Trib3 (tribbles pseudokinase 3) - Rat Genome Database

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Gene: Trib3 (tribbles pseudokinase 3) Rattus norvegicus
Analyze
Symbol: Trib3
Name: tribbles pseudokinase 3
RGD ID: 708432
Description: Predicted to enable enzyme binding activity; transcription corepressor activity; and ubiquitin-protein transferase regulator activity. Involved in regulation of autophagy. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human TRIB3 (tribbles pseudokinase 3); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kinase; LOC246273; Neuronal cell death Inducible Putative Kinase; neuronal cell death-inducible putative kinase; NIPK; TRB-3; tribbles homolog 3; tribbles homolog 3 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,269,939 - 161,275,533 (-)NCBIGRCr8
mRatBN7.23140,809,634 - 140,815,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,809,043 - 140,814,497 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,714,722 - 144,720,327 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,298,562 - 153,304,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,038,803 - 151,044,379 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,814,056 - 147,819,650 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,813,473 - 147,819,571 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,162,197 - 154,167,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,664,641 - 142,670,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,569,627 - 142,575,693 (-)NCBI
Celera3139,561,433 - 139,567,041 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dichloroaniline  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutylamine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
antimycin A  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
betulinic acid  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
cefaloridine  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
ferric oxide  (ISO)
flavokawain B  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fomepizole  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glucose  (EXP)
glutathione  (EXP)
glycidol  (EXP)
high-density lipoprotein cholesterol  (EXP)
hydrazines  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
lipoic acid  (ISO)
lithium chloride  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
nitroprusside  (ISO)
nobiletin  (EXP,ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
Octicizer  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phorone  (EXP)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium bromate  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
prothioconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torin 1  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of a novel kinase-like gene induced during neuronal cell death. Mayumi-Matsuda K, etal., Biochem Biophys Res Commun 1999 May 10;258(2):260-4.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Xu X, etal., Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017.
Additional References at PubMed
PMID:12477932   PMID:12743605   PMID:12749859   PMID:12791994   PMID:15299019   PMID:15469416   PMID:15775988   PMID:16452480   PMID:16794074   PMID:17576771   PMID:18497449   PMID:18726071  
PMID:18818302   PMID:19452573   PMID:19996382   PMID:20410507   PMID:20488947   PMID:21190014   PMID:21933987   PMID:22850683   PMID:23000510   PMID:23990361   PMID:24212932   PMID:24368111  
PMID:24925634   PMID:25898323   PMID:26224857   PMID:26410836   PMID:26818585   PMID:27977799   PMID:28011637   PMID:28476619   PMID:28534945   PMID:28600485   PMID:28782643   PMID:34553361  
PMID:34906150   PMID:38302075  


Genomics

Comparative Map Data
Trib3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,269,939 - 161,275,533 (-)NCBIGRCr8
mRatBN7.23140,809,634 - 140,815,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,809,043 - 140,814,497 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,714,722 - 144,720,327 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,298,562 - 153,304,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,038,803 - 151,044,379 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,814,056 - 147,819,650 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,813,473 - 147,819,571 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,162,197 - 154,167,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,664,641 - 142,670,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,569,627 - 142,575,693 (-)NCBI
Celera3139,561,433 - 139,567,041 (-)NCBICelera
Cytogenetic Map3q41NCBI
TRIB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3820380,760 - 397,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl20362,835 - 397,559 (+)EnsemblGRCh38hg38GRCh38
GRCh3720361,404 - 378,203 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3620309,308 - 326,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 3420309,307 - 326,201NCBI
Celera20456,158 - 473,052 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef20312,732 - 329,628 (+)NCBIHuRef
CHM1_120361,309 - 361,866 (+)NCBICHM1_1
T2T-CHM13v2.020424,107 - 440,963 (+)NCBIT2T-CHM13v2.0
Trib3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,179,345 - 152,185,980 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,179,342 - 152,185,952 (-)EnsemblGRCm39 Ensembl
GRCm382152,337,425 - 152,344,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,337,422 - 152,344,032 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,163,161 - 152,169,796 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,028,863 - 152,035,473 (-)NCBIMGSCv36mm8
Celera2158,151,551 - 158,158,172 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
Trib3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955597260,790 - 265,326 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955597259,209 - 265,896 (+)NCBIChiLan1.0ChiLan1.0
TRIB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,469,634 - 1,485,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1201,466,483 - 1,482,488 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v020583,267 - 605,416 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.120359,470 - 375,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl20359,879 - 375,486 (+)Ensemblpanpan1.1panPan2
TRIB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,450,281 - 20,461,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,451,001 - 20,457,510 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,103,931 - 20,114,798 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,143,266 - 21,154,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,143,273 - 21,150,479 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,418,511 - 20,429,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,524,537 - 20,535,390 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,955,034 - 20,966,099 (-)NCBIUU_Cfam_GSD_1.0
Trib3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640169,645,481 - 169,660,276 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,077,850 - 18,083,553 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,077,850 - 18,082,817 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1734,807,582 - 34,816,451 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11734,808,273 - 34,819,592 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,595,609 - 39,602,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRIB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1235,512,911 - 35,530,856 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl235,512,861 - 35,530,966 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660787,686,687 - 7,704,641 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trib3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247411,484,863 - 1,494,829 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247411,486,223 - 1,494,005 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trib3
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:136
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000009840
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000009840   ⟹   ENSRNOP00000009840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3140,809,043 - 140,814,497 (-)Ensembl
Rnor_6.0 Ensembl3147,813,473 - 147,819,571 (-)Ensembl
RefSeq Acc Id: NM_144755   ⟹   NP_653356
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,269,939 - 161,275,533 (-)NCBI
mRatBN7.23140,809,634 - 140,815,230 (-)NCBI
Rnor_6.03147,814,056 - 147,819,650 (-)NCBI
Rnor_5.03154,162,197 - 154,167,791 (-)NCBI
RGSC_v3.43142,664,641 - 142,670,135 (-)RGD
Celera3139,561,433 - 139,567,041 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_653356 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91120 (Get FASTA)   NCBI Sequence Viewer  
  BAA77582 (Get FASTA)   NCBI Sequence Viewer  
  EDL86074 (Get FASTA)   NCBI Sequence Viewer  
  EDL86075 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009840.3
  ENSRNOP00055035743
  ENSRNOP00060040749
  ENSRNOP00065030565
GenBank Protein Q9WTQ6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_653356   ⟸   NM_144755
- UniProtKB: Q5BKD1 (UniProtKB/Swiss-Prot),   Q9WTQ6 (UniProtKB/Swiss-Prot),   A6KHN0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009840   ⟸   ENSRNOT00000009840
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTQ6-F1-model_v2 AlphaFold Q9WTQ6 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692535
Promoter ID:EPDNEW_R3060
Type:initiation region
Name:Trib3_1
Description:tribbles pseudokinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03147,819,624 - 147,819,684EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708432 AgrOrtholog
BioCyc Gene G2FUF-47274 BioCyc
Ensembl Genes ENSRNOG00000007319 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055025380 UniProtKB/Swiss-Prot
  ENSRNOG00060028116 UniProtKB/Swiss-Prot
  ENSRNOG00065022177 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009840.6 UniProtKB/Swiss-Prot
  ENSRNOT00055043757 UniProtKB/Swiss-Prot
  ENSRNOT00060048841 UniProtKB/Swiss-Prot
  ENSRNOT00065037792 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7326024 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tribbles/Ser_Thr_kinase_40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246273 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108584 IMAGE-MGC_LOAD
NCBI Gene 246273 ENTREZGENE
PANTHER PTHR22961 UniProtKB/Swiss-Prot
  PTHR22961:SF14 UniProtKB/Swiss-Prot
  SER/THR PROTEIN KINASE-TRB UniProtKB/TrEMBL
  TRIBBLES HOMOLOG 3 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trib3 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007319 RatGTEx
  ENSRNOG00055025380 RatGTEx
  ENSRNOG00060028116 RatGTEx
  ENSRNOG00065022177 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KHN0 ENTREZGENE, UniProtKB/TrEMBL
  A6KHN1_RAT UniProtKB/TrEMBL
  Q5BKD1 ENTREZGENE
  Q9WTQ6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5BKD1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Trib3  tribbles pseudokinase 3  Trib3  tribbles homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Trib3  tribbles homolog 3 (Drosophila)  LOC246273  kinase  Symbol and Name updated 1299863 APPROVED