Akap6 (A-kinase anchoring protein 6) - Rat Genome Database

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Gene: Akap6 (A-kinase anchoring protein 6) Rattus norvegicus
Analyze
Symbol: Akap6
Name: A-kinase anchoring protein 6
RGD ID: 69412
Description: Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of protein metabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Located in several cellular components, including T-tubule; intercalated disc; and junctional sarcoplasmic reticulum membrane. Part of protein-containing complex. Colocalizes with nuclear envelope. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A kinase (PRKA) anchor protein 6; A-kinase anchor protein; A-kinase anchor protein 6; AKAP-6; mAkap; PRKA6; protein kinase A-anchoring protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2670,184,101 - 70,624,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl670,184,175 - 70,619,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx670,602,131 - 71,041,292 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0670,908,778 - 71,347,917 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0670,348,346 - 70,787,478 (+)NCBIRnor_WKY
Rnor_6.0673,553,111 - 73,991,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl673,553,210 - 73,990,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0683,111,409 - 83,547,031 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4673,010,779 - 73,354,520 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1673,016,484 - 73,357,646 (+)NCBI
Celera669,046,483 - 69,480,156 (+)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. alpha1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels. Alday A, etal., Channels (Austin). 2010 May-Jun;4(3):168-78.
2. PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex. Carlisle Michel JJ, etal., Biochem J. 2004 Aug 1;381(Pt 3):587-92.
3. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
4. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. Dodge KL, etal., EMBO J 2001 Apr 17;20(8):1921-30.
5. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Dodge-Kafka KL, etal., Nature. 2005 Sep 22;437(7058):574-8.
6. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. Earp M, etal., PLoS One. 2018 Jul 6;13(7):e0197561. doi: 10.1371/journal.pone.0197561. eCollection 2018.
7. AKAP-mediated targeting of protein kinase a regulates contractility in cardiac myocytes. Fink MA, etal., Circ Res. 2001 Feb 16;88(3):291-7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes. Kapiloff MS, etal., J Biol Chem. 2009 Aug 28;284(35):23540-6. Epub 2009 Jul 1.
11. mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. Kapiloff MS, etal., J Cell Sci 1999 Aug;112 ( Pt 16):2725-36.
12. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. Kapiloff MS, etal., J Cell Sci. 2001 Sep;114(Pt 17):3167-76.
13. The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Kritzer MD, etal., Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8.
14. The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. Li J, etal., J Mol Cell Cardiol. 2010 Feb;48(2):387-94. Epub 2009 Oct 31.
15. Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum. McCartney S, etal., J Biol Chem. 1995 Apr 21;270(16):9327-33.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Pare GC, etal., Exp Cell Res. 2005 Feb 15;303(2):388-99.
18. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. Pare GC, etal., J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Decreased mAKAP, ryanodine receptor, and SERCA2a gene expression in mdx hearts. Rohman MS, etal., Biochem Biophys Res Commun. 2003 Oct 10;310(1):228-35.
22. Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. Ruehr ML, etal., J Biol Chem. 2003 Jul 4;278(27):24831-6. Epub 2003 Apr 21.
23. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Schillace RV and Scott JD, Curr Biol. 1999 Mar 25;9(6):321-4.
24. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
25. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Wang K, etal., Mol Psychiatry. 2011 Sep;16(9):949-59. doi: 10.1038/mp.2010.107. Epub 2010 Nov 16.
26. Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. Wilhelm T, etal., Epigenetics. 2016;11(2):110-9. doi: 10.1080/15592294.2016.1145327. Epub 2016 Feb 18.
27. A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart. Yang J, etal., J Cell Biol. 1998 Jul 27;142(2):511-22.
28. Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema. Zan L, etal., Neurochem Int. 2011 Jul;58(8):872-9. doi: 10.1016/j.neuint.2011.02.014. Epub 2011 Feb 18.
29. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. Zhang L, etal., J Biol Chem. 2011 Jul 1;286(26):23012-21. Epub 2011 May 5.
Additional References at PubMed
PMID:10830164   PMID:11299204   PMID:20106966   PMID:20164376   PMID:23261540   PMID:25644384   PMID:26844267   PMID:29522762   PMID:29733383   PMID:30523159   PMID:32933333  


Genomics

Comparative Map Data
Akap6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2670,184,101 - 70,624,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl670,184,175 - 70,619,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx670,602,131 - 71,041,292 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0670,908,778 - 71,347,917 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0670,348,346 - 70,787,478 (+)NCBIRnor_WKY
Rnor_6.0673,553,111 - 73,991,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl673,553,210 - 73,990,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0683,111,409 - 83,547,031 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4673,010,779 - 73,354,520 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1673,016,484 - 73,357,646 (+)NCBI
Celera669,046,483 - 69,480,156 (+)NCBICelera
Cytogenetic Map6q23NCBI
AKAP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381432,329,298 - 32,837,684 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1432,329,298 - 32,837,684 (+)EnsemblGRCh38hg38GRCh38
GRCh371432,798,504 - 33,306,890 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361431,868,274 - 32,372,018 (+)NCBINCBI36Build 36hg18NCBI36
Build 341431,868,273 - 32,372,018NCBI
Celera1412,665,076 - 13,167,767 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1412,916,606 - 13,419,742 (+)NCBIHuRef
CHM1_11432,798,120 - 33,300,973 (+)NCBICHM1_1
T2T-CHM13v2.01426,401,181 - 27,034,449 (+)NCBIT2T-CHM13v2.0
Akap6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,745,371 - 53,202,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,746,166 - 53,202,382 (+)EnsemblGRCm39 Ensembl
GRCm381252,698,588 - 53,155,568 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,699,383 - 53,155,599 (+)EnsemblGRCm38mm10GRCm38
MGSCv371253,800,370 - 54,252,002 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361253,620,875 - 54,072,638 (+)NCBIMGSCv36mm8
Celera1254,009,109 - 54,451,716 (+)NCBICelera
Cytogenetic Map12C1NCBI
Akap6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540928,077,621 - 28,516,944 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540928,067,814 - 28,516,881 (-)NCBIChiLan1.0ChiLan1.0
AKAP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11432,747,476 - 33,372,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01412,978,221 - 13,602,732 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11431,290,939 - 31,792,166 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1431,395,026 - 31,792,166 (+)Ensemblpanpan1.1panPan2
AKAP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1811,403,655 - 11,882,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl811,406,280 - 11,874,406 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha811,299,751 - 11,679,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0811,415,673 - 11,984,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl811,508,505 - 11,986,716 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1811,188,259 - 11,668,695 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0811,269,184 - 11,750,344 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0811,547,419 - 12,028,362 (+)NCBIUU_Cfam_GSD_1.0
Akap6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864043,239,054 - 43,722,811 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364946,744,892 - 7,228,686 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364946,744,923 - 7,228,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl766,915,881 - 67,375,177 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1766,913,541 - 67,462,147 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2771,765,469 - 72,075,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Akap6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248383,999,663 - 4,393,055 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248383,992,769 - 4,393,055 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap6
2774 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir26brno-miR-26b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir543rno-miR-543-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:203
Interacting mature miRNAs:263
Transcripts:ENSRNOT00000006562
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)66304056271636266Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat

Markers in Region
D6Got90  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,277,257 - 70,277,484 (+)MAPPERmRatBN7.2
Rnor_6.0673,646,974 - 73,647,200NCBIRnor6.0
Rnor_5.0683,203,912 - 83,204,138UniSTSRnor5.0
RGSC_v3.4673,001,677 - 73,001,904RGDRGSC3.4
RGSC_v3.4673,001,678 - 73,001,904UniSTSRGSC3.4
RGSC_v3.1673,004,804 - 73,005,030RGD
Celera669,138,427 - 69,138,645UniSTS
RH 3.4 Map6516.5UniSTS
RH 3.4 Map6516.5RGD
RH 2.0 Map6669.7RGD
Cytogenetic Map6q23UniSTS
D6Got91  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,330,690 - 70,330,909 (+)MAPPERmRatBN7.2
Rnor_6.0673,700,738 - 73,700,956NCBIRnor6.0
Rnor_5.0683,257,121 - 83,257,339UniSTSRnor5.0
RGSC_v3.4673,057,488 - 73,057,707RGDRGSC3.4
RGSC_v3.4673,057,489 - 73,057,707UniSTSRGSC3.4
RGSC_v3.1673,060,615 - 73,060,833RGD
Celera669,191,173 - 69,191,391UniSTS
RH 3.4 Map6516.1UniSTS
RH 3.4 Map6516.1RGD
RH 2.0 Map6675.0RGD
Cytogenetic Map6q23UniSTS
D6Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,619,431 - 70,619,618 (+)MAPPERmRatBN7.2
Rnor_6.0673,990,228 - 73,990,414NCBIRnor6.0
Rnor_5.0683,545,270 - 83,545,456UniSTSRnor5.0
RGSC_v3.4673,354,214 - 73,354,400UniSTSRGSC3.4
Celera669,479,850 - 69,480,036UniSTS
Cytogenetic Map6q23UniSTS
AU047448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,307,844 - 70,308,027 (+)MAPPERmRatBN7.2
Rnor_6.0673,677,678 - 73,677,860NCBIRnor6.0
Rnor_5.0683,234,061 - 83,234,243UniSTSRnor5.0
RGSC_v3.4673,033,955 - 73,034,137UniSTSRGSC3.4
Celera669,168,313 - 69,168,497UniSTS
Cytogenetic Map6q23UniSTS
RH132511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,309,361 - 70,309,554 (+)MAPPERmRatBN7.2
Rnor_6.0673,679,195 - 73,679,387NCBIRnor6.0
Rnor_5.0683,235,578 - 83,235,770UniSTSRnor5.0
RGSC_v3.4673,035,472 - 73,035,664UniSTSRGSC3.4
Celera669,169,834 - 69,170,026UniSTS
RH 3.4 Map6513.7UniSTS
Cytogenetic Map6q23UniSTS
BM384496  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,305,244 - 70,305,425 (+)MAPPERmRatBN7.2
Rnor_6.0673,674,987 - 73,675,167NCBIRnor6.0
Rnor_5.0683,231,370 - 83,231,550UniSTSRnor5.0
RGSC_v3.4673,031,355 - 73,031,535UniSTSRGSC3.4
Celera669,165,713 - 69,165,893UniSTS
RH 3.4 Map6516.7UniSTS
Cytogenetic Map6q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 40 8 9 68 3 8
Low 3 3 28 12 19 12 2 6 13 31 8
Below cutoff 29 29 29 22 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006562   ⟹   ENSRNOP00000006562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl670,184,175 - 70,619,738 (+)Ensembl
Rnor_6.0 Ensembl673,553,210 - 73,990,534 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111927   ⟹   ENSRNOP00000091441
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl670,184,175 - 70,618,122 (+)Ensembl
RefSeq Acc Id: NM_022618   ⟹   NP_072140
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2670,184,175 - 70,619,738 (+)NCBI
Rnor_6.0673,553,210 - 73,990,534 (+)NCBI
Rnor_5.0683,111,409 - 83,547,031 (+)NCBI
RGSC_v3.4673,010,779 - 73,354,520 (+)RGD
Celera669,046,483 - 69,480,156 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594342   ⟹   XP_017449831
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2670,275,852 - 70,624,369 (+)NCBI
Rnor_6.0673,645,526 - 73,991,992 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594343   ⟹   XP_017449832
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2670,184,105 - 70,624,369 (+)NCBI
Rnor_6.0673,553,111 - 73,991,992 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112888   ⟹   XP_038968816
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2670,337,749 - 70,624,369 (+)NCBI
RefSeq Acc Id: XM_039112889   ⟹   XP_038968817
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2670,184,101 - 70,603,299 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_072140   ⟸   NM_022618
- Sequence:
RefSeq Acc Id: XP_017449832   ⟸   XM_017594343
- Peptide Label: isoform X1
- UniProtKB: G3V6M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449831   ⟸   XM_017594342
- Peptide Label: isoform X1
- UniProtKB: G3V6M0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006562   ⟸   ENSRNOT00000006562
RefSeq Acc Id: XP_038968817   ⟸   XM_039112889
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038968816   ⟸   XM_039112888
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000091441   ⟸   ENSRNOT00000111927

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVC7-F1-model_v2 AlphaFold Q9WVC7 1-2314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694593
Promoter ID:EPDNEW_R5118
Type:multiple initiation site
Name:Akap6_1
Description:A-kinase anchoring protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0673,553,192 - 73,553,252EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69412 AgrOrtholog
BioCyc Gene G2FUF-37567 BioCyc
Ensembl Genes ENSRNOG00000004841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006562 ENTREZGENE
  ENSRNOP00000006562.2 UniProtKB/TrEMBL
  ENSRNOP00000091441 ENTREZGENE
  ENSRNOP00000091441.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006562 ENTREZGENE
  ENSRNOT00000006562.4 UniProtKB/TrEMBL
  ENSRNOT00000111927 ENTREZGENE
  ENSRNOT00000111927.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64553 UniProtKB/Swiss-Prot
NCBI Gene 64553 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKA ANCHORING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akap6 PhenoGen
SMART SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GIZ8_RAT UniProtKB/TrEMBL
  AKAP6_RAT UniProtKB/Swiss-Prot
  G3V6M0 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVC7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap6  A-kinase anchoring protein 6  Akap6  A kinase (PRKA) anchor protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Akap6  A kinase (PRKA) anchor protein 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function anchoring protein that binds to Pde4d at perinuclear regions in hypertrophic cardiomyocytes 68716
gene_function anchoring protein that binds to Pde4d at perinuclear regions in hypertrophic cardiomyocytes 69370
gene_process orients and sustains multi-component signaling complexes of protein kinase A and other enzymes 68716
gene_process orients and sustains multi-component signaling complexes of protein kinase A and other enzymes 69370