/j.neuroscience.2009.10.016. Epub 2009 Oct 24.
19. Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN. Kreis P, etal., PLoS One. 2013 Aug 5;8(8):e71957. doi: 10.1371/journal.pone.0071957. Print 2013.
20. Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis. Li MW, etal., Spermatogenesis. 2011 Apr;1(2):123-136.
21. Interactions of drebrin and gephyrin with profilin. Mammoto A, etal., Biochem Biophys Res Commun. 1998 Feb 4;243(1):86-9.
22. Gene Data Set MGD Curation, June 12, 2002
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions. Mizui T, etal., J Neurochem. 2009 Apr;109(2):611-22. doi: 10.1111/j.1471-4159.2009.05993.x. Epub 2009 Feb 13.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia. Nishijima H, etal., Neuropathology. 2013 Aug;33(4):391-6. doi: 10.1111/neup.12009. Epub 2012 Dec 13.
27. Drebrin (developmentally regulated brain protein) is associated with axo-somatic synapses and neuronal gap junctions in rat mesencephalic trigeminal nucleus. Park H, etal., Neurosci Lett. 2009 Sep 18;461(2):95-9. doi: 10.1016/j.neulet.2009.06.027. Epub 2009 Jun 17.
28. F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse. Perez-Martinez M, etal., J Cell Sci. 2010 Apr 1;123(Pt 7):1160-70. doi: 10.1242/jcs.064238. Epub 2010 Mar 9.
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. [The changes of central nervous synapses after transient cerebral ischemia]. Saruki N, Masui. 1995 Dec;44(12):1639-47.
32. Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones. Sasaki Y, etal., J Neurochem. 1996 Mar;66(3):980-8.
33. Drebrin A expression is altered after pilocarpine-induced seizures: time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells. Sbai O, etal., Hippocampus. 2012 Mar;22(3):477-93. doi: 10.1002/hipo.20914. Epub 2011 Jan 14.
34. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Shim KS and Lubec G, Neurosci Lett. 2002 May 24;324(3):209-12.
35. Differential expression of rat brain synaptic proteins in development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 1998 Oct 9;251(1):394-8.
36. X irradiation changes dendritic spine morphology and density through reduction of cytoskeletal proteins in mature neurons. Shirai K, etal., Radiat Res. 2013 Jun;179(6):630-6. doi: 10.1667/RR3098.1. Epub 2013 Apr 11.
37. Cloning of drebrin A and induction of neurite-like processes in drebrin-transfected cells. Shirao T, etal., Neuroreport 1992 Jan;3(1):109-12.
38. Expression of drebrin E in migrating neuroblasts in adult rat brain: coincidence between drebrin E disappearance from cell body and cessation of migration. Song M, etal., Neuroscience. 2008 Mar 27;152(3):670-82. doi: 10.1016/j.neuroscience.2007.10.068. Epub 2008 Jan 19.
39. Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. Takahashi H, etal., J Neurosci. 2003 Jul 23;23(16):6586-95.
40. Suppression of an actin-binding protein, drebrin, by antisense transfection attenuates neurite outgrowth in neuroblastoma B104 cells. Toda M, etal., Brain Res Dev Brain Res. 1999 May 14;114(2):193-200.
41. Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. VanGuilder HD, etal., Neurobiol Dis. 2011 Jul;43(1):201-12. doi: 10.1016/j.nbd.2011.03.012. Epub 2011 Apr 1.
42. Temporal expression of alpha-smooth muscle actin and drebrin in septal interstitial cells during alveolar maturation. Yamada M, etal., J Histochem Cytochem. 2005 Jun;53(6):735-44.
43. Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines. Yamazaki H, etal., J Neurochem. 2014 Feb;128(4):507-22. doi: 10.1111/jnc.12486. Epub 2013 Nov 13.
44. Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress. Yang HJ, etal., Neurosci Lett. 2003 Nov 20;351(3):206-8.
Additional References at PubMed
PMID:11991718   PMID:12477932   PMID:15084279   PMID:16054392   PMID:16368245   PMID:16456930   PMID:17559090   PMID:18588530   PMID:18806788   PMID:20131911   PMID:20882566   PMID:23979715  
PMID:24327345   PMID:24465547   PMID:24625528   PMID:24720729   PMID:24814707   PMID:25002582   PMID:25468996   PMID:25865831   PMID:27996060   PMID:28553222   PMID:28865017   PMID:28865027  
PMID:28966017   PMID:29476059   PMID:30053369   PMID:34478582   PMID:35352799  


Genomics

Comparative Map Data
Dbn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,155,729 - 9,170,121 (+)NCBIGRCr8
mRatBN7.2179,150,608 - 9,164,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,150,659 - 9,164,984 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,166,818 - 9,180,807 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,696,845 - 10,710,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,163,206 - 9,177,195 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,679,511 - 9,693,878 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,679,628 - 9,693,820 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,788,527 - 11,802,863 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,194,687 - 15,208,660 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,194,686 - 15,208,660 (+)NCBI
Celera179,229,222 - 9,243,194 (+)NCBICelera
Cytogenetic Map17p14NCBI
DBN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,456,610 - 177,473,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,456,608 - 177,474,401 (-)EnsemblGRCh38hg38GRCh38
GRCh375176,883,611 - 176,900,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,816,220 - 176,833,271 (-)NCBINCBI36Build 36hg18NCBI36
Build 345176,816,219 - 176,832,805NCBI
Celera5171,601,010 - 171,618,030 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,803,862 - 171,820,946 (-)NCBIHuRef
CHM1_15176,316,642 - 176,333,751 (-)NCBICHM1_1
T2T-CHM13v2.05177,999,656 - 178,023,769 (-)NCBIT2T-CHM13v2.0
Dbn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,621,241 - 55,635,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,621,242 - 55,635,924 (-)EnsemblGRCm39 Ensembl
GRCm381355,473,428 - 55,488,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,473,429 - 55,488,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,574,789 - 55,589,437 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,483,409 - 55,497,790 (-)NCBIMGSCv36mm8
Celera1356,527,471 - 56,542,117 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
Dbn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,696,266 - 29,705,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,695,442 - 29,705,417 (-)NCBIChiLan1.0ChiLan1.0
DBN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,540,928 - 172,557,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,680,775 - 170,697,165 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,758,316 - 172,774,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,820,791 - 179,833,546 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,820,791 - 179,836,872 (-)Ensemblpanpan1.1panPan2
DBN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,899,969 - 35,913,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,889,392 - 35,912,507 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,866,175 - 35,880,615 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,265,157 - 36,279,633 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,240,908 - 36,279,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,090,417 - 36,104,899 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,276,383 - 36,290,861 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,785,850 - 36,800,327 (+)NCBIUU_Cfam_GSD_1.0
Dbn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,710,677 - 122,722,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,735,380 - 1,747,569 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365971,735,589 - 1,751,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,479,460 - 80,495,796 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,480,603 - 80,495,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DBN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,468,010 - 79,484,603 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,467,647 - 79,484,592 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,659,367 - 10,676,337 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dbn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,616,423 - 12,632,133 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,616,537 - 12,631,967 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dbn1
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:349
Count of miRNA genes:184
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000019393, ENSRNOT00000019569
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
RH128442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,164,466 - 9,164,678 (+)MAPPERmRatBN7.2
Rnor_6.0179,693,366 - 9,693,577NCBIRnor6.0
Rnor_5.01711,802,350 - 11,802,561UniSTSRnor5.0
RGSC_v3.41715,208,441 - 15,208,652UniSTSRGSC3.4
Celera179,242,975 - 9,243,186UniSTS
RH 3.4 Map1776.4UniSTS
Cytogenetic Map17p14UniSTS
UniSTS:237020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,164,659 - 9,164,756 (+)MAPPERmRatBN7.2
Rnor_6.0179,693,559 - 9,693,655NCBIRnor6.0
Rnor_5.01711,802,543 - 11,802,639UniSTSRnor5.0
RGSC_v3.41715,208,634 - 15,208,730UniSTSRGSC3.4
Celera179,243,168 - 9,243,264UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019393   ⟹   ENSRNOP00000019393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,150,659 - 9,164,984 (+)Ensembl
Rnor_6.0 Ensembl179,679,665 - 9,693,083 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000019569   ⟹   ENSRNOP00000019569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,150,659 - 9,164,984 (+)Ensembl
Rnor_6.0 Ensembl179,679,628 - 9,693,820 (+)Ensembl
RefSeq Acc Id: NM_031024   ⟹   NP_112286
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,155,856 - 9,169,828 (+)NCBI
mRatBN7.2179,150,713 - 9,164,686 (+)NCBI
Rnor_6.0179,679,612 - 9,693,585 (+)NCBI
Rnor_5.01711,788,527 - 11,802,863 (+)NCBI
RGSC_v3.41715,194,687 - 15,208,660 (+)RGD
Celera179,229,222 - 9,243,194 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253655   ⟹   XP_006253717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,155,754 - 9,170,121 (+)NCBI
mRatBN7.2179,150,608 - 9,164,979 (+)NCBI
Rnor_6.0179,679,511 - 9,693,878 (+)NCBI
Rnor_5.01711,788,527 - 11,802,863 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253656   ⟹   XP_006253718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,155,729 - 9,170,121 (+)NCBI
mRatBN7.2179,150,608 - 9,164,979 (+)NCBI
Rnor_6.0179,679,512 - 9,693,878 (+)NCBI
Rnor_5.01711,788,527 - 11,802,863 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253657   ⟹   XP_006253719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,155,751 - 9,170,121 (+)NCBI
mRatBN7.2179,150,609 - 9,164,982 (+)NCBI
Rnor_6.0179,679,512 - 9,693,878 (+)NCBI
Rnor_5.01711,788,527 - 11,802,863 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063276771   ⟹   XP_063132841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,155,753 - 9,170,121 (+)NCBI
RefSeq Acc Id: NP_112286   ⟸   NM_031024
- UniProtKB: A5D6R1 (UniProtKB/Swiss-Prot),   O70205 (UniProtKB/Swiss-Prot),   Q07266 (UniProtKB/Swiss-Prot),   A6KAS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253717   ⟸   XM_006253655
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHL9 (UniProtKB/TrEMBL),   A6KAS2 (UniProtKB/TrEMBL),   A6KAS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253718   ⟸   XM_006253656
- Peptide Label: isoform X2
- UniProtKB: C6L8E0 (UniProtKB/TrEMBL),   A6KAS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253719   ⟸   XM_006253657
- Peptide Label: isoform X3
- UniProtKB: A6KAS3 (UniProtKB/TrEMBL),   A6KAS4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019569   ⟸   ENSRNOT00000019569
Ensembl Acc Id: ENSRNOP00000019393   ⟸   ENSRNOT00000019393
RefSeq Acc Id: XP_063132841   ⟸   XM_063276771
- Peptide Label: isoform X4
Protein Domains
ADF-H

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07266-F1-model_v2 AlphaFold Q07266 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700305
Promoter ID:EPDNEW_R10827
Type:initiation region
Name:Dbn1_1
Description:drebrin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,679,552 - 9,679,612EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70885 AgrOrtholog
BioCyc Gene G2FUF-10207 BioCyc
Ensembl Genes ENSRNOG00000014170 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019393.5 UniProtKB/Swiss-Prot
  ENSRNOT00000019569.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8368018 IMAGE-MGC_LOAD
InterPro ADF-H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81653 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156631 IMAGE-MGC_LOAD
NCBI Gene 81653 ENTREZGENE
PANTHER CORTACTIN AND DREBRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10829:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cofilin_ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dbn1 PhenoGen
PROSITE ADF_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014170 RatGTEx
SMART ADF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHL9 ENTREZGENE, UniProtKB/TrEMBL
  A5D6R1 ENTREZGENE
  A6KAS2 ENTREZGENE, UniProtKB/TrEMBL
  A6KAS3 ENTREZGENE, UniProtKB/TrEMBL
  A6KAS4 ENTREZGENE, UniProtKB/TrEMBL
  A6KAS5_RAT UniProtKB/TrEMBL
  C6L8E0 ENTREZGENE, UniProtKB/TrEMBL
  DREB_RAT UniProtKB/Swiss-Prot
  O70205 ENTREZGENE
  Q07266 ENTREZGENE
UniProt Secondary A5D6R1 UniProtKB/Swiss-Prot
  O70205 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dbn1  drebrin 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization present at submembraneous regions 70708
gene_expression expressed in dendrites of the adult brain 70708