Srebf1 (sterol regulatory element binding transcription factor 1)

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Gene: Srebf1 (sterol regulatory element binding transcription factor 1) Rattus norvegicus

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Symbol:

Srebf1

Name:

sterol regulatory element binding transcription factor 1

RGD ID:

69423

Description:

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cellular response to insulin stimulus; response to glucagon; and response to progesterone. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetic neuropathy; kidney disease; lipid storage disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; disease of metabolism; and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; insulin signaling pathway; INTERACTS WITH (+)-catechin; (-)-cotinine; (25R)-cholest-5-ene-3beta,26-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ADD-1; ADD1; adipocyte determination- and differentiation-dependent factor 1; SREBP-1; SREBP-1c; Srebp1; sterol regulatory element binding factor 1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Srebf1_v1 Srebf1_v2

Is Marker For:

Strains: SHR.BN-(D10Mgh3-Srebf1)/Ipcv
QTLs: Hpcl2

Candidate Gene For:

Hpcl1 Hpcl2

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	45,507,152 - 45,529,164 (-)	NCBI		GRCr8
mRatBN7.2	10	45,007,637 - 45,029,650 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,007,637 - 45,029,650 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	49,707,833 - 49,729,854 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	49,198,201 - 49,220,219 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	44,701,803 - 44,723,821 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	46,570,996 - 46,593,021 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,570,996 - 46,593,009 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	46,326,015 - 46,348,035 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,461,684 - 46,483,646 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	44,264,866 - 44,286,830 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcoholic hepatitis (IEP)

atherosclerosis (ISO)

autistic disorder (ISO)

Birt-Hogg-Dube syndrome (ISO)

common variable immunodeficiency 2 (ISO)

coronary artery disease (ISO)

Diabetic Nephropathies (IEP,ISO)

diabetic neuropathy (IEP)

disease of metabolism (ISO)

end stage renal disease (ISO)

Experimental Diabetes Mellitus (IEP,ISO)

Experimental Liver Cirrhosis (ISO)

familial hyperlipidemia (ISO)

Fetal Growth Retardation (IEP)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hypercholesterolemia (IEP)

Hypertriglyceridemia (IEP)

Ichthyosis Follicularis, Atrichia, and Photophobia Syndrome 2 (ISO)

ichthyosis follicularis-alopecia-photophobia syndrome 1 (ISO)

Insulin Resistance (IEP,ISO)

Joubert syndrome 1 (ISO)

kidney disease (IEP)

lipid storage disease (IEP)

metabolic dysfunction-associated steatohepatitis (IEP)

metabolic dysfunction-associated steatotic liver disease (IEP,ISO)

Metabolic Syndrome (IEP,ISO)

obesity (ISO)

Potocki-Lupski syndrome (ISO)

Smith-Magenis syndrome (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (IEP,ISO)

Urban Schosser Spohn Syndrome (ISO)

Viral Myocarditis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (EXP)

(+)-isolariciresinol (ISO)

(+)-pinoresinol (ISO)

(-)-cotinine (EXP)

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(2,4,5-trichlorophenoxy)acetic acid (ISO)

(25R)-cholest-5-ene-3beta,26-diol (EXP)

(R)-carnitine (EXP)

(R)-lipoic acid (EXP)

(S)-nicotine (EXP,ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,10-phenanthroline (ISO)

1,3-dichloropropan-2-ol (ISO)

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile (ISO)

1-benzylpiperazine (EXP)

1-naphthyl isothiocyanate (EXP)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose 6-phosphate (ISO)

2-deoxy-D-glucose (ISO)

2-naphthylamine (ISO)

22-Hydroxycholesterol (ISO)

25-hydroxycholesterol (ISO)

26-hydroxycholesterol (EXP)

28-Homobrassinolide (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,3',5-triiodo-L-thyronine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-phenylprop-2-enal (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-nonylphenol (EXP)

4-phenylbutyric acid (EXP,ISO)

4-tert-Octylphenol (EXP)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (ISO)

6-propyl-2-thiouracil (EXP)

8'-apo-beta,psi-caroten-8'-al (ISO)

8-Br-cAMP (ISO)

9-cis,11-trans-octadecadienoic acid (ISO)

9-cis-retinoic acid (ISO)

acadesine (ISO)

acetaldehyde (EXP,ISO)

acetamide (EXP)

Acetyl tributyl citrate (ISO)

acetylleucyl-leucyl-norleucinal (ISO)

acrolein (ISO)

acrylamide (ISO)

Aescin (ISO)

aflatoxin B1 (EXP,ISO)

alcohol (ISO)

aldehydo-D-glucosamine 6-phosphate (ISO)

aldehydo-D-glucose (EXP,ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

alliin (ISO)

allopurinol (EXP,ISO)

alpha-D-galactose (ISO)

alpha-linolenic acid (EXP)

alpha-pinene (ISO)

amentoflavone (ISO)

amiodarone (EXP,ISO)

amitriptyline (ISO)

amlexanox (ISO)

ammonium chloride (EXP)

amphotericin B (ISO)

ampicillin (ISO)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

antimony(0) (ISO)

apigenin (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atazanavir sulfate (ISO)

atorvastatin (ISO)

atorvastatin calcium (EXP)

atrazine (EXP,ISO)

Azaspiracid (ISO)

AZD4547 (ISO)

azoxystrobin (ISO)

baicalein (ISO)

benzene (EXP,ISO)

benzo[a]pyrene (EXP,ISO)

benzylpenicillin (ISO)

berberine (ISO)

beta-carotene (ISO)

beta-D-glucosamine 6-sulfate (ISO)

beta-hexachlorocyclohexane (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

betulin (ISO)

bexarotene (EXP,ISO)

bezafibrate (EXP,ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (EXP)

boric acid (ISO)

brexpiprazole (ISO)

bromobenzene (EXP)

buspirone (EXP)

buta-1,3-diene (ISO)

butyric acid (ISO)

C60 fullerene (EXP)

Cacalol (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

caffeine (EXP,ISO)

calcitriol (ISO)

cannabidiol (ISO)

capivasertib (ISO)

capsaicin (ISO)

carbamazepine (EXP)

carbendazim (ISO)

CARBENOXOLONE (EXP)

carbon nanotube (ISO)

carvedilol (EXP)

cerivastatin (ISO)

chenodeoxycholic acid (ISO)

chitosan (EXP)

chloroethene (ISO)

chlorpyrifos (EXP)

cholate (EXP)

cholesterol (ISO)

cholic acid (EXP)

choline (EXP,ISO)

ciguatoxin CTX1B (ISO)

cis-caffeic acid (ISO)

cisplatin (ISO)

citalopram (ISO)

clavulanic acid (ISO)

clofazimine (EXP)

clofibrate (EXP,ISO)

clomipramine (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

colforsin daropate hydrochloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

cordycepin (ISO)

corn oil (EXP)

corticosterone (EXP,ISO)

cortisol (ISO)

Cuprizon (EXP)

curcumin (EXP,ISO)

cyclosporin A (ISO)

cyhalothrin (EXP,ISO)

D-gluconic acid (EXP)

D-glucose (EXP,ISO)

D-penicillamine (ISO)

dabrafenib (ISO)

dapagliflozin (EXP)

DDE (ISO)

decabromodiphenyl ether (ISO)

deoxycholic acid (ISO)

deoxypodophyllotoxin (ISO)

depsipeptide (ISO)

desferrioxamine B (ISO)

desmosterol (ISO)

dexamethasone (ISO)

diallyl disulfide (ISO)

Diallyl sulfide (ISO)

diallyl trisulfide (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

dichloroacetic acid (ISO)

diethyl maleate (EXP)

diethylstilbestrol (ISO)

difenoconazole (ISO)

dihydroartemisinin (EXP,ISO)

dimethyl sulfoxide (EXP)

dioxygen (ISO)

disodium selenite (EXP,ISO)

disulfiram (ISO)

dorsomorphin (EXP,ISO)

doxorubicin (EXP,ISO)

efavirenz (ISO)

elemental selenium (EXP,ISO)

endosulfan (EXP)

entinostat (ISO)

erythromycin A (ISO)

erythromycin estolate (EXP)

ethanol (EXP,ISO)

ethyl methanesulfonate (ISO)

ezetimibe (ISO)

fenofibrate (EXP,ISO)

fentin chloride (EXP,ISO)

folic acid (ISO)

formaldehyde (ISO)

fructose (EXP,ISO)

fumonisin B1 (ISO)

furan (EXP)

gadolinium trichloride (EXP)

galactose (ISO)

gamma-hexachlorocyclohexane (EXP)

Ganoderic acid A (ISO)

Gastrodin (ISO)

gefitinib (ISO)

Genipin (ISO)

genistein (ISO)

gentamycin (EXP)

geraniol (EXP)

Gingerenone A (ISO)

ginsenoside Re (ISO)

Ginsenoside Rh4 (ISO)

glucagon (ISO)

glucose (EXP,ISO)

glutathione (ISO)

glycerol 2-phosphate (ISO)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

glyphosate (ISO)

gold atom (ISO)

gold(0) (ISO)

guggulsterone (EXP,ISO)

GW 3965 (EXP,ISO)

GW 4064 (ISO)

GW 6471 (ISO)

GW 7647 (ISO)

herbacetin (ISO)

hexadecanoic acid (EXP,ISO)

Honokiol (EXP)

hydrazines (ISO)

hydrogen peroxide (ISO)

imidacloprid (ISO)

imipramine (ISO)

indole-3-methanol (EXP)

insulin (EXP,ISO)

iron dichloride (ISO)

isosilybin (ISO)

kahweol (ISO)

ketamine (EXP)

ketotifen (ISO)

L-ascorbic acid (ISO)

L-methionine (EXP,ISO)

L-serine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

linoleic acid (EXP)

lipoic acid (EXP)

lipopolysaccharide (ISO)

lithocholic acid (ISO)

loliolide (ISO)

losartan (EXP)

lovastatin (ISO)

luteolin (ISO)

LY294002 (EXP,ISO)

magnesium atom (EXP)

Magnolol (EXP)

melatonin (ISO)

metformin (EXP,ISO)

methyl methanesulfonate (ISO)

metronidazole (ISO)

mevastatin (EXP,ISO)

microcystin-LR (ISO)

miquelianin (EXP)

mirtazapine (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monocrotophos (EXP)

monosodium L-glutamate (EXP,ISO)

Morroniside (ISO)

Muraglitazar (EXP)

myricetin (EXP)

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide (ISO)

N-methylformamide (ISO)

N-methylnicotinate (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

naloxone (EXP)

naringin (ISO)

nefazodone (EXP,ISO)

nelfinavir (ISO)

neomycin (ISO)

nevirapine (EXP,ISO)

nicotinamide (ISO)

nicotine (EXP,ISO)

nimesulide (EXP)

nordihydroguaiaretic acid (EXP)

O-methyleugenol (ISO)

obeticholic acid (EXP,ISO)

olanzapine (ISO)

olaparib (ISO)

oleanolic acid (ISO)

oleic acid (EXP,ISO)

oleuropein (EXP)

Olmesartan medoxomil (EXP)

orlistat (ISO)

oroxylin A (ISO)

ozone (EXP,ISO)

p-menthan-3-ol (ISO)

p-tert-Amylphenol (EXP)

paclitaxel (ISO)

paracetamol (EXP,ISO)

paxilline (ISO)

PD 168393 (EXP)

penconazole (ISO)

perfluorobutanesulfonic acid (ISO)

perfluorobutyric acid (ISO)

perfluorodecanoic acid (ISO)

perfluorododecanoic acid (EXP,ISO)

perfluoroheptanoic acid (ISO)

perfluorohexanoic acid (ISO)

perfluorononanoic acid (EXP)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanesulfonamide (ISO)

perfluorooctanoic acid (EXP,ISO)

perfluoropentanoic acid (ISO)

perfluoroundecanoic acid (ISO)

permethrin (ISO)

phenformin (EXP)

phenobarbital (EXP,ISO)

picolinic acid (ISO)

pirinixic acid (EXP,ISO)

platycodin D (ISO)

pregnenolone 16alpha-carbonitrile (EXP,ISO)

progesterone (EXP,ISO)

propamocarb (ISO)

propiconazole (ISO)

puerarin (ISO)

Pyridostigmine bromide (ISO)

quercetin (EXP,ISO)

raffinose (ISO)

raloxifene (ISO)

reactive oxygen species (ISO)

resveratrol (EXP,ISO)

risperidone (ISO)

ritonavir (ISO)

rosiglitazone (EXP)

rosmarinic acid (ISO)

rotenone (EXP,ISO)

S-allylcysteine (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

salubrinal (EXP)

SB 431542 (ISO)

scopoletin (EXP)

selenium atom (EXP,ISO)

selenomethionine (ISO)

senecionine (ISO)

silibinin (ISO)

simvastatin (EXP,ISO)

sirolimus (ISO)

sirtinol (ISO)

sodium arsenite (EXP,ISO)

sodium cholate (ISO)

sodium dichromate (EXP)

Sodium oleate (ISO)

Sophocarpine (EXP)

starch (EXP)

stavudine (EXP)

streptozocin (EXP,ISO)

sucrose (EXP,ISO)

sulfluramid (ISO)

sulforaphane (EXP,ISO)

sunitinib (ISO)

tamoxifen (ISO)

tartrazine (ISO)

tauroursodeoxycholic acid (EXP)

tebuconazole (ISO)

tectorigenin (ISO)

testosterone (ISO)

testosterone cypionate (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (EXP,ISO)

tetramethylpyrazine (ISO)

thapsigargin (EXP,ISO)

theophylline (EXP)

thioacetamide (EXP)

thymol (ISO)

thymol sulfate(1-) (ISO)

tianeptine (ISO)

titanium dioxide (ISO)

toosendanin (ISO)

topiramate (EXP)

trametinib (ISO)

trans-caffeic acid (ISO)

tributyl phosphate (ISO)

tributylstannane (ISO)

Tributyltin oxide (EXP,ISO)

triclosan (ISO)

triolein (ISO)

triphenyl phosphate (ISO)

triphenylstannane (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tris(2-chloroethyl) phosphate (ISO)

Tris(2-ethylhexyl) phosphate (ISO)

troglitazone (EXP,ISO)

trovafloxacin (EXP)

tunicamycin (EXP,ISO)

tyloxapol (ISO)

tyrphostin AG 1478 (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

vanillic acid (ISO)

vemurafenib (ISO)

vincristine (ISO)

vitamin D (ISO)

withaferin A (ISO)

wortmannin (EXP)

xanthohumol (ISO)

xylose (ISO)

Y-27632 (EXP)

zearalenone (ISO)

zingerone (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to fatty acid (IEP)

cellular response to insulin stimulus (IEP)

cellular response to starvation (IDA,ISO)

cholesterol biosynthetic process (ISO)

cholesterol metabolic process (IMP)

circadian rhythm (ISO)

fat cell differentiation (ISO)

insulin receptor signaling pathway (ISO)

insulin secretion (ISO)

intracellular receptor signaling pathway (IEA)

lipid biosynthetic process (ISO,ISS,TAS)

lung development (IEP)

mRNA transcription by RNA polymerase II (ISO)

negative regulation of insulin secretion (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of triglyceride metabolic process (ISO)

positive regulation of cholesterol biosynthetic process (ISO,ISS)

positive regulation of DNA-templated transcription (IMP,ISO)

positive regulation of innate immune response (ISO)

positive regulation of lipid biosynthetic process (ISO)

positive regulation of miRNA transcription (ISO)

positive regulation of transcription by RNA polymerase II (IDA,ISO)

positive regulation of triglyceride biosynthetic process (ISO,ISS)

regulation of DNA-templated transcription (ISO)

regulation of fatty acid metabolic process (ISO)

regulation of heart rate by chemical signal (ISO)

regulation of insulin secretion (ISO)

regulation of lipid storage (IEP)

regulation of mitophagy (ISO)

regulation of protein stability (ISO)

regulation of protein targeting to mitochondrion (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO,ISS)

response to cAMP (IEP)

response to ethanol (IEP)

response to fatty acid (IEP)

response to food (IEP)

response to fructose (IEP)

response to glucagon (IEP)

response to glucose (ISO)

response to insulin (TAS)

response to lipid (IEP)

response to nutrient (IEP)

response to organic cyclic compound (IEP)

response to peptide hormone (IEP)

response to progesterone (IEP)

response to retinoic acid (IEP)

response to xenobiotic stimulus (IEP)

SREBP signaling pathway (ISO,ISS)

transcription by RNA polymerase II (ISO)

Cellular Component

cytoplasm (ISO,ISS)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (TAS)

ER to Golgi transport vesicle membrane (IEA)

Golgi membrane (IEA)

membrane (ISO)

nucleus (IBA,ISO,ISS)

protein-containing complex (IDA)

Molecular Function

chromatin binding (IDA,ISO)

DNA binding (ISO,ISS)

DNA-binding transcription activator activity, RNA polymerase II-specific (IDA,ISO)

DNA-binding transcription factor activity (ISO,ISS)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO,ISS)

nuclear receptor activity (ISO)

protein binding (ISO)

protein dimerization activity (IEA)

protein kinase binding (ISO)

protein-containing complex binding (IPI)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA,ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (IDA,ISO)

sequence-specific double-stranded DNA binding (ISO)

sterol response element binding (ISO,ISS)

transcription coregulator binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin signaling pathway (IEA)

mTOR signaling pathway (ISO)

sterol regulatory element-binding protein signaling pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased cholesterol level (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.	Amemiya-Kudo M, etal., J Biol Chem. 2005 Oct 14;280(41):34577-89. Epub 2005 Jul 29.
2.	Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors.	Boizard M, etal., J Biol Chem. 1998 Oct 30;273(44):29164-71.
3.	Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue.	Bonzon-Kulichenko E, etal., Endocrinology. 2009 Jan;150(1):169-78. Epub 2008 Sep 18.
4.	Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways.	Botolin D, etal., J Lipid Res. 2006 Jan;47(1):181-92. Epub 2005 Oct 12.
5.	HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus.	Carper MJ, etal., Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. Epub 2008 Jan 2.
6.	Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis.	Chen M, etal., Carbohydr Res. 2020 Aug;494:108055. doi: 10.1016/j.carres.2020.108055. Epub 2020 Jun 7.
7.	Protective effect of Chinese prescription Kangen-karyu and its crude drug Tanjin against age-related lipidosis in rats.	Cho EJ, etal., J Pharm Pharmacol. 2007 May;59(5):687-94.
8.	Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.	Costet P, etal., J Biol Chem. 2006 Mar 10;281(10):6211-8. Epub 2006 Jan 6.
9.	Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring.	Desai M, etal., Reprod Sci. 2008 Oct;15(8):785-96.
10.	Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.	Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
11.	ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose.	Foretz M, etal., Mol Cell Biol. 1999 May;19(5):3760-8.
12.	[Effects of wheat bran fiber on lipid metabolism in ApoE~(-/-) mice].	Gao H, etal., Wei Sheng Yan Jiu. 2019 Jul;48(4):601-605.
13.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
15.	Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.	Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
16.	Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis.	Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
17.	Involvement of glomerular SREBP-1c in diabetic nephropathy.	Ishigaki N, etal., Biochem Biophys Res Commun. 2007 Dec 21;364(3):502-8. Epub 2007 Oct 16.
18.	Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease.	Jiang T, etal., J Am Soc Nephrol. 2005 Aug;16(8):2385-94. Epub 2005 Jun 8.
19.	In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study.	Jun H, etal., Histochem Cell Biol. 2009 Mar;131(3):327-45. Epub 2008 Dec 2.
20.	Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1.	Jung YA, etal., Exp Mol Med. 2014 Jan 24;46(1):e73. doi: 10.1038/emm.2013.143.
21.	Testosterone stimulates cholesterol clearance from human macrophages by activating LXRα.	Kilby EL, etal., Life Sci. 2021 Mar 15;269:119040. doi: 10.1016/j.lfs.2021.119040. Epub 2021 Jan 13.
22.	Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus.	Kim JM, etal., Exp Mol Med. 2006 Aug 31;38(4):385-92.
23.	Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue.	Lacasa D, etal., J Biol Chem. 2001 Apr 13;276(15):11512-6. Epub 2001 Jan 16.
24.	Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation.	Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
25.	Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes.	Li N, etal., Scand Cardiovasc J. 2019 Feb;53(1):42-47. doi: 10.1080/14017431.2018.1516891.
26.	Increased renal collagen cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats.	Li Y, etal., Diabetes Metab Res Rev. 2008 Sep;24(6):498-506.
27.	Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population.	Liu JX, etal., Diabetes Res Clin Pract. 2008 Oct;82(1):42-7. Epub 2008 Aug 8.
28.	Dietary α-lactalbumin induced fatty liver by enhancing nuclear liver X receptor αβ/sterol regulatory element-binding protein-1c/PPARγ expression and minimising PPARα/carnitine palmitoyltransferase-1 expression and AMP-activated protein kinase α phosphorylation associated with atherogenic dyslipidaemia, insulin resistance and oxidative stress in Balb/c mice.	López-Oliva ME, etal., Br J Nutr. 2017 Dec;118(11):914-929. doi: 10.1017/S000711451700232X. Epub 2017 Nov 27.
29.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
30.	Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice.	Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
31.	Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha.	Nagai Y, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1180-90.
32.	Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.	Nakamura S, etal., J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.
33.	Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue.	Natarajan G, etal., Alcohol. 2019 Sep;79:71-79. doi: 10.1016/j.alcohol.2018.12.005. Epub 2019 Jan 3.
34.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
35.	Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.	Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
36.	Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.	Ota T, etal., Gastroenterology. 2007 Jan;132(1):282-93. Epub 2006 Oct 12.
37.	Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.	Ou J, etal., Proc Natl Acad Sci U S A 2001 May 22;98(11):6027-32.
38.	Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia.	Pallottini V, etal., J Cell Biochem. 2006 Aug 1;98(5):1044-53.
39.	Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis.	Papageorgiou AP, etal., Cardiovasc Res. 2015 Jul 1;107(1):78-88. doi: 10.1093/cvr/cvv157. Epub 2015 May 21.
40.	Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice.	Park HJ, etal., Circ Res. 2009 May 7.
41.	Down-regulated of SREBP-1 in circulating leukocyte is a risk factor for atherosclerosis: a case control study.	Peng C, etal., Lipids Health Dis. 2019 Oct 14;18(1):177. doi: 10.1186/s12944-019-1125-1.
42.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
43.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44.	Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat.	Pravenec M, etal., Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10.
45.	Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat.	Pravenec M, etal., Mamm Genome 2001 Apr;12(4):295-8.
46.	Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.	Proctor G, etal., Diabetes. 2006 Sep;55(9):2502-9.
47.	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.	Pérez-Belmonte LM, etal., Int J Med Sci. 2017 Feb 23;14(3):268-274. doi: 10.7150/ijms.17821. eCollection 2017.
48.	Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.	Repa JJ, etal., Genes Dev. 2000 Nov 15;14(22):2819-30.
49.	GOA pipeline	RGD automated data pipeline
50.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
52.	Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease.	Rios DL, etal., Clin Genet. 2003 May;63(5):380-5. doi: 10.1034/j.1399-0004.2003.00057.x.
53.	Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.	Sajan MP, etal., Diabetologia. 2009 Jun;52(6):1197-207. Epub 2009 Apr 9.
54.	An adipogenic basic helix-loop-helix-leucine zipper type transcription factor (ADD1) mRNA is expressed and regulated by retinoic acid in osteoblastic cells.	Sawada Y and Noda M, Mol Endocrinol. 1996 Oct;10(10):1238-48.
55.	Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.PG -	Sun L, etal., J Biol Chem 2002 May 24;277(21):18919-27.
56.	Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.	Tamehiro N, etal., J Biol Chem. 2007 Jul 20;282(29):21090-9. Epub 2007 May 27.
57.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
58.	(-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B.	Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
59.	Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes.	Wang Z, etal., Diabetes. 2005 Aug;54(8):2328-35.
60.	Cyclosporin-induced dyslipoproteinemia is associated with selective activation of SREBP-2.	Wu J, etal., Am J Physiol. 1999 Dec;277(6 Pt 1):E1087-94.
61.	Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms.	Xu J, etal., J Nutr. 2002 Nov;132(11):3333-9.
62.	Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner.	Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
63.	Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.	Yellaturu CR, etal., J Biol Chem. 2009 Mar 20;284(12):7518-32. Epub 2009 Jan 21.
64.	Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes.	Yin HQ, et al., Toxicol Appl Pharmacol. 2009 Apr 1;236(1):124-30. doi: 10.1016/j.taap.2008.12.030. Epub 2009 Jan 24.
65.	Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP).	You M, etal., J Biol Chem 2002 Aug 9;277(32):29342-7.
66.	Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase.	Zhang F, etal., Am J Respir Cell Mol Biol 2004 Feb;30(2):174-83. Epub 2003 Aug 01.
67.	Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis.	Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
68.	Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD.	Zhang Y, etal., J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
69.	Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis.	Zhong H, etal., FEBS J. 2018 Feb;285(3):501-517. doi: 10.1111/febs.14349. Epub 2017 Dec 26.

Additional References at PubMed

PMID:7739539	PMID:8336713	PMID:9329978	PMID:11739104	PMID:11829742	PMID:12016216	PMID:12031952	PMID:12031958	PMID:12202038	PMID:12242332	PMID:12488438	PMID:12600983
PMID:12764144	PMID:12771318	PMID:12865412	PMID:12941932	PMID:14505487	PMID:14654692	PMID:14668913	PMID:14674713	PMID:14744869	PMID:14988441	PMID:15001432	PMID:15037635
PMID:15039461	PMID:15123649	PMID:15123720	PMID:15249218	PMID:15266058	PMID:15280151	PMID:15281019	PMID:15330762	PMID:15358760	PMID:15561928	PMID:15637161	PMID:15896314
PMID:16002205	PMID:16046411	PMID:16091421	PMID:16092054	PMID:16100574	PMID:16380121	PMID:16554040	PMID:16772326	PMID:16787385	PMID:16834571	PMID:16890542	PMID:17074803
PMID:17296605	PMID:17313375	PMID:17449871	PMID:17456898	PMID:17632011	PMID:17636037	PMID:18060044	PMID:18157544	PMID:18178930	PMID:18635549	PMID:18665039	PMID:18989661
PMID:19125418	PMID:19244231	PMID:19299314	PMID:19366697	PMID:19375767	PMID:19564420	PMID:19616615	PMID:19672729	PMID:19682972	PMID:19716432	PMID:19786558	PMID:19966780
PMID:20005944	PMID:20041157	PMID:20211032	PMID:20589757	PMID:20615871	PMID:21036148	PMID:21038676	PMID:21167679	PMID:21459323	PMID:21540177	PMID:21652712	PMID:21731709
PMID:21757781	PMID:21906525	PMID:21986124	PMID:22031849	PMID:22093779	PMID:22292946	PMID:22331133	PMID:22415588	PMID:22511764	PMID:22645024	PMID:22898567	PMID:23028851
PMID:23065593	PMID:23106379	PMID:23239524	PMID:23257266	PMID:23295202	PMID:23542164	PMID:23583293	PMID:23610160	PMID:23823476	PMID:23913732	PMID:24296663	PMID:24362725
PMID:24425205	PMID:24625548	PMID:24912190	PMID:25046614	PMID:25348957	PMID:25398788	PMID:25616173	PMID:25796423	PMID:25847140	PMID:26218603	PMID:26327595	PMID:26437365
PMID:26449613	PMID:26589965	PMID:27321819	PMID:27352290	PMID:27382175	PMID:27614840	PMID:27826032	PMID:28027934	PMID:28264426	PMID:28465347	PMID:28719803	PMID:29366380
PMID:29627845	PMID:29735017	PMID:29952285	PMID:30998947	PMID:31541353	PMID:31677037	PMID:32332706	PMID:34655015	PMID:34923569	PMID:38079167	PMID:38369486

Genomics

Comparative Map Data

Srebf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	45,507,152 - 45,529,164 (-)	NCBI		GRCr8
mRatBN7.2	10	45,007,637 - 45,029,650 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,007,637 - 45,029,650 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	49,707,833 - 49,729,854 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	49,198,201 - 49,220,219 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	44,701,803 - 44,723,821 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	46,570,996 - 46,593,021 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,570,996 - 46,593,009 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	46,326,015 - 46,348,035 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,461,684 - 46,483,646 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	44,264,866 - 44,286,830 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

SREBF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	17,811,334 - 17,836,986 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	17,810,399 - 17,837,002 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	17,714,648 - 17,740,300 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	17,656,111 - 17,681,050 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	17,656,110 - 17,681,050	NCBI
Celera	17	18,654,135 - 18,680,982 (-)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	17,466,908 - 17,494,061 (-)	NCBI		HuRef
CHM1_1	17	17,723,458 - 17,749,109 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	17,757,927 - 17,783,669 (-)	NCBI		T2T-CHM13v2.0

Srebf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	60,089,910 - 60,113,407 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	60,089,915 - 60,113,407 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	60,199,084 - 60,224,186 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	60,199,089 - 60,222,581 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	60,012,591 - 60,034,106 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	60,015,284 - 60,036,799 (-)	NCBI		MGSCv36	mm8
Celera	11	66,655,030 - 66,676,425 (+)	NCBI		Celera
Cytogenetic Map	11	B2	NCBI
cM Map	11	37.81	NCBI

Srebf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955577	171,425 - 186,046 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955577	171,425 - 183,669 (+)	NCBI	ChiLan1.0	ChiLan1.0

SREBF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	52,328,005 - 52,355,769 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	57,040,217 - 57,065,965 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	33,458,196 - 33,484,643 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	38,405,794 - 38,432,045 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	38,405,794 - 38,432,045 (+)	Ensembl	panpan1.1		panPan2

SREBF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	41,663,809 - 41,686,764 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	41,663,773 - 41,686,776 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	41,802,335 - 41,825,236 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	41,769,693 - 41,792,654 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	41,769,687 - 41,925,702 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	41,737,352 - 41,760,245 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	41,684,736 - 41,707,631 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	41,876,687 - 41,899,587 (+)	NCBI		UU_Cfam_GSD_1.0

Srebf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	61,447,521 - 61,458,579 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936741	1,406,521 - 1,419,776 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936741	1,408,669 - 1,419,717 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SREBF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	60,733,907 - 60,751,267 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	60,733,967 - 60,750,951 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SREBF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	16,847,603 - 16,874,239 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	16,845,491 - 16,859,554 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	4,037,449 - 4,063,735 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srebf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	3,602,261 - 3,623,465 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624849	3,602,103 - 3,623,922 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Srebf1
112 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	94
Count of miRNA genes:	43
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000004753, ENSRNOT00000047053
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
152025229	Scl83	Serum cholesterol level QTL 83	4.33		blood cholesterol amount (VT:0000180)		10	35710580	68663659	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
11528631	Bss117	Bone structure and strength QTL 117	6.41	4e-07	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	10	44947163	45433933	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat

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Mammalian Phenotype