Smad7 (SMAD family member 7) - Rat Genome Database

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Gene: Smad7 (SMAD family member 7) Rattus norvegicus
Analyze
Symbol: Smad7
Name: SMAD family member 7
RGD ID: 69314
Description: Enables ubiquitin protein ligase binding activity. Involved in intracellular signal transduction; negative regulation of DNA-templated transcription; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including adherens junction; centrosome; and nuclear lumen. Predicted to be part of heteromeric SMAD protein complex. Predicted to be active in plasma membrane. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAD (mothers against decapentaplegic Drosophila) homolog 7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 7; MAD homolog 7 (Drosophila); Madh7; mothers against decapentaplegic homolog 7; mothers against DPP homolog 7; SMAD 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81871,263,508 - 71,291,849 (+)NCBIGRCr8
mRatBN7.21868,988,429 - 69,016,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,988,429 - 69,016,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,094,956 - 71,123,284 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01871,764,762 - 71,793,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01869,620,987 - 69,649,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01871,395,830 - 71,424,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1871,395,830 - 71,424,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,530,559 - 70,558,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41872,294,803 - 72,323,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11872,368,075 - 72,396,625 (+)NCBI
Celera1867,155,575 - 67,183,461 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-Methoxynobiletin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
antigen  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carvedilol  (EXP)
chlordecone  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
imidacloprid  (EXP)
indometacin  (ISO)
inulin  (ISO)
isobutyl nitrite  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
nitrofen  (ISO)
octreotide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pasireotide  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perindopril  (EXP)
picrotoxin  (EXP)
pirfenidone  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rebaudioside A  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction assembly  (IEA,ISO)
anatomical structure morphogenesis  (IBA)
artery morphogenesis  (IEA,ISO)
cell differentiation  (IBA)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
intracellular signal transduction  (IDA)
negative regulation of activin receptor signaling pathway  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of chondrocyte proliferation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEP)
negative regulation of ossification  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (IEA,ISO)
negative regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of SMAD protein signal transduction  (IEA,ISO)
negative regulation of T cell cytokine production  (IEA,ISO)
negative regulation of T-helper 17 cell differentiation  (IEA,ISO)
negative regulation of T-helper 17 type immune response  (ISO)
negative regulation of transcription by competitive promoter binding  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of cell-cell adhesion  (IEA,ISO)
positive regulation of chondrocyte hypertrophy  (IEA,ISO)
protein stabilization  (IEA,ISO)
protein-containing complex localization  (IEA,ISO)
regulation of cardiac muscle contraction  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial to mesenchymal transition  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transforming growth factor beta receptor signaling pathway  (IDA)
response to laminar fluid shear stress  (IEA,ISO)
SMAD protein signal transduction  (IBA)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,ISO)
ureteric bud development  (IEA,ISO)
ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. Asano Y, etal., J Clin Invest. 2004 Jan;113(2):253-64.
2. Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Dowdy SC, etal., Gynecol Oncol. 2005 Feb;96(2):368-73.
3. Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma. Feng T, etal., Clin Sci (Lond). 2015 Jun;128(11):761-74. doi: 10.1042/CS20140606.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Smad7 is induced by norepinephrine and protects rat hepatocytes from activin A-induced growth inhibition. Kanamaru C, etal., J Biol Chem 2001 Dec 7;276(49):45636-41.
7. The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Kleeff J, etal., Oncogene. 1999 Sep 23;18(39):5363-72. doi: 10.1038/sj.onc.1202909.
8. Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis. Liu FY, etal., Am J Nephrol. 2007;27(2):176-83. Epub 2007 Mar 7.
9. Phosphorylation regulation of the interaction between Smad7 and activin type I receptor. Liu X, etal., FEBS Lett 2002 May 22;519(1-3):93-8.
10. TGFbeta in Cancer. Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Morty RE, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells. Okado T, etal., Kidney Int 2002 Oct;62(4):1178-86.
15. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats. Park do Y, etal., J Korean Med Sci 2003 Aug;18(4):510-9.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
24. Genomic locus and promoter region of rat Smad7, an important antagonist of TGFbeta signaling. Stopa M, etal., Mamm Genome 2000 Feb;11(2):169-76.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Localization of Smad6 and Smad7 in the rat kidney and their regulated expression in the anti-Thy-1 nephritis. Uchida K, etal., Mol Cell Biol Res Commun. 2000 Aug;4(2):98-105.
27. Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart. Wang B, etal., Am J Physiol Heart Circ Physiol 2002 May;282(5):H1685-96.
28. Mutation analysis of the Smad6 and Smad7 gene in human ovarian cancers. Wang D, etal., Int J Oncol. 2000 Dec;17(6):1087-91.
29. Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Wang H, etal., Oncogene. 2008 Nov 20;27(54):6791-805. doi: 10.1038/onc.2008.291. Epub 2008 Sep 1.
Additional References at PubMed
PMID:9256479   PMID:11181520   PMID:11278251   PMID:11557747   PMID:12151385   PMID:12668667   PMID:14559231   PMID:14656760   PMID:15743788   PMID:16266486   PMID:16278212   PMID:16297324  
PMID:16380081   PMID:16601693   PMID:16720724   PMID:16931807   PMID:17437042   PMID:17438144   PMID:17541159   PMID:17634402   PMID:17704451   PMID:17723189   PMID:17855642   PMID:17928287  
PMID:18095586   PMID:18395914   PMID:18593713   PMID:18952608   PMID:18988920   PMID:19197123   PMID:19349682   PMID:19796622   PMID:19850029   PMID:20182310   PMID:20386537   PMID:20439489  
PMID:20943464   PMID:21049555   PMID:21144460   PMID:21429339   PMID:21505983   PMID:21718693   PMID:22338217   PMID:23595375   PMID:23610558   PMID:23661026   PMID:23959527   PMID:24211420  
PMID:24577865   PMID:24887517   PMID:24941323   PMID:25642768   PMID:25811233   PMID:25915722   PMID:26256678   PMID:26415649   PMID:26463627   PMID:26807862   PMID:26954391   PMID:27633729  
PMID:28440490   PMID:28473352   PMID:28731181   PMID:28929107   PMID:28988741   PMID:29199336   PMID:29484378   PMID:29503843   PMID:31710102   PMID:33867340   PMID:34709507   PMID:34951337  
PMID:35611880   PMID:35795857   PMID:37976598   PMID:38654161  


Genomics

Comparative Map Data
Smad7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81871,263,508 - 71,291,849 (+)NCBIGRCr8
mRatBN7.21868,988,429 - 69,016,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,988,429 - 69,016,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,094,956 - 71,123,284 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01871,764,762 - 71,793,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01869,620,987 - 69,649,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01871,395,830 - 71,424,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1871,395,830 - 71,424,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,530,559 - 70,558,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41872,294,803 - 72,323,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11872,368,075 - 72,396,625 (+)NCBI
Celera1867,155,575 - 67,183,461 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
SMAD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381848,919,853 - 48,950,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1848,919,853 - 48,950,965 (-)EnsemblGRCh38hg38GRCh38
GRCh371846,446,223 - 46,477,335 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361844,700,221 - 44,731,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 341844,700,221 - 44,731,079NCBI
Celera1843,299,268 - 43,330,141 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1843,299,249 - 43,329,936 (-)NCBIHuRef
CHM1_11846,441,162 - 46,472,026 (-)NCBICHM1_1
T2T-CHM13v2.01849,115,112 - 49,146,228 (-)NCBIT2T-CHM13v2.0
Smad7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391875,500,436 - 75,529,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1875,500,600 - 75,529,006 (+)EnsemblGRCm39 Ensembl
GRCm381875,367,365 - 75,395,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1875,367,529 - 75,395,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv371875,527,019 - 75,555,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361875,492,894 - 75,521,292 (+)NCBIMGSCv36mm8
Celera1876,602,062 - 76,630,688 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1851.06NCBI
Smad7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540234,028,063 - 34,058,291 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540234,028,184 - 34,058,949 (-)NCBIChiLan1.0ChiLan1.0
SMAD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21766,454,709 - 66,485,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11852,147,312 - 52,178,129 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01842,306,324 - 42,337,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11845,659,375 - 45,689,505 (-)NCBIpanpan1.1PanPan1.1panPan2
SMAD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1779,706,485 - 79,734,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl779,706,705 - 79,734,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha779,113,271 - 79,142,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0779,776,182 - 79,805,641 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl779,776,387 - 79,805,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1779,490,141 - 79,519,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0779,520,644 - 79,548,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0779,805,995 - 79,834,706 (+)NCBIUU_Cfam_GSD_1.0
Smad7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494438,655,545 - 38,682,943 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649713,894,580 - 13,922,065 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649713,894,586 - 13,921,978 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl198,514,267 - 98,542,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1198,512,800 - 98,543,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21108,087,677 - 108,118,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11831,993,543 - 32,024,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1831,993,681 - 32,024,850 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660506,227,954 - 6,258,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477812,415,282 - 12,444,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477812,415,364 - 12,444,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smad7
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:611
Count of miRNA genes:283
Interacting mature miRNAs:370
Transcripts:ENSRNOT00000024831
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat

Markers in Region
Smad7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21868,990,319 - 68,991,828 (+)MAPPERmRatBN7.2
Rnor_6.01871,397,721 - 71,399,229NCBIRnor6.0
Rnor_5.01870,532,450 - 70,533,958UniSTSRnor5.0
RGSC_v3.41872,296,695 - 72,298,203UniSTSRGSC3.4
Celera1867,157,237 - 67,158,745UniSTS
Cytogenetic Map18q12.3UniSTS
PMC193708P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21868,991,590 - 68,991,694 (+)MAPPERmRatBN7.2
Rnor_6.01871,398,992 - 71,399,095NCBIRnor6.0
Rnor_5.01870,533,721 - 70,533,824UniSTSRnor5.0
RGSC_v3.41872,297,966 - 72,298,069UniSTSRGSC3.4
Celera1867,158,508 - 67,158,611UniSTS
Cytogenetic Map18q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 13 5 10 5 18 33 31 11
Low 14 44 36 9 36 8 11 56 2 10 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000024831   ⟹   ENSRNOP00000024831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1868,988,429 - 69,016,765 (+)Ensembl
Rnor_6.0 Ensembl1871,395,830 - 71,424,157 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113860   ⟹   ENSRNOP00000081374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1868,989,851 - 69,016,765 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115038   ⟹   ENSRNOP00000082401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1868,990,974 - 69,016,765 (+)Ensembl
RefSeq Acc Id: NM_030858   ⟹   NP_110485
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81871,263,508 - 71,291,844 (+)NCBI
mRatBN7.21868,988,429 - 69,016,769 (+)NCBI
Rnor_6.01871,395,830 - 71,424,159 (+)NCBI
Rnor_5.01870,530,559 - 70,558,932 (+)NCBI
RGSC_v3.41872,294,803 - 72,323,354 (+)RGD
Celera1867,155,575 - 67,183,461 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254959   ⟹   XP_006255021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81871,264,930 - 71,291,849 (+)NCBI
mRatBN7.21868,989,821 - 69,016,774 (+)NCBI
Rnor_6.01871,396,777 - 71,424,164 (+)NCBI
Rnor_5.01870,530,559 - 70,558,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097138   ⟹   XP_038953066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81871,272,271 - 71,291,849 (+)NCBI
mRatBN7.21868,997,195 - 69,016,774 (+)NCBI
RefSeq Acc Id: NP_110485   ⟸   NM_030858
- UniProtKB: Q9QUG1 (UniProtKB/Swiss-Prot),   O88406 (UniProtKB/Swiss-Prot),   A0A0G2JSQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255021   ⟸   XM_006254959
- Peptide Label: isoform X1
- UniProtKB: Q9QUG1 (UniProtKB/Swiss-Prot),   O88406 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024831   ⟸   ENSRNOT00000024831
RefSeq Acc Id: XP_038953066   ⟸   XM_039097138
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000081374   ⟸   ENSRNOT00000113860
RefSeq Acc Id: ENSRNOP00000082401   ⟸   ENSRNOT00000115038
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88406-F1-model_v2 AlphaFold O88406 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69314 AgrOrtholog
BioCyc Gene G2FUF-6983 BioCyc
Ensembl Genes ENSRNOG00000018359 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024831 ENTREZGENE
  ENSRNOT00000024831.5 UniProtKB/TrEMBL
  ENSRNOT00000113860.1 UniProtKB/TrEMBL
  ENSRNOT00000115038.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81516 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81516 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad7 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018359 RatGTEx
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218914
UniProt A0A0G2JSQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRU4_RAT UniProtKB/TrEMBL
  A0A8I5ZXV4_RAT UniProtKB/TrEMBL
  O88406 ENTREZGENE
  Q9QUG1 ENTREZGENE
  SMAD7_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QUG1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad7  SMAD family member 7  Smad7  MAD homolog 7 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-05-18 Smad7    Madh7  MAD homolog 7 (Drosophila)  Symbol updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Madh7  MAD homolog 7 (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mediates the pathogenesis of cardiac fibrosis in the post-postmyocardial infarct (MI) heart 625758
gene_expression expressed in anterior pituitary cells 70231
gene_expression expressed in anterior pituitary cells 625758
gene_function forms protein complexes 68665
gene_function activates caspase-3 to induce apoptosis 727429
gene_physical_interaction directly associates with activin type I receptor (ALK-4) 729221
gene_process negatively modulates activin/TGFb signaling pathway 68665
gene_process inhibits expression of fibrillar collagen genes in cultured primary cardiac fibroblasts 625758
gene_regulation can be induced by TGF-beta and activin A 70231
gene_regulation can be induced by TGF-beta and activin A 625758
gene_regulation additive increase in expression caused by activin A and TGFb1 in anterior pituitary whereas inhibition occurs with follistatin 70231
gene_regulation additive increase in expression caused by activin A and TGFb1 in anterior pituitary whereas inhibition occurs with follistatin 625758
gene_regulation expression rapidly increased by norepinephrine (NE) through NF-kB activation 70231
gene_regulation expression is induced by TGF-b1 in several cell types, including primary cardiac fibroblasts 625758