Tmsb15b2 (thymosin beta 15B2) - Rat Genome Database

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Gene: Tmsb15b2 (thymosin beta 15B2) Rattus norvegicus
Analyze
Symbol: Tmsb15b2
Name: thymosin beta 15B2
RGD ID: 708373
Description: Predicted to enable actin monomer binding activity and actin monomer sequestering activity. Predicted to be involved in positive regulation of cell migration. Predicted to act upstream of or within negative regulation of actin filament polymerization and negative regulation of stress fiber assembly. Predicted to be located in stress fiber. Predicted to be part of filamentous actin. Orthologous to human TMSB15A (thymosin beta 15A); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC286978; thymosin beta-15B; thymosin beta-like protein; thymosin beta-like protein 1; Tmsbl1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X105,090,980 - 105,093,094 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX105,090,980 - 105,093,094 (-)EnsemblGRCr8
mRatBN7.2X100,298,705 - 100,300,820 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX100,298,514 - 100,300,886 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX102,428,865 - 102,430,979 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X105,927,537 - 105,929,651 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X103,496,711 - 103,498,826 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X107,612,518 - 107,614,632 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX107,612,518 - 107,614,632 (-)Ensemblrn6Rnor6.0
Rnor_5.0X107,491,614 - 107,493,728 (-)NCBIRnor_5.0Rnor_5.0rn5
CeleraX101,126,074 - 101,128,188 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3',5'-cyclic AMP  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
cisplatin  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
Lasiocarpine  (ISO)
methimazole  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
progesterone  (EXP,ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19233202   PMID:19296525  


Genomics

Comparative Map Data
Tmsb15b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X105,090,980 - 105,093,094 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX105,090,980 - 105,093,094 (-)EnsemblGRCr8
mRatBN7.2X100,298,705 - 100,300,820 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX100,298,514 - 100,300,886 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX102,428,865 - 102,430,979 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X105,927,537 - 105,929,651 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X103,496,711 - 103,498,826 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X107,612,518 - 107,614,632 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX107,612,518 - 107,614,632 (-)Ensemblrn6Rnor6.0
Rnor_5.0X107,491,614 - 107,493,728 (-)NCBIRnor_5.0Rnor_5.0rn5
CeleraX101,126,074 - 101,128,188 (-)NCBICelera
Cytogenetic MapXq32NCBI
TMSB15A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X102,513,682 - 102,516,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX102,513,674 - 102,516,795 (-)Ensemblhg38GRCh38
GRCh37X101,768,610 - 101,771,667 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X101,655,266 - 101,658,355 (-)NCBIBuild 36Build 36hg18NCBI36
CeleraX102,207,240 - 102,210,329 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,433,976 - 91,437,049 (-)NCBIHuRef
CHM1_1X101,661,281 - 101,664,370 (-)NCBICHM1_1
T2T-CHM13v2.0X100,958,170 - 100,961,227 (-)NCBIT2T-CHM13v2.0
Tmsb15b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X135,855,737 - 135,858,728 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX135,856,014 - 135,858,774 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X136,954,988 - 136,957,979 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX136,955,265 - 136,975,497 (-)Ensemblmm10GRCm38
MGSCv37X133,489,805 - 133,492,518 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X133,489,527 - 133,492,548 (-)NCBIMGSCv36mm8
CeleraX120,235,228 - 120,237,941 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX59.1NCBI
Tmsb15a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495554884,399 - 86,594 (-)NCBIChiLan1.0ChiLan1.0
TMSB15A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,124,449 - 102,127,539 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,128,054 - 102,131,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,742,014 - 91,745,110 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,122,672 - 102,125,764 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX102,122,671 - 102,125,780 (-)EnsemblpanPan2panpan1.1
TMSB15A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X83,744,536 - 83,747,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,684,765 - 97,687,815 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMSB15A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X90,497,649 - 90,500,805 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX90,498,057 - 90,499,132 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606515,327,664 - 15,330,777 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmsb15a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X87,801,050 - 87,802,155 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmsb15b2
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:28
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000057140
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH130085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,298,727 - 100,298,921 (+)MAPPERmRatBN7.2
Rnor_6.0X107,612,541 - 107,612,734NCBIRnor6.0
Rnor_5.0X107,491,637 - 107,491,830UniSTSRnor5.0
CeleraX101,126,097 - 101,126,290UniSTS
RH 3.4 Map21607.4UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 86 85 54 92 54 6 348 192 11 144 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000057140   ⟹   ENSRNOP00000053968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX105,090,980 - 105,093,094 (-)Ensembl
mRatBN7.2 EnsemblX100,298,514 - 100,300,886 (-)Ensembl
Rnor_6.0 EnsemblX107,612,518 - 107,614,632 (-)Ensembl
RefSeq Acc Id: NM_173313   ⟹   NP_775435
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X105,090,980 - 105,093,094 (-)NCBI
mRatBN7.2X100,298,705 - 100,300,820 (-)NCBI
Rnor_6.0X107,612,518 - 107,614,632 (-)NCBI
Rnor_5.0X107,491,614 - 107,493,728 (-)NCBI
CeleraX101,126,074 - 101,128,188 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_775435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB37101 (Get FASTA)   NCBI Sequence Viewer  
  EDL87991 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053968
  ENSRNOP00000053968.4
RefSeq Acc Id: NP_775435   ⟸   NM_173313
- UniProtKB: P97563 (UniProtKB/TrEMBL),   D3ZJE8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053968   ⟸   ENSRNOT00000057140

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97563-F1-model_v2 AlphaFold P97563 1-45 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701948
Promoter ID:EPDNEW_R12471
Type:multiple initiation site
Name:Tmsb15b2_1
Description:thymosin beta 15B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X107,614,643 - 107,614,703EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708373 AgrOrtholog
BioCyc Gene G2FUF-1602 BioCyc
Ensembl Genes ENSRNOG00000037661 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057140 ENTREZGENE
  ENSRNOT00000057140.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.520 UniProtKB/TrEMBL
InterPro Beta-thymosin_sf UniProtKB/TrEMBL
  Thymosin_b4 UniProtKB/TrEMBL
KEGG Report rno:286978 UniProtKB/TrEMBL
NCBI Gene 286978 ENTREZGENE
PANTHER PTHR12021 UniProtKB/TrEMBL
  THYMOSIN BETA-15A-RELATED UniProtKB/TrEMBL
Pfam Thymosin UniProtKB/TrEMBL
PhenoGen Tmsb15b2 PhenoGen
PIRSF Thymosin_beta UniProtKB/TrEMBL
PROSITE THYMOSIN_B4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037661 RatGTEx
SMART THY UniProtKB/TrEMBL
UniProt A0A8J8YFF8_RAT UniProtKB/TrEMBL
  D3ZJE8 ENTREZGENE
  P97563 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZJE8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-28 Tmsb15b2  thymosin beta 15B2  Tmsbl1  thymosin beta-like protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Tmsbl1  thymosin beta-like protein 1  LOC286978  thymosin beta-like protein  Symbol updated 1299863 APPROVED