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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Stxbp5 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STXBP5 mRNA | CTD | PMID:22079256 | Stxbp5 | Rat | 1,2-dimethylhydrazine | affects expression | ISO | Stxbp5 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of STXBP5 mRNA | CTD | PMID:22206623 | Stxbp5 | Rat | 17beta-estradiol | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Norethindrone Acetate] results in increased expression of STXBP5 mRNA | CTD | PMID:22217510 | Stxbp5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Stxbp5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STXBP5 mRNA | CTD | PMID:21354282 | Stxbp5 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of STXBP5 mRNA | CTD | PMID:34747641 | Stxbp5 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of STXBP5 mRNA | CTD | PMID:21346803 | Stxbp5 | Rat | 2,6-dimethoxyphenol | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of STXBP5 protein | CTD | PMID:38598786 | Stxbp5 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of STXBP5 mRNA | CTD | PMID:21346803 | Stxbp5 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:30851411 | Stxbp5 | Rat | 2-palmitoylglycerol | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of STXBP5 mRNA | CTD | PMID:37199045 | Stxbp5 | Rat | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of STXBP5 mRNA | CTD | PMID:21346803 | Stxbp5 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of STXBP5 mRNA | CTD | PMID:28959563 | Stxbp5 | Rat | aflatoxin B1 | increases methylation | ISO | STXBP5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of STXBP5 intron | CTD | PMID:30157460 | Stxbp5 | Rat | all-trans-retinoic acid | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of STXBP5 mRNA | CTD | PMID:33167477 | Stxbp5 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of STXBP5 mRNA | CTD | PMID:16483693 | Stxbp5 | Rat | antirheumatic drug | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of STXBP5 mRNA | CTD | PMID:24449571 | Stxbp5 | Rat | aristolochic acid A | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of STXBP5 mRNA | CTD | PMID:33212167 | Stxbp5 | Rat | benzo[a]pyrene | decreases methylation | ISO | Stxbp5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of STXBP5 intron | CTD | PMID:27901495 | Stxbp5 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of STXBP5 mRNA | CTD | PMID:25181051 | Stxbp5 | Rat | bisphenol A | decreases expression | ISO | Stxbp5 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of STXBP5 mRNA | CTD | PMID:32156529 | Stxbp5 | Rat | bisphenol A | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of STXBP5 protein | CTD | PMID:33376534 | Stxbp5 | Rat | bisphenol A | decreases methylation | ISO | STXBP5 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of STXBP5 gene | CTD | PMID:31601247 | Stxbp5 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of STXBP5 gene | CTD | PMID:28505145 | Stxbp5 | Rat | cadmium atom | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of STXBP5 mRNA | CTD | PMID:35301059 | Stxbp5 | Rat | cadmium dichloride | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of STXBP5 mRNA | CTD | PMID:35301059 | Stxbp5 | Rat | caffeine | decreases phosphorylation | ISO | STXBP5 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of STXBP5 protein | CTD | PMID:35688186 | Stxbp5 | Rat | CGP 52608 | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to STXBP5 gene] | CTD | PMID:28238834 | Stxbp5 | Rat | choline | multiple interactions | ISO | Stxbp5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STXBP5 gene | CTD | PMID:20938992 | Stxbp5 | Rat | chromium(6+) | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | chromium hexavalent ion results in decreased expression of STXBP5 mRNA | CTD | PMID:30690063 | Stxbp5 | Rat | cyclosporin A | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of STXBP5 mRNA | CTD | PMID:20106945 and PMID:25562108 | Stxbp5 | Rat | Dibutyl phosphate | affects expression | ISO | STXBP5 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of STXBP5 mRNA | CTD | PMID:37042841 | Stxbp5 | Rat | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of STXBP5 mRNA | CTD | PMID:37077353 | Stxbp5 | Rat | dorsomorphin | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Stxbp5 | Rat | doxorubicin | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of STXBP5 mRNA | CTD | PMID:29803840 | Stxbp5 | Rat | ethanol | affects splicing | ISO | Stxbp5 (Mus musculus) | 6480464 | Ethanol affects the splicing of STXBP5 mRNA | CTD | PMID:30319688 | Stxbp5 | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of STXBP5 mRNA | CTD | PMID:30307764 | Stxbp5 | Rat | folic acid | multiple interactions | ISO | Stxbp5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STXBP5 gene | CTD | PMID:20938992 | Stxbp5 | Rat | folic acid | decreases expression | ISO | Stxbp5 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:25629700 | Stxbp5 | Rat | formaldehyde | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of STXBP5 mRNA | CTD | PMID:23649840 | Stxbp5 | Rat | FR900359 | increases phosphorylation | ISO | STXBP5 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of STXBP5 protein | CTD | PMID:37730182 | Stxbp5 | Rat | furfural | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in decreased expression of and affects the localization of STXBP5 protein | CTD | PMID:38598786 | Stxbp5 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of STXBP5 mRNA | CTD | PMID:33387578 | Stxbp5 | Rat | ivermectin | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of STXBP5 protein | CTD | PMID:32959892 | Stxbp5 | Rat | ketoconazole | decreases expression | EXP | | 6480464 | Ketoconazole results in decreased expression of STXBP5 mRNA | CTD | PMID:37077353 | Stxbp5 | Rat | L-methionine | multiple interactions | ISO | Stxbp5 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STXBP5 gene | CTD | PMID:20938992 | Stxbp5 | Rat | methylmercury chloride | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of STXBP5 mRNA | CTD | PMID:28001369 | Stxbp5 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STXBP5 mRNA | CTD | PMID:25729387 | Stxbp5 | Rat | ozone | multiple interactions | ISO | Stxbp5 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of STXBP5 mRNA | CTD | PMID:27106289 | Stxbp5 | Rat | paracetamol | affects expression | ISO | Stxbp5 (Mus musculus) | 6480464 | Acetaminophen affects the expression of STXBP5 mRNA | CTD | PMID:17562736 | Stxbp5 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of STXBP5 mRNA | CTD | PMID:33387578 | Stxbp5 | Rat | phenylmercury acetate | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of STXBP5 mRNA | CTD | PMID:26272509 | Stxbp5 | Rat | phenylmercury acetate | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP5 mRNA | CTD | PMID:27188386 | Stxbp5 | Rat | pirinixic acid | multiple interactions | ISO | Stxbp5 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STXBP5 mRNA | CTD | PMID:19710929 | Stxbp5 | Rat | potassium chromate | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STXBP5 mRNA | CTD | PMID:22079256 | Stxbp5 | Rat | potassium chromate | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of STXBP5 mRNA | CTD | PMID:22079256 and PMID:22714537 | Stxbp5 | Rat | potassium dichromate | increases expression | ISO | Stxbp5 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of STXBP5 mRNA | CTD | PMID:23608068 | Stxbp5 | Rat | quercetin | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of STXBP5 mRNA | CTD | PMID:21632981 | Stxbp5 | Rat | rac-lactic acid | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:30851411 | Stxbp5 | Rat | SB 431542 | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Stxbp5 | Rat | sodium arsenate | increases expression | ISO | Stxbp5 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of STXBP5 mRNA | CTD | PMID:21795629 | Stxbp5 | Rat | sodium arsenite | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of STXBP5 mRNA | CTD | PMID:38568856 | Stxbp5 | Rat | sodium chloride | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in decreased expression of and affects the localization of STXBP5 protein more ... | CTD | PMID:38598786 | Stxbp5 | Rat | succimer | multiple interactions | ISO | Stxbp5 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of STXBP5 mRNA | CTD | PMID:21641980 | Stxbp5 | Rat | tetrachloromethane | affects expression | ISO | Stxbp5 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of STXBP5 mRNA | CTD | PMID:17484886 | Stxbp5 | Rat | titanium dioxide | increases methylation | ISO | Stxbp5 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of STXBP5 gene and titanium dioxide results in increased methylation of STXBP5 promoter | CTD | PMID:35295148 | Stxbp5 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of STXBP5 mRNA | CTD | PMID:25729387 | Stxbp5 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of STXBP5 mRNA | CTD | PMID:25729387 | Stxbp5 | Rat | trichostatin A | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of STXBP5 mRNA | CTD | PMID:24935251 and PMID:26272509 | Stxbp5 | Rat | trichostatin A | multiple interactions | ISO | STXBP5 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP5 mRNA | CTD | PMID:27188386 | Stxbp5 | Rat | triphenyl phosphate | affects expression | ISO | STXBP5 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of STXBP5 mRNA | CTD | PMID:37042841 | Stxbp5 | Rat | trovafloxacin | decreases expression | ISO | Stxbp5 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of STXBP5 mRNA | CTD | PMID:35537566 | Stxbp5 | Rat | tungsten | decreases expression | ISO | Stxbp5 (Mus musculus) | 6480464 | Tungsten results in decreased expression of STXBP5 mRNA | CTD | PMID:30912803 | Stxbp5 | Rat | urethane | increases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Urethane results in increased expression of STXBP5 mRNA | CTD | PMID:28818685 | Stxbp5 | Rat | valproic acid | decreases expression | ISO | STXBP5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of STXBP5 mRNA | CTD | PMID:23179753 and PMID:28001369 | |