Trpv4 (transient receptor potential cation channel, subfamily V, member 4) - Rat Genome Database

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Gene: Trpv4 (transient receptor potential cation channel, subfamily V, member 4) Rattus norvegicus
Analyze
Symbol: Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
RGD ID: 69337
Description: Enables calcium channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including calcium ion transport; cytoskeleton organization; and positive regulation of microtubule depolymerization. Located in several cellular components, including cytoskeleton; focal adhesion; and ruffle membrane. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3',5'-cyclic AMP; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NOT NULL; osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; Otrpc4; Otrpc4-pending; transient receptor potential cation channel subf V memb 4; transient receptor potential cation channel subfamily 5 member 4; transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; vanilloid receptor-related osmotically activated channel (Vroac); vanilloid receptor-related osmotically-activated channel; VR-OAC; Vroac
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Trpv4em5Mcwi   Trpv4em4Mcwi   Trpv4em1Sage  
Genetic Models: SD-Trpv4em1Sage WKY-Trpv4em4Mcwi WKY-Trpv4em5Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,599,161 - 47,638,143 (+)NCBIGRCr8
mRatBN7.21241,938,533 - 41,977,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,106,237 - 43,144,888 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,719,815 - 43,758,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,780,312 - 42,818,968 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,698,915 - 47,737,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,492,064 - 49,529,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,226,933 - 43,265,889 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,090,320 - 43,129,277 (+)NCBI
Celera1243,552,408 - 43,590,250 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
2-aminoadipic 2-oxoadipic aciduria  (ISO)
amyotrophic lateral sclerosis type 5  (ISO)
Auditory Neuropathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
autosomal dominant distal hereditary motor neuronopathy 8  (ISO)
autosomal dominant nonsyndromic deafness 25  (ISS)
bone disease  (ISO)
brachyolmia  (ISO)
Brachyolmia Type 2  (ISO)
Brachyolmia Type 3  (ISO)
cerebral creatine deficiency syndrome 1  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease axonal type 2C  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 4  (ISO)
chronic obstructive pulmonary disease  (ISO)
clubfoot  (ISO)
connective tissue disease  (ISO)
Digital Arthropathy-Brachydactyly, Familial  (ISO)
Femur Head Necrosis  (ISO)
genetic disease  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hyponatremia  (ISO)
metatropic dysplasia  (ISO)
myoepithelioma  (ISO)
neuromuscular disease  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
parastremmatic dwarfism  (ISO)
pulmonary hypertension  (IEP)
scapuloperoneal spinal muscular atrophy  (ISO)
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal  (ISO)
spinal muscular atrophy  (ISO)
spinocerebellar ataxia with axonal neuropathy 2  (ISO)
spondyloepimetaphyseal dysplasia, Strudwick type  (ISO)
spondyloepiphyseal dysplasia Maroteaux type  (ISO)
spondylometaphyseal dysplasia  (ISO)
spondylometaphyseal dysplasia Kozlowski type  (ISO)
Urination Disorders  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Cannabichromene  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (EXP)
capsaicin  (EXP)
choline  (ISO)
chrysene  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diuron  (EXP)
ethanol  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gadolinium atom  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
icosanoid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
prostaglandin E2  (ISO)
ruthenium red  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
serotonin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
vincristine  (EXP)
zalcitabine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IDA)
actin filament organization  (IBA,IDA,ISO)
ATP export  (ISO)
ATP transport  (ISO)
blood vessel endothelial cell delamination  (ISO)
calcium ion import  (IDA,ISO)
calcium ion import across plasma membrane  (IBA,ISO)
calcium ion import into cytosol  (ISO,ISS)
calcium ion transmembrane transport  (IEA,IMP,ISO)
calcium ion transport  (ISO)
cartilage development involved in endochondral bone morphogenesis  (ISO)
cartilage homeostasis  (ISO)
cell-cell junction assembly  (ISO,ISS)
cellular hypotonic response  (ISO)
cellular hypotonic salinity response  (ISO)
cellular response to heat  (ISO,ISS)
cellular response to osmotic stress  (ISO,ISS)
cortical microtubule organization  (IDA)
diet induced thermogenesis  (ISO)
energy homeostasis  (ISO)
glucose homeostasis  (ISO)
hyperosmotic salinity response  (ISO)
hypotonic response  (IDA)
intracellular calcium ion homeostasis  (ISO,ISS)
microtubule polymerization  (IDA)
multicellular organismal-level water homeostasis  (IMP,ISO)
negative regulation of brown fat cell differentiation  (ISO)
negative regulation of cell volume  (ISO)
negative regulation of neuron projection development  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
osmosensory signaling pathway  (IBA,ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage inflammatory protein 1 alpha production  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of microtubule depolymerization  (IDA)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of striated muscle contraction  (IMP)
positive regulation of vascular permeability  (IMP,ISO)
regulation of aerobic respiration  (ISO)
regulation of blood pressure  (IMP)
regulation of heart rate  (IMP)
regulation of p38MAPK cascade  (ISO)
regulation of response to osmotic stress  (IMP,ISO)
relaxation of vascular associated smooth muscle  (ISO)
response to fatty acid  (ISO)
response to hypoxia  (IEP)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to osmotic stress  (ISO)
vasopressin secretion  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Benfenati V, etal., Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2563-8. doi: 10.1073/pnas.1012867108. Epub 2011 Jan 24.
2. Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. Dahan D, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1;303(9):L824-33. doi: 10.1152/ajplung.00244.2011. Epub 2012 Sep 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. Goswami C, etal., PLoS One. 2010 Jul 19;5(7):e11654. doi: 10.1371/journal.pone.0011654.
5. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Liedtke W, etal., Cell 2000 Oct 27;103(3):525-35.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. Shukla AK, etal., J Biol Chem. 2010 Sep 24;285(39):30115-25. Epub 2010 Jul 22.
12. TRPV4 channels' dominant role in the temperature modulation of intrinsic contractility and lymph flow of rat diaphragmatic lymphatics. Solari E, etal., Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H507-H518. doi: 10.1152/ajpheart.00175.2020. Epub 2020 Jul 24.
13. An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Thorneloe KS, etal., Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.
Additional References at PubMed
PMID:11025659   PMID:12538589   PMID:12724311   PMID:12777254   PMID:14517216   PMID:14581619   PMID:15128858   PMID:15753126   PMID:15858826   PMID:16269659   PMID:16439673   PMID:16597741  
PMID:16675722   PMID:17071727   PMID:17669489   PMID:17712480   PMID:17719182   PMID:18024594   PMID:18174177   PMID:18323527   PMID:18458941   PMID:18682499   PMID:18684885   PMID:18845910  
PMID:19066426   PMID:19075100   PMID:19091909   PMID:19158342   PMID:19174160   PMID:19208258   PMID:19790068   PMID:19877445   PMID:19888909   PMID:20044482   PMID:20093626   PMID:20194297  
PMID:20304685   PMID:20413591   PMID:20424166   PMID:20605796   PMID:20956320   PMID:21316269   PMID:21356247   PMID:21938744   PMID:22038643   PMID:22049072   PMID:22184014   PMID:22187434  
PMID:22207590   PMID:22309793   PMID:22442563   PMID:22492652   PMID:22761937   PMID:22762361   PMID:22820913   PMID:22865090   PMID:23021218   PMID:23027348   PMID:23142541   PMID:23147107  
PMID:23288842   PMID:23411787   PMID:24002225   PMID:24075884   PMID:24286344   PMID:24392954   PMID:24474754   PMID:24631674   PMID:24789205   PMID:24917364   PMID:24965792   PMID:24966090  
PMID:25069877   PMID:25114176   PMID:25139746   PMID:25366609   PMID:25421636   PMID:25600591   PMID:25681460   PMID:25980432   PMID:26047504   PMID:26146187   PMID:26249260   PMID:26294342  
PMID:26413835   PMID:26702092   PMID:26842013   PMID:26947561   PMID:27350729   PMID:27366753   PMID:27436489   PMID:27705979   PMID:27872234   PMID:28274876   PMID:28359774   PMID:28472069  
PMID:28542130   PMID:28597396   PMID:29097199   PMID:29243846   PMID:29380056   PMID:29424275   PMID:29537229   PMID:29569183   PMID:29787869   PMID:29899501   PMID:30628831   PMID:31055086  
PMID:31358810   PMID:31392384   PMID:31428866   PMID:31619514   PMID:31622498   PMID:31693393   PMID:31974206   PMID:32234595   PMID:32274619   PMID:32479780   PMID:32810492   PMID:32892440  
PMID:32961227   PMID:32964544   PMID:33094506   PMID:33119551   PMID:33179099   PMID:34348138   PMID:34499186   PMID:34605007   PMID:34961860   PMID:35040999   PMID:35384152   PMID:35489198  
PMID:36103035   PMID:36210154   PMID:36618411   PMID:36869605   PMID:36946001   PMID:37103670   PMID:37683711   PMID:37838226   PMID:37881934   PMID:37966569   PMID:37981067   PMID:38226418  
PMID:38735619  


Genomics

Comparative Map Data
Trpv4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,599,161 - 47,638,143 (+)NCBIGRCr8
mRatBN7.21241,938,533 - 41,977,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,106,237 - 43,144,888 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,719,815 - 43,758,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,780,312 - 42,818,968 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,698,915 - 47,737,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,492,064 - 49,529,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,226,933 - 43,265,889 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,090,320 - 43,129,277 (+)NCBI
Celera1243,552,408 - 43,590,250 (+)NCBICelera
Cytogenetic Map12q16NCBI
TRPV4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,783,087 - 109,833,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,783,087 - 109,833,406 (-)EnsemblGRCh38hg38GRCh38
GRCh3712110,220,892 - 110,271,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,705,277 - 108,755,595 (-)NCBINCBI36Build 36hg18NCBI36
Celera12109,845,179 - 109,895,568 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,237,035 - 107,287,147 (-)NCBIHuRef
CHM1_112110,188,702 - 110,239,020 (-)NCBICHM1_1
T2T-CHM13v2.012109,758,559 - 109,808,862 (-)NCBIT2T-CHM13v2.0
Trpv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,760,213 - 114,796,497 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,760,213 - 114,796,482 (-)EnsemblGRCm39 Ensembl
GRCm385114,622,152 - 114,658,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,622,152 - 114,658,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,072,163 - 115,108,430 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,883,153 - 114,919,388 (-)NCBIMGSCv36mm8
Celera5111,719,696 - 111,755,858 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Trpv4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,744,176 - 8,783,741 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,744,865 - 8,781,644 (+)NCBIChiLan1.0ChiLan1.0
TRPV4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,849,960 - 117,900,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,846,362 - 117,896,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,359,005 - 107,409,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,754,238 - 110,786,182 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,754,238 - 110,786,182 (-)Ensemblpanpan1.1panPan2
TRPV4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,293,334 - 17,330,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,262,100 - 17,330,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,472,505 - 18,493,002 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02617,652,672 - 17,673,399 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2617,652,672 - 17,673,984 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,683,516 - 18,704,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,643,537 - 17,664,298 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,660,529 - 17,681,097 (+)NCBIUU_Cfam_GSD_1.0
Trpv4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,028,138 - 144,051,340 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367691,424,549 - 1,447,516 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367691,424,526 - 1,447,547 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPV4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,125,869 - 41,169,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,641,455 - 43,683,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPV4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,020,972 - 105,072,660 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037140,046,822 - 140,098,634 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpv4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,675,625 - 10,685,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpv4
308 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:104
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000001586
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

Markers in Region
D12Got95  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,936,584 - 41,936,713 (+)MAPPERmRatBN7.2
Rnor_6.01247,696,972 - 47,697,100NCBIRnor6.0
Rnor_5.01249,490,095 - 49,490,223UniSTSRnor5.0
RGSC_v3.41243,224,957 - 43,225,086RGDRGSC3.4
RGSC_v3.41243,224,958 - 43,225,086UniSTSRGSC3.4
RGSC_v3.11243,088,346 - 43,088,474RGD
Celera1243,550,435 - 43,550,561UniSTS
RH 3.4 Map12818.71UniSTS
RH 3.4 Map12818.71RGD
RH 2.0 Map12547.0RGD
Cytogenetic Map12q16UniSTS
Trpv4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,972,643 - 41,972,760 (+)MAPPERmRatBN7.2
Rnor_6.01247,733,030 - 47,733,146NCBIRnor6.0
Rnor_5.01249,525,084 - 49,525,200UniSTSRnor5.0
Celera1243,585,378 - 43,585,494UniSTS
Cytogenetic Map12q16UniSTS


Genetic Models
This gene Trpv4 is modified in the following models/strains:
SD-Trpv4em1Sage     WKY-Trpv4em4Mcwi     WKY-Trpv4em5Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 87 86 55 25 55 6 212 95 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001586   ⟹   ENSRNOP00000001586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)Ensembl
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103777   ⟹   ENSRNOP00000095633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116364   ⟹   ENSRNOP00000082684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)Ensembl
RefSeq Acc Id: NM_023970   ⟹   NP_076460
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,599,188 - 47,638,143 (+)NCBI
mRatBN7.21241,938,560 - 41,977,517 (+)NCBI
Rnor_6.01247,698,947 - 47,737,902 (+)NCBI
Rnor_5.01249,492,064 - 49,529,956 (+)NCBI
RGSC_v3.41243,226,933 - 43,265,889 (+)RGD
Celera1243,552,408 - 43,590,250 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249466   ⟹   XP_006249528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,599,161 - 47,638,143 (+)NCBI
mRatBN7.21241,938,533 - 41,977,517 (+)NCBI
Rnor_6.01247,698,915 - 47,737,902 (+)NCBI
Rnor_5.01249,492,064 - 49,529,956 (+)NCBI
Sequence:
RefSeq Acc Id: NP_076460   ⟸   NM_023970
- UniProtKB: Q9ERZ8 (UniProtKB/Swiss-Prot),   A0A8I6ANU0 (UniProtKB/TrEMBL),   A6J1Z3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249528   ⟸   XM_006249466
- Peptide Label: isoform X1
- UniProtKB: Q9ERZ8 (UniProtKB/Swiss-Prot),   A0A8I6ANU0 (UniProtKB/TrEMBL),   A6J1Z3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001586   ⟸   ENSRNOT00000001586
Ensembl Acc Id: ENSRNOP00000095633   ⟸   ENSRNOT00000103777
Ensembl Acc Id: ENSRNOP00000082684   ⟸   ENSRNOT00000116364
Protein Domains
Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERZ8-F1-model_v2 AlphaFold Q9ERZ8 1-871 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69337 AgrOrtholog
BioCyc Gene G2FUF-18952 BioCyc
Ensembl Genes ENSRNOG00000001195 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055001978 UniProtKB/Swiss-Prot
  ENSRNOG00060004776 UniProtKB/Swiss-Prot
  ENSRNOG00065007095 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001586.3 UniProtKB/Swiss-Prot
  ENSRNOT00000103777.1 UniProtKB/TrEMBL
  ENSRNOT00000116364.1 UniProtKB/TrEMBL
  ENSRNOT00055003153 UniProtKB/Swiss-Prot
  ENSRNOT00060007995 UniProtKB/Swiss-Prot
  ENSRNOT00065011080 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrpV1-4 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TRPV4_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:66026 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Trpv4 ENTREZGENE
PANTHER PTHR10582 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10582:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpv4 PhenoGen
PRINTS TRPVRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VRL2RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001195 RatGTEx
  ENSRNOG00055001978 RatGTEx
  ENSRNOG00060004776 RatGTEx
  ENSRNOG00065007095 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8A1UAL1_RAT UniProtKB/TrEMBL
  A0A8I5ZV19_RAT UniProtKB/TrEMBL
  A0A8I6ANU0 ENTREZGENE, UniProtKB/TrEMBL
  A6J1Z3 ENTREZGENE, UniProtKB/TrEMBL
  A6J1Z4_RAT UniProtKB/TrEMBL
  Q9ERZ8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Trpv4  transient receptor potential cation channel, subfamily V, member 4    ransient receptor potential cation channel, subfamily 5, member 4   Symbol and Name updated 629477 APPROVED
2002-06-10 Trpv4  ransient receptor potential cation channel, subfamily 5, member 4       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons of the circumventricular organs, inner-ear hair cells, sensory neurons, and Merkel cells 68824