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Gene: Slc5a6 (solute carrier family 5 member 6) Rattus norvegicus

Analyze

Symbol:

Slc5a6

Name:

solute carrier family 5 member 6

RGD ID:

69648

Description:

Enables sodium-dependent multivitamin transmembrane transporter activity. Involved in biotin transport and pantothenate transmembrane transport. Located in brush border membrane. Orthologous to human SLC5A6 (solute carrier family 5 member 6); INTERACTS WITH (R)-lipoic acid; (R)-pantothenic acid; 1,2,4-trimethylbenzene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Na(+)-dependent multivitamin transporter; SMVT; sodium-dependent multivitamin transporter; solute carrier family 5 (sodium-dependent vitamin transporter) member 6; solute carrier family 5 (sodium-dependent vitamin transporter), member 6; solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6; solute carrier family 5, member 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	31,039,865 - 31,051,671 (+)	NCBI		GRCr8
mRatBN7.2	6	25,319,187 - 25,331,713 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,320,442 - 25,331,712 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,621,246 - 25,632,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	25,937,114 - 25,948,381 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,416,026 - 25,427,321 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	26,685,823 - 26,697,110 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	26,686,033 - 26,697,116 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,499,460 - 36,512,085 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	25,301,630 - 25,312,901 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	25,304,582 - 25,315,853 (+)	NCBI
Celera	6	24,811,307 - 24,822,588 (+)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

NEURODEGENERATION, INFANTILE-ONSET, BIOTIN-RESPONSIVE (ISO)

PERIPHERAL MOTOR NEUROPATHY, CHILDHOOD-ONSET, BIOTIN-RESPONSIVE (ISO)

Tatton-Brown-Rahman syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(R)-lipoic acid (EXP,ISO)

(R)-pantothenic acid (EXP,ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrophenol (ISO)

2,4-dinitrotoluene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4-hydroxyphenyl retinamide (ISO)

4-phenylbutyric acid (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsenous acid (ISO)

azide (ISO)

benzo[a]pyrene (ISO)

biotin (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (ISO)

calmidazolium (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chelerythrine (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cordycepin (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dichloroacetic acid (ISO)

dicrotophos (ISO)

dieldrin (EXP)

dioxygen (ISO)

epoxiconazole (ISO)

flutamide (EXP)

FR900359 (ISO)

genistein (ISO)

glutathione (EXP)

heptachlor (EXP)

hydrogen peroxide (ISO)

isotretinoin (ISO)

lipoic acid (EXP,ISO)

methimazole (EXP)

methotrexate (ISO)

mirex (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosomorpholine (EXP)

ouabain (ISO)

p-chloromercuribenzenesulfonic acid (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

PhIP (EXP)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

probenecid (ISO)

propiconazole (EXP)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium atom (EXP,ISO)

staurosporine (ISO)

sulfadimethoxine (EXP)

thiram (ISO)

titanium dioxide (ISO)

tributylstannane (ISO)

trifluoperazine (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biotin import across plasma membrane (ISO,ISS)

biotin metabolic process (ISO)

biotin transport (IBA,IDA,ISO)

inorganic ion transmembrane transport (IEA)

iodide transmembrane transport (ISO,ISS)

monoatomic ion transmembrane transport (IEA)

pantothenate transmembrane transport (IBA,IDA,ISO)

sodium ion import across plasma membrane (IEA)

sodium ion transport (IBA,IEA)

transport across blood-brain barrier (ISO)

Cellular Component

apical plasma membrane (ISO,ISS)

basal plasma membrane (ISO)

basolateral plasma membrane (ISO)

brush border membrane (IDA)

plasma membrane (IEA,ISO)

Molecular Function

amide transmembrane transporter activity (ISO)

biotin transmembrane transporter activity (ISO,ISS)

iodide transmembrane transporter activity (ISO,ISS)

monoatomic ion transmembrane transporter activity (IEA)

monocarboxylate:sodium symporter activity (ISO)

pantothenate transmembrane transporter activity (ISO)

pantothenate:sodium symporter activity (ISO)

protein binding (ISO)

sodium-dependent multivitamin transmembrane transporter activity (IBA,IDA,ISO)

sulfur compound transmembrane transporter activity (ISO)

symporter activity (IEA)

vitamin transmembrane transporter activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular characterization of the 5' regulatory region of rat sodium-dependent multivitamin transporter gene.	Chatterjee NS, etal., Am J Physiol Cell Physiol 2001 Mar;280(3):C548-55.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat.	Nabokina SM, etal., Am J Physiol Renal Physiol 2003 Apr;284(4):F737-42.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate.	Prasad PD, etal., J Biol Chem 1998 Mar 27;273(13):7501-6.
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10516089	PMID:12477932	PMID:23104561	PMID:25809983

Genomics

Comparative Map Data

Slc5a6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	31,039,865 - 31,051,671 (+)	NCBI		GRCr8
mRatBN7.2	6	25,319,187 - 25,331,713 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,320,442 - 25,331,712 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,621,246 - 25,632,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	25,937,114 - 25,948,381 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,416,026 - 25,427,321 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	26,685,823 - 26,697,110 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	26,686,033 - 26,697,116 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,499,460 - 36,512,085 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	25,301,630 - 25,312,901 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	25,304,582 - 25,315,853 (+)	NCBI
Celera	6	24,811,307 - 24,822,588 (+)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

SLC5A6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	27,199,587 - 27,212,787 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	27,199,587 - 27,212,958 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	27,422,455 - 27,435,136 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	27,275,962 - 27,288,575 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	27,334,109 - 27,346,722	NCBI
Celera	2	27,268,776 - 27,281,501 (-)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	27,164,164 - 27,176,880 (-)	NCBI		HuRef
CHM1_1	2	27,352,374 - 27,365,079 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	27,241,206 - 27,254,815 (-)	NCBI		T2T-CHM13v2.0

Slc5a6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,193,380 - 31,206,268 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,193,380 - 31,206,268 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	31,036,036 - 31,048,924 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	31,036,036 - 31,048,924 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,338,409 - 31,351,297 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,312,617 - 31,324,830 (-)	NCBI		MGSCv36	mm8
Celera	5	28,507,988 - 28,520,955 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	16.93	NCBI

SLC5A6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	99,300,360 - 99,317,327 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	99,304,749 - 99,322,407 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	27,199,422 - 27,213,650 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	27,288,726 - 27,302,128 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	27,288,726 - 27,301,896 (-)	Ensembl	panpan1.1		panPan2

SLC5A6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	21,181,916 - 21,194,301 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	21,031,765 - 21,193,112 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	21,073,728 - 21,086,105 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,502,873 - 21,515,270 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,351,935 - 21,515,309 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	21,189,666 - 21,202,032 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	21,200,734 - 21,213,100 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	21,247,616 - 21,259,983 (-)	NCBI		UU_Cfam_GSD_1.0

Slc5a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,489,807 - 65,506,815 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,338,289 - 5,349,758 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	5,338,119 - 5,349,758 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC5A6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	111,922,848 - 111,930,940 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	111,919,298 - 111,930,944 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	118,917,508 - 118,929,193 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103220608
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,406,221 - 80,415,730 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,407,561 - 80,416,848 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	31,738,413 - 31,751,070 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Slc5a6
42 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	300
Count of miRNA genes:	194
Interacting mature miRNAs:	215
Transcripts:	ENSRNOT00000009042
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	16536140	27261739	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat

Markers in Region

RH130251

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	25,331,450 - 25,331,657 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	26,696,848 - 26,697,054	NCBI	Rnor6.0
Rnor_5.0	6	36,511,823 - 36,512,029	UniSTS	Rnor5.0
RGSC_v3.4	6	25,312,639 - 25,312,845	UniSTS	RGSC3.4
Celera	6	24,822,316 - 24,822,532	UniSTS
RH 3.4 Map	6	117.9	UniSTS
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001434151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_130746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF026554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF081204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF081205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF143309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF143310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF143311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF189010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000081167 ⟹ ENSRNOP00000071291

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,320,478 - 25,331,710 (+)	Ensembl
Rnor_6.0 Ensembl	6	26,686,033 - 26,697,116 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082623 ⟹ ENSRNOP00000075361

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,320,442 - 25,331,712 (+)	Ensembl
Rnor_6.0 Ensembl	6	26,686,205 - 26,696,957 (+)	Ensembl

RefSeq Acc Id:

NM_130746 ⟹ NP_570102

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	31,040,400 - 31,051,671 (+)	NCBI
mRatBN7.2	6	25,320,442 - 25,331,713 (+)	NCBI
Rnor_6.0	6	26,685,823 - 26,697,110 (+)	NCBI
Rnor_5.0	6	36,499,460 - 36,512,085 (+)	NCBI
RGSC_v3.4	6	25,301,630 - 25,312,901 (+)	RGD
Celera	6	24,811,307 - 24,822,588 (+)	RGD

Sequence:

show sequence

GTTCGCCACGTGTGGAGAGAAGGGAAAAACTGAGCCGAGAGAGGGGGGAAAAAAACCAATGCTG
ATTTCGGAAAGAACGAAGGAACTTCGGTAGCCCTGGCCGAACCACCGACGCAAGGAAGGTAGCG
CTTCCGCAGAGCGGCAGCAGTTCTGACTGGAGGGGCGCTCGCTGGGAGAGACCCATCACACCTA
AGGGGACAGCTATTGCTCTGGGTGACGACTCCTAAAAAGAGAATCGGTGCCTCTACCTCTCCAC
GTAGCTCTGCTTCAGAACGGGGATTGCTTCTCCAGCTCCCCCTGGACCATGCCACTGGGTGGAA
GAGGAACGCTGAGAGGCTGAGCGAGGAACCAGCTAGGTGACAACTCAGAGCCCAGGAGTACCAA
GTCACTGTAAAGCATAGGCACCGTGAGGATGACTGTGGCGAGCACTGCGGCTCCCTCCTATACA
ACCTCAGACACCAACCGGGTTATTTCCACCTTTTCTGTTGTGGACTATGTGGTGTTTGGCCTGT
TGCTGGTTCTCTCCCTTGTCATTGGGCTCTATCATGCTTGCCGAGGCTGGGGCCGCCATACTGT
TGGTGAGCTGCTGATGGCAGACCGAAAAATGGGCTGCCTTCCTGTGGCACTGTCCTTGCTGGCC
ACCTTCCAGTCAGCCGTGGCGATCCTTGGGGGACCAGCTGAGATCTACCGATTTGGAACCCAGT
ATTGGTTCCTGGGGTGCTCCTACTTCCTGGGGCTTCTGATCCCTGCTCACATCTTCATCCCTGT
CTTCTACCGCCTGCATCTTACCAGCGCCTATGAGTACCTAGAGCTCCGCTTCAATAAAGCAGTC
CGGATCTGTGGGACTGTGACCTTCATCTTTCAGATGGTGGTCTACATGGGAGTGGCTCTCTATG
CACCGTCCCTGGCCCTCAATGCAGTGACTGGATTTGATCTATGGCTGTCAGTCCTGGCCCTAGG
AATTGTCTGCAACATCTACACTGCACTGGGTGGGCTGAAGGCTGTCATCTGGACAGATGTGTTC
CAAACGTTGATCATGTTCCTAGGGCAGCTGGTGGTTATCATTGTAGGAGCGGCCAAAGTGGGCG
GCTTGGGGCATGTATGGGCTGTGGCTTCCCAGCATGGCCTCATCTCTGGGATTGAGCTGGATCC
TGACCCCTTTGTACGTCATACTTTCTGGACTTTGGCCTTTGGCGGCGTCTTCATGATGCTCTCC
TTATATGGAGTGAATCAGGCTCAGGTGCAGCGCTACCTCAGTTCCCACTCAGAGAAGGCTGCTG
TGCTCTCCTGCTATGCAGTGTTCCCTTGCCAGCAAGTGGCCCTCTGCATGAGCTGCCTCATTGG
TCTGGTCATGTTTGCCTATTATAAGAAATATAGTATGAGCCCCCAACAAGAGCAAGCAGCCCCT
GACCAGTTAGTCCTCTATTTTGTGATGGACCTCCTGAAAGACATGCCAGGGCTGCCCGGGCTCT
TCGTTGCTTGCCTCTTCAGTGGATCTCTCAGCACCATATCCTCCGCATTCAATTCACTGGCCAC
TGTCACAATGGAAGACCTGATCCAGCCCTGGTTCCCTCAGTTGACTGAAACCCGGGCCATCATG
CTCTCTCGAAGCCTTGCCTTTGCCTATGGGCTAGTTTGCCTGGGAATGGCCTATGTTTCCTCTC
ATCTGGGATCAGTGCTCCAGGCAGCACTCAGCATCTTTGGCATGGTTGGAGGGCCACTGCTGGG
ACTCTTCTGCCTTGGGATGTTCTTTCCGTGTGCCAACCCTCTTGGTGCCATTGTAGGCCTGTTG
ACGGGACTCACCATGGCCTTCTGGATTGGCATTGGGAGCATAGTAAGCAGGATGAGTTCTGCTG
CAGCATCCCCTCCCCTTAATGGATCCAGCTCCTTCCTGCCCAGCAATCTAACTGTCGCCACTGT
GACCACCCTGATGCCTTCTACCCTGTCCAAGCCCACAGGACTGCAGCAGTTCTATTCCCTGTCC
TATTTATGGTACAGTGCGCACAACTCCACCACAGTCATTGCAGTGGGCCTGATTGTCAGTCTGC
TCACTGGGGGAATGCGGGGCCGGTCCCTGAACCCTGGCACCATTTACCCTGTGTTGCCAAAGCT
CCTTGCACTCCTGCCCTTATCCTGCCAGAAGCGGCTTTGCTGGAGAAGCCACAACCAGGATATC
CCTGTGGTCACCAACCTGTTTCCAGAGAAGATGGGGAACGGAGCGCTGCAGGACAGCAGAGACA
AAGAGAGGATGGCTGAAGATGGCCTTGTCCATCAGCCATGCAGCCCCACCTACATTGTCCAAGA
GACGTCCCTGTGACCTGTGACGGACCTCTCACTGCAGAGCAGTGGCCAGAGATACTCTGGAGTG
CAGAGCTGAGTCACTGCATGAGTTCCGCAGCACTGGGGTGGATGACCTAGCTCACAGCAAAGGA
CCTTGATCTTTAATGTTTCACCGCCGTGGGAGCTGTCGCATGCAAGGGACAGACAGTTTTTCCT
TATCCCTTGCCAGTCTTCTTTTAGGATCAGGTTTGCAAGGTACAGAATCACAGCACACGTGGGG
AAATATACTGAGGAAAGGGTGGCTTTTGATTAAGTGACCAGGGTTCTTTGGGGTGAATAGGAAC
ATTTCTTACAACTCCCCTTGAGCAAGTTTGGCAGGATTGACCAGCTCCAGCATTTAGCATGAAG
TCCTCAGCCCTCTGGTGATTCCCTCACTCTCATGTCAACCTGGGTTATCTCAAGCCAGTGTGGG
CCTGTGGTCTTCAGGTTCTCTGTAAGACTCAAGTCTCCTCTCATTCTACCTACCTCTGTTTGTG
AGAGGGAGGCTTTGGAGCGCTTGGGTCTCAGCACTTAGTGCATCTACTTGGTGTATAGACCCTC
GCTCTCTTCAGGTGGTACATGAGAGACAGGTACATGAGAGAGGTCACCAGGACCTCTTATGCAG
TGTGCTATCCTCTAAACTCCTAAGCTAGGCCACCCTGGTGTCATTCTGTCATCTGTGCAATTCT
TATTTCCTTTGGGAGTTTCCTCCTCATGCATTTTGTTCCTAGGGAATAAAAATAGCCATTAGAC
CTGAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039111708 ⟹ XP_038967636

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	31,039,865 - 31,051,671 (+)	NCBI
mRatBN7.2	6	25,319,908 - 25,331,713 (+)	NCBI

RefSeq Acc Id:

XM_039111709 ⟹ XP_038967637

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	31,040,391 - 31,051,671 (+)	NCBI
mRatBN7.2	6	25,320,382 - 25,331,713 (+)	NCBI

RefSeq Acc Id:

XM_039111710 ⟹ XP_038967638

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	31,040,352 - 31,051,671 (+)	NCBI
mRatBN7.2	6	25,320,378 - 25,331,713 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001421080	(Get FASTA)	NCBI Sequence Viewer
	NP_001421081	(Get FASTA)	NCBI Sequence Viewer
	NP_001421082	(Get FASTA)	NCBI Sequence Viewer
	NP_570102	(Get FASTA)	NCBI Sequence Viewer
	XP_038967636	(Get FASTA)	NCBI Sequence Viewer
	XP_038967637	(Get FASTA)	NCBI Sequence Viewer
	XP_038967638	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC12270	(Get FASTA)	NCBI Sequence Viewer
	AAC64060	(Get FASTA)	NCBI Sequence Viewer
	AAC64061	(Get FASTA)	NCBI Sequence Viewer
	AAI68145	(Get FASTA)	NCBI Sequence Viewer
	AAK91810	(Get FASTA)	NCBI Sequence Viewer
	EDM02944	(Get FASTA)	NCBI Sequence Viewer
	EDM02945	(Get FASTA)	NCBI Sequence Viewer
	EDM02946	(Get FASTA)	NCBI Sequence Viewer
	EDM02947	(Get FASTA)	NCBI Sequence Viewer
	EDM02948	(Get FASTA)	NCBI Sequence Viewer
	EDM02949	(Get FASTA)	NCBI Sequence Viewer
	EDM02950	(Get FASTA)	NCBI Sequence Viewer
	EDM02951	(Get FASTA)	NCBI Sequence Viewer
	EDM02952	(Get FASTA)	NCBI Sequence Viewer
	EDM02953	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071291.2
	ENSRNOP00000075361.1
	ENSRNOP00055025463
	ENSRNOP00060017999
	ENSRNOP00065032119
GenBank Protein	O70247	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_570102 ⟸ NM_130746

- UniProtKB:

O70247 (UniProtKB/Swiss-Prot), B4F760 (UniProtKB/TrEMBL), A0A8L2R3T7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTVASTAAPSYTTSDTNRVISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGRHTVGELLMADRK
MGCLPVALSLLATFQSAVAILGGPAEIYRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSA
YEYLELRFNKAVRICGTVTFIFQMVVYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTAL
GGLKAVIWTDVFQTLIMFLGQLVVIIVGAAKVGGLGHVWAVASQHGLISGIELDPDPFVRHTFW
TLAFGGVFMMLSLYGVNQAQVQRYLSSHSEKAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYKK
YSMSPQQEQAAPDQLVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQP
WFPQLTETRAIMLSRSLAFAYGLVCLGMAYVSSHLGSVLQAALSIFGMVGGPLLGLFCLGMFFP
CANPLGAIVGLLTGLTMAFWIGIGSIVSRMSSAAASPPLNGSSSFLPSNLTVATVTTLMPSTLS
KPTGLQQFYSLSYLWYSAHNSTTVIAVGLIVSLLTGGMRGRSLNPGTIYPVLPKLLALLPLSCQ
KRLCWRSHNQDIPVVTNLFPEKMGNGALQDSRDKERMAEDGLVHQPCSPTYIVQETSL

hide sequence

Ensembl Acc Id:

ENSRNOP00000075361 ⟸ ENSRNOT00000082623

Ensembl Acc Id:

ENSRNOP00000071291 ⟸ ENSRNOT00000081167

RefSeq Acc Id:	XP_038967636 ⟸ XM_039111708
- Peptide Label:	isoform X1
- UniProtKB:	O70247 (UniProtKB/Swiss-Prot), B4F760 (UniProtKB/TrEMBL), A0A8L2R3T7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967638 ⟸ XM_039111710
- Peptide Label:	isoform X1
- UniProtKB:	O70247 (UniProtKB/Swiss-Prot), B4F760 (UniProtKB/TrEMBL), A0A8L2R3T7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967637 ⟸ XM_039111709
- Peptide Label:	isoform X1
- UniProtKB:	O70247 (UniProtKB/Swiss-Prot), B4F760 (UniProtKB/TrEMBL), A0A8L2R3T7 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O70247-F1-model_v2	AlphaFold	O70247	1-634	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69648	AgrOrtholog
BioCyc Gene	G2FUF-38340	BioCyc
Ensembl Genes	ENSRNOG00000057628	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055018542	UniProtKB/Swiss-Prot
	ENSRNOG00060013362	UniProtKB/Swiss-Prot
	ENSRNOG00065023118	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000081167.2	UniProtKB/TrEMBL
	ENSRNOT00000082623.2	UniProtKB/Swiss-Prot
	ENSRNOT00055031528	UniProtKB/Swiss-Prot
	ENSRNOT00060022753	UniProtKB/Swiss-Prot
	ENSRNOT00065039504	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1730.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Na/Glc_symporter_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Na/solute_symporter	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Na/solute_symporter_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sodium:Solute_Symporter_SSF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:170551	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	170551	ENTREZGENE
PANTHER	SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	SSF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc5a6	PhenoGen
PROSITE	NA_SOLUT_SYMP_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NA_SOLUT_SYMP_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000057628	RatGTEx
	ENSRNOG00055018542	RatGTEx
	ENSRNOG00060013362	RatGTEx
	ENSRNOG00065023118	RatGTEx
TIGR	TC217445
UniProt	A0A8L2R3T7	ENTREZGENE, UniProtKB/TrEMBL
	B4F760	ENTREZGENE, UniProtKB/TrEMBL
	O70247	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc5a6	solute carrier family 5 member 6	Slc5a6	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc5a6	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	Slc5a6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Slc5a6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6		solute carrier family 5, member 6	Name updated	1299863	APPROVED
2002-06-10	Slc5a6	solute carrier family 5, member 6			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_protein	634 amino acid, 68.6 kDa protein	68891
gene_protein	634 amino acid, 68.6 kDa protein	68917
gene_transcript	3.2 kb transcript	68891
gene_transcript	3.2 kb transcript	68917

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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