Ifi47 (interferon gamma inducible protein 47) - Rat Genome Database

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Gene: Ifi47 (interferon gamma inducible protein 47) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ifi47
Name: interferon gamma inducible protein 47
RGD ID: 708470
Description: Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly; cellular response to interferon-beta; and innate immune response. Predicted to be active in endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: interferon gamma inducible protein; interferon gamma inducible protein 1; LOC246208
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81033,798,744 - 33,806,374 (+)NCBIGRCr8
mRatBN7.21033,297,618 - 33,305,248 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,285,450 - 33,306,216 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1037,977,596 - 37,985,152 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0106,516,013 - 6,523,567 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01032,971,235 - 32,978,791 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,277,993 - 34,285,623 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,277,993 - 34,285,623 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,059,639 - 34,067,269 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41034,197,630 - 34,205,133 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11034,198,678 - 34,206,180 (+)NCBI
Celera1032,682,779 - 32,690,385 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The IRG-47 gene is IFN-gamma induced in B cells and encodes a protein with GTP-binding motifs. Gilly M and Wall R, J Immunol 1992 May 15;148(10):3275-81.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Ifi47
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:392
Count of miRNA genes:128
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000003343, ENSRNOT00000055872
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH134471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21033,305,048 - 33,305,231 (+)MAPPERmRatBN7.2
Rnor_6.01034,285,424 - 34,285,606NCBIRnor6.0
Rnor_5.01034,067,070 - 34,067,252UniSTSRnor5.0
RGSC_v3.41034,205,061 - 34,205,243UniSTSRGSC3.4
Celera1032,690,186 - 32,690,368UniSTS
RH 3.4 Map10342.81UniSTS
Cytogenetic Map10q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10 40 25 19 25 7 12 11
Low 25 17 16 16 8 11 72 28 27 8
Below cutoff 8 2 2

Sequence


RefSeq Acc Id: ENSRNOT00000003343   ⟹   ENSRNOP00000003343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,297,640 - 33,305,145 (+)Ensembl
Rnor_6.0 Ensembl1034,277,993 - 34,285,623 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000055872   ⟹   ENSRNOP00000052724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,297,512 - 33,306,216 (+)Ensembl
Rnor_6.0 Ensembl1034,277,993 - 34,285,494 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112040   ⟹   ENSRNOP00000091931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,300,185 - 33,306,216 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112448   ⟹   ENSRNOP00000094749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,285,450 - 33,306,216 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114557   ⟹   ENSRNOP00000088929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1033,292,864 - 33,306,216 (+)Ensembl
RefSeq Acc Id: NM_172019   ⟹   NP_742016
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,798,744 - 33,806,374 (+)NCBI
mRatBN7.21033,297,618 - 33,305,248 (+)NCBI
Rnor_6.01034,277,993 - 34,285,623 (+)NCBI
Rnor_5.01034,059,639 - 34,067,269 (+)NCBI
RGSC_v3.41034,197,630 - 34,205,133 (+)RGD
Celera1032,682,779 - 32,690,385 (+)NCBI
Sequence:
RefSeq Acc Id: NP_742016   ⟸   NM_172019
- UniProtKB: E9PU10 (UniProtKB/TrEMBL),   A6HDV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052724   ⟸   ENSRNOT00000055872
RefSeq Acc Id: ENSRNOP00000003343   ⟸   ENSRNOT00000003343
RefSeq Acc Id: ENSRNOP00000094749   ⟸   ENSRNOT00000112448
RefSeq Acc Id: ENSRNOP00000088929   ⟸   ENSRNOT00000114557
RefSeq Acc Id: ENSRNOP00000091931   ⟸   ENSRNOT00000112040
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAC0-F1-model_v2 AlphaFold F1MAC0 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697137
Promoter ID:EPDNEW_R7662
Type:multiple initiation site
Name:Ifi47_1
Description:interferon gamma inducible protein 47
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01034,278,000 - 34,278,060EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708470 AgrOrtholog
BioCyc Gene G2FUF-25317 BioCyc
Ensembl Genes ENSRNOG00000002470 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003343.9 UniProtKB/TrEMBL
  ENSRNOT00000055872 ENTREZGENE
  ENSRNOT00000055872.5 UniProtKB/TrEMBL
  ENSRNOT00000112040.1 UniProtKB/TrEMBL
  ENSRNOT00000112448.1 UniProtKB/TrEMBL
  ENSRNOT00000114557.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623225 IMAGE-MGC_LOAD
InterPro G_IRG_dom UniProtKB/TrEMBL
  Interferon-inducible_GTPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:246208 UniProtKB/TrEMBL
MGC_CLONE MGC:72279 IMAGE-MGC_LOAD
NCBI Gene 246208 ENTREZGENE
PANTHER GTP-BINDING PROTEIN UniProtKB/TrEMBL
  INTERFERON-INDUCIBLE GTPASE UniProtKB/TrEMBL
Pfam IIGP UniProtKB/TrEMBL
PhenoGen Ifi47 PhenoGen
PROSITE G_IRG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002470 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A6HDU9_RAT UniProtKB/TrEMBL
  A6HDV0 ENTREZGENE, UniProtKB/TrEMBL
  E9PU10 ENTREZGENE, UniProtKB/TrEMBL
  F1MAC0_RAT UniProtKB/TrEMBL
  Q6NYB8_RAT UniProtKB/TrEMBL
  Q8K580_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Ifi47  interferon gamma inducible protein 47  Ifi47  interferon gamma inducible protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ifi47  interferon gamma inducible protein  LOC246208  interferon gamma inducible protein 1  Symbol and Name updated 1299863 APPROVED