Ube2d2b (ubiquitin-conjugating enzyme E2D 2B)

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Gene: Ube2d2b (ubiquitin-conjugating enzyme E2D 2B) Rattus norvegicus

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Symbol:

Ube2d2b

Name:

ubiquitin-conjugating enzyme E2D 2B

RGD ID:

69425

Description:

Predicted to enable ubiquitin conjugating enzyme activity. Involved in cellular response to arsenite(3-) and cellular response to cadmium ion. Predicted to be active in nucleus. Orthologous to human UBE2D4 (ubiquitin conjugating enzyme E2 D4); PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E2 ubiquitin-conjugating enzyme D2B; E2(17)KB 2B; RGD69425; Ube2d2; Ube2d4; ubiquitin carrier protein D2B; ubiquitin-conjugating enzyme; ubiquitin-conjugating enzyme E2 D2B; ubiquitin-conjugating enzyme E2(17)KB 2B; ubiquitin-conjugating enzyme E2-17 kDa 2B; ubiquitin-conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2D 4; ubiquitin-conjugating enzyme E2D 4 (putative); ubiquitin-protein ligase D2B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	2,060,926 - 2,062,400 (-)	NCBI		GRCr8
mRatBN7.2	14	1,915,999 - 1,917,473 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,916,845 - 1,917,416 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	1,794,641 - 1,796,115 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	3,096,424 - 3,097,898 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,793,104 - 1,794,578 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,933,097 - 2,934,571 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,933,100 - 2,934,571 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,933,498 - 2,934,972 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,469,772 - 2,471,246 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,469,774 - 2,471,246 (-)	NCBI
Celera	14	1,935,554 - 1,937,028 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

amphotericin B (ISO)

arsane (EXP)

arsenic atom (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bucladesine (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

indometacin (ISO)

ketoconazole (ISO)

kojic acid (ISO)

medroxyprogesterone acetate (ISO)

methimazole (EXP)

ozone (ISO)

paracetamol (ISO)

potassium chromate (ISO)

sertraline (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tunicamycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to arsenite(3-) (IEP)

cellular response to cadmium ion (IEP)

protein K11-linked ubiquitination (IBA,ISO)

protein K27-linked ubiquitination (ISO)

protein K29-linked ubiquitination (ISO)

protein K48-linked ubiquitination (IBA,ISO)

protein K6-linked ubiquitination (ISO)

protein K63-linked ubiquitination (ISO)

protein ubiquitination (ISO)

ubiquitin-dependent protein catabolic process (IBA)

Cellular Component

nucleus (IBA)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin conjugating enzyme activity (IBA,ISO)

ubiquitin-protein transferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered ubiquitin/proteasome degradation pathway (IMP)

Alzheimer's disease pathway (IMP)

Endoplasmic Reticulum-associated degradation pathway (IEA)

ubiquitin/proteasome degradation pathway (IDA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Defective ubiquitination of cerebral proteins in Alzheimer's disease.	Lopez Salon M, etal., J Neurosci Res 2000 Oct 15;62(2):302-10.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo.	Tokumoto M, etal., J Toxicol Sci. 2011 Apr;36(2):191-200.
11.	Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells.	Tokumoto M, etal., J Toxicol Sci. 2013;38(6):815-20.
12.	Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E2(17)kB) highly expressed in rat testis.	Wing SS and Jain P, Biochem J 1995 Jan 1;305 ( Pt 1):125-32.
13.	A novel rat homolog of the Saccharomyces cerevisiae ubiquitin-conjugating enzymes UBC4 and UBC5 with distinct biochemical features is induced during spermatogenesis.	Wing SS, etal., Mol Cell Biol 1996 Aug;16(8):4064-72.

Additional References at PubMed

PMID:15489334	PMID:20061386	PMID:21685362

Genomics

Comparative Map Data

Ube2d2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	2,060,926 - 2,062,400 (-)	NCBI		GRCr8
mRatBN7.2	14	1,915,999 - 1,917,473 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,916,845 - 1,917,416 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	1,794,641 - 1,796,115 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	3,096,424 - 3,097,898 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	1,793,104 - 1,794,578 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,933,097 - 2,934,571 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,933,100 - 2,934,571 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,933,498 - 2,934,972 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	2,469,772 - 2,471,246 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	2,469,774 - 2,471,246 (-)	NCBI
Celera	14	1,935,554 - 1,937,028 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

UBE2D4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	43,926,436 - 43,956,136 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	43,926,436 - 43,956,136 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	43,966,035 - 43,995,735 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	43,932,572 - 43,959,688 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	43,739,286 - 43,766,403	NCBI
Celera	7	43,955,900 - 43,985,602 (+)	NCBI		Celera
Cytogenetic Map	7	p13	NCBI
HuRef	7	43,850,744 - 43,880,447 (+)	NCBI		HuRef
CHM1_1	7	43,969,950 - 43,999,662 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	44,084,736 - 44,114,438 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	44,005,536 - 44,035,229 (+)	NCBI

Ube2d2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	107,978,028 - 107,979,643 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	107,977,965 - 107,979,642 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	107,830,162 - 107,831,777 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	107,830,099 - 107,831,776 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	108,259,272 - 108,260,783 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	108,070,555 - 108,072,069 (+)	NCBI		MGSCv36	mm8
Celera	5	104,942,969 - 104,944,480 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	52.23	NCBI

Ube2d4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	7,924,977 - 7,952,155 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	7,928,715 - 7,952,155 (-)	NCBI	ChiLan1.0	ChiLan1.0

UBE2D4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	44,496,560 - 44,523,657 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	92,818,701 - 92,848,433 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	40,295,047 - 40,324,705 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

Ube2d4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	99,769,696 - 99,793,110 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936478	18,985,711 - 19,002,056 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936478	18,981,457 - 19,003,924 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UBE2D4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	48,733,395 - 48,756,291 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	48,735,258 - 48,756,314 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	53,448,345 - 53,469,534 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UBE2D4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	14,636,512 - 14,665,170 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	14,634,384 - 14,664,909 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666062	7,849,493 - 7,879,247 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ube2d4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624740	7,965,053 - 7,990,601 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ube2d2b
1 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	52
Count of miRNA genes:	51
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000049772
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat

Markers in Region

PMC166143P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	62,820,385 - 62,820,485 (+)	MAPPER	mRatBN7.2
mRatBN7.2	14	1,916,947 - 1,917,047 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	65,717,122 - 65,717,221	NCBI	Rnor6.0
Rnor_6.0	14	2,934,046 - 2,934,145	NCBI	Rnor6.0
Rnor_5.0	14	2,934,447 - 2,934,546	UniSTS	Rnor5.0
Rnor_5.0	11	68,811,340 - 68,811,439	UniSTS	Rnor5.0
Celera	11	62,318,530 - 62,318,629	UniSTS
Celera	14	1,936,503 - 1,936,602	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	11	15	47	58	56	28	25	28	5	116	59	28	13	35	28

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U56407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000049772 ⟹ ENSRNOP00000039621

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	2,933,100 - 2,934,571 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098826 ⟹ ENSRNOP00000082180

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	1,916,845 - 1,917,416 (-)	Ensembl

RefSeq Acc Id:

NM_031001 ⟹ NP_112263

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	2,060,926 - 2,062,400 (-)	NCBI
mRatBN7.2	14	1,915,999 - 1,917,473 (-)	NCBI
Rnor_6.0	14	2,933,097 - 2,934,571 (-)	NCBI
Rnor_5.0	14	2,933,498 - 2,934,972 (-)	NCBI
RGSC_v3.4	14	2,469,772 - 2,471,246 (-)	RGD
Celera	14	1,935,554 - 1,937,028 (-)	RGD

Sequence:

show sequence

GGCAGATAGTGTCCACGGTGGCTGGCCCGGAAGCTGAGTGGGCCTCGGCCCTCAGCGTATTCTG
CCAGGGCCAGGCCAGAACTGCCTGCCTCCTCTTCTGCGGCTGATCCAAAACCAACAAGGCAGCC
ACAGGCCGTCGGTGCCTGCCGCCTTCCACCAGGGGCCCGCCAAGACAACCTTCCACCATGGCTT
TGAAGAGAATCCACAAGGAACTGAACGACCTGGCGCAGGATCCCCCAGCACAGTGTTCAGCAGG
TCCTGTCGGGGAAGATATGTTCCATTGGCAAGCTACAATCATGGGGCCAAATGACAGTCCCTAC
CAGGGTGGAGCATTTTTCTTGACAATTGATTTCCCAACAGAGTACCCCTTCAAACCACCTAAGG
TTGAATTTACAACAAGAATTTATCATCCAAATGTTAACAGTAATGGCAGCATTTGTCTTGATAT
TCTTCGGTCACAGTGGTCTCCAGCACTAACTATTTCAAAAGTACTTTTGTCCATCAGTTCTCTG
TTGTGTGATCCCAATCCCGATGATCCCTTAGTGCCTGAGATTGCTCAGATCTACAAAACAGATA
GAGACAAGTACAACAGAACAGCTCGGGAATGGACTCAGAAGTATGCCATGTGACTAAAGAGATT
ATTGGATCCTCTGCGAATAAAAGCTAGGGGAACTCTGAAAGAGAAAGTCCTTTTGATTCCCACT
TGACTGTTTGCTGTGAACCCACGATGTACCGGCCTCGTCCTCCCTGGTGCACGGTCTTCATCTG
ATACAGTACTGTTGCATGTTGCACGCACCAAAAATACTGTGTTTCTGTACCAACACTGTCTCCT
AGCAGACGAGCCTTCTCCAGGCATAACCTAGGTGTGAGATTAAAAGTTTTCCTTATTGACTTAA
ATCTGGATAACAAGGTGTGAGTGAGGGTGGTGGGTACAAGATACTGCTCAGAAGGGGTAAAGGT
CCCCAACCTATAAGACAATGAGATGGCTTTTCAGTGGAAGCCATTTACAGCTAAATGTTTAAAT
GAATGAAAAGCTAGGTGAAGAACATGAATGTTCCTGTACTCATTTTATTCCAAAAGACCTAGAG
CTTAAATGAACATTAAAACCAACCAGACTAAGCCAACCCACCTCCTGTATTTTAAAGTCTAATT
GGTCAACAAAAATAGATCGGCACTATCGGTCCATAAAGTGTGCCTGGCTTTGTTCCCAAATCCT
TTATACACGGATGACTCAACCTATTTTCTTTCACACTTTCTCTCCATATTCTTTGGTTTACTTG
CGGTTTCTCAGTTGATTCATCACTAATAGCTCTTATTTTTATTATATTAACTGCTTAATCTATT
TGGATGTAAAGGTAGACATTCAACTTGATGAAAAAAGCTTGTGTATAGAGACCTAATTGCTCCT
CTGGAGCTTGTACAGTCAAGAATGATGCATCTGTGTAATAAACCAATTATTCTAGCCATTACAT
AAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_112263	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52942	(Get FASTA)	NCBI Sequence Viewer
	AAH78808	(Get FASTA)	NCBI Sequence Viewer
	EDL83991	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000082180.1
	ENSRNOP00055038718
	ENSRNOP00060015485
	ENSRNOP00065016764
GenBank Protein	P70711	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112263 ⟸ NM_031001
- UniProtKB:	P70711 (UniProtKB/Swiss-Prot), A6KPH8 (UniProtKB/TrEMBL), A0A8I5ZTI3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALKRIHKELNDLAQDPPAQCSAGPVGEDMFHWQATIMGPNDSPYQGGAFFLTIDFPTEYPFKP PKVEFTTRIYHPNVNSNGSICLDILRSQWSPALTISKVLLSISSLLCDPNPDDPLVPEIAQIYK TDRDKYNRTAREWTQKYAM hide sequence

Ensembl Acc Id:

ENSRNOP00000039621 ⟸ ENSRNOT00000049772

Ensembl Acc Id:

ENSRNOP00000082180 ⟸ ENSRNOT00000098826

Protein Domains

UBC core

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P70711-F1-model_v2	AlphaFold	P70711	1-147	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699155

Promoter ID:

EPDNEW_R9680

Type:

initiation region

Name:

Ube2d4_1

Description:

ubiquitin-conjugating enzyme E2D 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	2,934,599 - 2,934,659	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69425	AgrOrtholog
BioCyc Gene	G2FUF-16628	BioCyc
Ensembl Genes	ENSRNOG00000034016	Ensembl
	ENSRNOG00000063388	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00055027236	UniProtKB/Swiss-Prot
	ENSRNOG00060011616	UniProtKB/Swiss-Prot
	ENSRNOG00065013184	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000098826.1	UniProtKB/TrEMBL
	ENSRNOT00055047101	UniProtKB/Swiss-Prot
	ENSRNOT00060019669	UniProtKB/Swiss-Prot
	ENSRNOT00065021621	UniProtKB/Swiss-Prot
Gene3D-CATH	3.10.110.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113229	IMAGE-MGC_LOAD
InterPro	UBQ-conjugat_E2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBQ-conjugating_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBQ-conjugating_enzyme/RWD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:79435	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93393	IMAGE-MGC_LOAD
NCBI Gene	79435	ENTREZGENE
PANTHER	UBIQUITIN-CONJUGATING ENZYME E2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBIQUITIN-CONJUGATING ENZYME E2 D2B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	UQ_con	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ube2d2b	PhenoGen
PROSITE	UBC_1	UniProtKB/TrEMBL
	UBC_2	UniProtKB/TrEMBL
	UBIQUITIN_CONJUGAT_1	UniProtKB/Swiss-Prot
	UBIQUITIN_CONJUGAT_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000034016	RatGTEx
	ENSRNOG00000063388	RatGTEx
	ENSRNOG00055027236	RatGTEx
	ENSRNOG00060011616	RatGTEx
	ENSRNOG00065013184	RatGTEx
SMART	UBCc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF54495	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZTI3	ENTREZGENE, UniProtKB/TrEMBL
	A6KPH8	ENTREZGENE, UniProtKB/TrEMBL
	P70711	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-03-07	Ube2d2b	ubiquitin-conjugating enzyme E2D 2B	Ube2d4	ubiquitin-conjugating enzyme E2D 4 (putative)	Name and Symbol changed	629549	APPROVED
2012-02-02	Ube2d4	ubiquitin-conjugating enzyme E2D 4 (putative)	Ube2d4	ubiquitin-conjugating enzyme E2D 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-25	Ube2d4	ubiquitin-conjugating enzyme E2D 4	RGD69425	ubiquitin-conjugating enzyme	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-02-20	RGD69425	ubiquitin-conjugating enzyme	Ube2d2	ubiquitin-conjugating enzyme E2D 2	Symbol and Name updated	1299863	APPROVED
2002-06-10	Ube2d2	ubiquitin-conjugating enzyme E2D 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expression restricted to round spermatids and induced during puberty, protein found in mature spermatids as well	69394

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)