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Gene: Slc45a1 (solute carrier family 45, member 1) Rattus norvegicus

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Symbol:

Slc45a1

Name:

solute carrier family 45, member 1

RGD ID:

708502

Description:

Enables D-glucose:proton symporter activity and galactose:proton symporter activity. Involved in D-glucose transmembrane transport and galactose transmembrane transport. Predicted to be active in membrane. Orthologous to human SLC45A1 (solute carrier family 45 member 1); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Dnb5; Past-A; Pasta; proton-associated sugar transporter A; solute carrier family 45 member 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC45A1 (solute carrier family 45 member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Slc45a1 (solute carrier family 45, member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc45a1 (solute carrier family 45 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC45A1 (solute carrier family 45 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC45A1 (solute carrier family 45 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc45a1 (solute carrier family 45 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC45A1 (solute carrier family 45 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC45A1 (solute carrier family 45 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc45a1 (solute carrier family 45 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC45A1 (solute carrier family 45 member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc45a1 (solute carrier family 45, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc45a1 (solute carrier family 45 member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG45782	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc45a1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	166,388,115 - 166,412,183 (-)	NCBI		GRCr8
mRatBN7.2	5	161,105,137 - 161,129,375 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	161,105,235 - 161,129,303 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	163,821,902 - 163,846,153 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,641,057 - 165,665,239 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,600,544 - 165,624,787 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,672,134 - 167,696,331 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,672,145 - 167,696,348 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	171,299,997 - 171,322,391 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	167,784,827 - 167,807,254 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	167,795,015 - 167,817,442 (-)	NCBI
Celera	5	159,360,991 - 159,384,477 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 1p36 deletion syndrome (ISO)

epilepsy (ISO)

INTELLECTUAL DEVELOPMENTAL DISORDER WITH NEUROPSYCHIATRIC FEATURES (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

dibutyl phthalate (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

fulvestrant (ISO)

glyphosate (EXP)

hydrazine (ISO)

L-methionine (ISO)

N,N-diethyl-m-toluamide (EXP)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

paracetamol (ISO)

permethrin (EXP)

phenethyl caffeate (EXP)

pirinixic acid (ISO)

propanal (ISO)

silicon dioxide (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

D-glucose transmembrane transport (IEA,IMP,ISO)

galactose transmembrane transport (IDA)

proton transmembrane transport (IEA)

sucrose transport (IEA)

Cellular Component

membrane (IBA,IEA)

Molecular Function

D-glucose:proton symporter activity (IDA,IEA,IMP,ISO)

galactose:proton symporter activity (IDA)

sucrose:proton symporter activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain.	Shimokawa N, etal., J Neurosci 2002 Nov 1;22(21):9160-5.
6.	Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy.	Srour M, etal., Am J Hum Genet. 2017 May 4;100(5):824-830. doi: 10.1016/j.ajhg.2017.03.009. Epub 2017 Apr 20.

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Slc45a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	166,388,115 - 166,412,183 (-)	NCBI		GRCr8
mRatBN7.2	5	161,105,137 - 161,129,375 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	161,105,235 - 161,129,303 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	163,821,902 - 163,846,153 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,641,057 - 165,665,239 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,600,544 - 165,624,787 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,672,134 - 167,696,331 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,672,145 - 167,696,348 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	171,299,997 - 171,322,391 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	167,784,827 - 167,807,254 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	167,795,015 - 167,817,442 (-)	NCBI
Celera	5	159,360,991 - 159,384,477 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

SLC45A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	8,318,114 - 8,344,165 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	8,318,114 - 8,344,167 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	8,378,174 - 8,404,225 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	8,306,977 - 8,326,814 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	8,324,463 - 8,338,480	NCBI
Celera	1	7,492,236 - 7,512,007 (+)	NCBI		Celera
Cytogenetic Map	1	p36.23	NCBI
HuRef	1	7,532,573 - 7,552,503 (+)	NCBI		HuRef
CHM1_1	1	8,373,365 - 8,393,233 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	7,849,807 - 7,876,669 (+)	NCBI		T2T-CHM13v2.0

Slc45a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	150,713,853 - 150,736,614 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	150,713,029 - 150,736,631 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	150,629,396 - 150,652,176 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	150,628,572 - 150,652,174 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	150,003,505 - 150,026,283 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	149,473,196 - 149,495,974 (-)	NCBI		MGSCv36	mm8
Celera	4	152,906,467 - 152,928,714 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	81.44	NCBI

Slc45a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	4,701,991 - 4,716,939 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	4,701,889 - 4,732,008 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC45A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	219,886,438 - 219,918,027 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	218,531,186 - 218,559,560 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	7,071,109 - 7,102,698 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	8,314,224 - 8,340,248 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	8,314,224 - 8,340,248 (+)	Ensembl	panpan1.1		panPan2

SLC45A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	61,838,062 - 61,861,411 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	61,841,451 - 61,862,421 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	61,847,107 - 61,870,449 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	62,054,673 - 62,078,223 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	62,058,118 - 62,078,213 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	62,053,637 - 62,077,147 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	61,918,239 - 61,941,521 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	62,322,460 - 62,345,778 (+)	NCBI		UU_Cfam_GSD_1.0

Slc45a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	32,169,174 - 32,186,762 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936623	2,658,897 - 2,673,024 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936623	2,658,996 - 2,671,993 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC45A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	68,933,912 - 68,950,530 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	68,933,918 - 68,950,534 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	63,294,889 - 63,417,949 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC45A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	123,416,912 - 123,443,016 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	123,416,882 - 123,442,548 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	27,445,462 - 27,471,412 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc45a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	3,654,007 - 3,665,579 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	3,653,999 - 3,669,433 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc45a1
198 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	66
Count of miRNA genes:	63
Interacting mature miRNAs:	66
Transcripts:	ENSRNOT00000024581
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	151006154	161165494	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat

Markers in Region

SHGC-74183

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	161,095,599 - 161,095,773 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	167,662,428 - 167,662,601	NCBI	Rnor6.0
Rnor_5.0	5	171,290,435 - 171,290,608	UniSTS	Rnor5.0
RGSC_v3.4	5	167,775,193 - 167,775,366	UniSTS	RGSC3.4
Celera	5	159,351,438 - 159,351,611	UniSTS
Cytogenetic Map	5	q36	UniSTS

BI276205

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	161,095,586 - 161,095,767 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	167,662,415 - 167,662,595	NCBI	Rnor6.0
Rnor_5.0	5	171,290,422 - 171,290,602	UniSTS	Rnor5.0
RGSC_v3.4	5	167,775,180 - 167,775,360	UniSTS	RGSC3.4
Celera	5	159,351,425 - 159,351,605	UniSTS
RH 3.4 Map	5	1122.6	UniSTS
Cytogenetic Map	5	q36	UniSTS

BE095521

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	161,120,136 - 161,120,338 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	167,686,989 - 167,687,190	NCBI	Rnor6.0
Rnor_5.0	5	171,314,179 - 171,314,380	UniSTS	Rnor5.0
RGSC_v3.4	5	167,798,092 - 167,798,293	UniSTS	RGSC3.4
Celera	5	159,375,721 - 159,375,922	UniSTS
RH 3.4 Map	5	1121.4	UniSTS
Cytogenetic Map	5	q36	UniSTS

AI548909

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	161,097,434 - 161,097,524 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	167,664,263 - 167,664,352	NCBI	Rnor6.0
Rnor_5.0	5	171,292,270 - 171,292,359	UniSTS	Rnor5.0
RGSC_v3.4	5	167,777,028 - 167,777,117	UniSTS	RGSC3.4
Celera	5	159,353,273 - 159,353,362	UniSTS
RH 3.4 Map	5	1121.7	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	6	38	113	57	56	25	23	25	6	151	82	93	31	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_144747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB075229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC093599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024581 ⟹ ENSRNOP00000024581

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	161,105,235 - 161,129,303 (-)	Ensembl
Rnor_6.0 Ensembl	5	167,672,145 - 167,696,348 (-)	Ensembl

RefSeq Acc Id:

NM_144747 ⟹ NP_653348

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	166,388,115 - 166,412,183 (-)	NCBI
mRatBN7.2	5	161,105,235 - 161,129,303 (-)	NCBI
Rnor_6.0	5	167,672,134 - 167,696,331 (-)	NCBI
Rnor_5.0	5	171,299,997 - 171,322,391 (-)	NCBI
RGSC_v3.4	5	167,784,827 - 167,807,254 (-)	RGD
Celera	5	159,360,991 - 159,384,477 (-)	RGD

Sequence:

show sequence

CGGAGCTGTACCCGGGAGAACCAGGAGCCCAGCCTGGGAAAGGGATGCCTCCCGTCTGGACGCA
CAGCGACGCCCACCAGCCCTGCCTATGATGATCCCCCCAGCAGGCAGCACCCCTCCGGGAGAGG
CCCTCATCCCCAGTGTGGCTCCTCAGGACTTCTGGAGGTCTCCCATCTCCAGCTACTCAGGGTC
CGTGACACGACATATCAGCCACCGGGCCAACAACTTCAAACGCCACCCCAAGAGGAGGAAGTAC
ATTCGGCCCTCTCCACCCCCACCCCCCAACACCCCATGTCCCATTGAGCTGGTGGACTTTGAGG
ACTTGCACCCGCAGAGGTCCTTTTGGGAGCTGCTCTTCAATGGCTGCATTCTGTTTGGAATCGA
GTTCAGCTACGCCATGGAGACAGCGTACGTGACTCCAGTACTCCTGCAAATGGGCCTGCCTGAC
CAGCTCTACAGCCTAGTGTGGTTCATCAGCCCCATCCTCGGATTCTTGCTGCAGCCTCTGTTGG
GTGCCTGGAGTGACCGATGTACCTCAAGGTTTGGAAGGAGACGCCCTTTCATTCTTGTCCTGGC
CATAGGGGCGTTGCTGGGCCTCTCGCTCCTGCTCAATGGAAGGGACATTGGTATGGCCCTGGCT
GACACAGCCACCAATCACAAGTGGGGCATCCTCCTGACGGTATGCGGGGTGGTGCTGATGGACT
TCAGTGCAGACTCAGCAGATAACCCCAGCCACGCCTACATGATGGACGTGTGTGGCCCGGTGGA
CCAGGACCGGGGCCTGAACATCCATGCCCTCATGGCGGGTCTTGGAGGAGGGTTCGGCTACGTG
GTCGGAGGCATCCACTGGGACAAGACCAGCTTTGGGAGGGCCCTGGGGGGTCAGCTCCGCGTCA
TCTACATCTTCACAGCCATAACCCTTAGTGTCACCACCGTGCTCACCCTGGTTAGCATCCCCGA
GAGGCCCCTTCGGCCACTGGGAGAGAAGAGGACAGCTATGAAGAGCCCAAGTCTCCCACTGCCC
CCCTCCCCACCTGTCTTGTTGGAGGAGGGGGCGGGTGACACCCTCCCCTCTACTACAGCCACCA
GCTTGTACGCCAGTTTCTCCAGCCCCATCTCGCCACCCAGCCCGCTCACCCCCAAGTACGGCAG
CTTCATCAGCAGGGACAGTTCCCTCACAGGCATCAATGAGTTCGCATCGTCTTTCGGGACCTCC
AACATAGACAGCGTGCTCATCGACTGCTTCACGGCGGGCCACGATAATTACTTGGCTCTTCCCA
GCAGTGTCCCCAGGCAGGCCATCAGTGTCAGCTTCCCCCGGGCCCCCGATGGTTTCTACTGCCA
GGAGAGGGGACTGGAGAGGAGAGAGGGGCCCCTGACCTTGGGCTTGGATGGAGATGTGCTAAGG
GTAGGCTCTCTGGACACCTCTAAGCCACGGGCCTCGGGGATTCTGAAGAGGCCCCAGACCTTGG
CTCTCCCGGACGTGGCGGGAGGAAACGGCCCTGAAACCAGCAGGAGAAGGAACGTGACCTTCAG
CCAACAGGTGGCAAACATCCTCTTGAATGGTGTGAAGTACGAGAGTGAGCTGACGGGCTCCAGT
GAGCAGTCGGAGCAGCCGCTGTCTCTGCGGCGTCTCTGTTCCACCATCTACAACATGCCCAGGG
CCCTGCGCAATCTCTGTGTCAACCACTTCCTGGGGTGGCTCTCCTTCGAGGGCATGCTGCTCTT
CTACACGGACTTCATGGGCGAGGTGGTGTTTCAGGGTGACCCGAAGGCGCCGCACGCGTCGGAG
GCGTATCAGAAGTACAACAGCGGCGTGACCATGGGCTGCTGGGGCATGTGCATCTACGCCTTCA
GTGCGGCCTTCTACTCAGCCATCCTGGAGAAACTGGAGGAGTGCCTGAGCGTCCGTACCCTCTA
CTTCATCGCCTACCTCTCCTTCGGCCTGGGGACTGGACTGGCCACACTCTCCAGGAACCTGTAC
GTGGTCCTGTCCCTCTGCACCACCTACGGCATCCTGTTCTCCACGCTCTGTACCCTGCCCTACT
CTCTGCTCTGCGATTACTACCAGAGTAAGAAGTTTGCAGGGTCCAGTGCGGACGGCACACGGCG
CGGCATGGGAGTAGACATCTCGCTGCTCAGCTGCCAGTACTTTCTGGCTCAGATCCTCGTGTCT
CTGGTCCTGGGGCCCCTGACCTCCGCTGTGGGCAGTGCCAATGGTGTGATGTACTTCGCCAGCC
TCGTGTCCTTCCTCGGCTGCCTCTACTCCTCCCTGTGTGTCACCTACGAAATCCCCTCTGCCGA
TGCAGCTGACGAGGAGCGCCAGCCCCTCCTGTTGAACGTCTGATGTGTCATGATCTCAACCTTG
GACTTGAAGGTGGTCTGCTGCAGGCTGGCCCCTGAGGAACCAAAGGCCTTGGCAGCCGGCCAGG
CTCCCAGTGGGATGTAAATACAGGCTAAATAAACAACAGCAACAATCGTA

hide sequence

RefSeq Acc Id:

XM_039109270 ⟹ XP_038965198

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	166,388,115 - 166,403,865 (-)	NCBI
mRatBN7.2	5	161,105,137 - 161,121,010 (-)	NCBI

RefSeq Acc Id:

XM_063287159 ⟹ XP_063143229

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	166,388,115 - 166,403,978 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_653348	(Get FASTA)	NCBI Sequence Viewer
	XP_038965198	(Get FASTA)	NCBI Sequence Viewer
	XP_063143229	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH93599	(Get FASTA)	NCBI Sequence Viewer
	BAB97313	(Get FASTA)	NCBI Sequence Viewer
	EDL81189	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024581.6
GenBank Protein	Q8K4S3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_653348 ⟸ NM_144747

- UniProtKB:

A0A0G2QC36 (UniProtKB/TrEMBL), Q566E3 (UniProtKB/TrEMBL), A6IUD8 (UniProtKB/TrEMBL), F1LNK7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMIPPAGSTPPGEALIPSVAPQDFWRSPISSYSGSVTRHISHRANNFKRHPKRRKYIRPSPPPP
PNTPCPIELVDFEDLHPQRSFWELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWF
ISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGMALADTATNHKW
GILLTVCGVVLMDFSADSADNPSHAYMMDVCGPVDQDRGLNIHALMAGLGGGFGYVVGGIHWDK
TSFGRALGGQLRVIYIFTAITLSVTTVLTLVSIPERPLRPLGEKRTAMKSPSLPLPPSPPVLLE
EGAGDTLPSTTATSLYASFSSPISPPSPLTPKYGSFISRDSSLTGINEFASSFGTSNIDSVLID
CFTAGHDNYLALPSSVPRQAISVSFPRAPDGFYCQERGLERREGPLTLGLDGDVLRVGSLDTSK
PRASGILKRPQTLALPDVAGGNGPETSRRRNVTFSQQVANILLNGVKYESELTGSSEQSEQPLS
LRRLCSTIYNMPRALRNLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHASEAYQKYNSG
VTMGCWGMCIYAFSAAFYSAILEKLEECLSVRTLYFIAYLSFGLGTGLATLSRNLYVVLSLCTT
YGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTS
AVGSANGVMYFASLVSFLGCLYSSLCVTYEIPSADAADEERQPLLLNV

hide sequence

Ensembl Acc Id:

ENSRNOP00000024581 ⟸ ENSRNOT00000024581

RefSeq Acc Id:	XP_038965198 ⟸ XM_039109270
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063143229 ⟸ XM_063287159
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8K4S3-F1-model_v2	AlphaFold	Q8K4S3	1-751	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708502	AgrOrtholog
BioCyc Gene	G2FUF-39065	BioCyc
Ensembl Genes	ENSRNOG00000018229	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024581.8	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7315729	IMAGE-MGC_LOAD
InterPro	MFS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:246258	UniProtKB/TrEMBL
MGC_CLONE	MGC:105314	IMAGE-MGC_LOAD
NCBI Gene	246258	ENTREZGENE
PANTHER	PROTON-ASSOCIATED SUGAR TRANSPORTER A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUGAR TRANSPORTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MFS_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc45a1	PhenoGen
RatGTEx	ENSRNOG00000018229	RatGTEx
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2QC36	ENTREZGENE, UniProtKB/TrEMBL
	A6IUD8	ENTREZGENE, UniProtKB/TrEMBL
	F1LNK7	ENTREZGENE
	Q566E3	ENTREZGENE, UniProtKB/TrEMBL
	Q8K4S3	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	F1LNK7	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Slc45a1	solute carrier family 45, member 1	Dnb5	proton-associated sugar transporter A	Symbol and Name updated	1299863	APPROVED
2004-09-10	Dnb5	proton-associated sugar transporter A	Pasta		Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains 12 putative membrane-spanning helices with a long cytoplasmic loop between TM6 and TM7 and with intracellular orientation of N and C termini	628346
gene_domains	sequence motifs critical for the sugar transport function are RFGRR between TM2 and TM3, RG between TM4 and TM5, PERP motif after helix 6, and WLS motif in TM helix 7	628346
gene_expression	highly enriched in brain	628346
gene_expression	mRNA is expressed highly in the ventral medullary surface (VMS) and moderately in the cerebral cortex and cerebellum	628346
gene_process	mediates glucose uptake along the pH gradient	628346
gene_product	member of a novel class of mammalian sugar transporter	628346
gene_protein	751 amino acids; 82 kDa	628346
gene_regulation	increases after hypercapnia	628346
gene_regulation	glucose transport activity is controlled by the pH gradient	628346

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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