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Gene: Tert (telomerase reverse transcriptase) Rattus norvegicus
Symbol: Tert
Name: telomerase reverse transcriptase
Description: Predicted to have several functions, including chaperone binding activity; nucleic acid binding activity; and nucleotidyltransferase activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of transdifferentiation; and positive regulation of vascular associated smooth muscle cell migration. Localizes to mitochondrion and nucleus. Predicted to colocalize with PML body. Used to study chronic kidney disease and transient cerebral ischemia. Biomarker of hepatocellular carcinoma and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase reverse transcriptase); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: telomerase catalytic subunit
Homo sapiens (human) : TERT (telomerase reverse transcriptase)  HGNC  Alliance
Mus musculus (house mouse) : Tert (telomerase reverse transcriptase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tert (telomerase reverse transcriptase)
Pan paniscus (bonobo/pygmy chimpanzee) : TERT (telomerase reverse transcriptase)
Canis lupus familiaris (dog) : TERT (telomerase reverse transcriptase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tert (telomerase reverse transcriptase)
Sus scrofa (pig) : TERT (telomerase reverse transcriptase)
Chlorocebus sabaeus (African green monkey) : TERT (telomerase reverse transcriptase)
Heterocephalus glaber (naked mole-rat) : Tert (telomerase reverse transcriptase)
more info ...
Allele / Splice: Tertem2Mcwi  
Genetic Models: WKY-Tertem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0132,250,876 - 32,275,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,251,714 - 32,272,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,675,744 - 33,697,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,445,180 - 30,465,942 (-)NCBIRGSC3.4rn4RGSC3.4
Celera128,286,050 - 28,306,805 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tert
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70494
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.