Cdkn1a (cyclin-dependent kinase inhibitor 1A) - Rat Genome Database

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Gene: Cdkn1a (cyclin-dependent kinase inhibitor 1A) Rattus norvegicus
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Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
RGD ID: 69328
Description: Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to hyperoxia; and response to mineralocorticoid. Located in perinuclear region of cytoplasm. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A); PARTICIPATES IN G1/S transition pathway; Notch signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH (+)-dexrazoxane; (+)-schisandrin B; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cip1; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); UV96; Waf1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BUF.ACI-(D20Img2-Cdkn1a)/Ncc   ACI.BUF-(D20Img2-Cdkn1a)/Ncc  
Candidate Gene For: Prcs2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,150,820 - 7,161,373 (+)NCBIGRCr8
mRatBN7.2207,149,177 - 7,159,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,860,502 - 7,870,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,222,359 - 7,232,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,697,344 - 7,707,907 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,348,422 - 6,358,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,351,458 - 6,358,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,592,437 - 8,602,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,376,325 - 7,386,778 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,379,612 - 7,385,803 (+)NCBI
Celera208,699,290 - 8,709,718 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
Acute Experimental Pancreatitis  (IEP)
Animal Mammary Neoplasms  (ISO)
Arsenic Poisoning  (ISO)
atrial fibrillation  (ISO)
autosomal dominant polycystic kidney disease  (IEP)
Barrett's esophagus  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (IEP)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholesteatoma of middle ear  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
Congenital Cholesteatoma  (ISO)
Diabetic Nephropathies  (ISO)
ductal carcinoma in situ  (ISO)
Embryo Loss  (ISO)
Endometrial Neoplasms  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (IEP)
facioscapulohumeral muscular dystrophy  (ISO)
Fuchs' endothelial dystrophy  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
Habitual Abortions  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hepatocellular carcinoma  (ISS)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperoxia  (IEP,ISO)
Hyperplasia  (IEP)
Hypertrophy  (ISO)
Hypovolemia  (IEP)
Intestinal Neoplasms  (ISO)
inverted papilloma  (ISO)
kidney disease  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Lip Neoplasms  (ISO)
lipoid nephrosis  (IEP)
liver benign neoplasm  (IEP)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
malignant mesothelioma  (ISO)
maxillary sinus squamous cell carcinoma  (ISO)
melanoma  (ISO)
Neoplasm Metastasis  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (ISO)
pre-malignant neoplasm  (IEP)
Premature Aging  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (IEP,ISO)
renal hypertension  (IEP)
Reperfusion Injury  (IEP,ISO)
retinal degeneration  (IEP)
RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES  (IEP)
Salivary Gland Neoplasms  (ISO)
sarcoidosis  (ISO)
Sarcopenia  (ISO)
sebaceous gland neoplasm  (ISO)
Sepsis  (IEP)
serous cystadenocarcinoma  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (IEP,ISO)
systemic lupus erythematosus  (ISS)
T-cell non-Hodgkin lymphoma  (ISO)
Thyroid Neoplasms  (IEP)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP,ISO)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-noscapine  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(aminomethyl)phosphonic acid  (ISO)
(aminooxy)acetic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-(-)-perillyl alcohol  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-hydroxy-1-norresistomycin  (ISO)
1-methylphenanthrene  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2'-deoxyadenosine  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-diaminotoluene  (EXP,ISO)
2,4-dibromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-bis(aziridin-1-yl)-1,4-benzoquinone  (ISO)
2,6-diaminotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-nitrotoluene  (EXP,ISO)
2-pyridylethylamine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-hydroxypregn-4-en-3-one  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-acetylaminofluorene  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
4-tert-Octylphenol  (ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
Abemaciclib  (ISO)
abexinostat  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP,ISO)
Actein  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
Allylamine  (EXP)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
aluminium oxide  (ISO)
alvocidib  (ISO)
amentoflavone  (ISO)
amifostine  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amosite asbestos  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
andrographolide  (ISO)
anilines  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracen-2-amine  (EXP)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
aprepitant  (ISO)
arecoline hydrobromide  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
aucubin  (ISO)
auranofin  (ISO)
Aurin  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
Azoxymethane  (EXP)
azoxystrobin  (EXP,ISO)
baicalein  (EXP,ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[b]fluorene  (EXP)
Benzo[ghi]perylene  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (ISO)
beryllium sulfate  (ISO)
Besigomsin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
betalain  (ISO)
betaxolol  (ISO)
betulinic acid  (ISO)
bexarotene  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (EXP)
biochanin A  (ISO)
biotin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
brassinolide  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
bucladesine  (EXP,ISO)
budesonide  (ISO)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
C60 fullerene  (EXP,ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
calciol  (ISO)
calcitriol  (ISO)
Calpeptin  (ISO)
Calphostin C  (ISO)
calycosin  (ISO)
calyculin A  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
Carbadox  (EXP)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carboplatin  (EXP,ISO)
Cardanol  (ISO)
carmustine  (ISO)
carteolol  (ISO)
casticin  (ISO)
catechol  (EXP)
cefaloridine  (EXP)
celecoxib  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
Chlamydocin  (ISO)
chlorambucil  (ISO)
chloramphenicol  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorotoluron  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chymostatin  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
Cinobufagin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
citric acid  (ISO)
cladribine  (ISO)
clobenpropit  (ISO)
clodronic acid  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corn oil  (EXP)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
cudraflavone B  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanamide  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP,ISO)
cytarabine  (EXP,ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (ISO)
daidzein  (ISO)
danazol  (ISO)
daunorubicin  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
demethoxycurcumin  (ISO)
DENSPM  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
diacetylmonoxime  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (EXP,ISO)
diazene  (ISO)
diazinon  (ISO)
diaziquone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzofuran  (EXP)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichlorvos  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (ISO)
dieldrin  (EXP)
diethanolamine  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
digitonin  (ISO)
digitoxin  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydrolipoic acid  (ISO)
dihydroxyacetone  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
Dimefox  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
Echimidine  (EXP,ISO)
ellagic acid  (ISO)
ellipticine  (ISO)
emtricitabine  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (EXP,ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
esculetin  (EXP,ISO)
estriol  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl maltol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP,ISO)
eugenol  (EXP,ISO)
EUK-134  (ISO)
farnesol  (ISO)
farrerol  (ISO)
fenamidone  (ISO)
fenbendazole  (EXP)
fenitrothion  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
ferric ammonium citrate  (EXP,ISO)
ferric oxide  (EXP)
ferrostatin-1  (EXP)
ferulic acid  (EXP,ISO)
fisetin  (EXP,ISO)
flavanone  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
fludioxonil  (ISO)
flumethrin  (ISO)
fluoranthene  (ISO)
fluorometholone  (ISO)
fluoxetine  (ISO)
fluxapyroxad  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
fotemustine  (ISO)
FR900359  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furazolidone  (ISO)
galangin  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
ganglioside GM1  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
Gingerenone A  (ISO)
gingerol  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
gliclazide  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glycidol  (EXP)
glycitein  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
GSK-J4  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 6471  (EXP)
Heliotrine  (EXP)
hemin  (ISO)
heparin  (EXP)
hesperetin  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
hydroxyurea  (EXP,ISO)
ibuprofen  (EXP)
idarubicin  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
Inotodiol  (ISO)
inulin  (ISO)
inuviscolide  (ISO)
iodoacetic acid  (ISO)
irbesartan  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (ISO)
isobutanol  (ISO)
isocyanates  (ISO)
isoflavones  (ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
isoprene  (ISO)
isopropyl beta-D-thiogalactopyranoside  (ISO)
isotretinoin  (ISO)
isovitexin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
L-mimosine  (ISO)
lactucin  (ISO)
lamivudine  (ISO)
lanreotide  (EXP)
lapatinib  (ISO)
Lasiocarpine  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lenvatinib  (EXP)
leptomycin B  (ISO)
letrozole  (ISO)
Leucomalachite green  (EXP)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
linalool  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
lomustine  (ISO)
loperamide  (ISO)
losartan  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
lupeol  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (ISO)
lycopene  (ISO)
lycorine  (ISO)
Lysocellin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
manumycin A  (ISO)
Maxacalcitol  (ISO)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
menadione  (ISO)
menaquinone  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl caffeate  (ISO)
methyl carbamate  (ISO)
methyl isocyanate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (EXP,ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
mithramycin  (ISO)
mitomycin C  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monocrotaline  (ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
Morindone  (ISO)
morphine  (ISO)
Morroniside  (ISO)
motexafin gadolinium  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
naringin  (EXP,ISO)
nevirapine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nimesulide  (ISO)
nitenpyram  (ISO)
NMN zwitterion  (ISO)
NMS-873  (ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
NORCANTHARIDIN  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
O-methyleugenol  (EXP,ISO)
Obacunone  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
olaparib  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
omeprazole  (ISO)
omethoate  (ISO)
organoselenium compound  (EXP)
orlistat  (ISO)
ortho-Aminoazotoluene  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
oxazepam  (ISO)
oxfendazole  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panaxydol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
patulin  (ISO)
PD 168393  (ISO)
pectolinarigenin  (ISO)
pemetrexed  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pergolide  (ISO)
perifosine  (ISO)
perillyl alcohol  (ISO)
PF-3758309  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phloretin  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
pifithrin-alpha hydrobromide  (EXP,ISO)
pinostrobin  (ISO)
pinosylvin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(vinylpyrrolidone)  (ISO)
ponatinib  (ISO)
potassium bromate  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
promethazine  (EXP)
propylparaben  (ISO)
protoporphyrin  (EXP)
pterostilbene  (ISO)
PX-866  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinacrine  (ISO)
quinidine  (ISO)
quinolin-8-ol  (ISO)
quinoline  (ISO)
quizartinib  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
riddelliine  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
roflumilast  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rubitecan  (ISO)
ruthenium atom  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salinomycin  (ISO)
salubrinal  (EXP)
salvianolic acid B  (ISO)
Sanggenon C  (ISO)
sanguinarine  (ISO)
sapropterin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
SCH 23390  (EXP)
sclareol  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (ISO)
selumetinib  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (EXP)
sevoflurane  (EXP)
shikimic acid  (ISO)
Shikonin  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
sodium tungstate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sotorasib  (ISO)
staurosporine  (ISO)
stavudine  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
sulfonyldimethane  (ISO)
sulforaphane  (ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
taiwanin C  (ISO)
talazoparib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
teniposide  (ISO)
tenofovir disoproxil fumarate  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thiabendazole  (EXP,ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thioridazine  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
tirapazamine  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
tolbutamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (EXP,ISO)
toxaphene  (ISO)
trametinib  (ISO)
trans-pinosylvin  (ISO)
transplatin  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trimethylenediamine  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tyrphostin AG 1478  (ISO)
undecane  (EXP)
urethane  (ISO)
Urolithin A  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
venom  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP,ISO)
vincristine  (EXP,ISO)
vinyl carbamate  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
VX nerve agent  (ISO)
withaferin A  (ISO)
Withanone  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zebularine  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
cellular response to amino acid starvation  (ISO)
cellular response to cell-matrix adhesion  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to heat  (IEP)
cellular response to ionizing radiation  (ISO)
cellular response to UV-B  (ISO)
cellular senescence  (ISO)
DNA damage response  (IBA,ISO)
DNA damage response, signal transduction by p53 class mediator  (ISO)
epidermis development  (ISO)
fibroblast proliferation  (ISO)
heart development  (ISO)
import into nucleus  (ISO)
in utero embryonic development  (ISO)
intestinal epithelial cell maturation  (IEP)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
keratinocyte differentiation  (ISO)
keratinocyte proliferation  (ISO)
mitotic G1 DNA damage checkpoint signaling  (ISO)
mitotic G2 DNA damage checkpoint signaling  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cardiac muscle tissue regeneration  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cyclin-dependent protein kinase activity  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
oncogene-induced cell senescence  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of programmed cell death  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of response to biotic stimulus  (IMP)
protein import into nucleus  (ISO)
Ras protein signal transduction  (ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell cycle G1/S phase transition  (ISO)
regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
regulation of DNA biosynthetic process  (ISO)
regulation of G1/S transition of mitotic cell cycle  (IBA,ISO)
regulation of G2/M transition of mitotic cell cycle  (ISO)
regulation of mitotic cell cycle  (IEA,ISO)
response to aldosterone  (IEP)
response to arsenic-containing substance  (IEP)
response to corticosterone  (IEP)
response to glucocorticoid  (IEP)
response to hyperoxia  (IEP)
response to toxic substance  (IEP)
response to UV  (ISO)
response to X-ray  (IEP)
response to xenobiotic stimulus  (IEP)
signal transduction by p53 class mediator  (IEA)
tissue regeneration  (ISO)
wound healing  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. P21-dependent protective effects of a carbon monoxide-releasing molecule-3 in pulmonary hypertension. Abid S, etal., Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):304-12. doi: 10.1161/ATVBAHA.113.302302. Epub 2013 Dec 12.
2. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Adnane J, etal., Oncogene. 2000 Nov 9;19(47):5338-47.
3. Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma. Altavilla G, etal., Acta Otolaryngol. 2009 Nov;129(11):1242-9. doi: 10.3109/00016480802620647.
4. Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma. Baldursson B, etal., Acta Derm Venereol. 2000 Jul-Aug;80(4):251-5.
5. Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Beauchamp RD, etal., Ann Surg. 1996 May;223(5):620-7; discussion 627-8.
6. Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat. Belinsky SA, etal., Radiat Res 1996 Apr;145(4):449-56.
7. Basic helix-loop-helix protein E47-mediated p21Waf1/Cip1 gene expression regulates apoptosis of intestinal epithelial cells. Bhattacharya S, etal., Biochem J. 2007 Oct 15;407(2):243-54.
8. Expression of the cell cycle regulators p53, p21(WAF1/CIP1) and p16(INK4a) in human endometrial adenocarcinoma. Buchynska LG and Nesina IP, Exp Oncol. 2006 Jun;28(2):152-5.
9. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
10. Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Chen H, etal., J Cell Biochem. 2007 Dec 1;102(5):1281-9.
11. Microbiota matures colonic epithelium through a coordinated induction of cell cycle-related proteins in gnotobiotic rat. Cherbuy C, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G348-57. doi: 10.1152/ajpgi.00384.2009. Epub 2010 May 13.
12. p21(Cip1) restrains pituitary tumor growth. Chesnokova V, etal., Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17498-503. doi: 10.1073/pnas.0804810105. Epub 2008 Nov 3.
13. Arecoline-induced growth arrest and p21(WAF1) expression are dependent on p53 in rat hepatocytes. Chou WW, etal., Toxicology. 2008 Jan 14;243(1-2):1-10. Epub 2007 Sep 8.
14. Impairment of rat postnatal lung alveolar development by glucocorticoids: involvement of the p21CIP1 and p27KIP1 cyclin-dependent kinase inhibitors. Corroyer S, etal., Pediatr Res 2002 Feb;51(2):169-76.
15. Immunohistochemical expression of p16, p21, p27 and cyclin D1 in oral nevi and melanoma. de Andrade BA, etal., Head Neck Pathol. 2012 Sep;6(3):297-304. doi: 10.1007/s12105-012-0334-y. Epub 2012 Feb 5.
16. Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma. De la Cueva E, etal., Oncogene. 2006 Jul 6;25(29):4128-32. Epub 2006 Feb 6.
17. DNA damage and p21(WAF1/CIP1/SDI1) in experimental injury of the rat adrenal cortex and trauma-associated damage of the human adrenal cortex. Didenko VV, etal., J Pathol. 1999 Sep;189(1):119-26.
18. Association of single-nucleotide polymorphisms in the Cell Cycle genes with breast cancer in the British population. Driver KE, etal., Carcinogenesis. 2008 Jan 3;.
19. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. el-Deiry WS, etal., Cancer Res 1995 Jul 1;55(13):2910-9.
20. Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases. Esposito NN, etal., Arch Pathol Lab Med. 2006 Oct;130(10):1516-21.
21. Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin. Farah IO, etal., Biomed Sci Instrum. 2007;43:116-21.
22. [Expression and roles of CDK4 and p21 in lung tissues of premature rats with hyperoxia-induced chronic lung disease.] Gao Y, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Dec;9(6):595-600.
23. Cell cycle control related proteins (p53, p21, and Rb) and transforming growth factor beta (TGFbeta) in benign and carcinomatous (in situ and infiltrating) human breast: implications in malignant transformations. Garcia-Tunon I, etal., Cancer Invest. 2006 Mar;24(2):119-25.
24. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. P21/ WAF1 and cyclin D1 variants and oral squamous cell carcinoma. Gomes CC, etal., J Oral Pathol Med. 2008 Mar;37(3):151-6. doi: 10.1111/j.1600-0714.2007.00604.x.
27. Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts. Gomes WA and Kessler JA, Dev Biol. 2001 Sep 1;237(1):212-21.
28. Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage. Gratton MA, etal., Hear Res. 2011 Jul;277(1-2):211-26. doi: 10.1016/j.heares.2010.12.014. Epub 2010 Dec 25.
29. Protective effects of mesenchymal stromal cells on adriamycin-induced minimal change nephrotic syndrome in rats and possible mechanisms. Guo J, etal., Cytotherapy. 2014 Apr;16(4):471-84. doi: 10.1016/j.jcyt.2013.08.002. Epub 2013 Oct 10.
30. Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in pancreatic cancer. Harada N, etal., Br J Cancer. 1997;76(3):299-305.
31. Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids. Harms C, etal., J Neurosci. 2007 Apr 25;27(17):4562-71.
32. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
33. Up-regulation of p21WAF1/CIP1 in psoriasis and after the application of irritants and tape stripping. Healy E, etal., J Invest Dermatol. 1995 Aug;105(2):274-9.
34. Gene therapy using p21WAF-1/Cip-1 to modulate wound healing after glaucoma trabeculectomy surgery in a primate model of ocular hypertension. Heatley G, etal., Gene Ther. 2004 Jun;11(12):949-55.
35. Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus. Hirota M, etal., J Oral Pathol Med. 2002 Apr;31(4):204-12.
36. [The expression of P16, P21(WAF1/CIP1) and Cyclin D1 proteins in skin of patients with arseniasis caused by coal-burning and their significance]. Hong F, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2000 Nov;34(6):324-6.
37. p53 and p21WAF1/CIP1 overexpression at the invasive front of lower lip squamous cell carcinoma. Horta MC, etal., J Oral Pathol Med. 2007 Feb;36(2):88-92.
38. Functional expression of human p21(WAF1/CIP1) gene in rat glioma cells suppresses tumor growth in vivo and induces radiosensitivity. Hsiao M, etal., Biochem Biophys Res Commun. 1997 Apr 17;233(2):329-35. doi: 10.1006/bbrc.1997.6450.
39. T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression. Huang ZY, etal., Mol Cell Biol 2003 Jan;23(2):566-78.
40. Hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines with different radiothermosensitivity in vitro. Islam MS, etal., Oncol Rep. 2001 May-Jun;8(3):501-7.
41. Expression of p21Cip1/Waf1 and p27Kip1 in small cell neuroendocrine carcinoma of the uterine cervix. Kataoka TR, etal., Int J Surg Pathol. 2008 Jan;16(1):11-5.
42. Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation. Kavurma MM and Khachigian LM, J Biol Chem 2003 Aug 29;278(35):32537-43. Epub 2003 Jun 9.
43. Overexpression of p2lWaf1/Cip1 immunohistochemical staining in Bowen's disease, but not in disseminated superficial porokeratosis. Kawakami T, etal., Br J Dermatol. 1999 Oct;141(4):647-51.
44. Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain. Kaya SS, etal., Brain Res. 1999 Feb 6;818(1):23-33.
45. Diabetes-Induced Oxidative DNA Damage Alters p53-p21CIP1/Waf1 Signaling in the Rat Testis. Kilarkaje N and Al-Bader MM, Reprod Sci. 2014 May 14. pii: 1933719114533729.
46. Expression of G1 cell cycle regulators in rat liver upon repeated exposure to thioacetamide. Kim KT, etal., Korean J Hepatol. 2007 Mar;13(1):81-90.
47. Altered patterns of gene expression in response to chronic atrial fibrillation. Kim NH, etal., Int Heart J. 2005 May;46(3):383-95.
48. Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid. Kiyosaki K, etal., Invest Ophthalmol Vis Sci. 2010 Jan;51(1):7-11. doi: 10.1167/iovs.09-4127. Epub 2009 Jul 23.
49. Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Kovacheva EL, etal., Endocrinology. 2010 Feb;151(2):628-38. doi: 10.1210/en.2009-1177. Epub 2009 Dec 18.
50. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. Laine H, etal., J Neurosci. 2007 Feb 7;27(6):1434-44.
51. WAF1/Cip1 gene polymorphism and expression in carcinomas of the breast, ovary, and endometrium. Lukas J, etal., Am J Pathol. 1997 Jan;150(1):167-75.
52. Low expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci induced in rat liver by diethylnitrosamine or phenobarbital. Martens U, etal., Cancer Lett. 1996 Jun 24;104(1):21-6.
53. Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells. Matsuu-Matsuyama M, etal., J Radiat Res. 2008 Jul;49(4):341-7. Epub 2008 Apr 15.
54. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
55. Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. McBride SR, etal., J Clin Pathol. 2002 Oct;55(10):763-6.
56. Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer. McDonnell TJ, etal., BMC Med Genomics. 2008 Jan 31;1:1.
57. Induction of p21WAF/CIP1 during hyperoxia. McGrath SA Am J Respir Cell Mol Biol. 1998 Feb;18(2):179-87.
58. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
59. Significant correlation of morphological remodeling in ulcerative colitis with disease duration and between elevated p53 and p21 expression in rectal mucosa and neoplastic development. Mitsuhashi J, etal., Pathol Int. 2005 Mar;55(3):113-21.
60. The role of the DNA damage checkpoint pathway in intraductal papillary mucinous neoplasms of the pancreas. Miyasaka Y, etal., Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4371-7.
61. Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repair. Nakajima A, etal., Endocrinology 2003 Oct;144(10):4659-68. Epub 2003 Jul 3.
62. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
63. p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma. Nemes JA, etal., J Oral Pathol Med. 2005 May;34(5):274-9.
64. Clinical role of p53 and p21WAF1/CIP1 in squamous cell carcinoma of the pyriform sinus. Nibu KI, etal., Acta Otolaryngol. 1998 Jun;118(3):432-7.
65. Growth pattern and expressions of cell cycle regulator proteins p53 and p21WAF1/CIP1 in early gastric carcinoma. Noda H, etal., Cancer. 2001 Oct 1;92(7):1828-35.
66. Expression of cell cycle regulatory proteins in the multistep process of oesophageal carcinogenesis: stepwise over-expression of cyclin E and p53, reduction of p21(WAF1/CIP1) and dysregulation of cyclin D1 and p27(KIP1). Ohbu M, etal., Histopathology. 2001 Dec;39(6):589-96.
67. The role of p21 and p53 proteins in congenital cholesteatoma. Olszewska E, etal., Otol Neurotol. 2013 Feb;34(2):266-74. doi: 10.1097/MAO.0b013e31827c9d8d.
68. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
69. Frequency variations in the methylated pattern of p73/p21 genes and chromosomal aberrations correlating with different grades of glioma among south Indian population. Palani M, etal., Med Oncol. 2011 Dec;28 Suppl 1:S445-52. doi: 10.1007/s12032-010-9671-4. Epub 2010 Sep 16.
70. Protective role of a novel erythrocyte-derived depressing factor on blood vessels of renovascular hypertensive rats. Pang H, etal., Clin Exp Pharmacol Physiol. 2007 May-Jun;34(5-6):393-8.
71. p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. Park JY, etal., BMC Nephrol. 2007 Aug 22;8:12.
72. Expression of cyclin-dependent kinases inhibitors p21(WAF1) and p27(KIP1) in benign, premalignant and malignant laryngeal lesions. correlation with cell cycle regulatory proteins. Peschos D, etal., In Vivo. 2004 Nov-Dec;18(6):719-24.
73. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
74. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
75. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
76. Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast. Provenzano E, etal., Eur J Cancer. 2003 Mar;39(5):622-30.
77. Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer. Ralhan R, etal., Clin Cancer Res. 2000 Jun;6(6):2440-7.
78. A polymorphism at codon 31 of gene p21 is not associated with primary open angle glaucoma in Caucasians. Ressiniotis T, etal., BMC Ophthalmol. 2005 Apr 4;5:5.
79. GOA pipeline RGD automated data pipeline
80. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
81. p53 and p21 genetic polymorphisms and susceptibility to endometrial cancer. Roh JW, etal., Gynecol Oncol. 2004 May;93(2):499-505.
82. Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study. Sasaki M, etal., J Autoimmun. 2008 Aug;31(1):73-8. doi: 10.1016/j.jaut.2008.03.005. Epub 2008 May 5.
83. Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities. Schmidt-Grimminger DC, etal., Am J Pathol. 1998 Apr;152(4):1015-24.
84. Patterns of p21(waf1/cip1) expression in non-papillomatous nasal mucosa, endophytic sinonasal papillomas, and associated carcinomas. Schwerer MJ, etal., J Clin Pathol. 2001 Nov;54(11):871-6.
85. Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients. Sham CL, etal., Head Neck. 2012 Apr;34(4):520-33. doi: 10.1002/hed.21772. Epub 2011 May 23.
86. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
87. Correlation analysis between the expression of P21WAF1/CIP1, P16 proteins and human glioma. Song T, etal., Clin Exp Med. 2008 Sep;8(3):151-7. doi: 10.1007/s10238-008-0172-0. Epub 2008 Sep 13.
88. P21, p27, bax, cathepsin and survivin pathways in macular dystrophy corneas. Szentmary N, etal., Histol Histopathol. 2010 Mar;25(3):287-90.
89. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
90. Clinical significance of p21(WAF1/CIP1) and p53 expression in serous cystadenocarcinoma of the ovary. Terauchi F, etal., Oncol Rep. 2005 Aug;14(2):363-8.
91. p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. Topley GI, etal., Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9089-94.
92. Overexpression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in human cutaneous malignant melanoma. Trotter MJ, etal., J Cutan Pathol. 1997 May;24(5):265-71.
93. A codon 31ser-arg polymorphism of the WAF-1/CIP-1/p21/tumour suppressor gene in Chinese primary open-angle glaucoma. Tsai FJ, etal., Acta Ophthalmol Scand. 2004 Feb;82(1):76-80.
94. Expression of p21 and p53 in rat gingival and human oral epithelial cells after cyclosporine A treatment. Tu HP, etal., J Periodontal Res. 2008 Feb;43(1):32-9.
95. Proton pump inhibitors reduce cell cycle abnormalities in Barrett's esophagus. Umansky M, etal., Oncogene. 2001 Nov 29;20(55):7987-91.
96. Sulindac and Celecoxib regulate cell cycle progression by p53/p21 up regulation to induce apoptosis during initial stages of experimental colorectal cancer. Vaish V, etal., Cell Biochem Biophys. 2014 Mar;68(2):301-19. doi: 10.1007/s12013-013-9711-8.
97. Effect of Colla corii asini (E'jiao) on D-galactose induced aging mice. Wang D, etal., Biol Pharm Bull. 2012;35(12):2128-32.
98. [Expression of cell cycle regulators in squamous cell carcinoma of maxillary sinus and their significance]. Wang JB and Wang Y, Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Dec;38(6):471-5.
99. Loss of p21CIP1/WAF1 does not recapitulate accelerated malignant conversion caused by p53 loss in experimental skin carcinogenesis. Weinberg WC, etal., Oncogene. 1997 Aug 7;15(6):685-90.
100. Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas. Wu H, etal., Neuroscience. 2010 Sep 29;170(1):149-55. doi: 10.1016/j.neuroscience.2010.06.051. Epub 2010 Jul 1.
101. High expression of p21 Waf1 in sarcoid granulomas: a putative role for long-lasting inflammation. Xaus J, etal., J Leukoc Biol. 2003 Aug;74(2):295-301.
102. Prognostic significance of p21WAF1/CIP1 expression in tongue squamous cell carcinomas. Xie X, etal., Arch Otolaryngol Head Neck Surg. 2002 Aug;128(8):897-902.
103. [Expression and significance of P53 and P21 in nasal NK/T-cell lymphoma]. Xu G, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Jan;41(1):132-6.
104. Immunohistochemical cellular distribution of proteins related to M phase regulation in early proliferative lesions induced by tumor promotion in rat two-stage carcinogenesis models. Yafune A, etal., Exp Toxicol Pathol. 2014 Jan;66(1):1-11. doi: 10.1016/j.etp.2013.07.001. Epub 2013 Jul 23.
105. Increased expression of p53 and p21 (Waf1/Cip1) in the lesional skin of bleomycin-induced scleroderma. Yamamoto T and Nishioka K, Arch Dermatol Res. 2005 May;296(11):509-13. Epub 2005 Apr 1.
106. Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. Yang WC, etal., Cancer Res. 2001 Jan 15;61(2):565-9.
107. The clinicopathologic significance of p53 and p21 expression in the surgical management of lingual squamous cell carcinoma. Yuen PW, etal., Am J Clin Pathol. 2001 Aug;116(2):240-5.
108. Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter. Zhang C, etal., J Biol Chem 2003 Jul 25;278(30):27903-9. Epub 2003 May 9.
109. Activation of PPAR-gamma ameliorates pulmonary arterial hypertension via inducing heme oxygenase-1 and p21(WAF1): an in vivo study in rats. Zhang D, etal., Life Sci. 2014 Mar 7;98(1):39-43. doi: 10.1016/j.lfs.2013.12.208. Epub 2014 Jan 8.
Additional References at PubMed
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Genomics

Comparative Map Data
Cdkn1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,150,820 - 7,161,373 (+)NCBIGRCr8
mRatBN7.2207,149,177 - 7,159,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,860,502 - 7,870,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,222,359 - 7,232,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,697,344 - 7,707,907 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,348,422 - 6,358,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,351,458 - 6,358,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,592,437 - 8,602,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,376,325 - 7,386,778 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,379,612 - 7,385,803 (+)NCBI
Celera208,699,290 - 8,709,718 (+)NCBICelera
Cytogenetic Map20p12NCBI
CDKN1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,676,463 - 36,687,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,676,460 - 36,687,397 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,644,240 - 36,655,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,754,465 - 36,763,087 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,754,464 - 36,763,086NCBI
Celera638,201,500 - 38,210,146 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef636,362,600 - 36,373,330 (+)NCBIHuRef
CHM1_1636,645,994 - 36,657,029 (+)NCBICHM1_1
T2T-CHM13v2.0636,497,108 - 36,508,013 (+)NCBIT2T-CHM13v2.0
Cdkn1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,309,953 - 29,319,696 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,309,950 - 29,319,701 (+)EnsemblGRCm39 Ensembl
GRCm381729,090,979 - 29,100,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,090,976 - 29,100,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,227,931 - 29,237,667 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,821,439 - 28,828,386 (+)NCBIMGSCv36mm8
Celera1729,647,617 - 29,657,304 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.12NCBI
Cdkn1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,254,309 - 6,261,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,254,638 - 6,261,278 (-)NCBIChiLan1.0ChiLan1.0
CDKN1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2551,147,920 - 51,156,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1647,017,498 - 47,026,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,241,405 - 36,250,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,436,963 - 37,445,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,436,990 - 37,445,599 (+)Ensemblpanpan1.1panPan2
CDKN1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,746,898 - 5,755,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,745,852 - 5,892,281 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,765,839 - 5,774,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,095,734 - 6,103,965 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1125,750,615 - 5,758,848 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,829,928 - 5,838,160 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,928,229 - 5,936,457 (+)NCBIUU_Cfam_GSD_1.0
Cdkn1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,235,060 - 41,242,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,717,260 - 22,725,182 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647622,717,308 - 22,725,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,354,672 - 32,363,761 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,354,776 - 32,363,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,258,037 - 37,267,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,445,668 - 35,454,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,445,223 - 35,454,342 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,625,094 - 36,634,245 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,108,874 - 21,115,885 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,109,074 - 21,115,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdkn1a
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:535
Count of miRNA genes:238
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000000628
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
PMC316389P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,322 - 7,157,741 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,459 - 6,356,877NCBIRnor6.0
Rnor_5.0208,600,474 - 8,600,892UniSTSRnor5.0
RGSC_v3.4207,384,362 - 7,384,780UniSTSRGSC3.4
Celera208,707,313 - 8,707,731UniSTS
Cytogenetic Map20p12UniSTS
PMC85267P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,148,954 - 7,149,322 (+)MAPPERmRatBN7.2
Rnor_6.0206,348,091 - 6,348,458NCBIRnor6.0
Rnor_5.0208,592,106 - 8,592,473UniSTSRnor5.0
RGSC_v3.4207,375,994 - 7,376,361UniSTSRGSC3.4
Celera208,698,959 - 8,699,326UniSTS
Cytogenetic Map20p12UniSTS
RH130358  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,159,502 - 7,159,702 (+)MAPPERmRatBN7.2
Rnor_6.0206,358,640 - 6,358,839NCBIRnor6.0
Rnor_5.0208,602,655 - 8,602,854UniSTSRnor5.0
RGSC_v3.4207,386,554 - 7,386,753UniSTSRGSC3.4
Celera208,709,494 - 8,709,693UniSTS
Cytogenetic Map20p12UniSTS
PMC85267P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,149,834 - 7,150,254 (+)MAPPERmRatBN7.2
Rnor_6.0206,348,971 - 6,349,390NCBIRnor6.0
Rnor_5.0208,592,986 - 8,593,405UniSTSRnor5.0
RGSC_v3.4207,376,874 - 7,377,293UniSTSRGSC3.4
Celera208,699,825 - 8,700,244UniSTS
Cytogenetic Map20p12UniSTS
PMC114802P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,377 - 7,157,757 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,514 - 6,356,893NCBIRnor6.0
Rnor_5.0208,600,529 - 8,600,908UniSTSRnor5.0
RGSC_v3.4207,384,417 - 7,384,796UniSTSRGSC3.4
Celera208,707,368 - 8,707,747UniSTS
Cytogenetic Map20p12UniSTS
PMC125030P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,376 - 7,157,757 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,513 - 6,356,893NCBIRnor6.0
Rnor_5.0208,600,528 - 8,600,908UniSTSRnor5.0
RGSC_v3.4207,384,416 - 7,384,796UniSTSRGSC3.4
Celera208,707,367 - 8,707,747UniSTS
Cytogenetic Map20p12UniSTS
PMC126110P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8207,159,228 - 7,160,014 (+)Marker Load Pipeline
mRatBN7.2207,157,581 - 7,158,367 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,718 - 6,357,503NCBIRnor6.0
Rnor_5.0208,600,733 - 8,601,518UniSTSRnor5.0
RGSC_v3.4207,384,621 - 7,385,406UniSTSRGSC3.4
Celera208,707,572 - 8,708,357UniSTS
Cytogenetic Map20p12UniSTS
PMC149170P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,407 - 7,158,435 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,544 - 6,357,571NCBIRnor6.0
Rnor_5.0208,600,559 - 8,601,586UniSTSRnor5.0
RGSC_v3.4207,384,447 - 7,385,474UniSTSRGSC3.4
Celera208,707,398 - 8,708,425UniSTS
Cytogenetic Map20p12UniSTS
PMC307617P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,157,452 - 7,157,669 (+)MAPPERmRatBN7.2
Rnor_6.0206,356,589 - 6,356,805NCBIRnor6.0
Rnor_5.0208,600,604 - 8,600,820UniSTSRnor5.0
RGSC_v3.4207,384,492 - 7,384,708UniSTSRGSC3.4
Celera208,707,443 - 8,707,659UniSTS
Cytogenetic Map20p12UniSTS


Related Rat Strains
The following Strains have been annotated to Cdkn1a
ACI.BUF-(D20Img2-Cdkn1a)/Ncc     BUF.ACI-(D20Img2-Cdkn1a)/Ncc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001434559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB218281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB218282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB218283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U24172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U24174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000628   ⟹   ENSRNOP00000000628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,356,423 - 6,358,864 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091731   ⟹   ENSRNOP00000072242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)Ensembl
Rnor_6.0 Ensembl206,351,458 - 6,357,756 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101862   ⟹   ENSRNOP00000084354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,152,331 - 7,158,686 (+)Ensembl
RefSeq Acc Id: NM_080782   ⟹   NP_542960
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,150,932 - 7,161,373 (+)NCBI
mRatBN7.2207,149,286 - 7,159,727 (+)NCBI
Rnor_6.0206,348,422 - 6,358,864 (+)NCBI
Rnor_5.0208,592,437 - 8,602,879 (+)NCBI
RGSC_v3.4207,376,325 - 7,386,778 (+)RGD
Celera208,699,290 - 8,709,718 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256128   ⟹   XP_006256190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,153,768 - 7,161,373 (+)NCBI
mRatBN7.2207,152,255 - 7,159,727 (+)NCBI
Rnor_6.0206,351,439 - 6,358,864 (+)NCBI
Rnor_5.0208,592,437 - 8,602,879 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098379   ⟹   XP_038954307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,150,820 - 7,161,373 (+)NCBI
mRatBN7.2207,149,177 - 7,159,727 (+)NCBI
RefSeq Acc Id: XM_039098380   ⟹   XP_038954308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,153,977 - 7,161,373 (+)NCBI
mRatBN7.2207,152,416 - 7,159,727 (+)NCBI
RefSeq Acc Id: NP_542960   ⟸   NM_080782
- UniProtKB: Q64315 (UniProtKB/TrEMBL),   A6JJT7 (UniProtKB/TrEMBL),   A0A8I5ZZ18 (UniProtKB/TrEMBL),   A0A0G2K2H2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256190   ⟸   XM_006256128
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000000628   ⟸   ENSRNOT00000000628
Ensembl Acc Id: ENSRNOP00000072242   ⟸   ENSRNOT00000091731
RefSeq Acc Id: XP_038954307   ⟸   XM_039098379
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954308   ⟸   XM_039098380
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000084354   ⟸   ENSRNOT00000101862
Protein Domains
Cyclin-dependent kinase inhibitor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64315-F1-model_v2 AlphaFold Q64315 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701440
Promoter ID:EPDNEW_R11964
Type:single initiation site
Name:Cdkn1a_1
Description:cyclin-dependent kinase inhibitor 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0206,351,461 - 6,351,521EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69328 AgrOrtholog
BioCyc Gene G2FUF-4391 BioCyc
Ensembl Genes ENSRNOG00000000521 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091731 ENTREZGENE
  ENSRNOT00000091731.2 UniProtKB/TrEMBL
  ENSRNOT00000101862.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.365.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7938247 IMAGE-MGC_LOAD
InterPro CDI UniProtKB/TrEMBL
  CDI_dom_sf UniProtKB/TrEMBL
  CDKN1A_vertebrate UniProtKB/TrEMBL
KEGG Report rno:114851 UniProtKB/TrEMBL
MGC_CLONE MGC:124547 IMAGE-MGC_LOAD
NCBI Gene 114851 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 1 UniProtKB/TrEMBL
  PTHR46778 UniProtKB/TrEMBL
Pfam CDI UniProtKB/TrEMBL
PharmGKB CDKN1A RGD
PhenoGen Cdkn1a PhenoGen
RatGTEx ENSRNOG00000000521 RatGTEx
TIGR TC221101
UniProt A0A0G2K2H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ18 ENTREZGENE, UniProtKB/TrEMBL
  A6JJT7 ENTREZGENE
  Q2WFZ6_RAT UniProtKB/TrEMBL
  Q64315 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6JJT7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Cdkn1a  cyclin-dependent kinase inhibitor 1A  Cdkn1a  cyclin-dependent kinase inhibitor 1A (p21, Cip1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Cdkn1a  cyclin-dependent kinase inhibitor 1A (p21, Cip1)  Cdkn1a  cyclin-dependent kinase inhibitor 1A   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cdkn1a  cyclin-dependent kinase inhibitor 1A       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains upstream promoter region contains conserved p53-binding sites, shared by rat, human and mouse 68871
gene_domains upstream promoter region contains conserved p53-binding sites, shared by rat, human and mouse 68872
gene_function inhibits the activity of cyclin-CDK complexes 68871
gene_function inhibits the activity of cyclin-CDK complexes 68872
gene_process may play a role in cell senescence and in neoplasia 68871
gene_process may play a role in cell senescence and in neoplasia 68872
gene_process involved in glucocorticoid mediated lung development 1299184
gene_product member of the cell cycle regulator family