Atg3 (autophagy related 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Atg3 (autophagy related 3) Rattus norvegicus
Analyze
Symbol: Atg3
Name: autophagy related 3
RGD ID: 708464
Description: Enables Atg8-family conjugating enzyme activity. Involved in autophagy. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in cytosol and phagophore assembly site. Orthologous to human ATG3 (autophagy related 3); PARTICIPATES IN autophagy pathway; INTERACTS WITH 3,3',5,5'-tetrabromobisphenol A; 4-nonylphenol; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APG3 autophagy 3-like; APG3 autophagy 3-like (S. cerevisiae); APG3-like; Apg3l; ATG3 autophagy related 3 homolog; ATG3 autophagy related 3 homolog (S. cerevisiae); autophagy-related 3; autophagy-related 3 (yeast); autophagy-related protein 3; PIG-1; Pig1; preconditioning-inducible gene 1 protein; ubiquitin-like-conjugating enzyme ATG3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,130,948 - 69,159,280 (-)NCBIGRCr8
mRatBN7.21155,624,914 - 55,653,249 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,624,917 - 55,653,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,438,596 - 64,466,930 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,100,453 - 57,128,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,170,970 - 56,199,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,585,192 - 60,613,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,585,171 - 60,613,718 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,687,322 - 64,715,836 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,162,205 - 57,190,568 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,219,793 - 57,248,157 (-)NCBI
Celera1155,191,074 - 55,219,238 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-deoxy-D-glucose  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
cantharidin  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
enniatin  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
galangin  (ISO)
gentamycin  (EXP,ISO)
glucose  (EXP)
glyphosate  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lycopene  (ISO)
methidathion  (ISO)
nickel atom  (ISO)
oligopeptide  (ISO)
paracetamol  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
platycodin D  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulindac  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Atg12-Atg5-Atg16 complex  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
phagophore assembly site  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
autophagy pathway  (IEA,IEP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. Liang B, etal., Int J Mol Med. 2017 Dec;40(6):1781-1791. doi: 10.3892/ijmm.2017.3191. Epub 2017 Oct 16.
4. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nath S, etal., Nat Cell Biol. 2014 May;16(5):415-24. doi: 10.1038/ncb2940. Epub 2014 Apr 20.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
11. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. Tanida I, etal., J Biol Chem 2002 Apr 19;277(16):13739-44. Epub 2002 Feb 1.
12. The rat Apg3p/Aut1p homolog is upregulated by ischemic preconditioning in the retina. Wu BX, etal., Mol Vis. 2006 Oct 26;12:1292-302.
13. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
14. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Zhang XX, etal., Biomed Microdevices. 2022 Oct 29;24(4):37. doi: 10.1007/s10544-022-00622-2.
Additional References at PubMed
PMID:15489334   PMID:18321988   PMID:20723759   PMID:21220506   PMID:24035364   PMID:24089205   PMID:26061804   PMID:29311554  


Genomics

Comparative Map Data
Atg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,130,948 - 69,159,280 (-)NCBIGRCr8
mRatBN7.21155,624,914 - 55,653,249 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,624,917 - 55,653,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,438,596 - 64,466,930 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,100,453 - 57,128,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,170,970 - 56,199,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,585,192 - 60,613,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,585,171 - 60,613,718 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,687,322 - 64,715,836 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,162,205 - 57,190,568 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,219,793 - 57,248,157 (-)NCBI
Celera1155,191,074 - 55,219,238 (-)NCBICelera
Cytogenetic Map11q21NCBI
ATG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383112,532,510 - 112,561,962 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3112,532,510 - 112,562,046 (-)EnsemblGRCh38hg38GRCh38
GRCh373112,251,357 - 112,280,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363113,734,049 - 113,763,175 (-)NCBINCBI36Build 36hg18NCBI36
Build 343113,734,049 - 113,763,175NCBI
Celera3110,660,041 - 110,689,158 (-)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3109,635,431 - 109,664,875 (-)NCBIHuRef
CHM1_13112,215,286 - 112,244,741 (-)NCBICHM1_1
T2T-CHM13v2.03115,253,546 - 115,282,997 (-)NCBIT2T-CHM13v2.0
Atg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391644,979,192 - 45,008,901 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1644,979,148 - 45,008,901 (+)EnsemblGRCm39 Ensembl
GRCm381645,158,829 - 45,188,538 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1645,158,785 - 45,188,538 (+)EnsemblGRCm38mm10GRCm38
MGSCv371645,158,942 - 45,188,651 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361645,078,161 - 45,107,870 (+)NCBIMGSCv36mm8
Celera1645,552,434 - 45,582,081 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1629.45NCBI
Atg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542712,881,454 - 12,906,399 (-)NCBIChiLan1.0ChiLan1.0
ATG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22110,535,875 - 110,564,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13110,539,768 - 110,569,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03109,681,163 - 109,710,835 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13116,606,467 - 116,635,209 (-)NCBIpanpan1.1PanPan1.1panPan2
ATG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13317,046,951 - 17,073,203 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3317,046,973 - 17,073,150 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3317,150,094 - 17,176,355 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03317,290,643 - 17,316,985 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3317,290,665 - 17,316,925 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13317,095,504 - 17,121,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03317,142,968 - 17,169,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,692,507 - 17,718,820 (-)NCBIUU_Cfam_GSD_1.0
Atg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602137,263,965 - 137,289,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936536232,192 - 257,954 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936536232,343 - 257,949 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13147,279,437 - 147,309,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113147,279,110 - 147,309,597 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213156,876,859 - 156,907,063 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12268,227,772 - 68,256,555 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2268,228,203 - 68,257,503 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604198,205,946 - 98,234,553 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473135,978,595 - 36,004,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atg3
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000002906
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
WI-22015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,625,023 - 55,625,154 (+)MAPPERmRatBN7.2
Rnor_6.01160,585,281 - 60,585,411NCBIRnor6.0
Rnor_5.01164,687,411 - 64,687,541UniSTSRnor5.0
RGSC_v3.41157,162,294 - 57,162,424UniSTSRGSC3.4
Celera1155,191,163 - 55,191,293UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002906   ⟹   ENSRNOP00000002906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,624,935 - 55,653,224 (-)Ensembl
Rnor_6.0 Ensembl1160,585,185 - 60,613,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,624,917 - 55,653,054 (-)Ensembl
Rnor_6.0 Ensembl1160,585,171 - 60,586,048 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1160,594,412 - 60,597,961 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094798   ⟹   ENSRNOP00000084764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,624,935 - 55,652,930 (-)Ensembl
RefSeq Acc Id: NM_134394   ⟹   NP_599221
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,130,948 - 69,159,280 (-)NCBI
mRatBN7.21155,624,914 - 55,653,249 (-)NCBI
Rnor_6.01160,585,192 - 60,613,706 (-)NCBI
Rnor_5.01164,687,322 - 64,715,836 (-)NCBI
RGSC_v3.41157,162,205 - 57,190,568 (-)RGD
Celera1155,191,074 - 55,219,238 (-)RGD
Sequence:
RefSeq Acc Id: XM_039087948   ⟹   XP_038943876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,130,982 - 69,158,923 (-)NCBI
mRatBN7.21155,624,928 - 55,652,943 (-)NCBI
RefSeq Acc Id: XM_063270263   ⟹   XP_063126333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,130,982 - 69,143,332 (-)NCBI
RefSeq Acc Id: NP_599221   ⟸   NM_134394
- UniProtKB: Q6AZ50 (UniProtKB/Swiss-Prot),   Q9ESH2 (UniProtKB/Swiss-Prot),   A6IQZ2 (UniProtKB/TrEMBL),   A0A8I6GAZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002906   ⟸   ENSRNOT00000002906
RefSeq Acc Id: XP_038943876   ⟸   XM_039087948
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000084764   ⟸   ENSRNOT00000094798
RefSeq Acc Id: XP_063126333   ⟸   XM_063270263
- Peptide Label: isoform X2
- UniProtKB: A6IQZ3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AZ50-F1-model_v2 AlphaFold Q6AZ50 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698141
Promoter ID:EPDNEW_R8665
Type:initiation region
Name:Atg3_1
Description:autophagy related 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8666  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,613,460 - 60,613,520EPDNEW
RGD ID:13698142
Promoter ID:EPDNEW_R8666
Type:initiation region
Name:Atg3_2
Description:autophagy related 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8665  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,613,687 - 60,613,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708464 AgrOrtholog
BioCyc Gene G2FUF-21374 BioCyc
Ensembl Genes ENSRNOG00000002094 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002906 ENTREZGENE
  ENSRNOT00000002906.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1460.50 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112937 IMAGE-MGC_LOAD
InterPro Autophagy-rel_prot_3 UniProtKB/Swiss-Prot
KEGG Report rno:171415 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93202 IMAGE-MGC_LOAD
NCBI Gene 171415 ENTREZGENE
PANTHER PTHR12866 UniProtKB/Swiss-Prot
  UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 UniProtKB/Swiss-Prot
Pfam Autophagy_act_C UniProtKB/Swiss-Prot
PhenoGen Atg3 PhenoGen
RatGTEx ENSRNOG00000002094 RatGTEx
UniProt A0A8I6G762_RAT UniProtKB/TrEMBL
  A0A8I6GAZ4 ENTREZGENE, UniProtKB/TrEMBL
  A6IQZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6IQZ3 ENTREZGENE, UniProtKB/TrEMBL
  ATG3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9ESH2 ENTREZGENE
UniProt Secondary Q9ESH2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-07 Atg3  autophagy related 3  Atg3  ATG3 autophagy related 3 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atg3  ATG3 autophagy related 3 homolog (S. cerevisiae)  Atg3  autophagy-related 3 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-12-21 Atg3  autophagy-related 3 (yeast)  Apg3l  APG3 autophagy 3-like (S. cerevisiae)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Apg3l  APG3 autophagy 3-like (S. cerevisiae)  Pig1  preconditioning-inducible gene 1 protein  Symbol and Name updated 1299863 APPROVED