Nexn (nexilin (F actin binding protein)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nexn (nexilin (F actin binding protein)) Rattus norvegicus
Analyze
Symbol: Nexn
Name: nexilin (F actin binding protein)
RGD ID: 708354
Description: Enables actin filament binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; neuron development; and regulation of cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Located in Z disc and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Orthologous to human NEXN (nexilin F-actin binding protein); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC246172; nexilin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,846,736 - 243,878,268 (-)NCBIGRCr8
mRatBN7.22241,186,783 - 241,218,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2241,186,790 - 241,218,342 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2249,001,122 - 249,021,940 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02246,888,139 - 246,908,957 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02241,787,531 - 241,808,345 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02257,452,937 - 257,484,607 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2257,453,347 - 257,484,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02276,129,684 - 276,161,434 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42250,762,017 - 250,783,765 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12250,776,623 - 250,798,372 (-)NCBI
Celera2233,122,059 - 233,142,757 (-)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
glycidyl methacrylate  (ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IEA,ISO)
adherens junction  (IEA)
axon  (IBA)
cell-substrate junction  (IDA)
cytoskeleton  (IEA)
focal adhesion  (IBA,IDA)
plasma membrane  (IBA,IEA,ISO)
Z disc  (IBA,IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Hassel D, etal., Nat Med. 2009 Nov;15(11):1281-8. doi: 10.1038/nm.2037. Epub 2009 Nov 1.
3. Nexilin: a novel actin filament-binding protein localized at cell-matrix adherens junction. Ohtsuka T, etal., J Cell Biol 1998 Nov 30;143(5):1227-38.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15823560   PMID:21423176   PMID:23012479   PMID:23383252   PMID:25062485   PMID:35352799  


Genomics

Comparative Map Data
Nexn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,846,736 - 243,878,268 (-)NCBIGRCr8
mRatBN7.22241,186,783 - 241,218,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2241,186,790 - 241,218,342 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2249,001,122 - 249,021,940 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02246,888,139 - 246,908,957 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02241,787,531 - 241,808,345 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02257,452,937 - 257,484,607 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2257,453,347 - 257,484,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02276,129,684 - 276,161,434 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42250,762,017 - 250,783,765 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12250,776,623 - 250,798,372 (-)NCBI
Celera2233,122,059 - 233,142,757 (-)NCBICelera
Cytogenetic Map2q45NCBI
NEXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,888,624 - 77,943,895 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,888,513 - 77,943,895 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,354,309 - 78,409,580 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,126,788 - 78,182,168 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,095,828 - 78,120,930NCBI
Celera176,593,252 - 76,648,659 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef176,485,827 - 76,541,199 (+)NCBIHuRef
CHM1_1178,470,589 - 78,525,920 (+)NCBICHM1_1
T2T-CHM13v2.0177,727,428 - 77,782,694 (+)NCBIT2T-CHM13v2.0
Nexn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393151,942,619 - 151,972,000 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3151,942,619 - 151,971,987 (-)EnsemblGRCm39 Ensembl
GRCm383152,236,982 - 152,266,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3152,236,982 - 152,266,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv373151,899,946 - 151,929,284 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363152,174,368 - 152,216,670 (-)NCBIMGSCv36mm8
Celera3158,714,841 - 158,744,187 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map377.07NCBI
Nexn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542315,278,526 - 15,299,659 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542315,278,526 - 15,299,654 (-)NCBIChiLan1.0ChiLan1.0
NEXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,945,882 - 149,003,523 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,107,166 - 148,166,147 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,104,269 - 77,162,517 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,187,779 - 79,247,161 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,187,779 - 79,244,732 (+)Ensemblpanpan1.1panPan2
NEXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1668,963,953 - 69,014,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl668,964,187 - 69,107,009 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha671,621,447 - 71,672,401 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0669,548,680 - 69,599,798 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl669,549,074 - 69,597,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1669,055,004 - 69,106,149 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0669,000,304 - 69,051,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0669,486,699 - 69,537,684 (-)NCBIUU_Cfam_GSD_1.0
Nexn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505889,191,107 - 89,217,953 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365714,703,955 - 4,729,018 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365714,704,009 - 4,728,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6135,318,754 - 135,382,882 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16135,315,000 - 135,382,911 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26125,500,984 - 125,502,455 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12055,229,093 - 55,286,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2055,234,782 - 55,285,755 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603362,227,938 - 62,283,369 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nexn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474219,313,264 - 19,349,394 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474219,313,262 - 19,357,052 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nexn
120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:85
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000016967, ENSRNOT00000066780
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat

Markers in Region
AA799423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22241,186,902 - 241,186,998 (+)MAPPERmRatBN7.2
Rnor_6.02257,453,057 - 257,453,152NCBIRnor6.0
Rnor_5.02276,129,804 - 276,129,899UniSTSRnor5.0
RGSC_v3.42250,761,528 - 250,761,623UniSTSRGSC3.4
Celera2233,121,570 - 233,121,665UniSTS
RH 3.4 Map21650.31UniSTS
Cytogenetic Map2q45UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016967   ⟹   ENSRNOP00000016968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,186,798 - 241,207,216 (-)Ensembl
Rnor_6.0 Ensembl2257,453,546 - 257,474,733 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066780   ⟹   ENSRNOP00000058811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,186,798 - 241,218,342 (-)Ensembl
Rnor_6.0 Ensembl2257,453,546 - 257,474,733 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083344   ⟹   ENSRNOP00000073825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,186,798 - 241,207,216 (-)Ensembl
Rnor_6.0 Ensembl2257,453,347 - 257,484,587 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099274   ⟹   ENSRNOP00000080182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,186,798 - 241,218,342 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100634   ⟹   ENSRNOP00000096571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,186,790 - 241,218,342 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110679   ⟹   ENSRNOP00000077161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,186,790 - 241,218,342 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111795   ⟹   ENSRNOP00000082246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,186,790 - 241,218,342 (-)Ensembl
RefSeq Acc Id: NM_139230   ⟹   NP_631976
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,878,152 (-)NCBI
mRatBN7.22241,186,783 - 241,218,200 (-)NCBI
Rnor_6.02257,453,546 - 257,474,733 (-)NCBI
Rnor_5.02276,129,684 - 276,161,434 (-)NCBI
RGSC_v3.42250,762,017 - 250,783,765 (-)RGD
Celera2233,122,059 - 233,142,757 (-)RGD
Sequence:
RefSeq Acc Id: NM_139231   ⟹   NP_631977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,878,152 (-)NCBI
mRatBN7.22241,186,783 - 241,218,200 (-)NCBI
Rnor_6.02257,453,546 - 257,474,733 (-)NCBI
Rnor_5.02276,129,684 - 276,161,434 (-)NCBI
RGSC_v3.42250,762,017 - 250,783,765 (-)RGD
Celera2233,122,059 - 233,142,757 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233479   ⟹   XP_006233541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,878,268 (-)NCBI
mRatBN7.22241,186,783 - 241,218,297 (-)NCBI
Rnor_6.02257,452,937 - 257,484,607 (-)NCBI
Rnor_5.02276,129,684 - 276,161,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233480   ⟹   XP_006233542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,878,010 (-)NCBI
mRatBN7.22241,186,783 - 241,218,064 (-)NCBI
Rnor_6.02257,452,937 - 257,484,483 (-)NCBI
Rnor_5.02276,129,684 - 276,161,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233485   ⟹   XP_006233547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,878,266 (-)NCBI
mRatBN7.22241,186,783 - 241,218,294 (-)NCBI
Rnor_6.02257,452,937 - 257,484,607 (-)NCBI
Rnor_5.02276,129,684 - 276,161,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101726   ⟹   XP_038957654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,877,634 (-)NCBI
mRatBN7.22241,186,783 - 241,217,691 (-)NCBI
RefSeq Acc Id: XM_039101727   ⟹   XP_038957655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,878,078 (-)NCBI
mRatBN7.22241,186,783 - 241,218,064 (-)NCBI
RefSeq Acc Id: XM_063281296   ⟹   XP_063137366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,846,736 - 243,878,054 (-)NCBI
RefSeq Acc Id: NP_631977   ⟸   NM_139231
- Peptide Label: isoform s
- UniProtKB: A6HWK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_631976   ⟸   NM_139230
- Peptide Label: isoform b
- UniProtKB: Q9Z2J3 (UniProtKB/Swiss-Prot),   Q9Z2J4 (UniProtKB/Swiss-Prot),   A6HWK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233541   ⟸   XM_006233479
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QTU4 (UniProtKB/TrEMBL),   A0A8I5ZUL4 (UniProtKB/TrEMBL),   A6HWK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233547   ⟸   XM_006233485
- Peptide Label: isoform X3
- UniProtKB: A6HWK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233542   ⟸   XM_006233480
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QTU4 (UniProtKB/TrEMBL),   A0A8I5ZUL4 (UniProtKB/TrEMBL),   A6HWK9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016968   ⟸   ENSRNOT00000016967
Ensembl Acc Id: ENSRNOP00000073825   ⟸   ENSRNOT00000083344
Ensembl Acc Id: ENSRNOP00000058811   ⟸   ENSRNOT00000066780
RefSeq Acc Id: XP_038957655   ⟸   XM_039101727
- Peptide Label: isoform X2
- UniProtKB: A6HWK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957654   ⟸   XM_039101726
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QTU4 (UniProtKB/TrEMBL),   A0A8I5ZUL4 (UniProtKB/TrEMBL),   A6HWK9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080182   ⟸   ENSRNOT00000099274
Ensembl Acc Id: ENSRNOP00000082246   ⟸   ENSRNOT00000111795
Ensembl Acc Id: ENSRNOP00000077161   ⟸   ENSRNOT00000110679
Ensembl Acc Id: ENSRNOP00000096571   ⟸   ENSRNOT00000100634
RefSeq Acc Id: XP_063137366   ⟸   XM_063281296
- Peptide Label: isoform X3
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2J4-F1-model_v2 AlphaFold Q9Z2J4 1-656 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691834
Promoter ID:EPDNEW_R2350
Type:single initiation site
Name:Nexn_1
Description:nexilin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02257,484,584 - 257,484,644EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708354 AgrOrtholog
BioCyc Gene G2FUF-50805 BioCyc
Ensembl Genes ENSRNOG00000012512 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016967.8 UniProtKB/TrEMBL
  ENSRNOT00000066780.3 UniProtKB/TrEMBL
  ENSRNOT00000083344.2 UniProtKB/TrEMBL
  ENSRNOT00000099274.1 UniProtKB/Swiss-Prot
  ENSRNOT00000100634.1 UniProtKB/TrEMBL
  ENSRNOT00000110679.1 UniProtKB/TrEMBL
  ENSRNOT00000111795.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246172 UniProtKB/Swiss-Prot
NCBI Gene 246172 ENTREZGENE
PANTHER MITOGUARDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGUARDIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nexn PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012512 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6I3_RAT UniProtKB/TrEMBL
  A0A8I5ZJE5_RAT UniProtKB/TrEMBL
  A0A8I5ZUL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQU8_RAT UniProtKB/TrEMBL
  A0A8L2Q8C7_RAT UniProtKB/TrEMBL
  A0A8L2QTU4 ENTREZGENE, UniProtKB/TrEMBL
  A6HWK7 ENTREZGENE, UniProtKB/TrEMBL
  A6HWK8 ENTREZGENE, UniProtKB/TrEMBL
  A6HWK9 ENTREZGENE, UniProtKB/TrEMBL
  A6HWL0_RAT UniProtKB/TrEMBL
  NEXN_RAT UniProtKB/Swiss-Prot
  Q9Z2J3 ENTREZGENE
  Q9Z2J4 ENTREZGENE
UniProt Secondary Q9Z2J3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Nexn  nexilin (F actin binding protein)  Nexn  nexilin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Nexn  nexilin  LOC246172    Symbol updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein big b-nexilin and small s-nexillin isoforms are products of nexillin splicing variants 1299387