Fabp4 (fatty acid binding protein 4) - Rat Genome Database

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Gene: Fabp4 (fatty acid binding protein 4) Rattus norvegicus
Analyze
Symbol: Fabp4
Name: fatty acid binding protein 4
RGD ID: 69309
Description: Predicted to enable hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including fatty acid metabolic process; response to glucocorticoid; and response to gravity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Biomarker of impotence and muscular atrophy. Orthologous to human FABP4 (fatty acid binding protein 4); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 1,2-dimethylhydrazine; 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-FABP; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; AFABP; Albp; aP2; fatty acid binding protein 4 adipocyte; fatty acid binding protein 4, adipocyte; fatty acid-binding protein 4; fatty acid-binding protein, adipocyte
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bw131
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,488,251 - 93,492,961 (+)NCBIGRCr8
mRatBN7.2291,580,879 - 91,585,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,580,885 - 91,585,578 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx298,071,495 - 98,075,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,192,481 - 96,196,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,249,333 - 91,253,689 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,792,666 - 93,797,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,792,601 - 93,797,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02113,547,703 - 113,552,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4293,536,133 - 93,540,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1293,481,094 - 93,485,696 (+)NCBI
Celera287,183,534 - 87,187,814 (+)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6alpha-methylprednisolone  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (EXP,ISO)
AL 8810  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (ISO)
anthracen-2-amine  (EXP)
antimony(0)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
baicalein  (ISO)
barium sulfate  (EXP)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (ISO)
Benzyl parahydroxybenzoate  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bismuth atom  (ISO)
bismuthane  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (EXP,ISO)
celastrol  (ISO)
ceric oxide  (EXP)
chitosan  (EXP)
chlordecone  (ISO)
chlormequat chloride  (EXP)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP)
Citreoviridin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroresveratrol  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP,ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
equilin  (ISO)
ethanol  (EXP,ISO)
ethyl 3,4-dihydroxybenzoate  (ISO)
ethylparaben  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fipronil  (ISO)
fluprostenol  (ISO)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gadobutrol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Re  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (ISO)
graphite  (EXP)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
harmine  (ISO)
hesperetin  (ISO)
hydrazines  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
insulin  (ISO)
inulin  (ISO)
iopamidol  (ISO)
isoliquiritigenin  (ISO)
isonicotinamide  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
Licarin A  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
loliolide  (ISO)
LY294002  (ISO)
melatonin  (ISO)
Melengestrol acetate  (ISO)
Mesaconitine  (EXP)
methotrexate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nicotinic acid  (ISO)
nitrofen  (EXP)
norethisterone  (ISO)
norgestrel  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
octocrylene  (ISO)
oleic acid  (ISO)
osthole  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenacetin  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
Phenylamil  (ISO)
phenylephrine  (EXP)
phenylhydrazine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
prallethrin  (ISO)
prednisone  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propylparaben  (ISO)
prostaglandin D2  (ISO)
prostaglandin F2alpha  (ISO)
pyocyanine  (ISO)
quartz  (EXP)
quinoxyfen  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
Ro 41-5253  (ISO)
rofecoxib  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
spironolactone  (ISO)
splitomicin  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (EXP)
Thiocarbohydrazide  (ISO)
titanium dioxide  (ISO)
tolylfluanid  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triamcinolone  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin D  (ISO)
Y-27632  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Proliferation and differentiation of osteoblasts and adipocytes in rat bone marrow stromal cell cultures: effects of dexamethasone and calcitriol. Atmani H, etal., J Cell Biochem. 2003 May 15;89(2):364-72.
2. Fatty acid uptake in diabetic rat adipocytes. Fraser H, etal., Mol Cell Biochem. 1997 Feb;167(1-2):51-60.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Hotamisligil GS, etal., Science 1996 Nov 22;274(5291):1377-9.
6. Microarray analysis of gene expression profile in the corpus cavernosum of hypercholesterolemic rats after chronic treatment with PDE5 inhibitor. Jung HG, etal., Life Sci. 2007 Jan 23;80(7):699-708. Epub 2006 Nov 29.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Mechanism by which a novel non-thiazolidinedione peroxisome proliferator-activated receptor gamma agonist, FK614, ameliorates insulin resistance in Zucker fatty rats. Minoura H, etal., Diabetes Obes Metab. 2007 May;9(3):369-78.
9. Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity. Ogino T, etal., Mamm Genome 2003 Dec;14(12):839-44.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Transfection of L6 myoblasts with adipocyte fatty acid-binding protein cDNA does not affect fatty acid uptake but disturbs lipid metabolism and fusion. Prinsen CF and Veerkamp JH, Biochem J 1998 Jan 15;329 ( Pt 2):265-73.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Shangguan X, etal., Clin Chim Acta. 2009 Sep;407(1-2):58-61. doi: 10.1016/j.cca.2009.06.031. Epub 2009 Jun 29.
15. Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein. Shen WJ, etal., Proc Natl Acad Sci U S A 1999 May 11;96(10):5528-32.
16. Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome? Stejskal D and Karpisek M, Eur J Clin Invest. 2006 Sep;36(9):621-5.
17. Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. Syamsunarno MR, etal., PLoS One. 2014 Mar 6;9(6):e90825. doi: 10.1371/journal.pone.0090825. eCollection 2014.
18. Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight. Taylor WE, etal., J Gravit Physiol. 2002 Dec;9(2):61-70.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
Additional References at PubMed
PMID:1618860   PMID:9880671   PMID:11382783   PMID:12077340   PMID:12477932   PMID:15673614   PMID:15684432   PMID:17516629   PMID:17761196   PMID:18492766   PMID:19144635   PMID:19408657  
PMID:19608978   PMID:22262466   PMID:22808905   PMID:23012479   PMID:23533145   PMID:27697222   PMID:28405802   PMID:29849871   PMID:30904493   PMID:35297679   PMID:35357467  


Genomics

Comparative Map Data
Fabp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,488,251 - 93,492,961 (+)NCBIGRCr8
mRatBN7.2291,580,879 - 91,585,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,580,885 - 91,585,578 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx298,071,495 - 98,075,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,192,481 - 96,196,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,249,333 - 91,253,689 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,792,666 - 93,797,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,792,601 - 93,797,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02113,547,703 - 113,552,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4293,536,133 - 93,540,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1293,481,094 - 93,485,696 (+)NCBI
Celera287,183,534 - 87,187,814 (+)NCBICelera
Cytogenetic Map2q23NCBI
FABP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38881,478,419 - 81,483,233 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl881,478,419 - 81,483,236 (-)EnsemblGRCh38hg38GRCh38
GRCh37882,390,654 - 82,395,468 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,553,481 - 82,558,004 (-)NCBINCBI36Build 36hg18NCBI36
Build 34882,553,480 - 82,558,004NCBI
Celera878,395,692 - 78,400,433 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef877,880,663 - 77,885,404 (-)NCBIHuRef
CHM1_1882,442,333 - 82,447,074 (-)NCBICHM1_1
T2T-CHM13v2.0881,910,018 - 81,914,832 (-)NCBIT2T-CHM13v2.0
Fabp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39310,269,406 - 10,273,653 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl310,269,148 - 10,273,636 (-)EnsemblGRCm39 Ensembl
GRCm38310,204,342 - 10,208,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl310,204,088 - 10,208,576 (-)EnsemblGRCm38mm10GRCm38
MGSCv37310,204,342 - 10,208,576 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36310,186,879 - 10,191,086 (-)NCBIMGSCv36mm8
Celera310,234,558 - 10,238,773 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.56NCBI
Fabp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955444141,840 - 148,467 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955444141,955 - 146,279 (+)NCBIChiLan1.0ChiLan1.0
FABP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2797,216,084 - 97,221,109 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1872,843,910 - 72,848,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0878,001,476 - 78,006,006 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1879,624,899 - 79,629,442 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl879,624,899 - 79,630,168 (-)Ensemblpanpan1.1panPan2
FABP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12928,651,550 - 28,656,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2928,652,146 - 28,656,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2928,930,953 - 28,935,672 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02928,782,981 - 28,787,700 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2928,782,960 - 28,787,677 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12928,853,143 - 28,857,859 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02928,866,783 - 28,871,503 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02929,223,638 - 29,228,357 (-)NCBIUU_Cfam_GSD_1.0
Fabp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530350,532,455 - 50,536,868 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366562,722,713 - 2,729,046 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366562,722,970 - 2,727,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl455,096,404 - 55,101,896 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1455,096,400 - 55,101,209 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FABP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1876,895,516 - 76,900,153 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl876,894,512 - 76,900,212 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603964,295,119 - 64,299,651 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fabp4
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:147
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000014701
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)27478666494359546Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat

Markers in Region
RH128873  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2291,584,169 - 91,585,447 (+)MAPPERmRatBN7.2
Rnor_6.0293,795,912 - 93,797,189NCBIRnor6.0
Rnor_5.02113,550,949 - 113,552,226UniSTSRnor5.0
RGSC_v3.4293,539,379 - 93,540,656UniSTSRGSC3.4
Celera287,186,780 - 87,187,735UniSTS
RH 3.4 Map2569.0UniSTS
Cytogenetic Map2q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 9 3 2
Medium 3 31 39 32 16 32 8 11 31 16 11 8
Low 10 9 9 9 47 4 22
Below cutoff 27 1

Sequence


RefSeq Acc Id: ENSRNOT00000014701   ⟹   ENSRNOP00000014701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl291,580,885 - 91,585,578 (+)Ensembl
Rnor_6.0 Ensembl293,792,601 - 93,797,305 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077311   ⟹   ENSRNOP00000073333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl293,792,664 - 93,797,267 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102431   ⟹   ENSRNOP00000077522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl291,580,898 - 91,585,562 (+)Ensembl
RefSeq Acc Id: NM_053365   ⟹   NP_445817
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,488,273 - 93,492,961 (+)NCBI
mRatBN7.2291,580,879 - 91,585,567 (+)NCBI
Rnor_6.0293,792,666 - 93,797,267 (+)NCBI
Rnor_5.02113,547,703 - 113,552,304 (+)NCBI
RGSC_v3.4293,536,133 - 93,540,734 (+)RGD
Celera287,183,534 - 87,187,814 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282611   ⟹   XP_063138681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,488,251 - 93,492,961 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445817 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB18344 (Get FASTA)   NCBI Sequence Viewer  
  AAD37371 (Get FASTA)   NCBI Sequence Viewer  
  AAH84721 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014701
  ENSRNOP00000014701.5
  ENSRNOP00000077522.1
GenBank Protein P70623 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445817   ⟸   NM_053365
- UniProtKB: P70623 (UniProtKB/Swiss-Prot),   Q5XFV4 (UniProtKB/TrEMBL),   F7FMV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014701   ⟸   ENSRNOT00000014701
RefSeq Acc Id: ENSRNOP00000073333   ⟸   ENSRNOT00000077311
RefSeq Acc Id: ENSRNOP00000077522   ⟸   ENSRNOT00000102431
RefSeq Acc Id: XP_063138681   ⟸   XM_063282611
- Peptide Label: isoform X1
- UniProtKB: P70623 (UniProtKB/Swiss-Prot),   A0A8I5Y7N0 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70623-F1-model_v2 AlphaFold P70623 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691236
Promoter ID:EPDNEW_R1760
Type:single initiation site
Name:Fabp4_1
Description:fatty acid binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0293,792,619 - 93,792,679EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69309 AgrOrtholog
BioCyc Gene G2FUF-53753 BioCyc
Ensembl Genes ENSRNOG00000010805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014701 ENTREZGENE
  ENSRNOT00000014701.8 UniProtKB/TrEMBL
  ENSRNOT00000102431.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7310595 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ILBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79451 UniProtKB/TrEMBL
MGC_CLONE MGC:105374 IMAGE-MGC_LOAD
NCBI Gene 79451 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11955:SF83 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fabp4 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010805 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228687
UniProt A0A8I5Y7N0 ENTREZGENE, UniProtKB/TrEMBL
  F7FMV4 ENTREZGENE, UniProtKB/TrEMBL
  FABP4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XFV4 ENTREZGENE, UniProtKB/TrEMBL
  Q9R290_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Fabp4  fatty acid binding protein 4  Fabp4  fatty acid binding protein 4, adipocyte  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fabp4  fatty acid binding protein 4, adipocyte    fatty acid binding protein 4  Name updated 1299863 APPROVED
2002-06-10 Fabp4  fatty acid binding protein 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds and forms a complex with hormone-sensitive lipase (HSL) 68775