Prf1 (perforin 1) - Rat Genome Database

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Gene: Prf1 (perforin 1) Rattus norvegicus
Analyze
Symbol: Prf1
Name: perforin 1
RGD ID: 708463
Description: Predicted to enable calcium ion binding activity; identical protein binding activity; and wide pore channel activity. Involved in circadian rhythm and response to ethanol. Located in extracellular space. Used to study asthma; colon carcinoma; and glomerulonephritis. Biomarker of membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyta; cytolysin; lymphocyte pore-forming protein; MGC108712; P1; perforin 1 (pore forming protein); perforin-1; RATCYTA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,789,040 - 29,794,550 (+)NCBIGRCr8
mRatBN7.22029,246,202 - 29,251,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,246,202 - 29,251,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,262,194 - 30,267,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,648,492 - 29,654,002 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,390,949 - 30,396,459 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,915,294 - 30,920,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,915,213 - 30,921,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,706,313 - 32,711,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,658,367 - 28,663,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,672,166 - 28,677,670 (+)NCBI
Celera2030,679,378 - 30,684,888 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
5-azacytidine  (ISO)
acetamide  (EXP)
adenosine  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
bromodichloromethane  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
coformycin  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dichlorvos  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
halothane  (ISO)
ionomycin  (ISO)
L-ascorbic acid  (ISO)
mercaptopurine  (EXP)
methimazole  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
Pentoxifylline  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
purine-6-thiol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytolytic granule  (IEA,ISO,ISS)
cytoplasmic vesicle  (IEA,ISO)
cytosol  (IEA,ISO)
endosome  (IEA)
endosome lumen  (IEA)
extracellular region  (IEA)
extracellular space  (IDA)
immunological synapse  (IEA,ISO)
lysosome  (IEA)
membrane  (IBA,IEA,ISO,ISS)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence supporting a circadian control of natural killer cell function. Arjona A and Sarkar DK, Brain Behav Immun. 2006 Sep;20(5):469-76. Epub 2005 Nov 23.
2. Circadian rhythms of granzyme B, perforin, IFN-gamma, and NK cell cytolytic activity in the spleen: effects of chronic ethanol. Arjona A, etal., J Immunol. 2004 Mar 1;172(5):2811-7.
3. Involvement of IFN-gamma and perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis. Beeston T, etal., J Neuroimmunol. 2010 Dec 15;229(1-2):91-7. Epub 2010 Aug 12.
4. Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Brenu EW, etal., J Transl Med. 2011 May 28;9:81.
5. Gender-associated differences of perforin polymorphisms in the susceptibility to multiple sclerosis. Camina-Tato M, etal., J Immunol. 2010 Nov 1;185(9):5392-404. Epub 2010 Oct 4.
6. Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver. Cosgrove C, etal., PLoS One. 2014 Aug 22;9(8):e105950. doi: 10.1371/journal.pone.0105950. eCollection 2014.
7. Two systemic lupus erythematosus (SLE) global disease activity indexes--the SLE Disease Activity Index and the Systemic Lupus Activity Measure--demonstrate different correlations with activation of peripheral blood CD4+ T cells. Daca A, etal., Hum Immunol. 2011 Dec;72(12):1160-7. Epub 2011 Aug 26.
8. Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination. de Alencar BC, etal., Infect Immun. 2009 Oct;77(10):4383-95. Epub 2009 Aug 3.
9. Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis. Deb C, etal., J Neuropathol Exp Neurol. 2009 Sep;68(9):1037-48.
10. Allergen-specific CTL require perforin expression to suppress allergic airway inflammation. Enomoto N, etal., J Immunol. 2012 Feb 15;188(4):1734-41. Epub 2012 Jan 16.
11. Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis. Feldmann J, etal., Br J Haematol. 2002 Jun;117(4):965-72.
12. Anti-perforin antibody treatment ameliorates experimental crescentic glomerulonephritis in WKY rats. Fujinaka H, etal., Kidney Int. 2007 Oct;72(7):823-30. Epub 2007 Jul 11.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients. Giovanni F, etal., J Neuroimmunol. 2011 Dec 15;240-241:137-41. Epub 2011 Oct 15.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis. Goransdotter Ericson K, etal., Am J Hum Genet. 2001 Mar;68(3):590-7. Epub 2001 Feb 6.
17. Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria. Haque A, etal., J Immunol. 2011 Jun 1;186(11):6148-56. Epub 2011 Apr 27.
18. Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. Hersperger AR, etal., PLoS Pathog. 2010 May 27;6(5):e1000917.
19. An anti-CD5 monoclonal antibody ameliorates proteinuria and glomerular lesions in rat mesangioproliferative glomerulonephritis. Ikezumi Y, etal., Kidney Int. 2000 Jul;58(1):100-14.
20. Molecular cloning of rat cytolysin. Ishikawa H, etal., J Immunol 1989 Nov 1;143(9):3069-73.
21. High clonality of virus-specific T lymphocytes defined by TCR usage in the brains of mice infected with West Nile virus. Kitaura K, etal., J Immunol. 2011 Oct 15;187(8):3919-30. Epub 2011 Sep 9.
22. Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox. Kremer M, etal., PLoS Pathog. 2012 Mar;8(3):e1002557. Epub 2012 Mar 1.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Impaired immune function in children with Fanconi anaemia. Myers KC, etal., Br J Haematol. 2011 Jul;154(2):234-40. doi: 10.1111/j.1365-2141.2011.08721.x. Epub 2011 May 4.
25. Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Nimmo ER, etal., Inflamm Bowel Dis. 2012 May;18(5):889-99. doi: 10.1002/ibd.21912. Epub 2011 Oct 21.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice. Pachlopnik Schmid J, etal., EMBO Mol Med. 2009 May;1(2):112-24.
28. A polymorphism in PRF1 gene is associated with HIV-1 vertical transmission in Brazilian children. Padovan L, etal., AIDS. 2011 Feb 20;25(4):535-7.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Comprehensive gene review and curation RGD comprehensive gene curation
34. Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. Shi L, etal., J Immunol. 2005 May 1;174(9):5456-61.
35. Expression of cytolytic protein-perforin in peripheral blood lymphocytes in severe traumatic brain injured patients. Sotosek Tokmadzic V, etal., Injury. 2012 May;43(5):624-31. Epub 2010 May 26.
36. Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. Vastert SJ, etal., Rheumatology (Oxford). 2010 Mar;49(3):441-9. Epub 2009 Dec 17.
37. Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer. Waldner MJ, etal., Inflamm Bowel Dis. 2010 Apr;16(4):559-67.
38. The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis. Xie Y, etal., Virology. 2011 Dec 5;421(1):78-84. Epub 2011 Oct 11.
39. Dietary Mustard Seeds (Sinapis alba Linn) Suppress 1,2-Dimethylhydrazine-Induced Immuno-Imbalance and Colonic Carcinogenesis in Rats. Zhu M, etal., Nutr Cancer. 2012 Apr;64(3):464-72. Epub 2012 Mar 16.
40. [Expression of perforin and granzyme B in asthmatic rats and intervention of recombinant human growth hormone]. Zou LP, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2011 Mar;13(3):223-6.
Additional References at PubMed
PMID:8164737   PMID:9756476   PMID:11856751   PMID:12477932   PMID:15454490   PMID:15576364   PMID:15755897   PMID:19915045   PMID:19946888   PMID:20450731   PMID:20889983   PMID:21037563  
PMID:21438968   PMID:21685908   PMID:24070258   PMID:24506670  


Genomics

Comparative Map Data
Prf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,789,040 - 29,794,550 (+)NCBIGRCr8
mRatBN7.22029,246,202 - 29,251,712 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,246,202 - 29,251,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,262,194 - 30,267,704 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,648,492 - 29,654,002 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,390,949 - 30,396,459 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,915,294 - 30,920,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,915,213 - 30,921,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,706,313 - 32,711,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,658,367 - 28,663,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,672,166 - 28,677,670 (+)NCBI
Celera2030,679,378 - 30,684,888 (+)NCBICelera
Cytogenetic Map20q11NCBI
PRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,597,348 - 70,602,741 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,597,348 - 70,602,759 (-)EnsemblGRCh38hg38GRCh38
GRCh371072,357,104 - 72,362,497 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,027,110 - 72,032,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 341072,027,110 - 72,032,520NCBI
Celera1065,638,863 - 65,644,316 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,350,612 - 66,356,064 (-)NCBIHuRef
CHM1_11072,639,251 - 72,644,703 (-)NCBICHM1_1
T2T-CHM13v2.01071,467,050 - 71,472,469 (-)NCBIT2T-CHM13v2.0
Prf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,133,530 - 61,140,463 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,133,612 - 61,140,459 (+)EnsemblGRCm39 Ensembl
GRCm381061,297,751 - 61,304,684 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,297,833 - 61,304,680 (+)EnsemblGRCm38mm10GRCm38
MGSCv371060,760,584 - 60,767,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,693,191 - 60,699,667 (+)NCBIMGSCv36mm8
Celera1062,399,002 - 62,405,430 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.18NCBI
Prf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,700,718 - 20,706,929 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,700,912 - 20,705,076 (+)NCBIChiLan1.0ChiLan1.0
PRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,751,239 - 82,757,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,756,560 - 82,763,263 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,071,141 - 67,078,057 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,597,574 - 69,603,070 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,597,574 - 69,603,070 (-)Ensemblpanpan1.1panPan2
PRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,497,865 - 21,502,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,498,249 - 21,500,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,630,717 - 21,633,264 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,771,953 - 21,776,587 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,772,387 - 21,775,002 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,669,548 - 21,672,095 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,875,818 - 21,878,365 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,227,730 - 22,230,277 (-)NCBIUU_Cfam_GSD_1.0
Prf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,564,718 - 59,568,196 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,057,874 - 8,060,695 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,057,874 - 8,060,695 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,512,769 - 73,520,202 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,515,306 - 73,520,256 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,363,495 - 79,368,376 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,692,544 - 60,698,000 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl960,692,600 - 60,698,465 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,417,046 - 21,423,720 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,679,521 - 4,681,627 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,679,451 - 4,681,627 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prf1
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:14
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000000681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
D20Rat27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22029,244,388 - 29,244,578 (+)MAPPERmRatBN7.2
Rnor_6.02030,913,481 - 30,913,670NCBIRnor6.0
Rnor_5.02032,704,500 - 32,704,689UniSTSRnor5.0
RGSC_v3.42028,656,553 - 28,656,743RGDRGSC3.4
RGSC_v3.42028,656,554 - 28,656,743UniSTSRGSC3.4
RGSC_v3.12028,670,353 - 28,670,543RGD
Celera2030,677,565 - 30,677,754UniSTS
FHH x ACI Map2014.6699UniSTS
FHH x ACI Map2014.6699RGD
Cytogenetic Map20q11UniSTS
D20Got111  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22029,249,873 - 29,250,013 (+)MAPPERmRatBN7.2
Rnor_6.02030,918,966 - 30,919,105NCBIRnor6.0
Rnor_5.02032,709,985 - 32,710,124UniSTSRnor5.0
RGSC_v3.42028,662,039 - 28,662,178UniSTSRGSC3.4
Celera2030,683,050 - 30,683,189UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 37 61 89 88 57 25 57 6 199 84 41 41 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000000681   ⟹   ENSRNOP00000000681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,246,202 - 29,251,486 (+)Ensembl
Rnor_6.0 Ensembl2030,915,213 - 30,921,382 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100131   ⟹   ENSRNOP00000078379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,247,792 - 29,251,701 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117051   ⟹   ENSRNOP00000076990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,246,202 - 29,251,701 (+)Ensembl
RefSeq Acc Id: NM_017330   ⟹   NP_059026
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,789,040 - 29,794,550 (+)NCBI
mRatBN7.22029,246,202 - 29,251,712 (+)NCBI
Rnor_6.02030,915,294 - 30,920,804 (+)NCBI
Rnor_5.02032,706,313 - 32,711,823 (+)NCBI
RGSC_v3.42028,658,367 - 28,663,877 (+)RGD
Celera2030,679,378 - 30,684,888 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_059026 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41071 (Get FASTA)   NCBI Sequence Viewer  
  AAH89808 (Get FASTA)   NCBI Sequence Viewer  
  EDL93028 (Get FASTA)   NCBI Sequence Viewer  
  EDL93029 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078379
GenBank Protein P35763 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059026   ⟸   NM_017330
- Peptide Label: precursor
- UniProtKB: P35763 (UniProtKB/Swiss-Prot),   Q5FVS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000681   ⟸   ENSRNOT00000000681
Ensembl Acc Id: ENSRNOP00000078379   ⟸   ENSRNOT00000100131
Ensembl Acc Id: ENSRNOP00000076990   ⟸   ENSRNOT00000117051
Protein Domains
C2   EGF-like   MACPF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35763-F1-model_v2 AlphaFold P35763 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701601
Promoter ID:EPDNEW_R12125
Type:single initiation site
Name:Prf1_1
Description:perforin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02030,915,271 - 30,915,331EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708463 AgrOrtholog
BioCyc Gene G2FUF-3725 BioCyc
Ensembl Genes ENSRNOG00000000562 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000100131 ENTREZGENE
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7378633 IMAGE-MGC_LOAD
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  MACPF UniProtKB/Swiss-Prot
  MACPF_CS UniProtKB/Swiss-Prot
  Perforin-1_C2 UniProtKB/Swiss-Prot
  Perforin-1_pore-forming UniProtKB/Swiss-Prot
MGC_CLONE MGC:108712 IMAGE-MGC_LOAD
NCBI Gene 50669 ENTREZGENE
PANTHER PERFORIN-1 UniProtKB/Swiss-Prot
  PERFORIN-1 UniProtKB/Swiss-Prot
Pfam MACPF UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
PharmGKB PRF1 RGD
PhenoGen Prf1 PhenoGen
PROSITE MACPF_1 UniProtKB/Swiss-Prot
  MACPF_2 UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000562 RatGTEx
SMART MACPF UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
UniProt A0A8I5ZKR3_RAT UniProtKB/TrEMBL
  A6K3Z3_RAT UniProtKB/TrEMBL
  A6K3Z4_RAT UniProtKB/TrEMBL
  F7EPF5_RAT UniProtKB/TrEMBL
  P35763 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5FVS5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Prf1  perforin 1  Prf1  perforin 1 (pore forming protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-04-22 Prf1  perforin 1 (pore forming protein)  Cyta  cytolysin  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in lymphocytes 1299461