1. |
Stress, kappa manipulations, and aversive effects of ethanol in adolescent and adult male rats. |
Anderson RI, etal., Neuroscience. 2013 Sep 26;249:214-22. doi: 10.1016/j.neuroscience.2012.12.028. Epub 2012 Dec 29.
|
2. |
Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. |
Appleyard SM, etal., J Biol Chem. 2000 Dec 8;275(49):38281-5.
|
3. |
The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. |
Bazov I, etal., Addict Biol. 2013 Jan;18(1):161-9. doi: 10.1111/j.1369-1600.2011.00366.x. Epub 2011 Sep 28.
|
4. |
Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. |
Bruchas MR, etal., J Biol Chem. 2006 Jun 30;281(26):18081-9. Epub 2006 Apr 28.
|
5. |
Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. |
Chakrabarti S, etal., Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20115-9. doi: 10.1073/pnas.1009923107. Epub 2010 Nov 1.
|
6. |
G protein coupled receptor kinase-2 upregulation causes ¿-opioid receptor desensitization in diabetic heart. |
Chen X, etal., Biochem Biophys Res Commun. 2017 Jan 22;482(4):658-664. doi: 10.1016/j.bbrc.2016.11.090. Epub 2016 Nov 16.
|
7. |
Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors. |
Chen Y, etal., Biochem J 1993 Nov 1;295 ( Pt 3):625-8.
|
8. |
Opioid system genes in alcoholism: a case-control study in Croatian population. |
Cupic B, etal., Neuropeptides. 2013 Oct;47(5):315-9. doi: 10.1016/j.npep.2013.08.002. Epub 2013 Aug 28.
|
9. |
Kappa opioid receptors in the rostral ventromedial medulla of male and female rats. |
Drake CT, etal., J Comp Neurol. 2007 Jan 20;500(3):465-76.
|
10. |
Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis. |
Erikson CM, etal., Neuropharmacology. 2018 Sep 15;140:162-173. doi: 10.1016/j.neuropharm.2018.07.034. Epub 2018 Jul 31.
|
11. |
Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5alpha-dihydrotestosterone-induced rat polycystic ovary syndrome model. |
Feng Y, etal., Exp Physiol. 2012 May;97(5):651-62. doi: 10.1113/expphysiol.2011.063131. Epub 2012 Feb 15.
|
12. |
Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593. |
Fuentealba JA, etal., Synapse. 2007 Sep;61(9):771-7.
|
13. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
|
14. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
|
15. |
The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. |
Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
|
16. |
Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats. |
Groblewski PA, etal., Addict Biol. 2015 Mar;20(2):297-301. doi: 10.1111/adb.12123. Epub 2014 Feb 15.
|
17. |
The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat. |
Jarosz PA Biol Res Nurs. 2007 Apr;8(4):294-9.
|
18. |
Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats. |
Jolivalt CG, etal., Diabetologia. 2006 Nov;49(11):2775-85. Epub 2006 Aug 19.
|
19. |
kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. |
Joshi SK, etal., J Neurosci. 2000 Aug 1;20(15):5874-9.
|
20. |
OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder. |
Kaya-Akyüzlü D, etal., Environ Toxicol Pharmacol. 2023 Jun;100:104143. doi: 10.1016/j.etap.2023.104143. Epub 2023 May 3.
|
21. |
Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system. |
Le Guen S, etal., Eur J Neurosci. 2003 Jun;17(11):2425-37. doi: 10.1046/j.1460-9568.2003.02678.x.
|
22. |
Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. |
Lee JW, etal., J Neurochem. 1998 May;70(5):2203-11.
|
23. |
Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. |
Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
|
24. |
Molecular cloning and expression of a rat kappa opioid receptor. |
Li S, etal., Biochem J 1993 Nov 1;295 ( Pt 3):629-33.
|
25. |
Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction. |
Marchant NJ, etal., J Neurosci. 2010 Oct 20;30(42):14102-15. doi: 10.1523/JNEUROSCI.4079-10.2010.
|
26. |
Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. |
McLaughlin JP, etal., J Biol Chem. 2003 Sep 5;278(36):34631-40. Epub 2003 Jun 18.
|
27. |
Cloning and pharmacological characterization of a rat kappa opioid receptor. |
Meng F, etal., Proc Natl Acad Sci U S A 1993 Nov 1;90(21):9954-8.
|
28. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
|
29. |
Cloning and expression of a cDNA for the rat kappa-opioid receptor. |
Minami M, etal., FEBS Lett 1993 Aug 30;329(3):291-5.
|
30. |
dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. |
Mostari P, etal., J Reprod Dev. 2013;59(3):266-72. Epub 2013 Feb 8.
|
31. |
An analysis of genetic association in opioid dependence susceptibility. |
Nagaya D, etal., J Clin Pharm Ther. 2018 Feb;43(1):80-86. doi: 10.1111/jcpt.12585. Epub 2017 Jun 27.
|
32. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
|
33. |
cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands. |
Nishi M, etal., FEBS Lett 1993 Sep 6;330(1):77-80.
|
34. |
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population. |
Park CI, etal., CNS Neurosci Ther. 2020 Jan;26(1):30-38. doi: 10.1111/cns.13138. Epub 2019 Apr 19.
|
35. |
Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. |
Peart JN, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):410-5.
|
36. |
SMPDB Annotation Import Pipeline |
Pipeline to import SMPDB annotations from SMPDB into RGD
|
37. |
GOA pipeline |
RGD automated data pipeline
|
38. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
|
39. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
|
40. |
Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. |
Rosin A, etal., Neurosci Lett. 1999 Nov 5;275(1):1-4.
|
41. |
Bi-phasic intensity-dependent opioid-mediated neural amplitude changes in the chinchilla cochlea: partial blockade by an N-Methyl-D-Aspartate (NMDA)-receptor antagonist. |
Sahley TL, etal., Eur J Pharmacol. 2008 Feb 2;580(1-2):100-15. Epub 2007 Oct 25.
|
42. |
The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. |
Schank JR, etal., Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x.
|
43. |
Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. |
Schlosburg JE, etal., J Neurosci. 2013 Dec 4;33(49):19384-92. doi: 10.1523/JNEUROSCI.1979-13.2013.
|
44. |
Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. |
Seale SM, etal., Pharmacol Biochem Behav. 2012 Mar;101(1):77-84. doi: 10.1016/j.pbb.2011.12.006. Epub 2011 Dec 16.
|
45. |
A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats. |
Sedki F, etal., Addict Biol. 2014 Apr 13. doi: 10.1111/adb.12133.
|
46. |
Evaluation of dynorphin and kappa-opioid receptor level in the human blood lymphocytes and plasma: Possible role as a biomarker in severe opioid use disorder. |
Shahkarami K, etal., Drug Alcohol Depend. 2019 Dec 1;205:107638. doi: 10.1016/j.drugalcdep.2019.107638. Epub 2019 Nov 2.
|
47. |
Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. |
Silva RM, etal., J Pharmacol Exp Ther. 2002 May;301(2):513-8.
|
48. |
Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. |
Svingos AL, etal., Synapse. 2001 Dec 1;42(3):185-92. doi: 10.1002/syn.10005.
|
49. |
Tentative Sequence Identification Numbers |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
|
50. |
Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression. |
Teodorov E, etal., Braz J Med Biol Res. 2012 Oct;45(10):982-7. Epub 2012 May 31.
|
51. |
Treatment with steroid hormones and morphine alters general activity, sexual behavior, and opioid gene expression in female rats. |
Teodorov E, etal., Life Sci. 2014 May 28;104(1-2):47-54. doi: 10.1016/j.lfs.2014.03.021. Epub 2014 Mar 31.
|
52. |
Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. |
Teodorov E, etal., Neuroscience. 2006 Sep 1;141(3):1225-31. Epub 2006 Jun 6.
|
53. |
Upregulation of the kappa opioidergic system in left ventricular rat myocardium in response to volume overload: Adaptive changes of the cardiac kappa opioid system in heart failure. |
Treskatsch S, etal., Pharmacol Res. 2015 Dec;102:33-41. doi: 10.1016/j.phrs.2015.09.005. Epub 2015 Sep 10.
|
54. |
Regulation of kappa-opioid receptor mRNA level by cyclic AMP and growth factors in cultured rat glial cells. |
Tryoen-Toth P, etal., Brain Res Mol Brain Res. 1998 Mar 30;55(1):141-50.
|
55. |
Chronic nicotine-induced changes in gene expression of delta and kappa-opioid receptors and their endogenous ligands in the mesocorticolimbic system of the rat. |
Ugur M, etal., Synapse. 2017 Sep;71(9). doi: 10.1002/syn.21985. Epub 2017 May 29.
|
56. |
Variations in opioid receptor genes in neonatal abstinence syndrome. |
Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
|
57. |
Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. |
Wille-Bille A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. doi: 10.1016/j.pnpbp.2018.04.005. Epub 2018 Apr 18.
|
58. |
Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats. |
Wu G, etal., J Ethnopharmacol. 2011 Jun 14;136(1):254-9. doi: 10.1016/j.jep.2011.04.041. Epub 2011 Apr 28.
|
59. |
Association of the kappa-opioid system with alcohol dependence. |
Xuei X, etal., Mol Psychiatry. 2006 Nov;11(11):1016-24. doi: 10.1038/sj.mp.4001882. Epub 2006 Aug 22.
|
60. |
Structure and expression of a rat kappa opioid receptor gene. |
Yakovlev AG, etal., J Biol Chem 1995 Mar 24;270(12):6421-4.
|
61. |
Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. |
Yuferov V, etal., Neurosci Lett. 2022 Jan 18;768:136364. doi: 10.1016/j.neulet.2021.136364. Epub 2021 Nov 26.
|
62. |
Alterations in kappa opioid receptor mRNA levels in the paraventricular nucleus of the hypothalamus by stress and sex steroids. |
Yukhananov RY and Handa RJ, Neuroreport. 1996 Jul 8;7(10):1690-4.
|
63. |
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. |
Zhang H, etal., Mol Psychiatry. 2008 May;13(5):531-43. doi: 10.1038/sj.mp.4002035. Epub 2007 Jul 10.
|
64. |
κ Opioid Receptor 1 Single Nucleotide Polymorphisms were Associated with the Methadone Dosage. |
Zhang Q, etal., Genet Test Mol Biomarkers. 2020 Jan;24(1):17-23. doi: 10.1089/gtmb.2019.0159.
|
65. |
Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. |
Özkan-Kotiloğlu S, etal., Alcohol Alcohol. 2023 Jul 10;58(4):404-414. doi: 10.1093/alcalc/agad036.
|