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Gene: Plce1 (phospholipase C, epsilon 1) Rattus norvegicus
Symbol: Plce1
Name: phospholipase C, epsilon 1
RGD ID: 69424
Description: Exhibits Ras GTPase binding activity and phosphatidylinositol phospholipase C activity. Involved in G protein-coupled receptor signaling pathway and Ras protein signal transduction. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1; phospholipase C epsilon; phospholipase C epsilon 1; phospholipase C, epsilon; phospholipase C-epsilon-1; PLC-epsilon-1; Plce
Homo sapiens (human) : PLCE1 (phospholipase C epsilon 1)  HGNC  Alliance
Mus musculus (house mouse) : Plce1 (phospholipase C, epsilon 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plce1 (phospholipase C epsilon 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCE1 (phospholipase C epsilon 1)
Canis lupus familiaris (dog) : PLCE1 (phospholipase C epsilon 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plce1 (phospholipase C epsilon 1)
Sus scrofa (pig) : PLCE1 (phospholipase C epsilon 1)
Chlorocebus sabaeus (African green monkey) : PLCE1 (phospholipase C epsilon 1)
Heterocephalus glaber (naked mole-rat) : Plce1 (phospholipase C epsilon 1)
more info ...
Allele / Splice: Plce1Tn(sb-T2/Bart3)2.146Mcwi  
Genetic Models: F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01257,156,023 - 257,465,440 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,157,264 - 257,466,064 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01264,652,842 - 264,956,664 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,794,858 - 243,103,437 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,891,416 - 243,199,995 (+)NCBI
Celera1233,337,820 - 233,642,815 (+)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Plce1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69424
Created: 2001-11-27
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.